AG Mengji Lu

Hepatitis-B-Virusinfektion

Forschungsschwerpunkte

  • Rolle der innaten Immunantworten in der Kontrolle der Hepatitis-B-Virusinfektion
  • Regulation der HBV-Replikation durch miRNAs und Wirtsfaktoren
  • Immuntherapeutische Ansätze zur Behandlung chronischer HBV-Infektion
  • Tiermodelle für HBV-Forschung
     

Projekt

Weltweit sind ca. 350 Millionen Menschen mit dem chronischen Hepatitis-B-Virus (HBV) infiziert. Die verfügbaren Therapien mit Interferonen und Nukleosidanaloga stoßen jedoch an ihre Grenzen. Ein langfristiges Projekt unserer Gruppe ist die Entwicklung von geeigneten therapeutischen Vakzinen für die Behandlung chronischer HBV-Infektionen. In jüngerer Zeit hat die Rolle der angeborenen Immunantwort für die Kontrolle der HBV-Infektion an Wichtigkeit gewonnen. Unser Interesse ist die gezielte Aktivierung der angeborenen und antiviralen Immunantwort in der Leber. Ein wichtiger Aspekt ist der gegenseitige Einfluss von angeborener und adaptiver Immunantwort in der HBV-Infektion. Darüber hinaus untersuchen wir auch die epigenetische Kontrolle der Zelldifferenzierung sowie Metabolismen und ihre Beziehungen zu HBV-Infektionen.

Arbeitsgruppe

Leiter

Prof. Dr. rer. nat. Mengji Lu
Tel.: +49 (0)201 723 3530
E-Mail: mengji.lu@uni-due.de

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​Thekla Kemper, MTA
Tel.: +49 (0)201 723 3585

 

 

 

 

 

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​Xueyu Wang, M. Med.
Tel.: +49 (0)201 723 3540
E-Mail: xueyu.wang@uni-due.de

 

 

 

 

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​Qian Li, M. Med.
Tel.: +49 (0)201 723 3540
E-Mail: qian.li@uni-due.de

 

 

 

 

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​Shi Liu, M. Med.
Tel.: +49 (0)201 723 3540
E-Mail: shi.liu@uni-due.de

 

 

 

Publikationen

    2025

    Artikel in Zeitschriften

  • Wang, Jun; Xiao, Nan; Zhu, Zhengnong; Qiao, Haiyan; Zhao, Fang; Zhang, Lukun; Gou, Jizhou; Lu, Mengji; He, Yun; Lu, Hongzhou; Li, Qian
    Comparing acute versus AIDS ART initiation on HIV-1 integration sites and clonal expansion
    In: Signal Transduction and Targeted Therapy Jg. 10 (2025) Nr. 1, 23
    Online Volltext: dx.doi.org/ (Open Access)
  • Zhu, Dan; Du, Yanqin; Zhao, Mengxiao; Ablikim, Dilhumare; Huang, Hongming; Pan, Wen; Zeng, Xiaoqing; Xu, Chunli; Lu, Mengji; Sutter, Kathrin; Dittmer, Ulf; Zheng, Xin; Yang, Dongliang; Liu, Jia
    Functional B cell deficiency promotes intrahepatic HBV replication and impairs the development of anti-HBV T cell responses
    In: Hepatology International Jg. 19 (2025) Nr. 1, S. 93 - 105
    Online Volltext: dx.doi.org/
  • Deng, Yingying; Zheng, Jiaxin; Li, Fahong; Zou, Hecun; Tian, Shijun; Zhao, Zhenyu; Zeng, Huaqing; Zhai, Yongzhen; Deng, Wanyu; Zhang, Jiming; Lu, Mengji; Jia, Bei; Lin, Yong
    Hepatocyte-Enriched miRNA-193b-3p Promotes Hepatitis B Virus Replication by Dual Activation of Viral Core Promoter Activity and Autophagy Induction by Targeting IGF-1R
    In: Journal of Medical Virology Jg. 97 (2025) Nr. 4, e70330
    Online Volltext: dx.doi.org/

    • 2024

    Artikel in Zeitschriften

  • Yang, Li; Gong, Ying; Liu, Feifei; Chen, Wuhong; Wang, Xinran; Long, Guozhang; Li, Heng; Xiao, Fuling; Lu, Mengji; Hu, Youhong; Tong, Xiankun; Zuo, Jianping
    A novel phthalazinone derivative as a capsid assembly modulator inhibits hepatitis B virus expression
    In: Antiviral Research Jg. 221 (2024) 105763
    Online Volltext: dx.doi.org/
  • Wang, Jun; Li, Qian; Qiu, Yuanwang; Kitanovski, Simo; Wang, Chen; Zhang, Chenxia; Li, Fahong; Li, Xiaoguang; Zhang, Zhenfeng; Huang, Lihua; Zhang, Jiming; Hoffmann, Daniel; Lu, Mengji; Lu, Hongzhou
    Cell-type-specific expression analysis of liver transcriptomics with clinical parameters to decipher the cause of intrahepatic inflammation in chronic hepatitis B
    In: iMeta Jg. 3 (2024) Nr. 4, e221
    Online Volltext: dx.doi.org/ (Open Access)
  • Li, Qian; Wang, Cheng; Gou, Jizhou; Kitanovski, Simo; Tang, XiangYi; Cai, Yixuan; Zhang, Chenxia; Zhang, Xiling; Zhang, Zhenfeng; Qiu, Yuanwang; Zhao, Fang; Lu, Mengji; He, Yun; Wang, Jun; Lu, Hongzhou
    Deciphering lung granulomas in HIV & TB co-infection : unveiling macrophages aggregation with IL6R/STAT3 activation
    In: Emerging Microbes & Infections Jg. 13 (2024) Nr. 1, 2366359
    Online Volltext: dx.doi.org/ (Open Access)
  • Song, Jingjiao; Sun, Xiliang; Zhou, Yun; Li, Sheng; Wu, Jun; Yang, Lu; Zhou, Di; Yang, Yan; Liu, Anding; Lu, Mengji; Roggendorf, Michael; Qin, Li; Yang, Dongliang
    Early application of IFNγ mediated the persistence of HBV in an HBV mouse model
    In: Antiviral Research Jg. 225 (2024) 105872
    Online Volltext: dx.doi.org/
  • Liang, Yaojie; Luo, Xufeng; Schefczyk, Stefan; Muungani, Lorraine T.; Deng, Hui; Wang, Baoju; Baba, Hideo Andreas; Lu, Mengji; Wedemeyer, Heiner; Schmidt, Hartmut; Bröring, Ruth
    Hepatitis B surface antigen expression impairs endoplasmic reticulum stress-related autophagic flux by decreasing LAMP2
    In: JHEP Reports Jg. 6 (2024) Nr. 4, 101012
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Li, Jia; Lin, Yong; Wang, Xueyu; Lu, Mengji
    Interconnection of cellular autophagy and endosomal vesicle trafficking and its role in hepatitis B virus replication and release
    In: Virologica Sinica Jg. 39 (2024) Nr. 1, S. 24 - 30
    Online Volltext: dx.doi.org/ (Open Access)
  • Xu, Shilei; Deng, Ke-Qiong; Lu, Chengbo; Fu, Xin; Zhu, Qingmei; Wan, Shiqi; Zhang, Lin; Huang, Yu; Nie, Longyu; Cai, Huanhuan; Wang, Qiming; Zeng, Hao; Zhang, Yufeng; Wang, Fubing; Ren, Hong; Chen, Yu; Yan, Huan; Xu, Ke; Zhou, Li; Lu, Mengji; Zhu, Ying; Liu, Shi; Lu, Zhibing
    Interleukin-6 classic and trans-signaling utilize glucose metabolism reprogramming to achieve anti- or pro-inflammatory effects
    In: Metabolism Jg. 155 (2024) 155832
    Online Volltext: dx.doi.org/
  • Ye, Jianyu; Li, Fahong; Hua, Ting; Ma, Kewei; Wang, Jinyu; Zhao, Zixin; Yang, Zhongning; Luo, Chen; Jia, Ruohan; Li, Yaming; Hao, Menghan; Wu, Jian; Lu, Mengji; Yuan, Zhenghong; Zhang, Jiming; Chen, Jieliang
    Liver mechanosignaling as a natural anti-hepatitis B virus mechanism
    In: Nature Communications Jg. 15 (2024) Nr. 1, S. 8375
    Online Volltext: dx.doi.org/ (Open Access)
  • Du, Yanqin; Sun, Hang; Bhattacharjee, Sonakshi; Birkmann, Alexander; Dittmer, Ulf; Lu, Mengji
    TLR9 dependent activation by inactivated parapoxvirus ovis (iPPVO) in murine bone marrow-derived dendritic cells is associated with specific strain-dependent dendritic cell subsets
    In: Journal of Innate Immunity Jg. 16 (2024) Nr. 1, S. 354 - 366
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)

    • 2023

    Artikel in Zeitschriften

  • Wang, Qin; Liu, Yanan; Luo, Jinzhuo; Yang, Shangqing; Wang, Lu; Lu, Yinping; Feng, Xuemei; Yang, Xuecheng; Sutter, Kathrin; Dittmer, Ulf; Lu, Mengji; Zheng, Xin; Yang, Dongliang; Liu, Jia
    A systematic comparison reveals dynamic differences in early adaptive immune responses of acute-resolving versus chronic HBV replication
    In: Journal of Medical Virology Jg. 95 (2023) Nr. 3, e28670
    Online Volltext: dx.doi.org/ (Open Access)
  • Yang, Lu; Zhou, Di; Martin, Kächele; Wu, Jun; Chen, Mingfa; Lu, Mengji; Yang, Dongliang; Protzer, Ulrike; Roggendorf, Michael; Song, Jingjiao
    Aborted infection of human sodium taurocholate cotransporting polypeptide (hNTCP) expressing woodchuck hepatocytes with hepatitis B virus (HBV)
    In: Virus Genes Jg. 59 (2023) S. 823 - 830
    Online Volltext: dx.doi.org/
  • Zhao, Zhenyu; Wei, Zhen; Zheng, Jiaxin; Li, Zhihong; Zou, Hecun; Wen, Xiang; Li, Fahong; Wang, Xueyu; Huang, Qian; Zeng, Huaqing; Fan, Hui; Cai, Xuefei; Zhang, Jiming; Jia, Bei; Huang, Ailong; Lu, Mengji; Lin, Yong
    Hepatitis B virus promotes its own replication by enhancing RAB5A-mediated dual activation of endosomal and autophagic vesicle pathways
    In: Emerging Microbes & Infections Jg. 12 (2023) Nr. 2, 2261556
    Online Volltext: dx.doi.org/ (Open Access)
  • Yu, Jie; Shen, Zhongliang; Chen, Shiqi; Liu, Hongyan; Du, Zunguo; Mao, Richeng; Wang, Jinyu; Zhang, Yongmei; Zhu, Haoxiang; Yang, Sisi; Li, Jing; Wu, Jingwen; Dong, Minhui; Zhu, Mengqi; Huang, Yuxian; Li, Jianhua; Yuan, Zhenghong; Xie, Youhua; Lu, Mengji; Zhang, Jiming
    Inhibition of HBV replication by EVA1A via enhancing cellular degradation of HBV components and its potential therapeutic application
    In: Antiviral Research Jg. 216 (2023) 105643
    Online Volltext: dx.doi.org/
  • Zheng, Jiaxin; Deng, Yingying; Wei, Zhen; Zou, Hecun; Wen, Xiang; Cai, Jia; Zhang, Shujun; Jia, Bei; Lu, Mengji; Lu, Kefeng; Lin, Yong
    Lipid phosphatase SAC1 suppresses hepatitis B virus replication through promoting autophagic degradation of virions
    In: Antiviral Research Jg. 213 (2023) 105601
    Online Volltext: dx.doi.org/ (Open Access)
  • He, Qiao-qiao; Huang, Yu; Nie, Longyu; Ren, Sheng; Xu, Gang; Deng, Feiyan; Cheng, Zhikui; Zuo, Qi; Zhang, Lin; Cai, Huanhuan; Wang, Qiming; Wang, Fubing; Ren, Hong; Yan, Huan; Xu, Ke; Zhou, Li; Lu, Mengji; Lu, Zhibing; Zhu, Ying; Liu, Shi
    MAVS integrates glucose metabolism and RIG-I-like receptor signaling
    In: Nature Communications Jg. 14 (2023) Nr. 1, 5343
    Online Volltext: dx.doi.org/ (Open Access)
  • Westmeier, Jaana; Brochtrup, Annika; Paniskaki, Krystallenia; Karakoese, Zehra; Werner, Tanja; Sutter, Kathrin; Dolff, Sebastian; Limmer, Andreas; Mittermüller, Daniela; Liu, Jia; Zheng, Xin; Koval, Tetiana; Kaidashev, Igor; Berger, Marc Moritz; Herbstreit, Frank; Brenner, Thorsten; Witzke, Oliver; Trilling, Mirko; Lu, Mengji; Yang, Dongliang; Babel, Nina; Westhoff, Timm; Dittmer, Ulf; Zelinskyy, Gennadiy
    Macrophage migration inhibitory factor receptor CD74 expression is associated with expansion and differentiation of effector T cells in COVID-19 patients
    In: Frontiers in Immunology Jg. 14 (2023) 1236374
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Wang, Jinyu; Zhang, Xueyun; Han, Jiajia; Zhou, Pu; Yu, Xueping; Shen, Zhongliang; Mao, Richeng; Lu, Mengji; Huang, Yuxian; Zhang, Jiming
    MicroRNA-124 expression in Kupffer cells modulates liver injury by targeting IL-6/STAT3 signaling
    In: Antiviral Research Jg. 211 (2023) 105510
    Online Volltext: dx.doi.org/
  • Xie, Zhanglian; Shen, Sheng; Huang, Kuiyuan; Wang, Weibin; Liu, Ziying; Zhang, Haixing; Lu, Mengji; Sun, Jian; Hou, Jinlin; Liu, Hongyan; Guo, Haitao; Zhang, Xiaoyong
    Mitochondrial HIGD1A inhibits hepatitis B virus transcription and replication through the cellular PNKD-NF-κB-NR2F1 nexus
    In: Journal of Medical Virology Jg. 95 (2023) Nr. 4, e28749
    Online Volltext: dx.doi.org/
  • Luo, Xufeng; Zhang, Rui; Schefczyk, Stefan; Liang, Yaojie; Lin, Shu S.; Liu, Shi; Baba, Hideo Andreas; Lange, Christian M.; Wedemeyer, Heiner; Lu, Mengji; Bröring, Ruth
    Nuclear translocation of YAP drives BMI1-associated hepatocarcinogenesis in hepatitis B virus infection
    In: Liver International Jg. 43 (2023) Nr. 9, S. 2002 - 2016
    Online Volltext: dx.doi.org/ (Open Access)
  • Schefczyk, Stefan; Luo, Xufeng; Liang, Yaojie; Trippler, Martin; Lu, Mengji; Wedemeyer, Heiner; Schmidt, Hartmut; Bröring, Ruth
    Poly(I:C) Induces Distinct Liver Cell Type-Specific Responses in Hepatitis B Virus-Transgenic Mice In Vitro, but Fails to Induce These Signals In Vivo
    In: Viruses Jg. 15 (2023) Nr. 5, 1203
    Online Volltext: dx.doi.org/ (Open Access)
  • Li, Ziwei; Xiang, Tiandan; Liang, Boyun; Liu, Jing; Deng, Hui; Yang, Xuecheng; Wang, Hua; Feng, Xuemei; Zelinskyy, Gennadiy; Trilling, Mirko; Sutter, Kathrin; Lu, Mengji; Dittmer, Ulf; Wang, Baoju; Yang, Dongliang; Zheng, Xin; Liu, Jia
    SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infection
    In: Virologica Sinica Jg. 38 (2023) Nr. 4, S. 606 - 619
    Online Volltext: dx.doi.org/ (Open Access)
  • Karakoese, Zehra; Le-Trilling, Vu Thuy Khanh; Schuhenn, Jonas; Francois, Sandra; Lu, Mengji; Liu, Jia; Trilling, Mirko; Hoffmann, Daniel; Dittmer, Ulf; Sutter, Kathrin
    Targeted mutations in IFNα2 improve its antiviral activity against various viruses
    In: mBio Jg. 14 (2023) Nr. 6, e02357-23
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Schefczyk, Stefan; Luo, Xufeng; Liang, Yaojie; Hasenberg, Mike; Walkenfort, Bernd; Trippler, Martin; Schuhenn, Jonas; Sutter, Kathrin; Lu, Mengji; Wedemeyer, Heiner; Schmidt, Hartmut H.; Broering, Ruth
    Tg1.4HBV-s-rec mice, a crossbred hepatitis B virus-transgenic model, develop mild hepatitis
    In: Scientific Reports Jg. 13 (2023) Nr. 1, 22829
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)

    • 2022

    Artikel in Zeitschriften

  • Zhang, Yue; Yan, Hu; Li, Xian; Zhou, Dihan; Zhong, Maohua; Yang, Jingyi; Zhao, Bali; Fan, Xuxu; Fan, Jun; Shu, Jiayi; Lu, Mengji; Jin, Xia; Zhang, Ejuan; Yan, Huimin
    A high-dose inoculum size results in persistent viral infection and arthritis in mice infected with chikungunya virus
    In: PLoS Neglected Tropical Diseases Jg. 16 (2022) Nr. 1, e0010149
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Wang, Xueyu; Wei, Zhiqiang; Lan, Tingyu; He, Yulin; Cheng, Bin; Li, Ruimin; Chen, Hongxia; Li, Fahong; Liu, Guohua; Jiang, Bin; Lin, Yong; Lu, Mengji; Meng, Zhongji
    CCDC88A/GIV promotes HBV replication and progeny secretion via enhancing endosomal trafficking and blocking autophagic degradation
    In: Autophagy Jg. 18 (2022) Nr. 2, S. 357 - 374
    Online Volltext: dx.doi.org/ (Open Access)
  • Zheng, Jiaxin; Deng, Yingying; Zhao, Zhenyu; Mao, Binli; Lu, Mengji; Lin, Yong; Huang, Ailong
    Characterization of SARS-CoV-2-specific humoral immunity and its potential applications and therapeutic prospects
    In: Cellular & Molecular Immunology Jg. 19 (2022) Nr. 2, S. 150 - 157
    Online Volltext: dx.doi.org/ (Open Access)
  • Zhang, Ejuan; Ma, Zhiyong; Lu, Mengji
    Contribution of T- and B-cell intrinsic toll-like receptors to the adaptive immune response in viral infectious diseases
    In: Cellular and Molecular Life Sciences - CMLS Jg. 79 (2022) Nr. 11, 547
    Online Volltext: dx.doi.org/ (Open Access)
  • Wang, Xueyu; Wei, Zhiqiang; Cheng, Bin; Li, Jia; He, Yulin; Lan, Tingyu; Kemper, Thekla; Lin, Yong; Jiang, Bin; Jiang, Yongfang; Meng, Zhongji; Lu, Mengji
    Endoplasmic reticulum stress promotes HBV production by enhancing use of the autophagosome/multivesicular body axis
    In: Hepatology Jg. 75 (2022) Nr. 2, S. 438 - 454
    Online Volltext: dx.doi.org/ (Open Access)
  • Liu, Shuhui; Zhao, Kaitao; Su, Xi; Gao, Xiaoxiao; Yao, Yongxuan; Kong, Ranran; Wang, Yun; Wu, Chunchen; Lu, Mengji; Chen, Xinwen; Pei, Rongjuan
    Enhanced host immune responses in presence of HCV facilitate HBV clearance in coinfection
    In: Virologica Sinica Jg. 37 (2022) Nr. 3, S. 408 - 417
    Online Volltext: dx.doi.org/ (Open Access)
  • Xia, Jianbo; Cao, Liang; Zhao, Zhenyu; Deng, Yingying; Lu, Mengji; Wu, Chunchen; Lin, Yong
    HBV sL13H mutation impairs its surface antigen expression and ability to induce autophagy
    In: Genes & Diseases Jg. 9 (2022) Nr. 6, S. 1401 - 1404
    Online Volltext: dx.doi.org/ (Open Access)
  • Xie, Xiaohong; Luo, Jinzhuo; Zhu, Dan; Zhou, Wenqing; Yang, Xuecheng; Feng, Xuemei; Lu, Mengji; Zheng, Xin; Dittmer, Ulf; Yang, Dongliang; Liu, Jia
    HBeAg Is Indispensable for Inducing Liver Sinusoidal Endothelial Cell Activation by Hepatitis B Virus
    In: Frontiers in Cellular and Infection Microbiology Jg. 12 (2022) 797915
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Li, Fahong; Deng, Yingying; Zhang, Shenyan; Zhu, Beidi; Wang, Jun; Wang, Jinyu; Wang, Xueyu; Zhao, Zhenyu; Deng, Wanyu; Mao, Richeng; Shen, Zhongliang; Chen, Jieliang; Bröring, Ruth; Lin, Yong; Lu, Mengji; Zhang, Jiming
    Human hepatocyte-enriched miRNA-192-3p promotes HBV replication through inhibiting Akt/mTOR signalling by targeting ZNF143 in hepatic cell lines
    In: Emerging Microbes & Infections Jg. 11 (2022) Nr. 1, S. 616 - 628
    Online Volltext: dx.doi.org/ (Open Access)
  • Podschwadt, Philip; Malyshkina, Anna; Windmann, Sonja; Papadamakis, Athanasios; Kerkmann, Leonie; Lapuente, Dennis; Tenbusch, Matthias; Lu, Mengji; Schindler, Michael; Lang, Karl Sebastian; Hansen, Wiebke; Bayer, Wibke
    Immune suppression of vaccine-induced CD8⁺ T cell-responses by gamma retrovirus envelope is mediated by interleukin-10 producing CD4⁺ T cells
    In: Frontiers in Immunology Jg. 13 (2022) 934399
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Li, Jia; Kemper, Thekla; Bröring, Ruth; Chen, Jieliang; Yuan, Zhenghong; Wang, Xueyu; Lu, Mengji
    Interferon Alpha Induces Cellular Autophagy and Modulates Hepatitis B Virus Replication
    In: Frontiers in Cellular and Infection Microbiology Jg. 12 (2022) 804011
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Mao, Binli; Le-Trilling, Vu Thuy Khanh; Wang, Kai; Mennerich, Denise; Hu, Jie; Zhao, Zhenyu; Zheng, Jiaxin; Deng, Yingying; Katschinski, Benjamin; Xu, Shilei; Zhang, Guiji; Cai, Xuefei; Hu, Yuan; Wang, Jianwei; Lu, Mengji; Huang, Ailong; Tang, Ni; Trilling, Mirko; Lin, Yong
    Obatoclax inhibits SARS-CoV-2 entry by altered endosomal acidification and impaired cathepsin and furin activity in vitro
    In: Emerging Microbes & Infections Jg. 11 (2022) Nr. 1, S. 483 - 497
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Du, Yanqin; Wu, Jun; Liu, Jia; Zheng, Xin; Yang, Dongliang; Lu, Mengji
    Toll-like receptor-mediated innate immunity orchestrates adaptive immune responses in HBV infection
    In: Frontiers in Immunology Jg. 13 (2022) 965018
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)

    • Vorworte / Nachworte

  • Meng, Zhongji; Liu, Jia; Kosinska, Anna D.; Lu, Mengji
    Editorial: Targeting the Immune System to Treat Hepatitis B Virus Infection
    In: Frontiers in Immunology Jg. 13 (2022) 868616
    Online Volltext: dx.doi.org/ (Open Access)

    • Poster / Posterbeiträge

  • Liang, Yaojie; Luo, Xufeng; Schefczyk, Stefan; Baba, Hideo; Lu, Mengji; Bröring, Ruth;
    Expression of hepatitis B surface antigen in vivo and in vitro induces endoplasmic reticulum stress, impairs autophagy and promotes proliferation
    The International Liver Congress 2022 ; 22-26 June 2022, London, UK,
    In: Journal of Hepatology Jg. 77 (2022) Nr. Supplement 1: Abstracts of The International Liver CongressTM 2022, S. S643 - S644
    Online Volltext: dx.doi.org/ (Open Access)
  • Schefczyk, Stefan; Luo, Xufeng; Liang, Yaojie; Hasenberg, Mike; Walkenfort, Bernd; Trippler, Martin; Lu, Mengji; Wedemeyer, Heiner; Schmidt, Hartmut; Bröring, Ruth;
    Hepatitis B virus-replicating transgenic mice exhibit a functional but restricted responsiveness to exogenous Tlr3 and Rig-I stimuli
    The International Liver Congress 2022 ; 22-26 June 2022, London, UK,
    In: Journal of Hepatology Jg. 77 (2022) Nr. Supplement 1: Abstracts of The International Liver CongressTM 2022, S. S264 - S265
    Online Volltext: dx.doi.org/ (Open Access)
  • Luo, Xufeng; Zhang, Rui; Liang, Yaojie; Schefczyk, Stefan; Liu, Shi; Baba, Hideo; Lange, Christian; Wedemeyer, Heiner; Lu, Mengji; Bröring, Ruth;
    Hippo inactivation drives BMI1-associated proliferative hepatocarcinogenesis in chronic hepatitis B virus infection
    The International Liver Congress 2022 ; 22-26 June 2022, London, UK,
    In: Journal of Hepatology Jg. 77 (2022) Nr. Supplement 1: Abstracts of The International Liver CongressTM 2022, S. S642
    Online Volltext: dx.doi.org/ (Open Access)

    • 2021

    Artikel in Zeitschriften

  • Liu, Jia; Yang, Xuecheng; Wang, Hua; Li, Ziwei; Deng, Hui; Liu, Jing; Xiong, Shue; He, Junyi; Feng, Xuemei; Guo, Chunxia; Wang, Weixian; Zelinskyy, Gennadiy; Trilling, Mirko; Sutter, Kathrin; Senff, Tina; Menne, Christopher; Timm, Jörg; Zhang, Yanfang; Deng, Fei; Lu, Yinping; Wu, Jun; Lu, Mengji; Yang, Dongliang; Dittmer, Ulf; Wang, Baoju; Zheng, Xin
    Analysis of the long-term impact on cellular immunity in COVID-19-recovered individuals reveals a profound nkt cell impairment
    In: mBio Jg. 12 (2021) Nr. 2, S. e00085 - 21
    Online Volltext: dx.doi.org/ (Open Access)
  • Li, Qian; Wang, Jun; Zhou, Xueshi; Lu, Hongzhou; Lu, Mengji; Huang, Lihua
    Case Report: Viral Pneumonia Could Prompt the Advancement of Immune-Mediated Liver Disease
    In: Frontiers in Medicine Jg. 8 (2021) 582620
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Li, Ziwei; Xiang, Tiandan; Liang, Boyun; Deng, Hui; Wang, Hua; Feng, Xuemei; Quan, Xufeng; Wang, Xiaoyan; Li, Sumeng; Lu, Sihong; Yang, Xuecheng; Wang, Baoju; Zelinskyy, Gennadiy; Trilling, Mirko; Sutter, Kathrin; Lu, Mengji; Dittmer, Ulf; Yang, Dongliang; Zheng, Xin; Liu, Jia
    Characterization of SARS-CoV-2-Specific Humoral and Cellular Immune Responses Induced by Inactivated COVID-19 Vaccines in a Real-World Setting
    In: Frontiers in Immunology Jg. 12 (2021) 802858
    Online Volltext: dx.doi.org/ (Open Access)
  • Bröring, Ruth; Luo, Xufeng; Liu, Jia; Lu, Mengji
    Controversial: Early Innate Responses to Hepatitis B Virus Infection, an Explanation for Viral Persistence?
    In: Virologica Sinica Jg. 36 (2021) Nr. 1, S. 163 - 166
    Online Volltext: dx.doi.org/ (Open Access)
  • Xiang, Tiandan; Liang, Boyun; Fang, Yaohui; Lu, Sihong; Li, Sumeng; Wang, Hua; Li, Huadong; Yang, Xiaoli; Shen, Shu; Zhu, Bin; Wang, Baoju; Wu, Jun; Liu, Jia; Lu, Mengji; Yang, Dongliang; Dittmer, Ulf; Trilling, Mirko; Deng, Fei; Zheng, Xin
    Declining Levels of Neutralizing Antibodies Against SARS-CoV-2 in Convalescent COVID-19 Patients One Year Post Symptom Onset
    In: Frontiers in Immunology Jg. 12 (2021) 708523
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Du, Yanqin; Yang, Xiaoli; Li, Jia; Sokolova, Viktoriya; Zou, Shi; Han, Meihong; Yan, Hu; Wey, Karolin; Lu, Mengji; Dittmer, Ulf; Yang, Dongliang; Epple, Matthias; Wu, Jun
    Delivery of toll-like receptor 3 ligand poly(I:C) to the liver by calcium phosphate nanoparticles conjugated with an F4/80 antibody exerts an anti-hepatitis B virus effect in a mouse model
    In: Acta Biomaterialia Jg. 133 (2021) S. 297 - 307
    Online Volltext: dx.doi.org/
  • Chen, Jieliang; Li, Yaming; Lai, Fritz; Wang, Yang; Sutter, Kathrin; Dittmer, Ulf; Ye, Jianyu; Zai, Wenjing; Liu, Min; Shen, Fang; Wu, Min; Hu, Kongying; Li, Baocun; Lu, Mengji; Zhang, Xiaonan; Zhang, Jiming; Li, Jianhua; Chen, Qingfeng; Yuan, Zhenghong
    Functional Comparison of Interferon-α Subtypes Reveals Potent Hepatitis B Virus Suppression by a Concerted Action of Interferon-α and Interferon-γ Signaling
    In: Hepatology Jg. 73 (2021) Nr. 2, S. 486 - 502
    Online Volltext: dx.doi.org/
  • Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Buitrago-Molina, Laura Elisa; Lu, Mengji; Meyer, Hemmo; Tong, Chun-Kit
    Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
    In: Autophagy Jg. 17 (2021) Nr. 1, S. 1 - 382
    Online Volltext: dx.doi.org/ (Open Access)
  • Xie, Xiaohong; Luo, Jinzhuo; Bröring, Ruth; Zhu, Dan; Zhou, Wenqing; Lu, Mengji; Zheng, Xin; Dittmer, Ulf; Yang, Dongliang; Liu, Jia
    HBeAg induces liver sinusoidal endothelial cell activation to promote intrahepatic CD8 T cell immunity and HBV clearance
    In: Cellular & Molecular Immunology Jg. 18 (2021) Nr. 11, S. 2572 - 2574
    Online Volltext: dx.doi.org/ (Open Access)
  • Li, Qian; Wang, Jun; Islam, Heba; Kirschning, Carsten Jürgen; Lu, Hongzhou; Hoffmann, Daniel; Dittmer, Ulf; Lu, Mengji
    Hepatitis B virus particles activate B cells through the TLR2–MyD88–mTOR axis
    In: Cell Death and Disease Jg. 12 (2021) Nr. 1, 34
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Zhou, Li; He, Rui; Fang, Peining; Li, Mengqi; Yu, Haisheng; Wang, Qiming; Yu, Yi; Wang, Fubing; Zhang, Yi; Chen, Aidong; Peng, Nanfang; Lin, Yong; Zhang, Rui; Trilling, Mirko; Bröring, Ruth; Lu, Mengji; Zhu, Ying; Liu, Shi
    Hepatitis B virus rigs the cellular metabolome to avoid innate immune recognition
    In: Nature Communications Jg. 12 (2021) Nr. 1, S. 98
    Online Volltext: dx.doi.org/ (Open Access)
  • Luo, Xufeng; Zhang, Rui; Lu, Mengji; Liu, Shi; Baba, Hideo Andrea; Gerken, Guido; Wedemeyer, Heiner; Bröring, Ruth
    Hippo Pathway Counter-Regulates Innate Immunity in Hepatitis B Virus Infection
    In: Frontiers in Immunology Jg. 12 (2021) 684424
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Du, Yanqin; Bröring, Ruth; Li, Xiaoran; Zhang, Xiaoyong; Liu, Jia; Yang, Dongliang; Lu, Mengji
    In Vivo Mouse Models for Hepatitis B Virus Infection and Their Application
    In: Frontiers in Immunology Jg. 12 (2021) 766534
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Xiong, Shue; Zhu, Dan; Liang, Boyun; Li, Mingyue; Pan, Wen; He, Junyi; Wang, Hua; Sutter, Kathrin; Dittmer, Ulf; Lu, Mengji; Liu, Di; Yang, Dongliang; Liu, Jia; Zheng, Xin
    Longitudinal characterization of phenotypic profile of T cells in chronic hepatitis B identifies immune markers associated with HBsAg loss
    In: eBioMedicine Jg. 69 (2021) 103464
    Online Volltext: dx.doi.org/ (Open Access)
  • Du, Yanqin; Yan, Hu; Zou, Shi; Khera, Tanvi; Li, Jia; Han, Meihong; Yang, Xiaoli; Wang, Baoju; Liu, Jia; Sun, Shuilin; Zheng, Xin; Dittmer, Ulf; Lu, Mengji; Yang, Dongliang; Wedemeyer, Heiner; Wu, Jun
    Natural Killer Cells Regulate the Maturation of Liver Sinusoidal Endothelial Cells Thereby Promoting Intrahepatic T‐Cell Responses in a Mouse Model
    In: Hepatology Communications Jg. 5 (2021) Nr. 5, S. 865 - 881
    Online Volltext: dx.doi.org/ (Open Access)
  • Wu, Jun; Liang, Bo-Yun; Fang, Yao-Hui; Wang, Hua; Yang, Xiao-Li; Shen, Shu; Chen, Liang-Kai; Li, Su-Meng; Lu, Si-Hong; Xiang, Tian-Dan; Liu, Jia; Le-Trilling, Vu Thuy Khanh; Lu, Mengji; Yang, Dong-Liang; Deng, Fei; Dittmer, Ulf; Trilling, Mirko; Zheng, Xin
    Occurrence of COVID-19 Symptoms During SARS-CoV-2 Infection Defines Waning of Humoral Immunity
    In: Frontiers in Immunology Jg. 12 (2021) 722027
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Lin, Yong; Yuan, Jun; Long, Quanxin; Hu, Jieli; Deng, Haijun; Zhao, Zhenyu; Chen, Juan; Lu, Mengji; Huang, Ailong
    Patients with SARS-CoV-2 and HBV co-infection are at risk of greater liver injury
    In: Genes & Diseases Jg. 8 (2021) Nr. 4, S. 484 - 492
    Online Volltext: dx.doi.org/ (Open Access)
  • Huang, Hongming; Rückborn, Meike; Le-Trilling, Vu Thuy Khanh; Zhu, Dan; Yang, Shangqing; Zhou, Wenqing; Yang, Xuecheng; Feng, Xuemei; Lu, Yinping; Lu, Mengji; Dittmer, Ulf; Yang, Dongliang; Trilling, Mirko; Liu, Jia
    Prophylactic and therapeutic HBV vaccination by an HBs-expressing cytomegalovirus vector lacking an interferon antagonist in mice
    In: European Journal of Immunology Jg. 51 (2021) Nr. 2, S. 393 - 407
    Online Volltext: dx.doi.org/ (Open Access)
  • Zhang, Hongjun; Zhou, Jiao; Xiao, Peng; Lin, Yong; Gong, Xin; Liu, Shiyan; Xu, Qingjia; Wang, Minjin; Ren, Haiyan; Lu, Mengji; Wang, Yuan; Zhu, Jing; Xie, Zhiping; Li, Huihui; Lu, Kefeng
    PtdIns4P restriction by hydrolase SAC1 decides specific fusion of autophagosomes with lysosomes
    In: Autophagy Jg. 17 (2021) Nr. 8, S. 1907 - 1917
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Huang, Xuan; Zhang, Xiaoyong; Lu, Mengji
    Recent trends in the development of Toll-like receptor 7/8-targeting therapeutics
    In: Expert Opinion on Drug Discovery Jg. 16 (2021) Nr. 8, S. 869 - 880
    Online Volltext: dx.doi.org/
  • Wu, Jun; Liang, Boyun; Chen, Cunrong; Wang, Hua; Fang, Yaohui; Shen, Shu; Yang, Xiaoli; Wang, Baoju; Chen, Liangkai; Chen, Qi; Wu, Yang; Liu, Jia; Yang, Xuecheng; Li, Wei; Zhu, Bin; Zhou, Wenqing; Wang, Huan; Li, Sumeng; Lu, Sihong; Liu, Di; Li, Huadong; Krawczyk, Adalbert; Lu, Mengji; Yang, Dongliang; Deng, Fei; Dittmer, Ulf; Trilling, Mirko; Zheng, Xin
    SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19
    In: Nature Communications Jg. 12 (2021) Nr. 1, S. 1813
    Online Volltext: dx.doi.org/ (Open Access)
  • Zou, Shi; Du, Yanqin; Huang, Shunmei; Chen, Mingfa; Yang, Xiaoli; Li, Sumeng; Chen, Yingshan; Han, Meihong; Li, Jia; Yu, Qing; Littwitz-Salomon, Elisabeth; Huang, Hongming; Trilling, Mirko; Liu, Shi; Pei, Rongjuan; Liu, Jia; Wang, Baoju; Zheng, Xin; Lu, Mengji; Dittmer, Ulf; Sun, Shuilin; Yang, Dongliang; Wu, Jun
    Simultaneous or Prior Activation of Intrahepatic Type I Interferon Signaling Leads to Hepatitis B Virus Persistence in a Mouse Model
    In: Journal of Virology Jg. 95 (2021) Nr. 24, e00034-21
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Du, Yanqin; Anastasiou, Olympia E.; Strunz, Benedikt; Scheuten, Janina; Bremer, Birgit; Kraft, Anke; Kleinsimglinhaus, Karolina; Todt, Daniel; Bröring, Ruth; Hardtke-Wolenski, Matthias; Wu, Jun; Yang, Dongliang; Dittmer, Ulf; Lu, Mengji; Cornberg, Markus; Björkström, Niklas K.; Khera, Tanvi; Wedemeyer, Heiner
    The impact of hepatitis B surface antigen on natural killer cells in patients with chronic hepatitis B virus infection
    In: Liver International Jg. 41 (2021) Nr. 9, S. 2046 - 2058
    Online Volltext: dx.doi.org/ (Open Access)
  • Zhao, Zhenyu; Lu, Kefeng; Mao, Binli; Liu, Shi; Trilling, Mirko; Huang, Ailong; Lu, Mengji; Lin, Yong
    The interplay between emerging human coronavirus infections and autophagy
    In: Emerging Microbes & Infections Jg. 10 (2021) Nr. 1, S. 196 - 205
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Wang, Xueyu; Wei, Zhiqiang; Jiang, Yongfang; Meng, Zhongji; Lu, Mengji
    mTOR Signaling : The Interface Linking Cellular Metabolism and Hepatitis B Virus Replication
    In: Virologica Sinica Jg. 36 (2021) Nr. 6, S. 1303 - 1314
    Online Volltext: dx.doi.org/ (Open Access)

    • 2020

    Artikel in Zeitschriften

  • Wang, Shichuan; Trilling, Mirko; Sutter, Kathrin; Dittmer, Ulf; Lu, Mengji; Zheng, Xin; Yang, Dongliang; Liu, Jia
    A Crowned Killer’s Résumé : Genome, Structure, Receptors, and Origin of SARS-CoV-2
    In: Virologica Sinica (2020)
    Online Volltext: dx.doi.org/ (Open Access)
  • Wang, Xueyu; Lin, Yong; Kemper, Thekla; Chen, Jieliang; Yuan, Zhenghong; Liu, Shi; Zhu, Ying; Bröring, Ruth; Lu, Mengji
    AMPK and Akt/mTOR signalling pathways participate in glucose-mediated regulation of hepatitis B virus replication and cellular autophagy
    In: Cellular Microbiology Jg. 22 (2020) Nr. 2, S. e13131
    Online Volltext: dx.doi.org/ (Open Access)
  • Weng, Zhihong; Chen, Qiaosen; Li, Sumeng; Li, Huadong; Zhang, Qian; Lu, Sihong; Wu, Li; Xiong, Leiqun; Mi, Bobin; Liu, Di; Lu, Mengji; Yang, Dongliang; Jiang, Hongbo; Zheng, Shaoping; Zheng, Xin
    ANDC : An early warning score to predict mortality risk for patients with Coronavirus Disease 2019
    In: Journal of Translational Medicine Jg. 18 (2020) Nr. 1, S. 328
    Online Volltext: dx.doi.org/ (Open Access)
  • Li, Qian; Wang, Jun; Lu, Mengji; Qiu, Yuanwang; Lu, Hongzhou
    Acute-on-Chronic Liver Failure From Chronic-Hepatitis-B, Who Is the Behind Scenes
    In: Frontiers in Microbiology Jg. 11 (2020) S. 583423
    Online Volltext: dx.doi.org/ (Open Access)
  • Meng, Zhongji; Chen, Yuanyuan; Lu, Mengji
    Advances in Targeting the Innate and Adaptive Immune Systems to Cure Chronic Hepatitis B Virus Infection
    In: Frontiers in Immunology Jg. 10 (2020) S. 3217
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Han, Mingfeng; Xu, Mengyuan; Zhang, Yafei; Liu, Zhongping; Li, Shasha; He, Tengfei; Li, Jinsong; Gao, Yong; Liu, Wanjun; Li, Tuantuan; Chen, Zixiang; Huang, Xin; Cheng, Guoling; Wang, Jun; Dittmer, Ulf; Witzke, Oliver; Zou, Guizhou; Li, Xiuyong; Lu, Mengji; Zhang, Zhenhua
    Assessing SARS-CoV-2 RNA levels and lymphocyte/T cell counts in COVID-19 patients revealed initial immune status as a major determinant of disease severity
    In: Medical Microbiology and Immunology Jg. 209 (2020) S. 657 - 668
    Online Volltext: dx.doi.org/ (Open Access)
  • Xu, Ling; Liu, Jia; Lu, Mengji; Yang, Dongliang; Zheng, Xin
    Author response to Letter to the Editor : Potential implications of COVID-19 in non-alcoholic fatty liver disease
    In: Liver International Jg. 40 (2020) Nr. 10, S. 2569 - 2570
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Zhang, Yafei; Wang, Changtai; Han, Mingfeng; Ye, Jun; Gao, Yong; Liu, Zhongping; He, Tengfei; Li, Tuantuan; Xu, Mengyuan; Zhou, Luping; Zou, Guizhou; Lu, Mengji; Zhang, Zhenhua
    Correction to: Discrimination of False Negative Results in RT-PCR Detection of SARS-CoV-2 RNAs in Clinical Specimens by Using an Internal Reference
    In: Virologica Sinica Jg. 35 (2020) Nr. 6, S. 885 - 886
    Online Volltext: dx.doi.org/ (Open Access)
  • Xu, Chunli; Lu, Yinping; Zheng, Xin; Feng, Xuemei; Yang, Xuecheng; Timm, Jörg; Wu, Jun; Wang, Baoju; Lu, Mengji; Yang, Dongliang; Liu, Jia
    Corrigendum: TLR2 Expression in Peripheral CD4+ T Cells Promotes Th17 Response and Is Associated with Disease Aggravation of Hepatitis B Virus-Related Acute-On-Chronic Liver Failure (Frontiers in Immunology, (2017), 8, 10.3389/fimmu.2017.01609)
    In: Frontiers in Immunology Jg. 11 (2020) S. 1566
    Online Volltext: dx.doi.org/ (Open Access)
  • Li, Mengmeng; Xiong, Yan; Li, Mingyue; Zhang, Wenjing; Liu, Jia; Zhang, Yanfang; Xiong, Shue; Zou, Congcong; Liang, Boyun; Lu, Mengji; Yang, Dongliang; Peng, Cheng; Zheng, Xin
    Depletion but Activation of CD56dⁱmCD16⁺ NK Cells in Acute Infection with Severe Fever with Thrombocytopenia Syndrome Virus
    In: Virologica Sinica (2020)
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Liu, Anding; Wang, Wenjie; Zhao, Xuecheng; Zhou, Xiaoxi; Yang, Dongliang; Lu, Mengji; Lv, Yongman
    Disappearance of antibodies to SARS-CoV-2 in a -COVID-19 patient after recovery
    In: Clinical Microbiology and Infection Jg. 26 (2020) Nr. 12, S. 1703 - 1705
    Online Volltext: dx.doi.org/ (Open Access)
  • Zhang, Yafei; Wang, Changtai; Han, Mingfeng; Ye, Jun; Gao, Yong; Liu, Zhongping; He, Tengfei; Li, Tuantuan; Xu, Mengyuan; Zhou, Luping; Zou, Guizhou; Lu, Mengji; Zhang, Zhenhua
    Discrimination of False Negative Results in RT-PCR Detection of SARS-CoV-2 RNAs in Clinical Specimens by Using an Internal Reference
    In: Virologica Sinica Jg. 35 (2020) Nr. 6, S. 758 - 767
    Online Volltext: dx.doi.org/ (Open Access)
  • Westmeier, Jaana; Paniskaki, Krystallenia; Karaköse, Zehra; Werner, Tanja; Sutter, Kathrin; Dolff, Sebastian; Overbeck, Marvin; Limmer, Andreas; Liu, Jia; Zheng, Xin; Brenner, Thorsten; Berger, Marc; Witzke, Oliver; Trilling, Mirko; Lu, Mengji; Yang, Dongliang; Babel, Nina; Westhoff, Timm; Dittmer, Ulf; Zelinskyy, Gennadiy
    Erratum for Westmeier et al., "Impaired Cytotoxic CD8⁺ T Cell Response in Elderly COVID-19 Patients"
    In: mBio Jg. 11 (2020) Nr. 5, S. 02243 - 02220
    Online Volltext: dx.doi.org/ (Open Access)
  • Wang, Jun; Li, Qian; Yin, Yongmei; Zhang, Yingying; Cao, Yingying; Lin, Xiaoming; Huang, Lihua; Hoffmann, Daniel; Lu, Mengji; Qiu, Yuanwang
    Excessive Neutrophils and Neutrophil Extracellular Traps in COVID-19
    In: Frontiers in Immunology Jg. 11 (2020)
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Rojas-Sánchez, Leonardo; Zhang, Ejuan; Sokolova, Viktoriya; Zhong, Maohua; Yan, Hu; Lu, Mengji; Li, Qian; Yan, Huimin; Epple, Matthias
    Genetic immunization against hepatitis B virus with calcium phosphate nanoparticles in vitro and in vivo
    In: Acta Biomaterialia Jg. 110 (2020) S. 254 - 265
    Online Volltext: dx.doi.org/
  • Lin, Yong; Wu, Chunchen; Wang, Xueyu; Liu, Shi; Zhao, Kaitao; Kemper, Thekla; Yu, Haisheng; Li, Mengqi; Zhang, Jiming; Chen, Mingzhou; Zhu, Ying; Chen, Xinwen; Lu, Mengji
    Glucosamine promotes hepatitis B virus replication through its dual effects in suppressing autophagic degradation and inhibiting MTORC1 signaling
    In: Autophagy Jg. 16 (2020) Nr. 3, S. 548 - 561
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Zhang, Zhenhua; Trippler, Martin; Real, Catherine I.; Werner, Melanie; Luo, Xufeng; Schefczyk, Stefan; Kemper, Thekla; Anastasiou, Olympia E.; Ladiges, Yvonne; Treckmann, Jürgen-Walter; Paul, Andreas; Baba, Hideo Andreas; Allweiss, Lena; Dandri, Maura; Gerken, Guido; Wedemeyer, Heiner; Schlaak, Jörg Friedrich; Lu, Mengji; Bröring, Ruth
    Hepatitis B Virus Particles Activate Toll-Like Receptor 2 Signaling Initially Upon Infection of Primary Human Hepatocytes
    In: Hepatology Jg. 72 (2020) Nr. 3, S. 829 - 844
    Online Volltext: dx.doi.org/ (Open Access)
  • Westmeier, Jaana; Paniskaki, Krystallenia; Karaköse, Zehra; Werner, Tanja; Sutter, Kathrin; Dolff, Sebastian; Overbeck, Marvin; Limmer, Andreas; Liu, Jia; Zheng, Xin; Brenner, Thorsten; Berger, Marc; Witzke, Oliver; Trilling, Mirko; Lu, Mengji; Yang, Dongliang; Babel, Nina; Westhoff, Timm; Dittmer, Ulf; Zelinskyy, Gennadiy
    Impaired cytotoxic CD8⁺ T cell response in elderly COVID-19 patients
    In: mBio Jg. 11 (2020) Nr. 5, S. e02243 - 20
    Online Volltext: dx.doi.org/ (Open Access)
  • Lin, Yong; Zhao, Zhenyu; Huang, Ailong; Lu, Mengji
    Interplay between Cellular Autophagy and Hepatitis B Virus Replication : A Systematic Review
    In: Cells Jg. 9 (2020) Nr. 9, S. 2101
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Xu, Ling; Liu, Jia; Lu, Mengji; Yang, Dongliang; Zheng, Xin
    Liver injury during highly pathogenic human coronavirus infections
    In: Liver International Jg. 40 (2020) Nr. 5, S. 998 - 1004
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Liu, Jing; Li, Sumeng; Liu, Jia; Liang, Boyun; Wang, Xiaobei; Wang, Hua; Li, Wei; Tong, Qiaoxia; Yi, Jianhua; Zhao, Lei; Xiong, Lijuan; Guo, Chunxia; Tian, Jin; Luo, Jinzhuo; Yao, Jinghong; Pang, Ran; Shen, Hui; Peng, Cheng; Liu, Ting; Zhang, Qian; Wu, Jun; Xu, Ling; Lu, Sihong; Wang, Baoju; Weng, Zhihong; Han, Chunrong; Zhu, Huabing; Zhou, Ruxia; Zhou, Helong; Chen, Xiliu; Ye, Pian; Zhu, Bin; Wang, Lu; Zhou, Wenqing; He, Shengsong; He, Yongwen; Jie, Shenghua; Wei, Ping; Zhang, Jianao; Lu, Yinping; Wang, Weixian; Zhang, Li; Li, Ling; Zhou, Fengqin; Wang, Jun; Dittmer, Ulf; Lu, Mengji; Hu, Yu; Yang, Dongliang; Zheng, Xin
    Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients
    In: eBioMedicine Jg. 55 (2020) 102763
    Online Volltext: dx.doi.org/ (Open Access)
  • Yu, Haisheng; Li, Menqui; He, Rui; Fang, Peining; Wang, Qiming; Yi, Yu; Wang, Fubing; Zhou, Li; Zhang, Yi; Chen, Aidong; Peng, Nanfang; Liu, Dan; Trilling, Mirko; Bröring, Ruth; Wiemer, Erik A.C.; Lu, Mengji; Zhu, Ying; Liu, Shi
    Major Vault Protein Promotes Hepatocellular Carcinoma Through Targeting Interferon Regulatory Factor 2 and Decreasing p53 Activity
    In: Hepatology Jg. 72 (2020) Nr. 2, S. 518 - 534
    Online Volltext: dx.doi.org/
  • Wang, Qiming; Fang, Peining; He, Rui; Li, Mengqi; Yu, Haisheng; Zhou, Li; Yi, Yu; Wang, Fubing; Rong, Yuan; Zhang, Yi; Chen, Aidong; Peng, Nanfang; Lin, Yong; Lu, Mengji; Zhu, Ying; Peng, Guoping; Rao, Liqun; Liu, Shi
    O-GlcNAc transferase promotes influenza A virus-induced cytokine storm by targeting interferon regulatory factor-5
    In: Science Advances Jg. 6 (2020) Nr. 16,
    Online Volltext: dx.doi.org/ (Open Access)
  • Wang, Xueyu; Lin, Yong; Liu, Shi; Zhu, Ying; Lu, Kefeng; Bröring, Ruth; Lu, Mengji
    O-GlcNAcylation modulates HBV replication through regulating cellular autophagy at multiple levels
    In: The FASEB Journal Jg. 34 (2020) Nr. 11, S. 14473 - 14489
    Online Volltext: dx.doi.org/ (Open Access)
  • Liu, Jia; Zheng, Xin; Tong, Qiaoxia; Li, Wei; Wang, Baoju; Sutter, Kathrin; Trilling, Mirko; Lu, Mengji; Dittmer, Ulf; Yang, Dongliang
    Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoV
    In: Journal of Medical Virology Jg. 92 (2020) Nr. 5, S. 491 - 494
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Yan, Hu; Zhong, Maohua; Yang, Jingyi; Guo, Jiabao; Yu, Jie; Yang, Yi; Ma, Zhiyong; Zhao, Bali; Zhang, Yue; Wang, Junzhong; Wu, Chunchen; Dittmer, Ulf; Yang, Dongliang; Lu, Mengji; Zhang, Ejuan; Yan, Huimin
    TLR5 activation in hepatocytes alleviates the functional suppression of intrahepatic CD8⁺ T cells
    In: Immunology Jg. 161 (2020) Nr. 4, S. 325 - 344
    Online Volltext: dx.doi.org/ (Open Access)

    • 2019

    Artikel in Zeitschriften

  • Zhang, Ejuan; Yan, Hu; Li, Qian; Dittmer, Ulf; Yan, Huimin; Lu, Mengji
    Activation of the TLR signaling pathway in CD8+ T cells counteracts liver endothelial cell-induced T cell tolerance
    In: Cellular & Molecular Immunology Jg. 16 (2019) Nr. 9, S. 774 - 776
    Online Volltext: dx.doi.org/ (Open Access)
  • Yan, Yan; Chen, Renfang; Wang, Xu; Hu, Kai; Huang, Lihua; Lu, Mengji; Hu, Qinxue
    CCL19 and CCR7 Expression, Signaling Pathways, and Adjuvant Functions in Viral Infection and Prevention
    In: Frontiers in Cell and Developmental Biology Jg. 7 (2019) 212
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Wu, Chunchen; Li, Baolin; Zhang, Xiaoyong; Zhao, Kaitao; Chen, Yingshan; Yuan, Yifei; Liu, Yan; Chen, Rongjuan; Xu, Dongping; Chen, Xinwen; Lu, Mengji
    Complementation of Wild-Type and Drug-Resistant Hepatitis B Virus Genomes to Maintain Viral Replication and Rescue Virion Production under Nucleos(t)ide Analogs
    In: Virologica Sinica Jg. 34 (2019) Nr. 4, S. 377 - 385
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Liu, Shi; Liu, Li; Xu, Gang; Cao, Zhongying; Wang, Qing; Li, Shun; Peng, Nanfang; Yin, Jingchuan; Yu, Haisheng; Li, Mengqi; Xia, Zhangchuan; Zhou, Li; Lin, Yong; Wang, Xueyu; Li, Qian; Zhu, Chengliang; Yang, Xuecheng; Wang, Jun; She, Yinglong; Lu, Mengji; Zhu, Ying
    Epigenetic Modification Is Regulated by the Interaction of Influenza A Virus Nonstructural Protein 1 with the De Novo DNA Methyltransferase DNMT3B and Subsequent Transport to the Cytoplasm for K48-Linked Polyubiquitination
    In: Journal of Virology Jg. 93 (2019) Nr. 7, e01587-18
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Lin, Yong; Wu, Chunchen; Wang, Xueyu; Kemper, Thekla; Squire, Anthony; Gunzer, Matthias; Zhang, Jiming; Chen, Xinwen; Lu, Mengji
    Hepatitis B virus is degraded by autophagosome-lysosome fusion mediated by Rab7 and related components
    In: Protein & Cell Jg. 10 (2019) Nr. 1, S. 60 - 66
    Online Volltext: dx.doi.org/ (Open Access)
  • Liu, Yan; Zhou, Yi; Li, Xiaodong; Niu, Ming; Chen, Rongjuan; Shao, Jinman; Si, Lanlan; Luo, Dan; Lin, Yayun; Li, Le; Zhang, Kai; Xiao, Xiaohe; Xu, Zhihui; Liu, Min; Lu, Mengji; Zoulim, Fabien; Xu, Dongping
    Hepatitis B virus mutation pattern rtL180M+A181C+M204V may contribute to entecavir resistance in clinical practice
    In: Emerging Microbes & Infections Jg. 8 (2019) Nr. 1, S. 354 - 365
    Online Volltext: dx.doi.org/ (Open Access)
  • Wang, Jinyu; Li, Jing; Wu, Jingwen; Dong, Minhui; Shen, Zhongliang; Lin, Yong; Li, Fahong; Zhang, Yongmei; Mao, Richeng; Lu, Mengji; Zhang, Jiming
    Host Gene SEL1L Involved in Endoplasmic Reticulum-Associated Degradation Pathway Could Inhibit Hepatitis B Virus at RNA, DNA, and Protein Levels
    In: Frontiers in Microbiology Jg. 10 (2019)
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Zhang, Zhenhua; Wang, Changtai; Liu, Zhongping; Zou, Guizhou; Li, Jun; Lu, Mengji
    Host Genetic Determinants of Hepatitis B Virus Infection
    In: Frontiers in Genetics Jg. 10 (2019) 696
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Xu, Gang; Xia, Zhangchuan; Deng, Feiyan; Liu, Lin; Wang, Qiming; Yu, Yi; Wang, Fubing; Zhu, Chengliang; Liu, Weiyong; Cheng, Zhikui; Zhu, Ying; Zhou, Li; Zhang, Yi; Lu, Mengji; Liu, Shi
    Inducible LGALS3BP/90K activates antiviral innate immune responses by targeting TRAF6 and TRAF3 complex
    In: PLoS Pathogens Jg. 15 (2019) Nr. 8, S. 1008002
    Online Volltext: dx.doi.org/ (Open Access)
  • Yang, Shangqing; Wang, Lu; Pan, Wen; Bayer, Wibke; Thoens, Christine; Heim, Kathrin; Dittmer, Ulf; Timm, Jörg; Wang, Qin; Yu, Qing; Luo, Jinzhuo; Liu, Yanan; Hofmann, Maike; Thimme, Robert; Zhang, Xiaoyong; Chen, Hongtao; Wang, Hua; Feng, Xuemei; Yang, Xuecheng; Lu, Yinping; Lu, Mengji; Yang, Dongliang; Liu, Jia
    MMP2/MMP9-mediated CD100 shedding is crucial for inducing intrahepatic anti-HBV CD8 T cell responses and HBV clearance
    In: Journal of Hepatology Jg. 71 (2019) Nr. 4, S. 685 - 698
    Online Volltext: dx.doi.org/
  • Liu, Yan; Wu, Chunchen; Chen, Rongjuan; Li, Xiaodong; Xu, Zhihui; Li, Qi; Li, Le; Wang, Fu-Sheng; Yang, Dongliang; Lu, Mengji; Xu, Dongping
    Molecular cloning and phenotypic analysis of drug‑resistance mutants with relevant S‑region variants of HBV for a patient during 189‑month anti‑HBV treatment
    In: Antiviral Therapy Jg. 24 (2019) Nr. 4, S. 237 - 246
    Online Volltext: dx.doi.org/
  • Wu, Jun; Han, Meihong; Li, Jia; Yang, Xiaoli; Zhen, Xin; Friedrich Schlaak, Joerg; Yang, Dongliang; Lu, Mengji
    Pattern recognition receptors and liver failure
    In: Critical Reviews in Immunology Jg. 39 (2019) Nr. 4, S. 289 - 311
    Online Volltext: dx.doi.org/
  • Yao, Yongxuan; Yang, Bo; Chen, Yingshan; Wang, Hui; Hu, Xue; Zhou, Yuan; Gao, Xiuzhu; Lu, Mengji; Niu, Junqi; Wen, Zhe; Wu, Chunchen; Chen, Xinwen
    RNA-binding motif protein 24 (RBM24) is involved in pregenomic RNA packaging by mediating interaction between hepatitis B virus polymerase and the epsilon element
    In: Journal of Virology Jg. 93 (2019) Nr. 6, S. e02161 - 18
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Lin, Yong; Wu, Chunchen; Wang, Xueyu; Liu, Shi; Kemper, Thekla; Li, Fahong; Squire, Anthony; Zhu, Ying; Zhang, Jiming; Chen, Xinwen; Lu, Mengji
    Synaptosomal-associated protein 29 is required for the autophagic degradation of hepatitis B virus
    In: The FASEB Journal Jg. 33 (2019) Nr. 5, S. 6023 - 6034
    Online Volltext: dx.doi.org/ (Open Access)
  • Zhang, Ejuan; Ma, Zhiyong; Li, Qian; Yan, Hu; Liu, Jia; Wu, Weimin; Guo, Jiabao; Zhang, Xiaoyong; Kirschning, Carsten Jürgen; Xu, Haifeng; Lang, Philipp A.; Yang, Dongliang; Dittmer, Ulf; Yan, Huimin; Lu, Mengji
    TLR2 stimulation increases cellular metabolism in CD8⁺ T cells and thereby enhances CD8⁺ T cell activation, function, and antiviral activity
    In: The Journal of Immunology (JI) Jg. 203 (2019) Nr. 11, S. 2872 - 2886
    Online Volltext: dx.doi.org/ (Open Access)
  • Li, Qian; Yan, Yan; Liu, Jia; Huang, Xuan; Zhang, Xiaoyong; Kirschning, Carsten Jürgen; Xu, Haifeng C.; Lang, Philipp A.; Dittmer, Ulf; Zhang, Ejuan; Lu, Mengji
    Toll-Like Receptor 7 Activation Enhances CD8+ T Cell Effector Functions by Promoting Cellular Glycolysis
    In: Frontiers in Immunology Jg. 10 (2019) S. 2191
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Ma, Zhiyong; Zhang, Ejuan; Gao, Shicheng; Xiong, Yong; Lu, Mengji
    Toward a functional cure for hepatitis B: The rationale and challenges for therapeutic targeting of the b cell immune response
    In: Frontiers in Immunology Jg. 10 (2019) S. 2308
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Yang, Li; Liu, Feifei; Tong, Xiankun; Hoffmann, Daniel; Zuo, Jianping; Lu, Mengji
    Treatment of Chronic Hepatitis B Virus Infection Using Small Molecule Modulators of Nucleocapsid Assembly : Recent Advances and Perspectives
    In: ACS Infectious Diseases Jg. 5 (2019) Nr. 5, S. 713 - 724
    Online Volltext: dx.doi.org/

    • 2018

    Artikel in Zeitschriften

  • Schöneweis, Katrin; Motter, Neil; Roppert, Pia L.; Lu, Mengji; Wang, Baoju; Roehl, Ingo; Glebe, Dieter; Yang, Dongliang; Morrey, John D.; Roggendorf, Michael; Vaillant, Andrew
    Activity of nucleic acid polymers in rodent models of HBV infection
    In: Antiviral Research Jg. 149 (2018) S. 26 - 33
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Li, Meng-Meng; Zhang, Wen-Jing; Weng, Xiu-Fang; Li, Ming-Yue; Liu, Jia; Xiong, Yan; Xiong, Shu-E; Zou, Cong-Cong; Wang, Hua; Lu, Mengji; Yang, Dong-Liang; Peng, Cheng; Zheng, Xin
    CD4 T cell loss and Th2 and Th17 bias are associated with the severity of severe fever with thrombocytopenia syndrome (SFTS)
    In: Clinical Immunology Jg. 195 (2018) S. 8 - 17
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Zhu, Bin; Zhu, Zhenni; Wang, Junzhong; Huang, Shunmei; Li, Fanghui; Wang, Lu; Liu, Yanan; Yan, Qi; Zhou, Shunchang; Lu, Mengji; Yang, Dongliang; Wang, Baoju
    Chinese woodchucks with different susceptibility to WHV infection differ in their genetic background exemplified by cytochrome B and MHC-DRB molecules
    In: Virology Journal Jg. 15 (2018) 101
    Online Volltext: dx.doi.org/ (Open Access)
  • Liu, Hongyan; Li, Fahong; Zhang, Xiaoyong; Yu, Jie; Wang, Jinyu; Jia, Jia; Yu, Xueping; Shen, Zhongliang; Yuan, Zhenghong; Zhang, Xiaonan; Zhang, Zhanqing; Zhang, Xinxin; Lu, Lungen; Li, Hai; Lu, Mengji; Zhang, Jiming
    Differentially Expressed Intrahepatic Genes Contribute to Control of Hepatitis B Virus Replication in the Inactive Carrier Phase
    In: The Journal of Infectious Diseases (JID) Jg. 217 (2018) Nr. 7, S. 1044 - 1054
    Online Volltext: dx.doi.org/ (Open Access)
  • Li, Meng-Meng; Zhang, Wen-Jing; Liu, Jia; Li, Ming-Yue; Zhang, Yan-Fang; Xiong, Yan; Xiong, Shu-E; Zou, Cong-Cong; Xiong, Lei-Qun; Liang, Bo-Yun; Lu, Mengji; Yang, Dong-Liang; Peng, Cheng; Zheng, Xin
    Dynamic changes in the immunological characteristics of T lymphocytes in surviving patients with severe fever with thrombocytopenia syndrome (SFTS)
    In: International Journal of Infectious Diseases Jg. 70 (2018) S. 72 - 80
    Online Volltext: dx.doi.org/ (Open Access)
  • Wang, Qin; Pan, Wen; Liu, Yanan; Luo, Jinzhuo; Zhu, Dan; Lu, Yinping; Feng, Xuemei; Yang, Xuecheng; Dittmer, Ulf; Lu, Mengji; Yang, Dongliang; Liu, Jia
    Hepatitis B Virus-Specific CD8+ T Cells Maintain Functional Exhaustion after Antigen Reexposure in an Acute Activation Immune Environment
    In: Frontiers in Immunology Jg. 9 (2018) S. 219
    Online Volltext: dx.doi.org/ (Open Access)
  • Wu, Chun-Chen; Chen, Ying-Shan; Cao, Liang; Chen, Xin-Wen; Lu, Mengji
    Hepatitis B virus infection : Defective surface antigen expression and pathogenesis
    In: World Journal of Gastroenterology Jg. 24 (2018) Nr. 31, S. 3488 - 3499
    Online Volltext: dx.doi.org/ (Open Access)
  • Shen, Fang; Li, Yaming; Wang, Yang; Sozzi, Vitina; Revill, Peter A.; Liu, Jiangxia; Gao, Lu; Yang, Guang; Lu, Mengji; Sutter, Kathrin; Dittmer, Ulf; Chen, Jieliang; Yuan, Zhenghong
    Hepatitis B virus sensitivity to interferon-α in hepatocytes is more associated with cellular interferon response than with viral genotype
    In: Hepatology Jg. 67 (2018) Nr. 4, S. 1237 - 1252
    Online Volltext: dx.doi.org/ (Open Access)
  • Ma, Zhiyong; Cao, Qian; Xiong, Yong; Zhang, Ejuan; Lu, Mengji
    Interaction between Hepatitis B Virus and Toll-Like Receptors : current status and potential therapeutic use for chronic hepatitis B
    In: Vaccines Jg. 6 (2018) Nr. 1, S. 6
    Online Volltext: dx.doi.org/ (Open Access)
  • Huang, Shunmei; Wu, Jun; Gao, Xiaoyan; Zou, Shi; Chen, Liwen; Yang, Xilang; Sun, Chan; Du, Yanqin; Zhu, Bin; Li, Jia; Yang, Xuecheng; Feng, Xuemei; Wu, Chunchen; Shi, Chunwei; Wang, Baoju; Lu, Yinping; Liu, Jia; Zheng, Xin; Gong, Feili; Lu, Mengji; Yang, Dongliang
    LSECs express functional NOD1 receptors : A role for NOD1 in LSEC maturation-induced T cell immunity in vitro
    In: Molecular Immunology Jg. 101 (2018) S. 167 - 175
    Online Volltext: dx.doi.org/ (Open Access)
  • Huang, Shunmei; Zou, Shi; Chen, Mingfa; Gao, Xiaoyan; Chen, Liwen; Yang, Xilang; Yu, Qing; Zhao, Xiaoli; Du, Yanqin; Yang, Xuecheng; Lin, Yong; Wang, Baoju; Lu, Yinping; Liu, Jia; Zheng, Xin; Gong, Feili; Lu, Mengji; Yang, Dongliang; Wu, Jun
    Local stimulation of liver sinusoidal endothelial cells with a NOD1 agonist activates t cells and suppresses hepatitis b virus replication in mice
    In: The Journal of Immunology (JI) Jg. 200 (2018) Nr. 9, S. 3170 - 3179
    Online Volltext: dx.doi.org/ (Open Access)
  • Peng, Nanfang; Yang, Xuecheng; Zhu, Chengliang; Zhou, Li; Yu, Haisheng; Li, Mengqi; Lin, Yong; Wang, Xueyu; Li, Qian; She, Yinglong; Wang, Jun; Zhao, Qian; Lu, Mengji; Zhu, Ying; Liu, Shi
    MicroRNA-302 cluster downregulates enterovirus 71–Induced innate immune response by targeting KPNA2
    In: The Journal of Immunology (JI) Jg. 201 (2018) Nr. 1, S. 145 - 156
    Online Volltext: dx.doi.org/ (Open Access)
  • Lin, Yong; Huang, Xuan; Wu, Jun; Liu, Jia; Chen, Mingfa; Ma, Zhiyong; Zhang, Ejuan; Liu, Yan; Huang, Shunmei; Li, Qian; Zhang, Xiaoyong; Hou, Jinlin; Yang, Dongliang; Lu, Mengji; Xu, Yang
    Pre-activation of Toll-like receptor 2 enhances CD8⁺ T-cell responses and accelerates hepatitis B virus clearance in the mouse models
    In: Frontiers in Immunology Jg. 9 (2018) S. 1495
    Online Volltext: dx.doi.org/ (Open Access)
  • Yao, Yongxuan; Yang, Bo; Cao, Huang; Zhao, Kaitao; Yuan, Yifei; Chen, Yingshan; Zhang, Zhenhua; Wang, Yun; Pei, Rongjuan; Chen, Jizheng; Hu, Xue; Zhou, Yuan; Lu, Mengji; Wu, Chunchen; Chen, Xinwen
    RBM24 stabilizes hepatitis B virus pregenomic RNA but inhibits core protein translation by targeting the terminal redundancy sequence article
    In: Emerging Microbes & Infections Jg. 7 (2018) S. 86
    Online Volltext: dx.doi.org/ (Open Access)
  • Cao, Huang; Zhao, Kaitao; Yao, Yongxuan; Guo, Jing; Gao, Xiaoxiao; Yang, Qi; Guo, Min; Zhu, Wandi; Wang, Yun; Wu, Chunchen; Chen, Jizheng; Zhou, Yuan; Hu, Xue; Lu, Mengji; Chen, Xinwen; Pei, Rongjuan
    RNA binding protein 24 regulates the translation and replication of hepatitis C virus
    In: Protein & Cell Jg. 9 (2018) Nr. 11, S. 930 - 944
    Online Volltext: dx.doi.org/ (Open Access)
  • Du, Keye; Liu, Jia; Bröring, Ruth; Zhang, Xiaoyong; Yang, Dongliang; Dittmer, Ulf; Lu, Mengji
    Recent advances in the discovery and development of TLR ligands as novel therapeutics for chronic HBV and HIV infections
    In: Expert Opinion on Drug Discovery Jg. 13 (2018) Nr. 7, S. 661 - 670
    Online Volltext: dx.doi.org/
  • Yang, Jingyi; Zhao, Yue; Li, Peng; Yang, Yi; Zhang, Ejuan; Zhong, Maohua; Li, Yaoming; Zhou, DIhan; Cao, Yuan; Lu, Mengji; Shao, Feng; Yan, Huimin
    Sequence determinants of specific pattern-recognition of bacterial ligands by the NAIP-NLRC4 inflammasome
    In: Cell Discovery Jg. 4 (2018) Nr. 1, 18
    Online Volltext: dx.doi.org/ (Open Access)
  • Yang, Li; Lu, Mengji
    Small molecule inhibitors of hepatitis B virus nucleocapsid assembly : a new approach to treat chronic HBV infection
    In: Current Medicinal Chemistry Jg. 25 (2018) Nr. 7, S. 802 - 813
    Online Volltext: dx.doi.org/
  • Liu, Jia; Yu, Qing; Wu, Weimin; Huang, Xuan; Bröring, Ruth; Werner, Melanie; Roggendorf, Michael; Yang, Dongliang; Lu, Mengji
    TLR2 stimulation strengthens intrahepatic myeloid-derived cell-mediated T cell tolerance through inducing kupffer cell expansion and IL-10 production
    In: The Journal of Immunology (JI) Jg. 200 (2018) Nr. 7, S. 2341 - 2351
    Online Volltext: dx.doi.org/ (Open Access)
  • Zhao, Kaitao; Liu, Shuhui; Chen, Yingshan; Yao, Yongxuan; Zhou, Ming; Yuan, Yifei; Wang, Yun; Pei, Rongjuan; Chen, Jizheng; Hu, Xue; Zhou, Yuan; Zhao, He; Lu, Mengji; Wu, Chunchen; Chen, Xinwen
    Upregulation of HBV transcription by sodium taurocholate cotransporting polypeptide at the postentry step is inhibited by the entry inhibitor Myrcludex B
    In: Emerging Microbes & Infections Jg. 7 (2018) S. 186
    Online Volltext: dx.doi.org/ (Open Access)

    • Abstracts

  • Zhenhua, Zhu; Trippler, Martin; Real, Catherine Isabell; Werner, Melanie; Kemper, Thekla; Baba, Hideo Andreas; Treckmann, Jürgen-Walter; Paul, A.; Gerken, Guido; Schlaak, Jörg Friedrich; Lu, Mengji; Bröring, Ruth
    Hepatitis B virus entry in primary human hepatocytes initiates toll-like receptor 2-dependent immune signaling
    In: Journal of Hepatology Jg. 68 (2018) Nr. Suppl. 1, S. 793
    Online Volltext: dx.doi.org/
  • Anastasiou, Olympia E.; Westhaus, Sandra; Anspach, Marie Christine; Timmer, Lejla; Susser, Simone; Sarrazin, Christoph; Gerken, Guido; Keitel, Verena; Wedemeyer, Heiner; Lu, Mengji; Stindt, Jan; Ciesek, Sandra
    Sodium taurocholate cotransporting popypeptide variants modulate HDV entry according to their function as a bile acid transporter but do not influence the antiviral effect of Myrcludex-B
    In: Journal of Hepatology Jg. 68 (2018) Nr. Suppl. 1, S. 781
    Online Volltext: dx.doi.org/

    • 2017

    Artikel in Zeitschriften

  • Zhao, Kaitao; Wu, Chunchen; Yao, Yongxuan; Cao, Liang; Zhang, Zhenhua; Yuan, Yifei; Wang, Yun; Pei, Rongjuan; Chen, Jizheng; Hu, Xue; Zhou, Yuan; Lu, Mengji; Chen, Xinwen
    Ceruloplasmin inhibits the production of extracellular hepatitis B virions by targeting its middle surface protein
    In: Journal of General Virology Jg. 98 (2017) Nr. 6, S. 1410 - 1421
    Online Volltext: dx.doi.org/
  • Zhang, Wenjing; Li, Mengmeng; Xiong, Shue; Wang, Hua; Xiong, Yan; Li, Mingyue; Lu, Mengji; Yang, Dongliang; Peng, Cheng; Zheng, Xin
    Decreased myeloid dendritic cells indicate a poor prognosis in patients with severe fever with thrombocytopenia syndrome
    In: International Journal of Infectious Diseases Jg. 54 (2017) S. 113 - 120
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Zhou, Yun; Li, Sheng; Tang, Zongsheng; Xu, Chunli; Huang, Shunmei; Wu, Jun; Dittmer, Ulf; Dickow, Julia; Sutter, Kathrin; Lu, Mengji; Yang, Dongliang; Song, Jingjiao
    Different antiviral effects of IFNα and IFNβ in an HBV mouse model
    In: Immunobiology Jg. 222 (2017) Nr. 3, S. 562 - 570
    Online Volltext: dx.doi.org/
  • Song, Jingjiao; Li, Sheng; Zhou, Yun; Liu, Jia; Francois, Sandra; Lu, Mengji; Yang, Dongliang; Dittmer, Ulf; Sutter, Kathrin
    Different antiviral effects of IFNα subtypes in a mouse model of HBV infection
    In: Scientific Reports Jg. 7 (2017) Nr. 1, S. 334
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Liu, Chao; Huang, Xuan; Werner, Melanie; Bröring, Ruth; Ge, Jun; Li, Yongyin; Liao, Baolin; Sun, Jian; Peng, Jie; Lu, Mengji; Hou, Jinlin; Zhang, Xiaoyong
    Elevated expression of chemokine CXCL13 in chronic hepatitis B patients links to immune control during antiviral therapy
    In: Frontiers in Immunology Jg. 8 (2017) S. 323
    Online Volltext: dx.doi.org/ (Open Access)
  • Cao, Yuan; Zhang, Ejuan; Yang, Jingyi; Yang, Yi; Yu, Jie; Xiao, Yang; Li, Wei; Zhou, Dihan; Li, Yaoming; Zhao, Bali; Yan, Hu; Lu, Mengji; Zhong, Maohua; Yan, Huimin
    Frontline science : Nasal epithelial GM-CSF contributes to TLR5-mediated modulation of airway dendritic cells and subsequent iga response
    In: Journal of Leukocyte Biology (JLB) Jg. 102 (2017) Nr. 3, S. 575 - 587
    Online Volltext: dx.doi.org/
  • Liu, C.; Bröring, Ruth; Hideo, B.A.; Real, C.I.; Zhang, R.; Lu, Mengji; Gerken, Guido
    Hepatic expression of oncogenes Bmi1 and Dkk1 can be induced by treatment with hepatitis B virus particles or Lipopolysaccharide in vitro and is up-regulated in liver biopsies of patients with chronic HBV infection
    In: Journal of Hepatology Jg. 66 (2017) Nr. 1, S. S700
    Online Volltext: dx.doi.org/
  • Zhang, Ruiyong; Real, Catherine I.; Liu, Chao; Baba, Hideo Andreas; Gerken, Guido; Lu, Mengji; Bröring, Ruth
    Hepatic expression of oncogenes Bmi1 and Dkk1 is up-regulated in hepatitis B virus surface antigen–transgenic mice and can be induced by treatment with HBV particles or lipopolysaccharides in vitro
    In: International Journal of Cancer Jg. 141 (2017) Nr. 2, S. 354 - 363
    Online Volltext: dx.doi.org/
  • Wan, Yushun; Cao, Wei; Han, Tao; Ren, Sheng; Feng, Jian; Chen, TieLong; Wang, Jun; Bröring, Ruth; Lu, Mengji; Zhu, Ying
    Inducible Rubicon facilitates viral replication by antagonizing interferon production
    In: Cellular & Molecular Immunology Jg. 14 (2017) Nr. 7, S. 607 - 620
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Fang, Zhong; Roggendorf, Michael; Wang, Cong; Lin, Yong; Liu, Jia; Lu, Mengji; Dietze, Kirsten; Chen, Jieliang; Dittmer, Ulf; Yeh, Shiou-Hwei; Wu, Weimin; Kemper, Thekla; Kosinska, Anna D.; Lenart, Marzena; Yuan, Zhenghong; Pishraft-Sabet, Leila
    Low hepatitis B virus-specific T-cell response in males correlates with high regulatory T-cell numbers in murine models
    In: Hepatology Jg. 66 (2017) Nr. 1, S. 69 - 83
    Online Volltext: dx.doi.org/
  • Liu, Shuhui; Zhao, Kaitao; Su, Xi; Lu, Lu; Zhao, He; Zhang, Xianwen; Wang, Yun; Wu, Chunchen; Chen, Jizheng; Zhou, Yuan; Hu, Xue; Wang, Yanyi; Lu, Mengji; Chen, Xinwen; Pei, Rongjuan
    MITA/STING and its alternative splicing isoform MRP restrict hepatitis B virus replication
    In: PLoS ONE Jg. 12 (2017) Nr. 1, S. e0169701
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Deng, Wanyu; Zhang, Xiaoyong; Ma, Zhiyong; Lin, Yong; Lu, Mengji
    MicroRNA-125b-5p mediates post-transcriptional regulation of hepatitis B virus replication via the LIN28B/let-7 axis
    In: RNA Biology Jg. 14 (2017) Nr. 10, S. 1389 - 1398
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Chen, Xueyuan; Zhou, Li; Peng, Nanfang; Yu, Haisheng; Li, Mengqi; Cao, Zhongying; Lin, Yong; Wang, Xueyu; Li, Qian; Wang, Jun; She, Yinglong; Zhu, Chengliang; Lu, Mengji; Zhu, Ying; Liu, Shi
    MicroRNA-302a suppresses influenza A virus-stimulated interferon regulatory factor-5 expression and cytokine storm induction
    In: The Journal of Biological Chemistry (JBC) Jg. 292 (2017) Nr. 52, S. 21291 - 21303
    Online Volltext: dx.doi.org/
  • Pett, Christian; Cai, Hui; Liu, Jia; Palitzsch, Björn; Schorlemer, Manuel; Hartmann, Sebastian; Stergiou, Natascha; Lu, Mengji; Kunz, Horst; Schmitt, Edgar; Westerlind, Ulrika
    Microarray analysis of antibodies induced with synthetic antitumor vaccines : specificity against diverse mucin core structures
    In: Chemistry - A European Journal Jg. 23 (2017) Nr. 16, S. 3875 - 3884
    Online Volltext: dx.doi.org/
  • Liu, Yanan; Wang, Junzhong; Wang, Lu; Wang, Baoju; Yang, Shangqing; Wang, Qin; Luo, Jinzhuo; Feng, Xuemei; Yang, Xuecheng; Lu, Yinping; Roggendorf, Michael; Lu, Mengji; Yang, Dongliang; Liu, Jia
    Molecular cloning, characterization and expression analysis of Tim-3 and Galectin-9 in the woodchuck model
    In: Molecular Immunology Jg. 83 (2017) S. 127 - 136
    Online Volltext: dx.doi.org/
  • Wu, Weimin; Liu, Yan; Lin, Yong; Pan, Danzhen; Yang, Dongliang; Lu, Mengji; Xu, Yang
    PreC and C Regions of Woodchuck Hepatitis Virus Facilitate Persistent Expression of Surface Antigen of Chimeric WHV-HBV Virus in the Hydrodynamic Injection BALB/c Mouse Model
    In: Viruses Jg. 9 (2017) Nr. 2, S. 35
    Online Volltext: dx.doi.org/ (Open Access)
  • Meng, Zhongji; Lu, Mengji
    RNA Interference-Induced Innate Immunity, Off-Target Effect, or Immune Adjuvant?
    In: Frontiers in Immunology Jg. 8 (2017) S. 331
    Online Volltext: dx.doi.org/ (Open Access)
  • Su, Xi; Liu, Shuhui; Zhang, Xianwen; Lam, Sin Man; Hu, Xue; Zhou, Yuan; Chen, Jizheng; Wang, Yun; Wu, Chunchen; Shui, Guanghou; Lu, Mengji; Pei, Rongjuan; Chen, Xinwen
    Requirement of cytosolic phospholipase A2 gamma in lipid droplet formation
    In: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids Jg. 1862 (2017) Nr. 7, S. 692 - 705
    Online Volltext: dx.doi.org/
  • Xu, Chunli; Lu, Yinping; Zheng, Xin; Feng, Xuemei; Yang, Xuecheng; Timm, Jörg; Wu, Jun; Wang, Baoju; Lu, Mengji; Yang, Dongliang; Liu, Jia
    TLR2 Expression in Peripheral CD4+ T Cells Promotes Th17 Response and Is Associated with Disease Aggravation of Hepatitis B Virus-Related Acute-On-Chronic Liver Failure
    In: Frontiers in Immunology Jg. 8 (2017) S. 1609
    Online Volltext: dx.doi.org/ (Open Access)
  • Ma, Zhiyong; Liu, Jia; Wu, Weimin; Zhang, Ejuan; Zhang, Xiaoyong; Li, Qian; Zelinskyy, Gennadiy; Buer, Jan; Dittmer, Ulf; Kirschning, Carsten Jürgen; Lu, Mengji
    The IL-1R/TLR signaling pathway is essential for efficient CD8+ T-cell responses against hepatitis B virus in the hydrodynamic injection mouse model
    In: Cellular & Molecular Immunology Jg. 14 (2017) Nr. 12, S. 997 - 1008
    Online Volltext: dx.doi.org/ (Open Access)
  • Li, Lei; Li, Sheng; Zhou, Yun; Yang, Lu; Zhou, Di; Yang, Yan; Lu, Mengji; Yang, Dongliang; Song, Jingjiao
    The dose of HBV genome contained plasmid has a great impact on HBV persistence in hydrodynamic injection mouse model
    In: Virology Journal Jg. 14 (2017) 205
    Online Volltext: dx.doi.org/ (Open Access)
  • Lin, Yong; Deng, Wanyu; Pang, Jinke; Kemper, Thekla; Hu, Jing; Yin, Jian; Zhang, Jiming; Lu, Mengji
    The microRNA-99 family modulates hepatitis B virus replication by promoting IGF-1R/PI3K/Akt/mTOR/ULK1 signaling-induced autophagy
    In: Cellular Microbiology Jg. 19 (2017) Nr. 5, S. e12709
    Online Volltext: dx.doi.org/ (Open Access)
  • Pang, Jinke; Zhang, Geng; Lin, Yong; Xie, Zhanglian; Liu, Hongyan; Tang, Libo; Lu, Mengji; Yan, Ran; Guo, Haitao; Sun, Jian; Hou, Jinlin; Zhang, Xiaoyong
    Transforming growth factor β-activated kinase 1 transcriptionally suppresses hepatitis B virus replication
    In: Scientific Reports Jg. 7 (2017) S. 39901
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)

    • Beiträge in Sammelwerken und Tagungsbänden

  • Liu, Jia; Huang, Xuan; Werner, Melanie; Bröring, Ruth; Yang, Dongliang; Lu, Mengji
    Advanced Method for Isolation of Mouse Hepatocytes, Liver Sinusoidal Endothelial Cells, and Kupffer Cells
    In: Hepatitis B Virus: Methods and Protocols / Guo, Haitao; Cuconati, Andrea (Hrsg.) 2017, S. 249 - 258
    Online Volltext: dx.doi.org/

    • 2016

    Artikel in Zeitschriften

  • Dietze, Kirsten; Schimmer, Simone; Kretzmer, Freya; Wang, Junzhong; Lin, Yong; Huang, Xuan; Wu, Weimin; Wang, Baoju; Lu, Mengji; Dittmer, Ulf; Yang, Dongliang; Liu, Jia
    Characterization of the Treg Response in the Hepatitis B Virus Hydrodynamic Injection Mouse Model
    In: PLoS ONE Jg. 11 (2016) Nr. 3, S. e0151717
    Online Volltext: dx.doi.org/ (Open Access)
  • Meng, Zhongji; Zhang, Xiaoyong; Pei, Rongjuan; Zhang, Ejuan; Kemper, Thekla; Vollmer, Jörg; Davis, Heather L.; Glebe, Dieter; Gerlich, Wolfram; Roggendorf, Michael; Lu, Mengji
    Combination therapy including CpG oligodeoxynucleotides and entecavir induces early viral response and enhanced inhibition of viral replication in a woodchuck model of chronic hepadnaviral infection
    In: Antiviral Research Jg. 125 (2016) S. 14 - 24
    Online Volltext: dx.doi.org/
  • Zhang, Xiaoyong; Liu, Hongyan; Xie, Zhanglian; Deng, Wangyu; Wu, Chunchen; Qin, Bo; Hou, Jinlin; Lu, Mengji
    Epigenetically regulated miR-449a enhances hepatitis B virus replication by targeting cAMP-responsive element binding protein 5 and modulating hepatocytes phenotype
    In: Scientific Reports Jg. 6 (2016) S. 25389
    Online Volltext: dx.doi.org/ (Open Access)
  • Zhang, Zhen-Hua; Wu, Chun-Chen; Chen, Xin-Wen; Li, Xu; Li, Jun; Lu, Mengji
    Genetic variation of hepatitis B virus and its significance for pathogenesis
    In: World Journal of Gastroenterology Jg. 22 (2016) Nr. 1, S. 126 - 144
    Online Volltext: dx.doi.org/ (Open Access)
  • Real, Catherine Isabell; Bröring, Ruth; Schlaak, Jörg Friedrich; Gerken, Guido; Schirmbeck, Reinhold; Vornlocher, Hans-Peter; Dittmer, Ulf; Gibbert, Kathrin; John, Matthias Johannes; Ickenstein, Ludger Markus; Jahn-Hofmann, Kerstin; Deckert, Jochen; Hossbach, Markus; Trippler, Martin; Huang, Xuan; Lu, Mengji; Liu, Jia
    Hepatitis B virus genome replication triggers toll-like receptor 3-dependent interferon responses in the absence of hepatitis B surface antigen
    In: Scientific Reports Jg. 6 (2016) S. 24865
    Online Volltext: dx.doi.org/ (Open Access)
  • Peng, Cheng; Wang, Hua; Zhang, Wen-Jing; Jie, Sheng-Hua; Tong, Qiao-Xia; Lu, Mengji; Yang, Dong-Liang
    Inhibitory effect of miR-125b on hepatitis C virus core protein-induced TLR2/MyD88 signaling in THP-1 cells
    In: World Journal of Gastroenterology Jg. 22 (2016) Nr. 17, S. 4354 - 4361
    Online Volltext: dx.doi.org/ (Open Access)
  • Yan, Qi; Li, Mengmeng; Liu, Qin; Li, Fanghui; Zhu, Bin; Wang, Junzhong; Lu, Yinping; Liu, Jia; Wu, Jun; Zheng, Xin; Lu, Mengji; Wang, Baoju; Yang, Dongliang
    Molecular characterization of woodchuck IFI16 and AIM2 and their expression in woodchucks infected with woodchuck hepatitis virus (WHV)
    In: Scientific Reports Jg. 6 (2016) S. 28776
    Online Volltext: dx.doi.org/ (Open Access)
  • Wang, Lu; Wang, Junzhong; Liu, Yana; Wang, Baoju; Yang, Shangqing; Yu, Qing; Roggendorf, Michael; Lu, Mengji; Liu, Jia; Yang, Dongliang
    Molecular cloning, characterization and expression analysis of TGF-? and receptor genes in the woodchuck model
    In: Gene Jg. 595 (2016) Nr. 1, S. 1 - 8
    Online Volltext: dx.doi.org/
  • Yan, Qi; Liu, Qin; Li, Meng-Meng; Li, Fang-Hui; Zhu, Bin; Wang, Jun-Zhong; Lu, Yin-Ping; Liu, Jia; Wu, Jun; Zheng, Xin; Lu, Mengji; Wang, Bao-Ju; Yang, Dong-Liang
    Molecular cloning, characterization and expression analysis of woodchuck retinoic acid-inducible gene I
    In: Journal of Huazhong University of Science and Technology (Medical Sciences) Jg. 36 (2016) Nr. 3, S. 335 - 343
    Online Volltext: dx.doi.org/
  • Liu, Wei; Lu, Mengji; Liu, Yutian; Zhang, Wenjing; Chen, Qian; Song, Hongxuan
    Multidrug resistance protein 4 is a critical protein associated with the antiviral efficacy of nucleos(t)ide analogues
    In: Liver International Jg. 36 (2016) Nr. 9, S. 1284 - 1294
    Online Volltext: dx.doi.org/
  • Li, Fahong; Lu, Mengji; Li, Ji; Zhang, Yijun; Wang, Jinyu; Deng, Wangyu; Zhou, Pu
    Serum microRNA-125b correlates with hepatitis B viral replication and liver necroinflammation
    In: Clinical Microbiology and Infection Jg. 22 (2016) Nr. 4, S. 384.e1 - 384.e10
    Online Volltext: dx.doi.org/ (Open Access)
  • Deng, Wanyu; Lu, Mengji
    The role of microRNAs in hepatocyte metabolism and hepatitis B virus replication
    In: Virologica Sinica Jg. 31 (2016) Nr. 6, S. 472 - 479
    Online Volltext: dx.doi.org/
  • Liu, Yanan; Wang, Baoju; Wang, Lu; Vikash, Vikash; Wang, Qin; Roggendorf, Michael; Lu, Mengji; Yang, Dongliang; Liu, Jia
    Transcriptome Analysis and Comparison of Marmota monax and Marmota himalayana
    In: PLoS ONE Jg. 11 (2016) Nr. 11, S. e0165875
    Online Volltext: dx.doi.org/ (Open Access)
  • Ye, Zhou; Zhang, Quan; Wang, Shengtao; Bharate, Priya; Varela-Aramburu, Silvia; Lu, Mengji; Seeberger, Peter H; Yin, Jian
    Tumour-Targeted Drug Delivery with Mannose-Functionalized Nanoparticles Self-Assembled from Amphiphilic β-Cyclodextrins
    In: Chemistry - A European Journal Jg. 22 (2016) Nr. 43, S. 15216 - 15221
    Online Volltext: dx.doi.org/

    • Abstracts

  • Zhang, X.; Ge, J.; Huang, Z.; Sun, J.; Lu, Mengji; Hou, J.
    Expression and Function of Toll-Like Receptor 7 in Chronic Hepatitis B Patients Links to Antiviral Effect of PEG-IFN-A-2A Therapy
    In: Journal of Hepatology Jg. 64 (2016) Nr. 2, Suppl., S. S380 - S381
    Online Volltext: dx.doi.org/
  • Liu, J.; Yang, D.; Lu, Mengji
    HBV Strengthens Intrahepatic Myeloid-Derived Cells Mediated T Cell Tolerance through TLR1/2 Induced Kupffer Cell Expansion and IL-10 Production
    In: Journal of Hepatology Jg. 64 (2016) Nr. 2, Suppl., S. S515
    Online Volltext: dx.doi.org/
  • Bröring, Ruth; Zhang, Z.; Trippler, M.; Real, C.; Werner, M.; Gerken, Guido; Schlaak, Jörg Friedrich; Lu, Mengji
    Hepatitis B virus activates toll-like receptor 2 signaling upon infection of primary human hepatocytes
    In: Journal of Hepatology Jg. 64 (2016) Nr. 2, Suppl., S. S394
    Online Volltext: dx.doi.org/
  • Liu, J.; Xu, C.; Zheng, X.; Lu, Mengji; Yang, D.
    Increased TLR2 Expression in Peripheral CD4+T Cells Promotes TH17 Cells Responses and is Associated with Disease Aggravation of HBV-Related Acute-on-Chronic Liver Failure
    In: Journal of Hepatology Jg. 64 (2016) Nr. 2, Suppl., S. S307
    Online Volltext: dx.doi.org/

    • 2015

    Artikel in Zeitschriften

  • Huang, Zuxiong; Ge, Jun; Pang, Jinke; Liu, Hongyan; Chen, Jinjun; Liao, Baolin; Huang, Xuan; Zuo, Daming; Sun, Jian; Lu, Mengji; Zhang, Xiaoyong; Hou, Jinlin
    Aberrant expression and dysfunction of TLR2 and its soluble form in chronic HBV infection and its regulation by antiviral therapy
    In: Antiviral Research Jg. 118 (2015) S. 10 - 19
    Online Volltext: dx.doi.org/
  • Peng, Cheng; Lu, Mengji; Yang, Dongliang
    CRISPR/Cas9-based tools for targeted genome editing and replication control of HBV
    In: Virologica Sinica Jg. 30 (2015) Nr. 5, S. 317 - 325
    Online Volltext: dx.doi.org/
  • Hu, Jing; Qiu, Liying; Wang, Xiaoli; Zou, Xiaopeng; Lu, Mengji; Yin, Jian
    Carbohydrate-based vaccine adjuvants : discovery and development
    In: Expert Opinion on Drug Discovery Jg. 10 (2015) Nr. 10, S. 1133 - 1144
    Online Volltext: dx.doi.org/
  • Ma, Zhiyong; Zhang, Ejuan; Yang, Dongliang; Lu, Mengji
    Contribution of Toll-like receptors to the control of hepatitis B virus infection by initiating antiviral innate responses and promoting specific adaptive immune responses
    In: Cellular & Molecular Immunology Jg. 12 (2015) Nr. 3, S. 273 - 282
    Online Volltext: dx.doi.org/
  • Zhang, Ejuan; Kosinska, Anna; Lu, Mengji; Yan, Huimin; Roggendorf, Michael
    Current status of immunomodulatory therapy in chronic hepatitis B, fifty years after discovery of the virus : Search for the "magic bullet" to kill cccDNA
    In: Antiviral Research Jg. 123 (2015) S. 193 - 203
    Online Volltext: dx.doi.org/
  • Li, Songxia; Zhao, Kaitao; Liu, Shuhui; Wu, Chunchen; Yao, Yongxuan; Cao, Liang; Hu, Xue; Zhou, Yuan; Wang, Yun; Pei, Rongjuan; Lu, Mengji; Chen, Xinwen
    HBsAg sT123N mutation induces stronger antibody responses to HBsAg and HBcAg and accelerates in vivo HBsAg clearance
    In: Virus Research Jg. 210 (2015) Nr. December, S. 119 - 125
    Online Volltext: dx.doi.org/
  • Zhang, Zhenhua; Xia, Jianbo; Sun, Binghu; Dai, Yu; Li, Xu; Schlaak, Jörg Friedrich; Lu, Mengji
    In vitro and in vivo replication of a chemically synthesized consensus genome of hepatitis B virus genotype B
    In: Journal of Virological Methods Jg. 213 (2015) S. 57 - 64
    Online Volltext: dx.doi.org/
  • Lin, Y.; Lu, Mengji; Pang, J.; Kemper, T.; Deng, W.
    Microrna-99 family modulates hepatitis B virus replication by targeting the phosphoinositide 3-KINASE/Akt/mTOR signaling pathway
    In: Journal of Hepatology Jg. 62 (2015) Nr. Suppl. 2, S. S526
    Online Volltext: dx.doi.org/
  • Wang, Chang-Tai; Zhang, Ya-Fei; Sun, Bing-Hu; Dai, Yu; Zhu, Hui-Lan; Xu, Yuan-Hong; Lu, Mengji; Yang, Dong-Liang; Li, Xu; Zhang, Zhen-Hua
    Models for predicting hepatitis B e antigen seroconversion in response to interferon-α in chronic hepatitis B patients
    In: World Journal of Gastroenterology Jg. 21 (2015) Nr. 18, S. 5668 - 5676
    Online Volltext: dx.doi.org/ (Open Access)
  • Sun, C.; Huang, S.; Wu, J.; Lu, Mengji; Zhao, X.; Lin, Y.; Zheng, X.; Chen, M.; Xia, Y.; Wang, B.; Yang, D.
    NOD1 ligand modulates the course of hepatitis B virus infection in hydrodynamic injection mouse model
    In: Journal of Clinical Virology Jg. 69 (2015) S. 236
    Online Volltext: dx.doi.org/
  • Pan, Danzhen; Lin, Yong; Wu, Weimin; Song, Jingjiao; Zhang, Ejuan; Wu, Chunchen; Chen, Xinwen; Hu, Kanghong; Yang, Dongliang; Xu, Yang; Lu, Mengji
    Persistence of the recombinant genomes of woodchuck hepatitis virus in the mouse model
    In: PLoS ONE Jg. 10 (2015) Nr. 5, S. e0125658
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Guo, Min; Pei, Rongjuan; Yang, Qi; Cao, Huang; Wang, Yun; Wu, Chunchen; Chen, Jizheng; Zhou, Yuan; Hu, Xue; Lu, Mengji; Chen, Xinwen
    Phosphatidylserine-specific phospholipase A1 involved in hepatitis C virus assembly through NS2 complex formation
    In: Journal of Virology Jg. 89 (2015) Nr. 4, S. 2367 - 2377
    Online Volltext: dx.doi.org/ (Open Access)
  • Wang, Jin-Yu; Mao, Ri-Cheng; Zhang, Yong-Mei; Zhang, Yi-Jun; Liu, Hong-Yan; Qin, Yan-Li; Lu, Mengji; Zhang, Ji-Ming
    Serum microRNA-124 is a novel biomarker for liver necroinflammation in patients with chronic hepatitis B virus infection
    In: Journal of Viral Hepatitis Jg. 22 (2015) Nr. 2, S. 126 - 134
    Online Volltext: dx.doi.org/
  • Han, Tao; Wan, Yushun; Wang, Jun; Zhao, Peng; Yuan, Yue; Wang, Li; She, Yinglong; Bröring, Ruth; Lu, Mengji; Ye, Linbai; Zhu, Ying
    Set7 facilitates hepatitis C virus replication via enzymatic activity-dependent attenuation of the IFN-related pathway
    In: The Journal of Immunology (JI) Jg. 194 (2015) Nr. 6, S. 2757 - 2768
    Online Volltext: dx.doi.org/ (Open Access)
  • Wu, Weimin; Dietze, Kirsten; Gibbert, Kathrin; Lang, Karl S.; Trilling, Mirko; Yan, Huimin; Wu, Jun; Yang, Dongliang; Lu, Mengji; Roggendorf, Michael; Dittmer, Ulf; Liu, Jia
    TLR ligand induced IL-6 counter-regulates the anti-viral CD8+ T cell response during an acute retrovirus infection
    In: Scientific Reports Jg. 5 (2015) 10501
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Roggendorf, Michael; Kosinska, Anna D; Liu, Jia; Lu, Mengji
    The Woodchuck, a Nonprimate Model for Immunopathogenesis and Therapeutic Immunomodulation in Chronic Hepatitis B Virus Infection
    In: Cold Spring Harbor Perspectives in Medicine Jg. 5 (2015) Nr. 12, S. a021451
    Online Volltext: dx.doi.org/
  • Kosinska, Anna D.; Liu, Jia; Lu, Mengji; Roggendorf, Michael
    Therapeutic vaccination and immunomodulation in the treatment of chronic hepatitis B : preclinical studies in the woodchuck
    In: Medical Microbiology and Immunology (2015) Nr. 204,1, S. 103 - 114
    Online Volltext: dx.doi.org/ (Open Access)
  • Zhang, Ejuan; Lu, Mengji
    Toll-like receptor (TLR)-mediated innate immune responses in the control of hepatitis B virus (HBV) infection
    In: Medical Microbiology and Immunology Jg. 204 (2015) Nr. 1, S. 11 - 20
    Online Volltext: dx.doi.org/ (Open Access)
  • Zhang, Ejuan; Kosinska, Anna D; Ma, Zhiyong; Dietze, Kirsten; Xu, Yang; Meng, Zhongji; Zhang, Xiaoyong; Wang, Junzhong; Wang, Baoju; Dittmer, Ulf; Roggendorf, Michael; Yang, Dongliang; Lu, Mengji
    Woodchuck hepatitis virus core antigen-based DNA and protein vaccines induce qualitatively different immune responses that affect T cell recall responses and antiviral effects
    In: Virology Jg. 475 (2015) S. 56 - 65
    Online Volltext: dx.doi.org/ (Open Access)

    • 2014

    Artikel in Zeitschriften

  • Chen, H.; Pei, R.; Zhu, W.; Zeng, R.; Wang, Y.; Lu, Mengji; Chen, X.
    An alternative splicing isoform of MITA antagonizes MITA-mediated induction of type i IFNs
    In: The Journal of Immunology (JI) Jg. 192 (2014) Nr. 3, S. 1162 - 1170
    Online Volltext: dx.doi.org/ (Open Access)
  • Cao, L.; Wu, C.; Shi, H.; Gong, Z.; Zhang, E.; Wang, H.; Zhao, K.; Liu, S.; Li, S.; Gao, X.; Wang, Y.; Pei, R.; Lu, Mengji; Chen, X.
    Coexistence of Hepatitis B virus quasispecies enhances viral replication and the ability to induce host antibody and cellular immune responses
    In: Journal of Virology Jg. 88 (2014) Nr. 15, S. 8656 - 8666
    Online Volltext: dx.doi.org/
  • Pei, Rong-Juan; Chen, Xin-Wen; Lu, Mengji
    Control of hepatitis B virus replication by interferons and Toll-like receptor signaling pathways
    In: World Journal of Gastroenterology Jg. 20 (2014) Nr. 33, S. 11618 - 11629
    Online Volltext: dx.doi.org/ (Open Access)
  • Liu, Jia; Zhang, Ejuan; Ma, Zhiyong; Wu, Weimin; Kosinska, Anna; Zhang, Xiaoyong; Möller, Inga; Seiz, Pia; Glebe, Dieter; Wang, Baoju; Yang, Dongliang; Lu, Mengji; Roggendorf, Michael
    Enhancing Virus-Specific Immunity In Vivo by Combining Therapeutic Vaccination and PD-L1 Blockade in Chronic Hepadnaviral Infection
    In: PLoS Pathogens Jg. 10 (2014) Nr. 1, S. e1003856
    Online Volltext: dx.doi.org/ (Open Access)
  • Yang, Jingyi; Zhang, Ejuan; Liu, Fang; Zhang, Yan; Zhong, Maohua; Li, Yaoming; Zhou, Dihan; Chen, Yaoqing; Cao, Yuan; Xiao, Yang; He, Benxia; Yang, Yi; Sun, Ying; Lu, Mengji; Yan, Huimin
    Flagellins of salmonella typhi and nonpathogenic escherichia coli are differentially recognized through the NLRC4 pathway in macrophages
    In: Journal of Innate Immunity Jg. 6 (2014) Nr. 1, S. 47 - 57
    Online Volltext: dx.doi.org/
  • Zhang, Yijun; Zhang, Yongmei; Kang, Yaoyue; Wang, Jinyu; Liu, Hongyan; Zhu, Haoxiang; Qin, Yanli; Mao, Richeng; Lin, Xu; Lu, Mengji; Zhang, Jiming
    Generation of a human hepatoma cell line supporting efficient replication of a lamivudine resistant hepatitis B virus
    In: Journal of Virological Methods Jg. 201 (2014) S. 51 - 56
    Online Volltext: dx.doi.org/
  • Wang, Junzhong; Wang, Baoju; Huang, Shunmei; Song, Zhitao; Wu, Jun; Zhang, Ejuan; Zhu, Zhenni; Zhu, Bin; Yin, Ying; Lin, Yong; Xu, Yang; Zheng, Xin; Lu, Mengji; Yang, Dongliang
    Immunosuppressive drugs modulate the replication of hepatitis B virus (HBV) in a hydrodynamic injection mouse model
    In: PLoS ONE Jg. 9 (2014) Nr. 1, S. 85832
    Online Volltext: dx.doi.org/ (Open Access)
  • Lu, Mengji; Wen, Yumei
    Interaction of viruses with host immune system and immunomodulation in chronic viral infections
    In: Virologica Sinica Jg. 29 (2014) Nr. 1, S. 1 - 2
    Online Volltext: dx.doi.org/
  • Pei, Ronjuan; Qin, Bo; Zhang, Xiaoyong; Zhu, Wandi; Kemper, Thekla; Ma, Zhiong; Trippler, Martin; Schlaak, Jörg Friedrich; Chen, Xinwen; Lu, Mengji
    Interferon-induced proteins with tetratricopeptide repeats 1 and 2 are cellular factors that limit hepatitis B virus replication
    In: Journal of Innate Immunity Jg. 6 (2014) Nr. 2, S. 182 - 191
    Online Volltext: dx.doi.org/
  • Xun, Yunhao; Zhang, Jijun; Pan, Qingchun; Mao, Richeng; Qin, Yanli; Liu, Hongyan; Zhang, Y.-M.; Yu, Yongsheng; Tang, Zhenghao; Lu, Mengji; Zang, Guoqing; Zhang, Jiming
    Metformin inhibits hepatitis B virus protein production and replication in human hepatoma cells
    In: Journal of Viral Hepatitis Jg. 21 (2014) Nr. 8, S. 597 - 603
    Online Volltext: dx.doi.org/
  • Xu, Leibo; Beckebaum, Susanne; Iacob, Speranta; Wu, Gang; Kaiser, Gernot Maximil; Radtke, Arnold; Liu, Chao; Kabar, Iyad; Schmidt, Hartmut H; Zhang, Xiaoyong; Lu, Mengji; Cicinnati, Vito
    MicroRNA-101 inhibits human hepatocellular carcinoma progression through EZH2 downregulation and increased cytostatic drug sensitivity
    In: Journal of Hepatology Jg. 60 (2014) Nr. 3, S. 590 - 598
    Online Volltext: dx.doi.org/
  • Jiang, M.; Bröring, Ruth; Trippler, M.; Wu, J.; Zhang, E.; Zhang, X.; Gerken, Guido; Lu, Mengji; Schlaak, Jörg Friedrich
    MicroRNA-155 controls Toll-like receptor 3- and hepatitis C virus-induced immune responses in the liver
    In: Journal of Viral Hepatitis Jg. 21 (2014) Nr. 2, S. 99 - 110
    Online Volltext: dx.doi.org/
  • Liu, Jia; Kosinska, Anna; Lu, Mengji; Roggendorf, Michael
    New therapeutic vaccination strategies for the treatment of chronic hepatitis B
    In: Virologica Sinica Jg. 29 (2014) Nr. 1, S. 10 - 16
    Online Volltext: dx.doi.org/
  • Meng, Zhongji; Ma, Zhiyong; Zhang, Ejuan; Kosinska, Anna D.; Liu, Jia; Zhang, Xiaoyong; Zhou, Tianlun; Wu, Jun; Dahmen, Uta; Dirsch, Olaf; Yang, Dongliang; Roggendorf, Michael; Lu, Mengji
    Novel woodchuck hepatitis virus (WHV) transgene mouse models show sex-dependent WHV replicative activity and development of spontaneous immune responses to WHV proteins
    In: Journal of Virology Jg. 88 (2014) Nr. 3, S. 1573 - 1581
    Online Volltext: dx.doi.org/
  • Zhu, Wandi; Pei, Rongjuan; Jin, Rui; Hu, Xue; Zhou, Yuan; Wang, Yun; Wu, Chunchen; Lu, Mengji; Chen, Xinwen
    Nuclear receptor 4 group A member 1 determines hepatitis C virus entry efficiency through the regulation of cellular receptor and apolipoprotein E expression
    In: Journal of General Virology Jg. 95 (2014) S. 1510 - 1521
    Online Volltext: dx.doi.org/
  • Wang, Baoju; Zhu, Zhenni; Zhu, Bin; Wang, Junzhong; Song, Zhitao; Huang, Shunmei; Fan, Wei; Tao, Yuanqing; Wang, Zhongdong; Wang, Hu; Lu, Mengji; Yang, Dongliang
    Nucleoside analogues alone or combined with vaccination prevent hepadnavirus viremia and induce protective immunity : Alternative strategy for hepatitis B virus post-exposure prophylaxis
    In: Antiviral Research Jg. 105 (2014) Nr. 1, S. 118 - 125
    Online Volltext: dx.doi.org/
  • Hu, Jing; Liu, Jia; Yang, Dongliang; Lu, Mengji; Yin, Jian
    Physiological roles of asialoglycoprotein receptors (ASGPRs) variants and recent advances in hepatic-targeted delivery of therapeutic molecules via ASGPRs
    In: Protein & Peptide Letters Jg. 21 (2014) Nr. 10, S. 1025 - 1030
    Online Volltext: dx.doi.org/
  • Wu, Jun; Huang, Shunmei; Zhao, Xiaoli; Chen, Minfei; Lin, Yong; Xia, Youchen; Sun, Chan; Yang, Xuecheng; Wang, Junzhong; Guo, Yan; Song, Jingjiao; Zhang, Ejuan; Wang, Baoju; Zheng, Xin; Schlaak, Jörg Friedrich; Lu, Mengji; Yang, Dongliang
    Poly(I:C) Treatment Leads to Interferon-Dependent Clearance of Hepatitis B Virus in a Hydrodynamic Injection Mouse Model
    In: Journal of Virology Jg. 88 (2014) Nr. 18, S. 10421 - 10431
    Online Volltext: dx.doi.org/
  • Pei, Ronjuan; Grund, Sebastian; Verheyen, Jens; Esser, Stefan; Chen, Xinwen; Lu, Mengji
    Spontaneous reactivation of hepatitis B virus replication in an HIV coinfected patient with isolated anti-Hepatitis B core antibodies
    In: Virology Journal Jg. 11 (2014) 9
    Online Volltext: dx.doi.org/ (Open Access)
  • Song, Jingjiao; Zhou, Yun; Li, Sheng; Wang, Baoju; Zheng, Xin; Wu, Jun; Gibbert, Kathrin; Dittmer, Ulf; Lu, Mengji; Yang, Dongliang
    Susceptibility of Different Hepatitis B Virus Isolates to Interferon-Alpha in a Mouse Model Based on Hydrodynamic Injection
    In: PLoS ONE Jg. 9 (2014) Nr. 3, S. e90977
    Online Volltext: dx.doi.org/ (Open Access)
  • Jiang, M; Bröring, Ruth; Trippler, M; Poggenpohl, L; Fiedler, Melanie; Gerken, Guido; Lu, Mengji; Schlaak, Jörg Friedrich
    Toll-like receptor-mediated immune responses are attenuated in the presence of high levels of hepatitis B virus surface antigen
    In: Journal of Viral Hepatitis Jg. 21 (2014) Nr. 12, S. 860 - 872
    Online Volltext: dx.doi.org/

    • 2013

    Artikel in Zeitschriften

  • Wu, Chunchen; Shi, Hui; Lu, Mengji; Xu, Yang; Chen, Xinwen
    A case of hepatitis B reactivation in an anti-HBs positive, anti-HBc positive non-Hodgkin’s lymphoma patient
    In: Virologica Sinica Jg. 28 (2013) Nr. 1, S. 49 - 52
    Online Volltext: dx.doi.org/
  • Kosinska, Anna D.; Zhang, Ejuan; Johrden, Lena; Liu, Jia; Seiz, Pia L.; Zhang, Xiaoyong; Ma, Zhiyong; Kemper, Thekla; Fiedler, Melanie; Glebe, Dieter; Wildner, Oliver; Dittmer, Ulf; Lu, Mengji; Roggendorf, Michael
    Combination of DNA Prime - Adenovirus Boost Immunization with Entecavir Elicits Sustained Control of Chronic Hepatitis B in the Woodchuck Model
    In: PLoS Pathogens Jg. 9 (2013) Nr. 6, S. e100339
    Online Volltext: dx.doi.org/ (Open Access)
  • Zhang, X.; Kosinska, A.; Wang, B.; Seiz, P.; Lu, Mengji; Yang, D.; Zhang, E.; Möller, I.; Liu, J.; Ma, Z.; Glebe, D.; Roggendorf, Michael
    Enhancing virus-specific immunity in vivo by combining therapeutic vaccination and PD1/PD-L1 blockade in chronic hepadnaviral infection
    In: Journal of Hepatology Jg. 58 (2013) Nr. Suppl. 1, S. S160
    Online Volltext: dx.doi.org/
  • Chen, Ming-Fa; Lin, Yong; Xia, You-Chen; Sun, Chan; Feng, Xue-Mei; Lu, Mengji; Yang, Dong-Liang; Wu, Jun
    Establishment and application of hepatitis B virus persistent replication model in IFNAR⁻/⁻ mouse
    In: Journal of Huazhong University of Science and Technology (Medical Sciences) Jg. 33 (2013) Nr. 3, S. 392 - 397
    Online Volltext: dx.doi.org/
  • Chen, Jieliang; Wu, Min; Zhang, Xiaonan; Zhang, Wen; Zhang, Zhanqing; Chen, Lixian; He, Jing; Zheng, Ye; Chen, Cuncun; Wang, Fan; Hu, Yunwen; Zhou, Xiaohui; Wang, Cong; Xu, Yang; Lu, Mengji; Yuan, Zhenghong
    Hepatitis B virus polymerase impairs interferon-α-induced STA T activation through inhibition of importin-α5 and protein kinase C-δ
    In: Hepatology Jg. 57 (2013) Nr. 2, S. 470 - 482
    Online Volltext: dx.doi.org/
  • Li, Lei; Shen, Hong; Li, Anyi; Zhang, Zhenhua; Wang, Baoju; Wang, Junzhong; Zheng, Xin; Wu, Jun; Yang, Dongliang; Lu, Mengji; Song, Jingjiao
    Inhibition of hepatitis B virus (HBV) gene expression and replication by HBx gene silencing in a hydrodynamic injection mouse model with a new clone of HBV genotype B
    In: Virology Journal Jg. 10 (2013) 214
    Online Volltext: dx.doi.org/ (Open Access)
  • Yang, Yinke; Zhang, Xiaoyong; Zhang, Chunyan; Tao, Yuanqing; Fan, Wei; Wang, Zhongdong; Wang, Hu; Lu, Mengji; Yang, Dongliang; Fiedler, Melanie; Wang, Baoju
    Molecular characterization of woodchuck CD4 (wCD4) and production of a depletion monoclonal antibody against wCD4
    In: Molecular Immunology Jg. 56 (2013) Nr. 1/2, S. 64 - 71
    Online Volltext: dx.doi.org/
  • Zhu, B.; Yang, D.; Wang, Z.; Lu, Mengji; Fan, W.; Tao, Y.; Wang, B.; Huang, S.; Song, Z.; Zhu, Z.; Wang, H.
    Nucleoside analogues alone or combined with vaccination prevent WHV infection and induce protective immunity IMMUNITY : new strategy for HBV post-exposure prophylaxis
    In: Journal of Hepatology Jg. 58 (2013) Nr. Suppl. 1, S. S164 - S165
    Online Volltext: dx.doi.org/
  • Lu, Mengji; Wang, B.; Pan, D.; Wu, W.; Xu, Y.; Yang, D.; Lin, Y.
    Persistence of chimeric Hepatitis B viruses in the hydrodynamic injection mouse model
    In: Journal of Hepatology Jg. 58 (2013) Nr. Suppl. 1, S. S165
    Online Volltext: dx.doi.org/
  • Qin, Bo; Pei, RongJuan; He, TingTing; Huang, ZhaoHui; Pan, GuoShao; Tu, ChunYu; Lu, Mengji; Chen, XinWen
    Polymerase mutations rtN238R, rtT240Y and rtN248H of hepatitis B virus decrease susceptibility to adefovir
    In: Chinese Science Bulletin Jg. 58 (2013) Nr. 15, S. 1760 - 1766
    Online Volltext: dx.doi.org/ (Open Access)
  • Fiedler, Melanie; Kosinska, Anna; Schumann, Alexandra; Brovko, Olena; Walker, Andreas; Lu, Mengji; Johrden, Lena; Mayer, Anja; Wildner, Oliver; Roggendorf, Michael
    Prime/boost immunization with DNA and adenoviral vectors protects from hepatitis D virus (HDV) infection after simultaneous infection with HDV and woodchuck hepatitis virus
    In: Journal of Virology Jg. 87 (2013) Nr. 13, S. 7708 - 7716
    Online Volltext: dx.doi.org/
  • Meng, Zhongji; Zhang, Xiaoyong; Wu, Jun; Pei, Rongjuan; Xu, Yang; Yang, Dongliang; Roggendorf, Michael; Lu, Mengji
    RNAi induces innate immunity through multiple cellular signaling pathways
    In: PLoS ONE Jg. 8 (2013) Nr. 5, e 64708
    Online Volltext: dx.doi.org/ (Open Access)
  • Huang, S.; Wang, J.; Song, Z.; Yang, D.; Zhu, Z.; Feng, X.; Lu, Mengji; Zhu, B.; Wang, B.
    Rapamycin modulates the course of Hepatitis B Virus (HBV) infection in hydrodynamic injection mouse model : the role of Treg in HBV persistence
    In: Journal of Hepatology Jg. 58 (2013) Nr. Suppl. 1, S. S156 - S157
    Online Volltext: dx.doi.org/
  • Lu, Mengji; Zhang, X.; Deng, W.; Li, B.; Hou, J.; Liu, H.
    Regulation of HBV replication bymicroRNA-449a through targeting creb5 in hepatoma cells
    In: Journal of Hepatology Jg. 58 (2013) Nr. Suppl. 1, S. S165
    Online Volltext: dx.doi.org/
  • Liu, Jia; Jiang, Min; Ma, Zhiyong; Dietze, Kirsten; Zelinskyy, Gennadiy; Yang, Dongliang; Dittmer, Ulf; Schlaak, Jörg Friedrich; Roggendorf, Michael; Lu, Mengji
    TLR1/2 ligand-stimulated mouse liver endothelial cells secrete IL-12 and trigger CD8+ T cell immunity in vitro
    In: The Journal of Immunology (JI) Jg. 191 (2013) Nr. 12, S. 6178 - 6190
    Online Volltext: dx.doi.org/
  • Qin, Bo; Budeus, Bettina; Cao, Liang; Wu, Chunchen; Wang, Yun; Zhang, Xiaoyong; Rayner, Simon; Hoffmann, Daniel; Lu, Mengji; Chen, Xinwen
    The amino acid substitutions rtP177G and rtF249A in the reverse transcriptase domain of hepatitis B virus polymerase reduce the susceptibility to tenofovir
    In: Antiviral Research Jg. 97 (2013) Nr. 2, S. 93 - 100
    Online Volltext: dx.doi.org/

    • Beiträge in Sammelwerken und Tagungsbänden

  • Bauer, Dirk; Wasmuth, Susanne; Lu, Mengji; Heiligenhaus, Arnd
    Particle-mediated administration of plasmid DNA on corneas of BALB/c mice
    In: Biolistic DNA Delivery: Methods and Protocols / Sudowe, Stephan; Reske-Kunz, Angelika B. (Hrsg.) 2013, S. 215 - 220
    Online Volltext: dx.doi.org/

    • 2012

    Artikel in Zeitschriften

  • Wu, Chunchen; Shi, Hui; Wang, Yun; Lu, Mengji; Xu, Yang; Chen, Xinwen
    A case of hepatitis B reactivation due to the hepatitis B virus escape mutant in a patient undergoing chemotherapy
    In: Virologica Sinica Jg. 27 (2012) Nr. 6, S. 369 - 372
    Online Volltext: dx.doi.org/
  • Wu, Chunchen; Deng, Wanyu; Deng, Liu; Cao, Liang; Qin, Bo; Li, Songxia; Wang, Yun; Pei, Rongjuan; Yang, Dongliang; Lu, Mengji; Chen, Xinwen
    Amino acid substitutions at positions 122 and 145 of hepatitis B virus surface antigen (HBsAg) determine the antigenicity and immunogenicity of HBsAg and influence in vivo HBsAg clearance
    In: Journal of Virology Jg. 86 (2012) Nr. 8, S. 4658 - 4669
    Online Volltext: dx.doi.org/ (Open Access)
  • Xu, Song; Pei, Rongjuan; Guo, Min; Han, Qingxia; Lai, Juan; Wang, Yun; Wu, Chunchen; Zhou, Yuan; Lu, Mengji; Chen, Xinwen
    Cytosolic phospholipase A2 gamma is involved in hepatitis C virus replication and assembly
    In: Journal of Virology Jg. 86 (2012) Nr. 23, S. 13025 - 13037
    Online Volltext: dx.doi.org/
  • Kosinska, Anna D.; Johrden, Lena; Zhang, Ejuan; Fiedler, Melanie; Mayer, Anja; Wildner, Oliver; Lu, Mengji; Roggendorf, Michael
    DNA Prime-adenovirus boost immunization induces a vigorous and multifunctional T-cell response against hepadnaviral proteins in the mouse and woodchuck model
    In: Journal of Virology Jg. 86 (2012) Nr. 17, S. 9297 - 9310
    Online Volltext: dx.doi.org/
  • Sallam, T.A.; Raja'a, Y.A.; Bahaj, S.; Al-Shami, A.M.; Lu, Mengji; Roggendorf, Michael; Tong, C.Y.W.
    Hepatitis B virus carrier rate, prevalence and susceptibility and impact of immunization program among households in the city of Taiz, Yemen
    In: Vaccine Jg. 30 (2012) Nr. 37, S. 5564 - 5568
    Online Volltext: dx.doi.org/
  • Zhu, Wenbo; Wu, Chunchen; Deng, Wanyu; Pei, Rongjun; Wang, Yun; Cao, Liang; Qin, Bo; Lu, Mengji; Chen, Xinwen
    Inhibition of the HCV Core Protein on the Immune Response to HBV Surface Antigen and on HBV Gene Expression and Replication In Vivo
    In: PLoS ONE Jg. 7 (2012) Nr. 9, S. e45146
    Online Volltext: dx.doi.org/ (Open Access)
  • Fan, Hebin; Zhu, Zhenni; Wang, Yang; Zhang, Xiaoyong; Lu, Yinping; Tao, Yuanqing; Fan, Wei; Wang, Zhongdong; Wang, Hu; Roggendorf, Michael; Lu, Mengji; Wang, Baoju; Yang, Dongliang
    Molecular characterization of the type I IFN receptor in two woodchuck species and detection of its expression in liver samples from woodchucks infected with woodchuck hepatitis virus (WHV)
    In: Cytokine Jg. 60 (2012) Nr. 1, S. 179 - 185
    Online Volltext: dx.doi.org/
  • Jiang, Min; Liu, Jia; Zhang, Ejuan; Meng, Zhongji; Wang, Baoju; Roggendorf, Michael; Yang, Dongliang; Lu, Mengji; Xu, Yang
    Molecular characterization of woodchuck interleukin-10 receptor and enhanced function of specific T cells from chronically infected woodchucks following its blockade
    In: Comparative Immunology, Microbiology and Infectious Diseases Jg. 35 (2012) Nr. 6, S. 563 - 573
    Online Volltext: dx.doi.org/
  • Zhang, Xiaoyong; Kraft, Anke; Bröring, Ruth; Schlaak, Jörg Friedrich; Dittmer, Ulf; Lu, Mengji
    Preclinical development of TLR ligands as drugs for the treatment of chronic viral infections
    In: Expert Opinion on Drug Discovery Jg. 7 (2012) Nr. 7, S. 597 - 611
    Online Volltext: dx.doi.org/
  • Yang, Yinke; Wang, Baoju; Yang, Dongliang; Lu, Mengji; Xu, Yang
    Prokaryotic expression of woodchuck cytotoxic T lymphocyte antigen 4 (wCTLA-4) and preparation of polyclonal antibody to wCTLA-4
    In: Protein Expression and Purification Jg. 81 (2012) Nr. 2, S. 181 - 185
    Online Volltext: dx.doi.org/
  • Pei, Rongjuan; Zhang, Xiaoyong; Xu, Song; Meng, Zhongji; Roggendorf, Michael; Lu, Mengji; Chen, Xinwen
    Regulation of Hepatitis C virus replication and gene expression by the MAPK-ERK pathway
    In: Virologica Sinica Jg. 27 (2012) Nr. 5, S. 278 - 285
    Online Volltext: dx.doi.org/
  • Zhang, Xiaoyong; Ma, Zhiyong; Liu, Hongyan; Liu, Jia; Meng, Zhongji; Bröring, Ruth; Yang, Dongliang; Schlaak, Jörg Friedrich; Roggendorf, Michael; Lu, Mengji
    Role of Toll-like receptor 2 in the immune response against hepadnaviral infection
    In: Journal of Hepatology Jg. 57 (2012) Nr. 3, S. 522 - 528
    Online Volltext: dx.doi.org/
  • Fang, Haoshu; Liu, Anding; Dirsch, Olaf; Sun, Jian; Jin, Hao; Lu, Mengji; Yang, Dongliang; Dahmen, Uta
    Serum LBP levels reflect the impaired synthetic capacity of the remnant liver after partial hepatectomy in rats
    In: Journal of Immunological Methods Jg. 382 (2012) Nr. 1-2, S. 68 - 75
    Online Volltext: dx.doi.org/

    • Abstracts

  • Zhang, X.; Liu, H.; Wang, B.; Ma, Z.; Zhang, J.; Yang, D.; Schlaak, Jörg Friedrich; Roggendorf, Michael; Lu, Mengji
    Epigenetic control of Hepatitis B virus replication and farnesoid X receptor alpha expression by histone deacetylases 3
    In: Journal of Hepatology Jg. 56 (2012) Nr. Suppl. 2, S. S17
    Online Volltext: dx.doi.org/
  • Liu, H.; Zhang, J.; Zhang, X.; Bleekmann, B.; Kemper, T.; Roggendorf, Michael; Dittmer, Ulf; Lu, Mengji
    Genomic analysis of the host response to hepatitis b virus infection
    In: Journal of Hepatology Jg. 56 (2012) Nr. Supplement 2, S. S187
    Online Volltext: dx.doi.org/
  • Jiang, M.; Trippler, M.; Bröring, Ruth; Poggenpohl, L.; Gerken, Guido; Lu, Mengji; Schlaak, Jörg Friedrich
    Hepatitis B virus surface antigen suppresses innate and adaptive immune responses of murine and human liver cells
    In: Journal of Hepatology Jg. 56 (2012) Nr. Supplement 2, S. S174
    Online Volltext: dx.doi.org/
  • Jiang, M.; Trippler, M.; Bröring, Ruth; Wu, J.; Zhang, E.; Zhang, X.; Gerken, Guido; Lu, Mengji; Schlaak, Jörg Friedrich
    TLR-3 dependent immunological properties of liver cells are controlled by anti-inflammatory cytokines through modulation of MIR-155 expression
    In: Journal of Hepatology Jg. 56 (2012) Nr. Supplement 2, S. S302 - S303
    Online Volltext: dx.doi.org/
  • Liu, J.; Jiang, M.; Ma, Z.; Schlaak, Jörg Friedrich; Roggendorf, Michael; Lu, Mengji
    TLR1/2 ligand stimulated mouse liver endothelial cells produce IL-12 and trigger CD8+ T-Cell immunity
    In: Journal of Hepatology Jg. 56 (2012) Nr. Supplement 2, S. S311
    Online Volltext: dx.doi.org/
  • Ma, Z.; Zhang, E.; Zhang, X.; Liu, J.; Lin, Y.; Wu, J.; Kosinska, A.; Dittmer, Ulf; Roggendorf, Michael; Yang, D.; Lu, Mengji
    TLR2 ligand PAM3CSK4 inhibits peptide-induced deletion of CD8 T cells to viral antigens in mouse model
    In: Journal of Hepatology Jg. 56 (2012) Nr. Supplement 2, S. S312
    Online Volltext: dx.doi.org/
  • Wu, J.; Chen, M.; Xia, Y.; Sun, C.; Lin, Y.; Wang, J.; Guo, Y.; Wang, B.; Song, J.; Lu, Mengji; Yang, D.
    The clearance of Hepatitis B virus (HBV) n hydrodynamik injection mouse model by polyinosinic-polycytidylic acid (POLYIC) treatment is dependent on interferon-gamma
    In: Journal of Hepatology Jg. 56 (2012) Nr. Supplement 2, S. S319
    Online Volltext: dx.doi.org/

    • 2011

    Artikel in Zeitschriften

  • Bröring, Ruth; Montag, Mario; Jiang, Min; Lu, Mengji; Sowa, Jan-Peter; Kleinehr, Kathrin; Gerken, Guido; Schlaak, Jörg Friedrich
    Corticosteroids shift the Toll-like receptor response pattern of primary-isolated murine liver cells from an inflammatory to an anti-inflammatory state
    In: International Immunology Jg. 23 (2011) Nr. 9, S. 537 - 544
    Online Volltext: dx.doi.org/
  • Yin, Ying; Wu, Chunchen; Song, Jingjiao; Wang, Junzhong; Zhang, Ejuan; Liu, Hongyan; Yang, Dongliang; Chen, Xinwen; Lu, Mengji; Xu, Yang
    DNA Immunization with Fusion of CTLA-4 to Hepatitis B Virus (HBV) Core Protein Enhanced Th2 Type Responses and Cleared HBV with an Accelerated Kinetic
    In: PLoS ONE Jg. 6 (2011) Nr. 7, S. 0022524
    Online Volltext: dx.doi.org/ (Open Access)
  • Zhang, Zhenhuan; Li, Lei; Zhao, Xiping; Glebe, Dieter; Bremer, Corinna M.; Zhang, Zheng Mao; Tian, Yong Jun; Wang, Bao Ju; Yang, Yinke; Gerlich, Wolfram Hubert; Roggendorf, Michael; Li, Xu; Lu, Mengji; Yang, Dong Liang
    Elimination of hepatitis B virus surface antigen and appearance of neutralizing antibodies in chronically infected patients without viral clearance
    In: Journal of Viral Hepatitis Jg. 18 (2011) Nr. 6, S. 424 - 433
    Online Volltext: dx.doi.org/
  • Wang, Bao-Ju; Tian, Yong-Jun; Meng, Zhong-Ji; Jiang, Min; Wei, Bo-Qing; Tao, Yuan-Qing; Fan, Wei; Li, An-Yi; Bao, Jun-Jie; Li, Xin-Yu; Zhang, Zheng-Mao; Wang, Zhong-Dong; Wang, Hu; Roggendorf, Michael; Lu, Mengji; Yang, Dong-Liang
    Establishing a new animal model for hepadnaviral infection : Susceptibility of Chinese Marmota-species to woodchuck hepatitis virus infection
    In: Journal of General Virology Jg. 92 (2011) Nr. 3, S. 681 - 691
    Online Volltext: dx.doi.org/ (Open Access)
  • Pei, Rongjuan; Chen, Honghe; Lu, Lu; Zhu, Wandi; Beckebaum, Susanne; Cicinnati, Vito; Lu, Mengji; Chen, Xinwen
    Hepatitis C virus infection induces the expression of amphiregulin, a factor related to the activation of cellular survival pathways and required for efficient viral assembly
    In: Journal of General Virology Jg. 92 (2011) Nr. 10, S. 2237 - 2248
    Online Volltext: dx.doi.org/
  • Wang, Bao-Ju; Bao, Jun-Jie; Wang, Jun-Zhong; Wang, Yang; Jiang, Min; Xing, Ming-You; Zhang, Wan-Guang; Qi, Jun-Ying; Roggendorf, Michael; Lu, Mengji; Yang, Dong-Liang
    Immunostaining of PD-1/PD-Ls in liver tissues of patients with hepatitis and hepatocellular carcinoma
    In: World Journal of Gastroenterology Jg. 17 (2011) Nr. 28, S. 3322 - 3329
    Online Volltext: dx.doi.org/
  • Liu, Min; Hao, Youhua; Ding, Honghui; Yang, Dongliang; Lu, Mengji
    Interleukin-10 is expressed in HepG2.2.15 cells and regulated by STAT1 pathway
    In: Journal of Huazhong University of Science and Technology (Medical Sciences) Jg. 31 (2011) Nr. 5, S. 625 - 631
    Online Volltext: dx.doi.org/
  • Zhang, Xiaoyong; Zhang, Ejuan; Ma, Zhiyong; Pei, Rongjuan; Jiang, Min; Schlaak, Jörg Friedrich; Roggendorf, Michael; Lu, Mengji
    Modulation of hepatitis B virus replication and hepatocyte differentiation by MicroRNA-1
    In: Hepatology Jg. 53 (2011) Nr. 5, S. 1476 - 1485
    Online Volltext: dx.doi.org/ (Open Access)
  • Bröring, Ruth; Lu, Mengji; Schlaak, Jörg Friedrich; Schlaak, Joerg F.
    Role of Toll-like receptors in liver health and disease
    In: Clinical Science Jg. 121 (2011) Nr. 10, S. 415 - 426
    Online Volltext: dx.doi.org/
  • Xu, Yang; Köck, Josef; Lu, Yinping; Yang, Dongliang; Lu, Mengji; Zhao, Xiping
    Suppression of hepatitis B virus replication in Tupaia hepatocytes by tumor necrosis factor alpha of Tupaia belangeri
    In: Comparative Immunology, Microbiology and Infectious Diseases Jg. 34 (2011) Nr. 4, S. 361 - 368
    Online Volltext: dx.doi.org/
  • Zhang, Ejuan; Zhang, Xiaoyong; Liu, Jia; Wang, Baoju; Tian, Yongjun; Kosinska, Anna D.; Ma, Zhiyong; Xu, Yang; Dittmer, Ulf; Roggendorf, Michael; Yang, Dongliang; Lu, Mengji
    The Expression of PD-1 Ligands and Their Involvement in Regulation of T Cell Functions in Acute and Chronic Woodchuck Hepatitis Virus Infection
    In: PLoS ONE Jg. 6 (2011) Nr. 10, S. 0026196
    Online Volltext: dx.doi.org/ (Open Access)
  • Zelinskyy, Gennadiy; Myers, Lara; Dietze, Kirsten; Gibbert, Kathrin; Roggendorf, Michael; Liu, Jia; Lu, Mengji; Kraft, Anke R.; Teichgräber, Volker; Hasenkrug, Kim J.; Dittmer, Ulf
    Virus-Specific CD8+ T Cells Upregulate Programmed Death-1 Expression during Acute Friend Retrovirus Infection but Are Highly Cytotoxic and Control Virus Replication
    In: The Journal of Immunology (JI) Jg. 187 (2011) Nr. 7, S. 3730 - 3737
    Online Volltext: dx.doi.org/

    • Abstracts

  • Meng, Z.; Zhang, E.; Zhang, X.; Kosinska, A.; Xu, Y.; Yang, D.; Zhou, T.; Mason, W.; Roggendorf, Michael; Lu, Mengji
    DNA vaccination induces WHS/CAG specific T Cell immune responses in the newly constructed WHV transgenic mouse model
    In: Journal of Hepatology Jg. 54 (2011) Nr. Suppl. 1, S. S441
    Online Volltext: dx.doi.org/
  • Wang, J. Z.; Wang, B. J.; Huang, S. M.; Wu, J.; Zhu, Z. N.; Zhu, B.; Ding, H. H.; Feng, X. M.; Yin, Y.; Roggendorf, Michael; Lu, Mengji; Yang, D. L.
    Immunosuppression modulates the course of hepatitis B virus (HBV) infection in hydrodynamic injection mouse model
    In: Journal of Hepatology Jg. 54 (2011) Nr. Suppl. 1, S. S127
    Online Volltext: dx.doi.org/
  • Zhang, X.; Ma, Z.; Wu, C.; Zhang, E.; Bröring, Ruth; Schlaak, Jörg Friedrich; Roggendorf, Michael; Lu, Mengji
    Modulation of HBV replication by cell cycle and differentiation related micrornas
    In: Journal of Hepatology Jg. 54 (2011) Nr. Suppl. 1, S. S448 - S449
    Online Volltext: dx.doi.org/
  • Fiedler, Melanie; Schumann, A.; Kosinska, A.; Lu, Mengji; Johrden, L.; Wildner, O.; Roggendorf, Michael
    Prime/boost immunization with DNA and adenoviral vectors protects woodchucks from hepatitis D virus infection
    In: Journal of Hepatology Jg. 54 (2011) Nr. Suppl. 1, S. S439
    Online Volltext: dx.doi.org/
  • Xu, L.; Beckebaum, Susanne; Wu, G.; Zhang, X.; Lu, Mengji; Iacob, S.; Paul, Andreas; Gerken, Guido; Cicinnati, Vito R.;
    The putative tumor suppressor microrna-101 negatively regulates the polycomb group protein enhancer of zeste homolog 2 (EZH2) in human hepatocellular carcinoma cells
    46th annual meeting of the European Association for the Study of the Liver ; Berlin, 30 March-3 April 2011,
    In: Journal of Hepatology Jg. 54 (2011) Nr. Suppl. 1, S. S110
    Online Volltext: dx.doi.org/

    • 2010

    Artikel in Zeitschriften

  • Zhang, X.; Zhang, E.; Meng, Z.; Ma, Z.; Schlaak, Jörg Friedrich; Lu, Mengji
    110 Modulation of HBV replication and cellular gene expression by microrna-1
    In: Journal of Hepatology Jg. 52 (2010) Nr. Suppl. 1, S. S49 - S50
    Online Volltext: dx.doi.org/
  • Jiang, M.; Trippler, M.; Bröring, Ruth; Poggenpohl, L.; Wu, J.; Roggendorf, Michael; Gerken, Guido; Lu, Mengji; Schlaak, Jörg Friedrich
    627 HBV suppresses TLR signaling and the crosstalk to the adaptive immune system in murine and human cells
    In: Journal of Hepatology Jg. 52 (2010) Nr. Suppl. 1, S. S246
    Online Volltext: dx.doi.org/
  • Liu, Jia; Hu, Bin; Yang, Yan; Ma, Zhiyong; Yu, Yuan; Liu, Shenpei; Wang, Baoju; Zhao, Xiping; Lu, Mengji; Yang, Dongliang
    A new splice variant of the major subunit of human asialoglycoprotein receptor encodes a secreted form in hepatocytes
    In: PLoS ONE Jg. 5 (2010) Nr. 9,
    Online Volltext: dx.doi.org/ (Open Access)
  • Wu, Chunchen; Zhang, Xiaoyong; Tian, Zhang; Song, Jianhua; Yang, Dongliang; Roggendorf, Michael; Lu, Mengji; Chen, Xinwen; Tian, Y.
    Biological significance of amino acid substitutions in hepatitis B surface antigen (HBsAg) for glycosylation, secretion, antigenicity and immunogenicity of HBsAg and hepatitis B virus replication
    In: Journal of General Virology Jg. 91 (2010) Nr. 2, S. 483 - 492
    Online Volltext: dx.doi.org/
  • Liu, Jia; Yang, Yan; Hu, Bin; Ma, Zhi-Yong; Huang, Hong-Ping; Yu, Yuan; Liu, Shen-Pei; Lu, Mengji; Yang, Dong-Liang
    Development of HBsAg-binding aptamers that bind HepG2.2.15 cells via HBV surface antigen
    In: Virologica Sinica Jg. 25 (2010) Nr. 1, S. 27 - 35
    Online Volltext: dx.doi.org/
  • Hu, Bin; Yang, Yan; Liu, Jia; Ma, Zhiyong; Huang, Hongping; Liu, Shenpei; Yu, Yuan; Hao, Youhua; Wang, Baoju; Lu, Mengji; Yang, Dongliang
    Establishment of a functional cell line expressing both subunits of H1a and H2c of human hepatocyte surface molecule ASGPR
    In: Journal of Huazhong University of Science and Technology (Medical Sciences) Jg. 30 (2010) Nr. 5, S. 556 - 561
    Online Volltext: dx.doi.org/
  • Li, Yanmei; Chen, Jizheng; Wu, Chunchen; Wang, Linding; Lu, Mengji; Chen, Xinwen
    Hepatitis B virus/hepatitis C virus upregulate angiopoietin-2 expression through mitogen-activated protein kinase pathway
    In: Hepatology Research Jg. 40 (2010) Nr. 10, S. 1022 - 1033
    Online Volltext: dx.doi.org/
  • Shen, Qingli; Cicinnati, Vito; Zhang, Xiaoyong; Iacob, Speranta; Weber, Frank; Sotiropoulos, Georgios; Radtke, Arnold; Lu, Mengji; Paul, Andreas; Gerken, Guido; Beckebaum, Susanne
    Role of microRNA-199a-5p and discoidin domain receptor 1 in human hepatocellular carcinoma invasion
    In: Molecular Cancer Jg. 9 (2010) 227
    Online Volltext: dx.doi.org/ (Open Access)
  • Zhu, Wenbo; Chang, Yanzi; Wu, Chunchen; Han, Qingxia; Pei, Rongjuan; Lu, Mengji; Chen, Xinwen
    The Wild-Type Hepatitis C Virus Core Inhibits Initiation of Antigen-Specific T- and B-Cell Immune Responses in BALB/c Mice
    In: Clinical and Vaccine Immunology Jg. 17 (2010) Nr. 7, S. 1139 - 1147
    Online Volltext: dx.doi.org/
  • Bröring, Ruth; Zhang, Xiaozhen; Kottilil, Shyam; Trippler, Martin; Jiang, Min; Lu, Mengji; Gerken, Guido; Schlaak, Jörg Friedrich
    The interferon stimulated gene 15 functions as a proviral factor for the hepatitis C virus and as a regulator of the IFN response
    In: Gut Jg. 59 (2010) Nr. 8, S. 1111 - 1119
    Online Volltext: dx.doi.org/
  • Roggendorf, Michael; Yang, D.; Lu, Mengji
    The woodchuck : A model for therapeutic vaccination against hepadnaviral infection
    In: Pathologie - Biologie Jg. 58 (2010) Nr. 4, S. 308 - 314
    Online Volltext: dx.doi.org/
  • Wu, Jun; Meng, Zhongji; Jiang, Min; Zhang, Ejuan; Trippler, Martin; Bröring, Ruth; Bucchi, Agnes; Krux, Frank; Dittmer, Ulf; Yang, Dongliang; Roggendorf, Michael; Gerken, Guido; Lu, Mengji; Schlaak, Jörg Friedrich
    Toll-like receptor-induced innate immune responses in non-parenchymal liver cells are cell type-specific
    In: Immunology Jg. 129 (2010) Nr. 3, S. 363 - 374
    Online Volltext: dx.doi.org/

    • Abstracts

  • Jiang, M.; Wu, J.; Zhang, E.; Meng, Z.; Trippler, M.; Bröring, Ruth; Roggendorf, Michael; Gerken, Guido; Lu, Mengji; Schlaak, Jörg Friedrich
    446 HCV/TLR3- dependent innate and adaptive immune functions of non-parenchymal liver cells are controlled by interleukin-10 and transforming growth factor beta
    In: Journal of Hepatology Jg. 52 (2010) Nr. Suppl. 1, S. S180
    Online Volltext: dx.doi.org/
  • Zhang, E.; Kosinska, A.; Zhang, X.; Meng, Z.; Xu, Y.; Yang, D.; Roggendorf, Michael; Lu, Mengji;
    637 Enhanced TH2 type immune response in DNA immunization by fusion of WCTLA-4 to woodchuck hepatitis core antigen
    International Liver Congress™ 2010 – the 45th annual meeting of the European Association for the Study of the Liver,
    In: Journal of Hepatology Jg. 52 (2010) Nr. Suppl. 1, S. S249
    Online Volltext: dx.doi.org/
  • Roggendorf, Michael; Ke, X.Y.; Yang, Y.; Yang, D.L.; Zhang, X.Y.; Meng, Z.J.; Kemper, T.; Wang, Q.J.; Lu, Mengji; Lu, L.;
    OL-022 The effect of double-stranded DNA on replication of hepatitis B virus and cellular signalling
    Fourth Ditan International Conference on Infectious Diseases - Changing Face of Infectious Diseases. 15-18 July 2010, Beijing,
    In: International Journal of Infectious Diseases Jg. 14 (2010) Nr. Suppl. 2, S. S10
    Online Volltext: dx.doi.org/ (Open Access)

    • 2006

    Artikel in Zeitschriften

  • Lu, Mengji; Viazov, Sergey; Dittmer, Ulf; Roggendorf, Michael; aus dem Siepen, Marc
    Chronische Infektionen : ein Versagen des Immunsystems
    In: Essener Unikate: Berichte aus Forschung und Lehre (2006) Nr. 27 : Medizin – Immunologie, S. 34 - 47
    Online Volltext; Online Volltext (Open Access)

    • 2005

    Artikel in Zeitschriften

  • Lu, M.; Isogawa, M.; Hilken, Gero
    Immunization with the gene expressing woodchuck hepatitis virus nucleocapsid protein fused to cytotoxic-T-lymphocyte-associated antigen 4 leads to enhanced specific immune response in mice and woodchucks.
    In: (J. Virol.) Jg. 79 (2005) Nr. 10, S. 6368 - 6376

    • 2004

    Artikel in Zeitschriften

  • Dahmen, Uta; Dirsch, Olaf; Li, Jun; Fiedler, Melanie; Lu, Mengji; Rispeter, Kai; Picucci, Martha; Broelsch, Christoph E.; Roggendorf, Michael
    Adoptive transfer of immunity : A new strategy to interfere with severe hepatitis virus reinfection after woodchuck liver transplantation
    In: Transplantation Jg. 77 (2004) Nr. 7, S. 965 - 972
    Online Volltext: dx.doi.org/
  • Fiedler, Melanie; Rödicker, Florian; Salucci, Valentina; Lu, Mengji; Aurisicchio, Luigi; Dahmen, Uta; Jun, Li; Dirsch, Olaf; Pützer, Brigitte M.; Palombo, Fabio; Roggendorf, Michael
    Helper-dependent adenoviral vector-mediated delivery of woodchuck-specific genes for alpha interferon (IFN-α) and IFN-γ : IFN-α but not IFN-γ reduces woodchuck hepatitis virus replication in chronic infection in vivo
    In: Journal of Virology Jg. 78 (2004) Nr. 18, S. 10111 - 10121
    Online Volltext: dx.doi.org/ (Open Access)
  • Zeng, X.; Weinberger, K.M.; Gehrke, R.; Isogawa, M.; Hilken, Gero; Kemper, T.; Xu, Y.; Yang, D.; Jilg, W.; Roggendorf, Michael; Lu, M.
    Mutant hepatitis B virus surface antigen (HbsAg) are immunogenic but may have a change specificity
    In: Virology Jg. 329 (2004) S. 454 - 464

    • 2002

    Artikel in Zeitschriften

  • Dahmen, Uta; Li, Jun; Dirsch, Olaf; Fiedler, Melanie; Lu, Mengji; Roggendorf, Michael; Broelsch, Christoph Erich
    A new model of hepatitis B virus reinfection : Liver transplantation in the woodchuck
    In: Transplantation Jg. 74 (2002) Nr. 3, S. 373 - 380
    Online Volltext: dx.doi.org/
  • Lu, M.; Lohrengel, B.; Hilken, Gero; Kemper, T.; Roggendorf, Michael
    Woodchuck gamma interferon upregulates major histocompartibility complex class I transcription but is unable to deplete woodchuck hepatitis virus replication intermediatesand RNAs in persistently infected woodchuck primary hepatocytes
    In: Journal of Virology Jg. 76 (2002) Nr. 1, S. 58 - 67
    Online Volltext: dx.doi.org/

    • 2001

    Artikel in Zeitschriften

  • Haupt, Katharina; Siegel, F.; Lu, M.; Yang, D.; Hilken, Gero; Mann, K.; Roggendorf, Michael; Saller, B.
    Induction of a cellular and humoral Immune response against preprocalcitonin by genetic immunization : A potential new treatment for medullary thyroid carcinoma
    In: Endocrinology Jg. 142 (2001) Nr. 3, S. 1017 - 1023
    Online Volltext: dx.doi.org/
  • Lu, M.; Hilken, Gero; Dongliang, Y.; Kemper, T.; Roggendorf, Michael
    Replication of naturally occurring Woodchuck Hepatitis Virus : Deletion Mutants in primary hepatocytes cultures and after transmission to naive woodchucks
    In: Journal of Virology Jg. 75 (2001) Nr. 8, S. 3811 - 3818
    Online Volltext: dx.doi.org/

    • 2000

    Vorträge

  • Lu, Mengji; Hilken, Gero; Yang, D.; Roggendorf, Michael;
    Replikation von Deletionsmutanten des Woodchuck Hepatitis Virus (WHV) in primären Woodchuck Hepatitis Kulturen und in vivo nach einer Übertragung
    38. Tagung der GV-SOLAS, September 2000, Essen,
    (2000)

    • 1999

    Artikel in Zeitschriften

  • Lu, Mengji; Hilken, Gero; Kruppenbacher, Johannes; Reimann, Jörg; Roggendorf, Michael
    Immunization of Woodchucks with Plasmids Expressing Woodchuck Hepatitis Virus (WHV) Core Antigen and Surface Antigen Suppresses WHV Infection
    In: Journal of Virology Jg. 73 (1999) Nr. 1, S. 281 - 289
    Online Volltext: dx.doi.org/ (Open Access)

    • 1998

    Abstracts

  • Lu, Mengji; Hilken, Gero; Kruppenbacher, J.; Reimann, J.; Roggendorf, Michael
    Protektion von Woodchucks gegen Woodchuckhepatitisvirus (WHV)-Infektion durch DNA-Immunisierung mit WHcAg- und WHsAg-exprimierenden Plasmiden
    In: Jahrestagung Gesellschaft für Virologie, Regensburg 2.-5. März 1998,: Abstracts / Jahrestagung Gesellschaft für Virologie, Regensburg 2.-5. März 1998 (1998) S. 30

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