AG Adalbert Krawczyk

Herpes Simplex Viren

Forschungsschwerpunkte

  • Anti-HSV-Antikörper
  • Nanopartikel-basierte HSV-Impfstoffe
  • Isolierung von humanen HSV-spezifischen Antikörpern
  • Anti-CMV-Antikörper
  • HBV-Impfstoffe der 3. Generation
  • Modifikation von Exosomen für neue Impfstoffe

Projekt

Die Herpes Simplex Viren vom Typ 1 (HSV-1) und Typ 2 (HSV-2) gehören zu den häufigsten Krankheitserregern beim Menschen. Bei Patienten mit intaktem Immunsystem können sowohl Primär- als auch chronische HSV-Infektionen schmerzhafte Läsionen im Oral- bzw. Genitalbereich verursachen. Diese sind jedoch lokal begrenzt und lassen sich in der Regel gut mit den verfügbaren Medikamenten behandeln.

Schwerwiegende und zum Teil lebensbedrohliche Komplikationen sind bei Infektionen im Augenbereich sowie bei Patienten mit Immunsuppression zu erwarten. Häufig wiederkehrende HSV-Infektionen am Auge können beispielsweise zur HSV-1 Keratitis führen, die zu den führenden Ursachen von Erblindung in der industrialisierten Welt zählt. Bei Patienten mit Immunsuppression können HSV-Reaktivierungen zu generalisierten Infektionen führen, die ohne wirksame Behandlung tödlich sind. Des Weiteren führt die Übertragung des Virus auf Neugeborene zu lebensbedrohlichen Infektionen. Die Ausbildung von resistenten Virusstämmen erschwert die Behandlung zunehmend. Neuartige Ansätze zur Prävention und Therapie von HSV-Infektionen sind daher dringend erforderlich.

Im Rahmen unserer Forschungsarbeiten beschäftigen wir uns daher mit der Entwicklung neuartiger Strategien zur Vorbeugung und Behandlung von HSV-Infektionen. Wir konnten einen humanisierten Antikörper entwickeln, der bereits erfolgreich bei immunsupprimierten Versuchstieren sowie im Mausmodel der Herpes-Keratitis getestet werden konnte. Gegenwärtig arbeiten wir an einem Nanopartikel-basierenden Impfstoff, der die Induktion von neutralisierenden Antikörpern gegen HSV vermitteln soll. Diese Antikörper sollen zudem in der Lage sein, die direkte Virusausbreitung über den „cell-to-cell spread“ zu inhibieren. Diesen Mechanismus benutzen Herpesviren, um der Immunantwort des Menschen zu umgehen. Das Ziel unserer Arbeit ist es, neue Erkenntnisse über die Prävention von HSV-Infektionen zu gewinnen, die zur Entwicklung eines erfolgreichen Impfstoffes beitragen sollen.

Arbeitsgruppe

Leiter

Dr. rer. nat. Adalbert Krawczyk
Tel.: +49 (0)201 723 85458
E-Mail: adalbert.krawczyk@uni-due.de

Mira Alt, Dr. rer. nat.
Tel.: +49 (0) 201 723 4244
E-Mail: mira.alt@uk-essen.de
 

Publikationen

    2024

    Artikel in Zeitschriften

  • Helmer, Lorena; van de Sand, Lukas; Wojtakowski, Thea; Otte, Mona; Witzke, Oliver; Sondermann, Wiebke; Krawczyk, Adalbert; Lindemann, Monika
    Antibody responses after sequential vaccination with PCV13 and PPSV23 in patients with moderate to severe plaque psoriasis under immunosuppressive therapy
    In: mBio Jg. 15 (2024) Nr. 7, e00482-24
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Hopff, Sina M.; Appel, Katharina S.; Miljukov, Olga; Schneider, Johannes; Addo, Marylyn M.; Bals, Robert; Bercker, Sven; Blaschke, Sabine; Bröhl, Isabel; Büchner, Nikolaus; Dashti, Hiwa; Erber, Johanna; Friedrichs, Anette; Geisler, Ramsia; Göpel, Siri; Hagen, Marina; Hanses, Frank; Jensen, Björn-Erik Ole; Keul, Maria; Krawczyk, Adalbert; Lorenz-Depiereux, Bettina; Meybohm, Patrick; Milovanovic, Milena; Mitrov, Lazar; Nürnberger, Carolin; Obst, Wilfried; Römmele, Christoph; Schäfer, Christian; Scheer, Christian; Scherer, Margarete; Schmidt, Julia; Seibel, Kristina; Sikdar, Shimita; Tebbe, Johannes Josef; Tepasse, Phil-Robin; Thelen, Philipp; Vehreschild, Maria J. G. T.; Weismantel, Christina; Vehreschild, J. Janne
    Comparison of post-COVID-19 symptoms in patients infected with the SARS-CoV-2 variants delta and omicron : results of the Cross-Sectoral Platform of the German National Pandemic Cohort Network (NAPKON-SUEP)
    In: Infection - A Journal of Infectious Disease Jg. 52 (2024) Nr. 6, S. 2253 - 2267
    Online Volltext: dx.doi.org/ (Open Access)
  • Thümmler, Laura; Beckmann, Nadine; Sehl, Carolin; Soddemann, Matthias; Braß, Peer; Bormann, Maren; Brochhagen, Leonie; Elsner, Carina; Hoertel, Nicolas; Cougoule, Céline; Ciesek, Sandra; Widera, Marek; Dittmer, Ulf; Lindemann, Monika; Horn, Peter A.; Witzke, Oliver; Kadow, Stephanie; Kamler, Markus; Gulbins, Erich; Becker, Katrin Anne; Krawczyk, Adalbert
    Fluoxetine and Sertraline Potently Neutralize the Replication of Distinct SARS-CoV-2 Variants
    In: Viruses Jg. 16 (2024) Nr. 4, 545
    Online Volltext: dx.doi.org/ (Open Access)
  • Stammkötter, Christian; Thümmler, Laura; Korth, Johannes; Marenbach, Beate; Braß, Peer; Horn, Peter; Lindemann, Monika; Dittmer, Ulf; Witzke, Oliver; Rohn, Hana; Krawczyk, Adalbert
    Frequency of SARS-CoV-2 Infections among Healthcare Workers in Germany: 3-Year Follow-Up Study
    In: Infectious Disease Reports Jg. 16 (2024) Nr. 4, S. 615 - 627
    Online Volltext: dx.doi.org/ (Open Access)
  • Cherneha, Maxim; Zydek, Isabel; Braß, Peer; Korth, Johannes; Jansen, Sarah; Esser, Stefan; Karsten, Christina; Meyer, Folker; Kraiselburd, Ivana; Dittmer, Ulf; Lindemann, Monika; Horn, Peter; Witzke, Oliver; Thümmler, Laura; Krawczyk, Adalbert
    Immunogenicity of the Monovalent Omicron XBB.1.5-Adapted BNT162b2 COVID-19 Vaccine in People Living with HIV (PLWH)
    In: Vaccines Jg. 12 (2024) Nr. 7, 785
    Online Volltext: dx.doi.org/ (Open Access)
  • Rohn, Hana; Elischer, Fynn; Larbig, Louisa; Jansen, Sarah; Schramm, Sabine; Otte, Mona; Konik, Margarethe; Paniskaki, Krystallenia; Weber, Peter; Reinold, Johanna; Gäckler, Anja; Krawczyk, Adalbert; Wilde, Benjamin; Trilling, Mirko; Michita, Rafael T.; Möhlendick, Birte; Siffert, Winfried; Brenner, Thorsten; Dinse, Hannah; Skoda, Eva M.; Horn, Peter; Witzke, Oliver; Rebmann, Vera
    Influence of HLA-G 3′ Untranslated Region Haplotypes and SNP +3422 Gene Variants as Host Genetic Factors on the Outcomes of SARS-CoV-2 Infection During Acute and Post-Acute Phases in a German Cohort
    In: HLA: Immune Response Genetics (Human Leukocyte Antigens) Jg. 104 (2024) Nr. 6, e15799
    Online Volltext: dx.doi.org/ (Open Access)
  • Lindemann, Monika; van de Sand, Lukas; Mülling, Nils; Völk, Kim L.; Aufderhorst, Ulrich W.; Wilde, Benjamin; Horn, Peter; Kribben, Andreas; Krawczyk, Adalbert; Witzke, Oliver; Heinemann, Falko M.
    Sequential Vaccination Against Streptococcus pneumoniae Appears as Immunologically Safe in Clinically Stable Kidney Transplant Recipients
    In: Vaccines Jg. 12 (2024) Nr. 11, 1244
    Online Volltext: dx.doi.org/ (Open Access)

    • 2023

    Artikel in Zeitschriften

  • Mülling, Nils; van de Sand, Lukas; Völk, Kim; Aufderhorst, Ulrich Wilhelm; van der Linden, Mark; Horn, Peter; Kribben, Andreas; Wilde, Benjamin; Krawczyk, Adalbert; Witzke, Oliver; Lindemann, Monika
    Antibody responses after sequential vaccination with PCV13 and PPSV23 in kidney transplant recipients
    In: Infection - A Journal of Infectious Disease Jg. 51 (2023) Nr. 6, S. 1703 - 1716
    Online Volltext: dx.doi.org/ (Open Access)
  • Alt, Mira; Wolf, Susanne; van de Sand, Lukas; Dittrich, Robin; Tertel, Tobias; Brochhagen, Leonie; Dirks, Miriam; Aufderhorst, Ulrich Wilhelm; Thümmler, Laura; Otte, Mona; Rainer, Kordula; Dittmer, Ulf; Giebel, Bernd; Trilling, Mirko; Heilingloh, Christiane Silke; Lotfi, Ramin; Roggendorf, Michael; Witzke, Oliver; Krawczyk, Adalbert
    Cell-to-cell spread inhibiting antibodies constitute a correlate of protection against herpes simplex virus type 1 reactivations : A retrospective study
    In: Frontiers in Immunology Jg. 14 (2023) 1143870
    Online Volltext: dx.doi.org/; Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Elsner, Carina; Appeltrath, Gwenllian A.; Konik, Margarethe; Parreuter, Janine; Bröcker-Preuß, Martina; Krawczyk, Adalbert; Esser, Stefan; Sammet, Stefanie; Karsten, Christina B.
    False-Positive Screening and Confirmatory HIV Diagnostic Test in a Patient with Cured SARS-CoV-2 Infection Is Not Mediated by Env/Spike Cross-Reactive Antibodies
    In: Viruses Jg. 15 (2023) Nr. 5, 1161
    Online Volltext: dx.doi.org/ (Open Access)
  • Bormann, Maren; Brochhagen, Leonie; Alt, Mira; Otte, Mona; Thümmler, Laura; van de Sand, Lukas; Kraiselburd, Ivana; Thomas, Alexander; Gosch, Jule; Braß, Peer; Ciesek, Sandra; Widera, Marek; Dolff, Sebastian; Dittmer, Ulf; Witzke, Oliver; Meyer, Folker; Lindemann, Monika; Schönfeld, Andreas; Rohn, Hana; Krawczyk, Adalbert
    Immune responses in COVID-19 patients during breakthrough infection with SARS-CoV-2 variants Delta, Omicron-BA.1 and Omicron-BA.5
    In: Frontiers in Immunology Jg. 14 (2023) 1150667
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Paniskaki, Krystallenia; Konik, Margarethe; Anft, Moritz; Heidecke, Harald; Meister, Toni L.; Pfaender, Stephanie; Krawczyk, Adalbert; Zettler, Markus; Jäger, Jasmin; Gäckler, Anja; Dolff, Sebastian; Westhoff, Timm H.; Rohn, Hana; Stervbo, Ulrik; Scheibenbogen, Carmen; Witzke, Oliver; Babel, Nina
    Low avidity circulating SARS-CoV-2 reactive CD8+ T cells with proinflammatory TEMRA phenotype are associated with post-acute sequelae of COVID-19
    In: Frontiers in Microbiology Jg. 14 (2023) 1196721
    Online Volltext: dx.doi.org/ (Open Access)
  • Limmer, Andreas; Engler, Andrea; Kattner, Simone; Gregorius, Jonas; Pattberg, Kevin Thomas; Schulz, Rebecca; Schwab, Jansje; Roth, Johannes; Vogl, Thomas; Krawczyk, Adalbert; Witzke, Oliver; Zelinskyy, Gennadiy; Dittmer, Ulf; Brenner, Thorsten; Berger, Marc
    Patients with SARS-CoV-2-Induced Viral Sepsis Simultaneously Show Immune Activation, Impaired Immune Function and a Procoagulatory Disease State
    In: Vaccines Jg. 11 (2023) Nr. 2, 435
    Online Volltext: dx.doi.org/ (Open Access)
  • Rohn, Hana; Schramm, Sabine; Pansikaki, Krystallenia; Jansen, Sarah; Hendriks, Celina; Platte, Maximilian; Konik, Margarethe; Dolff, Sebastian; Wilde, Benjamin; Kordelas, Lambros; Trilling, Mirko; Krawczyk, Adalbert; Horn, Peter; Witzke, Oliver; Rebmann, Vera
    Peripheral HLA-G/ILT-2 immune checkpoint axis in acute and convalescent COVID-19 patients
    In: Human Immunology Jg. 84 (2023) Nr. 8, S. 393 - 400
    Online Volltext: dx.doi.org/ (Open Access)
  • Zehner, Matthias; Alt, Mira; Ashurov, Artem; Goldsmith, Jory A.; Spies, Rebecca; Weiler, Nina; Lerma, Justin; Gieselmann, Lutz; Stöhr, Dagmar; Gruell, Henning; Schultz, Eric P.; Kreer, Christoph; Schlachter, Linda; Janicki, Hanna; Laib Sampaio, Kerstin; Stegmann, Cora; Nemetchek, Michelle D.; Dähling, Sabrina; Ullrich, Leon; Dittmer, Ulf; Witzke, Oliver; Koch, Manuel; Ryckman, Brent J.; Lotfi, Ramin; McLellan, Jason S.; Krawczyk, Adalbert; Sinzger, Christian; Klein, Florian
    Single-cell analysis of memory B cells from top neutralizers reveals multiple sites of vulnerability within HCMV Trimer and Pentamer
    In: Immunity Jg. 56 (2023) Nr. 11, S. 2602 - 2620.e10
    Online Volltext: dx.doi.org/
  • Sand, Lukas van de; Braß, Peer; Gregorius, Jonas; Pattberg, Kevin; Engler, Andrea; Dittmer, Ulf; Taube, Christian; Brock, Stephan; Berger, Marc Moritz; Brenner, Thorsten; Witzke, Oliver; Krawczyk, Adalbert
    Upregulation of miRNA-200c during Disease Progression in COVID-19 Patients
    In: Journal of Clinical Medicine (JCM) Jg. 12 (2023) Nr. 1, 283
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)

    • Abstracts

  • Elsner, Carina; Konik, Margarethe; Appeltrath, Gwenllian A.; Krause, Jil; Bröcker-Preuß, Martina; Krawczyk, Adalbert; Dittmer, Ulf; Esser, Stefan; Sammet, Stefanie; Karsten, Christina B.;
    False-positive HIV diagnosis post SARSCoV-2 infection : a case report
    DÖAK 2023 / German-Austrian AIDS Conference, Bonn, Germany, 23-25 March 2023,
    In: HIV Medicine Jg. 24 (2023) Nr. Supplement 1, S. 90
    Online Volltext: dx.doi.org/
  • Mülling, Nils; van de Sand, Lukas; Völk, Kim; Aufderhorst, Ulrich W.; van der Linden, Mark; Horn, Peter A.; Kribben, Andreas; Wilde, Benjamin; Krawczyk, Adalbert; Witzke, Oliver; Lindemann, Monika
    Follow-up of serotype-specific antibodies after sequential vaccination with two pneumococcal vaccines in kidney transplant recipients
    In: HLA: Immune Response Genetics (Human Leukocyte Antigens) Jg. 102 (2023) Nr. Suppl. 1, S. 4

    • 2022

    Artikel in Zeitschriften

  • Wünsch, Korbinian; Anastasiou, Olympia E.; Alt, Mira; Brochhagen, Leonie; Cherneha, Maxim; Thümmler, Laura; van Baal, Lukas; Madel, Rabea J.; Lindemann, Monika; Taube, Christian; Witzke, Oliver; Rohn, Hana; Krawczyk, Adalbert; Jansen, Sarah
    COVID-19 in Elderly, Immunocompromised or Diabetic Patients : From Immune Monitoring to Clinical Management in the Hospital
    In: Viruses Jg. 14 (2022) Nr. 4, 746
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Thümmler, Laura; Koldehoff, Michael; Fisenkci, Neslinur; Brochhagen, Leonie; Horn, Peter; Krawczyk, Adalbert; Lindemann, Monika
    Cellular and Humoral Immunity after the Third Vaccination against SARS-CoV-2 in Hematopoietic Stem-Cell Transplant Recipients
    In: Vaccines Jg. 10 (2022) Nr. 6, 972
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Thümmler, Laura; Gäckler, Anja; Bormann, Maren; Ciesek, Sandra; Widera, Marek; Rohn, Hana; Fisenkci, Neslinur; Otte, Mona; Alt, Mira; Dittmer, Ulf; Horn, Peter; Witzke, Oliver; Krawczyk, Adalbert; Lindemann, Monika
    Cellular and Humoral Immunity against Different SARS-CoV-2 Variants Is Detectable but Reduced in Vaccinated Kidney Transplant Patients
    In: Vaccines Jg. 10 (2022) Nr. 8, 1348
    Online Volltext: dx.doi.org/ (Open Access)
  • Jahn, Michael; Korth, Johannes; Dorsch, Oliver; Anastasiou, Olympia Evdoxia; Krawczyk, Adalbert; Brochhagen, Leonie; van de Sand, Lukas; Sorge-Hädicke, Burkhard; Tyczynski, Bartosz; Witzke, Oliver; Dittmer, Ulf; Dolff, Sebastian; Wilde, Benjamin; Kribben, Andreas
    Decline of Humoral Responses 6 Months after Vaccination with BNT162b2 (Pfizer–BioNTech) in Patients on Hemodialysis
    In: Vaccines Jg. 10 (2022) Nr. 2, 327
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Schuhenn, Jonas; Meister, Toni Luise; Todt, Daniel; Bracht, Thilo; Schork, Karin; Billaud, Jean-Noel; Elsner, Carina; Heinen, Natalie; Karakoese, Zehra; Haid, Sibylle; Kumar, Sriram; Brunotte, Linda; Eisenacher, Martin; Di, Yunyun; Lew, Jocelyne; Falzarano, Darryl; Chen, Jieliang; Yuan, Zhenghong; Pietschmann, Thomas; Wiegmann, Bettina; Uebner, Hendrik; Taube, Christian; Le-Trilling, Vu Thuy Khanh; Trilling, Mirko; Krawczyk, Adalbert; Ludwig, Stephan; Sitek, Barbara; Steinmann, Eike; Dittmer, Ulf; Lavender, Kerry J.; Sutter, Kathrin; Pfaender, Stephanie
    Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Jg. 119 (2022) Nr. 8, e2111600119
    Online Volltext: dx.doi.org/ (Open Access)
  • Thümmler, Laura; Lindemann, Monika; Horn, Peter; Lenz, Veronika; Konik, Margarethe; Gäckler, Anja; Boss, Kristina; Theodoropoulos, Fotis; Besa, Vasiliki; Taube, Christian; Brenner, Thorsten; Witzke, Oliver; Krawczyk, Adalbert; Rohn, Hana
    Early Treatment with Monoclonal Antibodies or Convalescent Plasma Reduces Mortality in Non-Vaccinated COVID-19 High-Risk Patients
    In: Viruses Jg. 15 (2022) Nr. 1, 119
    Online Volltext: dx.doi.org/ (Open Access)
  • Thümmler, Laura; Konik, Margarethe; Lindemann, Monika; Fisenkci, Neslinur; Koldehoff, Michael; Gäckler, Anja; Horn, Peter; Theodoropoulos, Fotis; Taube, Christian; Zettler, Markus; Anastasiou, Olympia Evdoxia; Braß, Peer; Jansen, Sarah; Witzke, Oliver; Rohn, Hana; Krawczyk, Adalbert
    Long-term cellular immune response in immunocompromised unvaccinated COVID-19 patients undergoing monoclonal antibody treatment
    In: Frontiers in Immunology Jg. 13 (2022) 980698
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Lindemann, Monika; Baumann, Charleen; Wilde, Benjamin; Gäckler, Anja; Meller, Lara; Horn, Peter; Krawczyk, Adalbert; Witzke, Oliver
    Prospective, Longitudinal Study on Specific Cellular Immune Responses after Vaccination with an Adjuvanted, Recombinant Zoster Vaccine in Kidney Transplant Recipients
    In: Vaccines Jg. 10 (2022) Nr. 6, 844
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Wolff, Natalie; Kollenda, Sebastian; Klein, Kai; Loza, Kateryna; Heggen, Marc; Brochhagen, Leonie; Witzke, Oliver; Krawczyk, Adalbert; Hilger, Ingrid; Epple, Matthias
    Silencing of proinflammatory NF-κB and inhibition of herpes simplex virus (HSV) replication by ultrasmall gold nanoparticles (2 nm) conjugated with small-interfering RNA
    In: Nanoscale Advances Jg. 4 (2022) S. 4502 - 4516
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Schmitz, Yasmin; Schwerdtfeger, Mara; Westmeier, Jaana; Littwitz-Salomon, Elisabeth; Alt, Mira; Brochhagen, Leonie; Krawczyk, Adalbert; Sutter, Kathrin
    Superior antiviral activity of IFNβ in genital HSV-1 infection
    In: Frontiers in Cellular and Infection Microbiology Jg. 12 (2022) 949036
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Paniskaki, Krystallenia; Konik, Margarethe; Anft, Moritz; Meister, Toni L.; Marheinecke, Corinna; Pfaender, Stephanie; Jäger, Jasmin; Krawczyk, Adalbert; Zettler, Markus; Dolff, Sebastian; Westhoff, Timm H.; Rohn, Hana; Stervbo, Ulrik; Witzke, Oliver; Babel, Nina
    Superior humoral immunity in vaccinated SARS-CoV-2 convalescence as compared to SARS-COV-2 infection or vaccination
    In: Frontiers in Immunology Jg. 13 (2022) 1031254
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)

    • 2021

    Artikel in Zeitschriften

  • Todt, Daniel; Meister, Toni Luise; Tamele, Barbora; Howes, John; Paulmann, Dajana; Becker, Britta; Brill, Florian H.; Wind, Mark; Schijven, Jack; Heinen, Natalie; Kinast, Volker; Mhlekude, Baxolele; Goffinet, Christine; Krawczyk, Adalbert; Steinmann, Jörg; Pfaender, Stephanie; Brüggemann, Yannick; Steinmann, Eike
    A realistic transfer method reveals low risk of SARS-CoV-2 transmission via contaminated euro coins and banknotes
    In: iScience Jg. 24 (2021) Nr. 8, 102908
    Online Volltext: dx.doi.org/ (Open Access)
  • van de Sand, Lukas; Bormann, Maren; Schmitz, Yasmin; Heilingloh, Christiane Silke; Witzke, Oliver; Krawczyk, Adalbert
    Antiviral Active Compounds Derived from Natural Sources against Herpes Simplex Viruses
    In: Viruses Jg. 13 (2021) Nr. 7, 1386
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Bazinet, Michel; Pântea, Victor; Placinta, Gheorghe; Moscalu, Iurie; Cebotarescu, Valentin; Cojuhari, Lilia; Jimbei, Pavlina; Iarovoi, Liviu; Smesnoi, Valentina; Musteata, Tatiana; Jucov, Alina; Dittmer, Ulf; Krawczyk, Adalbert; Vaillant, Andrew
    Benefit of transaminase elevations in establishing functional cure of HBV infection during nap-based combination therapy
    In: Journal of Viral Hepatitis Jg. 28 (2021) Nr. 5, S. 817 - 825
    Online Volltext: dx.doi.org/
  • Schwarzkopf, Sina; Krawczyk, Adalbert; Knop, Dietmar; Klump, Hannes; Heinold, Andreas; Heinemann, Falko M.; Thümmler, Laura; Temme, Christian; Breyer, Marianne; Witzke, Oliver; Dittmer, Ulf; Lenz, Veronika; Horn, Peter; Lindemann, Monika
    Cellular immunity in COVID-19 convalescents with PCR-confirmed infection but with undetectable SARS-CoV-2-Specific IgG
    In: Emerging Infectious Diseases (EID) Jg. 27 (2021) Nr. 1, S. 122 - 129
    Online Volltext: dx.doi.org/ (Open Access)
  • Steinhauer, Katrin; Meister, Toni Luise; Todt, Daniel; Krawczyk, Adalbert; Paßvogel, Lars; Becker, Britta; Paulmann, Dajana; Bischoff, Birte; Pfaender, Stephanie; Brill, Florian Holger Hubert; Steinmann, Eike
    Comparison of the in-vitro efficacy of different mouthwash solutions targeting SARS-CoV-2 based on the European Standard EN 14476
    In: The Journal of Hospital Infection Jg. 111 (2021) S. 180 - 183
    Online Volltext: dx.doi.org/ (Open Access)
  • Lindemann, Monika; Lenz, Veronika; Knop, Dietmar; Klump, Hannes; Alt, Mira; Aufderhorst, Ulrich W.; Schipper, Leonie; Schwarzkopf, Sina; Meller, Lara; Steckel, Nina Kristin; Koldehoff, Michael; Heinold, Andreas; Heinemann, Falko M.; Fischer, Johannes; Hutschenreuter, Gabriele; Knabbe, Cornelius; Dolff, Sebastian; Brenner, Thorsten; Dittmer, Ulf; Witzke, Oliver; Herbstreit, Frank; Horn, Peter; Krawczyk, Adalbert
    Convalescent plasma treatment of critically ill intensive care COVID-19 patients
    In: Transfusion Jg. 61 (2021) Nr. 5, S. 1394 - 1403
    Online Volltext: dx.doi.org/ (Open Access)
  • Bormann, Maren; Alt, Mira; Schipper, Leonie; van de Sand, Lukas; Otte, Mona; Meister, Toni Luise; Dittmer, Ulf; Witzke, Oliver; Steinmann, Eike; Krawczyk, Adalbert
    Disinfection of SARS-CoV-2 Contaminated Surfaces of Personal Items with UVC-LED Disinfection Boxes
    In: Viruses Jg. 13 (2021) Nr. 4, 598
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Meister, Toni Luise; Brüggemann, Yannick; Todt, Daniel; Conzelmann, Carina; Müller, Janis A; Groß, Rüdiger; Münch, Jan; Krawczyk, Adalbert; Steinmann, Jörg; Steinmann, Jochen; Pfaender, Stephanie; Steinmann, Eike
    Erratum to: Virucidal Efficacy of Different Oral Rinses Against Severe Acute Respiratory Syndrome Coronavirus 2
    In: The Journal of Infectious Diseases (JID) Jg. 223 (2021) Nr. 3, S. 541 - 541
    Online Volltext: dx.doi.org/ (Open Access)
  • van de Sand, Lukas; Bormann, Maren; Alt, Mira; Schipper, Leonie; Heilingloh, Christiane Silke; Steinmann, Eike; Todt, Daniel; Dittmer, Ulf; Elsner, Carina; Witzke, Oliver; Krawczyk, Adalbert
    Glycyrrhizin Effectively Inhibits SARS-CoV-2 Replication by Inhibiting the Viral Main Protease
    In: Viruses Jg. 13 (2021) Nr. 4, 609
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Konik, Margarethe; Lindemann, Monika; Zettler, Markus; Meller, Lara; Dolff, Sebastian; Rebmann, Vera; Horn, Peter; Dittmer, Ulf; Krawczyk, Adalbert; Schipper, Leonie; Trilling, Mirko; Anastasiou, Olympia Evdoxia; Schwarzkopf, Sina; Thümmler, Laura; Taube, Christian; Schöbel, Christoph; Brenner, Thorsten; Skoda, Eva-Maria; Wilde, Benjamin; Gäckler, Anja; Witzke, Oliver; Rohn, Hana
    Long-term sars-cov-2 specific immunity is affected by the severity of initial covid-19 and patient age
    In: Journal of Clinical Medicine (JCM) Jg. 10 (2021) Nr. 19, 4606
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Conzelmann, Carina; Groß, Rüdiger; Meister, Toni Luise; Todt, Daniel; Krawczyk, Adalbert; Dittmer, Ulf; Stenger, Steffen; Münch, Jan; Steinmann, Eike; Müller, Janis A.; Pfaender, Stephanie
    Pasteurization Inactivates SARS-CoV-2-Spiked Breast Milk
    In: Pediatrics Jg. 147 (2021) Nr. 1, S. e2020031690
    Online Volltext: dx.doi.org/
  • Bazinet, Michel; Pântea, Victor; Cebotarescu, Valentin; Cojuhari, Lilia; Jimbei, Pavlina; Anderson, Mark; Gersch, Jeff; Holzmayer, Vera; Elsner, Carina; Krawczyk, Adalbert; Kuhns, Mary C.; Cloherty, Gavin; Dittmer, Ulf; Vaillant, Andrew
    Persistent Control of Hepatitis B Virus and Hepatitis Delta Virus Infection Following REP 2139‐Ca and Pegylated Interferon Therapy in Chronic Hepatitis B Virus/Hepatitis Delta Virus Coinfection
    In: Hepatology Communications Jg. 5 (2021) Nr. 2, S. 189 - 202
    Online Volltext: dx.doi.org/ (Open Access)
  • Bormann, Maren; van de Sand, Lukas; Witzke, Oliver; Krawczyk, Adalbert
    Recent Antiviral Treatment and Vaccination Strategies against SARS-CoV-2
    In: Klinische Monatsblätter für Augenheilkunde Jg. 238 (2021) Nr. 5, S. 569 - 578
    Online Volltext: dx.doi.org/
  • Wu, Jun; Liang, Boyun; Chen, Cunrong; Wang, Hua; Fang, Yaohui; Shen, Shu; Yang, Xiaoli; Wang, Baoju; Chen, Liangkai; Chen, Qi; Wu, Yang; Liu, Jia; Yang, Xuecheng; Li, Wei; Zhu, Bin; Zhou, Wenqing; Wang, Huan; Li, Sumeng; Lu, Sihong; Liu, Di; Li, Huadong; Krawczyk, Adalbert; Lu, Mengji; Yang, Dongliang; Deng, Fei; Dittmer, Ulf; Trilling, Mirko; Zheng, Xin
    SARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19
    In: Nature Communications Jg. 12 (2021) Nr. 1, S. 1813
    Online Volltext: dx.doi.org/ (Open Access)
  • Lindemann, Monika; Krawczyk, Adalbert; Dolff, Sebastian; Konik, Margarethe; Rohn, Hana; Platte, Maximillian; Thümmler, Laura; Schwarzkopf, Sina; Schipper, Leonie; Bormann, Maren; van de Sand, Lukas; Breyer, Marianne; Klump, Hannes; Knop, Dietmar; Lenz, Veronika; Temme, Christian; Dittmer, Ulf; Horn, Peter; Witzke, Oliver
    SARS-CoV-2-specific humoral and cellular immunity in two renal transplants and two hemodialysis patients treated with convalescent plasma
    In: Journal of Medical Virology Jg. 93 (2021) Nr. 5, S. 3047 - 3054
    Online Volltext: dx.doi.org/ (Open Access)
  • Korth, Johannes; Wilde, Benjamin; Dolff, Sebastian; Frisch, Jasmin; Jahn, Michael; Krawczyk, Adalbert; Trilling, Mirko; Schipper, Leonie; Cordes, Sebastian; Ross, Birgit; Lindemann, Monika; Kribben, Andreas; Dittmer, Ulf; Witzke, Oliver; Herrmann, Anke; Anastasiou, Olympia Evdoxia
    Sars-cov-2 seroprevalence in healthcare workers in Germany : A follow-up study
    In: International Journal of Environmental Research and Public Health = IJERPH Jg. 18 (2021) Nr. 9, 4540
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Bormann, Maren; Alt, Mira; Schipper, Leonie; van de Sand, Lukas; Le-Trilling, Vu Thuy Khanh; Rink, Lydia; Heinen, Natalie; Madel, Rabea Julia; Otte, Mona; Wuensch, Korbinian; Heilingloh, Christiane Silke; Mueller, Thorsten; Dittmer, Ulf; Elsner, Carina; Pfaender, Stephanie; Trilling, Mirko; Witzke, Oliver; Krawczyk, Adalbert
    Turmeric root and its bioactive ingredient curcumin effectively neutralize sars-cov-2 in vitro
    In: Viruses Jg. 13 (2021) Nr. 10, 1914
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Steinhauer, Katrin; Meister, Toni Luise; Todt, Daniel; Krawczyk, Adalbert; Paßvogel, Lars; Becker, Britta; Paulmann, Dajana; Bischoff, Birte; Eggers, Maren; Pfaender, Stephanie; Brill, Florian Holger Hubert; Steinmann, Eike
    Virucidal efficacy of different formulations for hand and surface disinfection targeting SARS CoV-2
    In: The Journal of Hospital Infection Jg. 112 (2021) S. 27 - 30
    Online Volltext: dx.doi.org/

    • 2020

    Artikel in Zeitschriften

  • Schöler, Lara; Le-Trilling, Vu Thuy Khanh; Eilbrecht, Mareike; Mennerich, Denise; Anastasiou, Olympia E.; Krawczyk, Adalbert; Herrmann, Anke; Dittmer, Ulf; Trilling, Mirko
    A Novel In-Cell ELISA Assay Allows Rapid and Automated Quantification of SARS-CoV-2 to Analyze Neutralizing Antibodies and Antiviral Compounds
    In: Frontiers in Immunology Jg. 11 (2020) S. 573526
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Ruzsics, Zsolt; Hoffmann, Katja; Riedl, André; Krawczyk, Adalbert; Widera, Marek; Sertznig, Helene; Schipper, Leonie; Kapper-Falcone, Valeria; Debreczeny, Monika; Ernst, Wolfgang; Grabherr, Reingard; Hengel, Hartmut; Harant, Hanna
    A Novel, Broad-Acting Peptide Inhibitor of Double-Stranded DNA Virus Gene Expression and Replication
    In: Frontiers in Microbiology Jg. 11 (2020) S. 601555
    Online Volltext: dx.doi.org/ (Open Access)
  • Lang, Judith; Bohn, Patrick; Bhat, Hilal; Jastrow, Holger; Walkenfort, Bernd; Cansiz, Feyza; Fink, Julian; Bauer, Michael; Olszewski, Dominik; Ramos-Nascimento, Ana; Duhan, Vikas; Friedrich, Sarah-Kim; Becker-Flegler, Katrin; Krawczyk, Adalbert; Edwards, Michael J.; Burchert, Andreas; Huber, Magdalena; Friebus-Kardash, Justa; Göthert, Joachim Rudolf; Hardt, Cornelia; Probst, Hans Christian; Schumacher, Fabian; Köhrer, Karl; Kleuser, Burkhard; Babiychuk, Eduard B.; Sodeik, Beate; Seibel, Jürgen; Greber, Urs F.; Lang, Philipp A.; Gulbins, Erich; Lang, Karl S.
    Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease
    In: Nature Communications Jg. 11 (2020) Nr. 1, S. 1338
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Reuter, Nina; Kropff, Barbara; Schneiderbanger, Julia Karin; Alt, Mira; Krawczyk, Adalbert; Sinzger, Christian; Winkler, Thomas H.; Britt, William J.; Mach, Michael; Thomas, Marco
    Cell fusion induced by a fusion-active form of human cytomegalovirus glycoprotein B (gB) is inhibited by antibodies directed at antigenic domain 5 in the ectodomain of gB
    In: Journal of Virology Jg. 94 (2020) Nr. 18,
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Birzer, Alexandra; Krawczyk, Adalbert; Draßner, Christina; Kuhnt, Christine; Mühl-Zürbes, Petra; Heilingloh, Christiane Silke; Steinkasserer, Alexander; Popella, Linda
    HSV-1 Modulates IL-6 Receptor Expression on Human Dendritic Cells
    In: Frontiers in Immunology Jg. 11 (2020) S. 1970
    Online Volltext: dx.doi.org/ (Open Access)
  • Heilingloh, Christiane Silke; Lull, Christopher; Kleiser, Elissa; Alt, Mira; Schipper, Leonie; Witzke, Oliver; Trilling, Mirko; Eis-Hübinger, Anna-Maria; Dittmer, Ulf; Krawczyk, Adalbert
    Herpes Simplex Virus Type 2 Is More Difficult to Neutralize by Antibodies Than Herpes Simplex Virus Type 1
    In: Vaccines Jg. 8 (2020) Nr. 3, S. 478
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Grosche, Linda; Mühl-Zürbes, Petra; Ciblis, Barbara; Krawczyk, Adalbert; Kuhnt, Christine; Kamm, Lisa; Steinkasserer, Alexander; Heilingloh, Christiane Silke
    Herpes Simplex Virus Type-2 Paralyzes the Function of Monocyte-Derived Dendritic Cells
    In: Viruses Jg. 12 (2020) Nr. 1, 112
    Online Volltext: dx.doi.org/ (Open Access)
  • Shekhtman, Louis; Cotler, Scott J.; Hershkovich, Leeor; Uprichard, Susan L.; Bazinet, Michel; Pantea, Victor; Cebotarescu, Valentin; Cojuhari, Lilia; Jimbei, Pavlina; Krawczyk, Adalbert; Dittmer, Ulf; Vaillant, Andrew; Dahari, Harel
    Modelling hepatitis D virus RNA and HBsAg dynamics during nucleic acid polymer monotherapy suggest rapid turnover of HBsAg
    In: Scientific Reports Jg. 10 (2020) Nr. 1, S. 7837
    Online Volltext: dx.doi.org/ (Open Access)
  • Witzke, Oliver; Wilde, Benjamin; Krawczyk, Adalbert
    Moderne Infektiologie: Eindringlinge unschädlich machen: : Universitäre Infektiologie als fächerübergreifendes Konzept der stationären Patient*innenversorgung
    In: Unikate: Berichte aus Forschung und Lehre (2020) Nr. 54: Medizin: Infektionskrankheiten - ein globales Problem, S. 70 - 81
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Zettl, Ferdinand; Meister, Toni Luise; Vollmer, Tanja; Fischer, Bastian; Steinmann, Jörg; Krawczyk, Adalbert; V’kovski, Philip; Todt, Daniel; Steinmann, Eike; Pfaender, Stephanie; Zimmer, Gert
    Rapid quantification of SARS-CoV-2-neutralizing antibodies using propagation-defective vesicular stomatitis virus pseudotypes
    In: Vaccines Jg. 8 (2020) Nr. 3, S. 386
    Online Volltext: dx.doi.org/ (Open Access)
  • Korth, Johannes; Wilde, Benjamin; Dolff, Sebastian; Anastasiou, Olympia E.; Krawczyk, Adalbert; Jahn, Michael; Cordes, Sebastian; Ross, Birgit; Esser, Stefan; Lindemann, Monika; Kribben, Andreas; Dittmer, Ulf; Witzke, Oliver; Herrmann, Anke
    SARS-CoV-2-specific antibody detection in healthcare workers in Germany with direct contact to COVID-19 patients
    In: Journal of Clinical Virology Jg. 128 (2020) 104437
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Bazinet, Michel; Pântea, Victor; Placinta, Gheorghe; Moscalu, Iurie; Cebotarescu, Valentin; Cojuhari, Lilia; Jimbei, Pavlina; Iarovoi, Liviu; Smesnoi, Valentina; Musteata, Tatiana; Jucov, Alina; Dittmer, Ulf; Krawczyk, Adalbert; Vaillant, Andrew
    Safety and Efficacy of 48 Weeks REP 2139 or REP 2165, Tenofovir Disoproxil, and Pegylated Interferon Alfa-2a in Patients With Chronic HBV Infection Naïve to Nucleos(t)ide Therapy
    In: Gastroenterology Jg. 158 (2020) Nr. 8, S. 2180 - 2194
    Online Volltext: dx.doi.org/ (Open Access)
  • Heilingloh, Christiane Silke; Aufderhorst, Ulrich Wilhelm; Schipper, Leonie; Dittmer, Ulf; Witzke, Oliver; Yang, Dongliang; Zheng, Xin; Sutter, Kathrin; Trilling, Mirko; Alt, Mira; Steinmann, Eike; Krawczyk, Adalbert
    Susceptibility of SARS-CoV-2 to UV irradiation
    In: American Journal of Infection Control Jg. 48 (2020) Nr. 10, S. 1273 - 1275
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Meister, Toni Luise; Brüggemann, Yannick; Todt, Daniel; Conzelmann, Carina; Müller, Janis A.; Groß, Rüdiger; Münch, Jan; Krawczyk, Adalbert; Steinmann, Jörg; Steinmann, Jochen; Pfaender, Stephanie; Steinmann, Eike
    Virucidal Efficacy of Different Oral Rinses Against Severe Acute Respiratory Syndrome Coronavirus 2
    In: The Journal of Infectious Diseases (JID) Jg. 222 (2020) Nr. 8, S. 1289 - 1292
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)

    • 2019

    Artikel in Zeitschriften

  • Turan, Aykut; Grosche, Linda; Krawczyk, Adalbert; Mühl-Zürbes, Petra; Drassner, Christina; Düthorn, Alexandra; Kummer, Mirko; Hasenberg, Mike; Voortmann, Sylvia; Jastrow, Holger; Dörrie, Jan; Schaft, Niels; Kraner, Max; Döhner, Katinka; Sodeik, Beate; Steinkasserer, Alexander; Heilingloh, Christiane Silke
    Autophagic degradation of lamins facilitates the nuclear egress of herpes simplex virus type 1
    In: The Journal of Cell Biology (JCB) Jg. 218 (2019) Nr. 2, S. 508 - 523
    Online Volltext: dx.doi.org/ (Open Access)
  • Bauer, Dirk; Keller, Jessica; Alt, Mira; Schubert, Axel; Aufderhorst, Ulrich Wilhelm; Palapys, Vivien; Kasper, Maren; Heilingloh, Christiane Silke; Dittmer, Ulf; Laffer, Björn; Eis-Hübinger, Anna Maria; Verjans, Georges M.; Heiligenhaus, Arnd; Roggendorf, Michael; Krawczyk, Adalbert
    Corrigendum to “Antibody-based immunotherapy of acyclovir resistant ocular herpes simplex virus infection” [Virology 512 (2017) 194–200]
    In: Virology Jg. 526 (2019) S. 231 - 232
    Online Volltext: dx.doi.org/ (Open Access)
  • Kopp, Mathis; Aufderhorst, Ulrich Wilhelm; Alt, Mira; Dittmer, Ulf; Eis-Hübinger, Anna-Maria; Giebel, Bernd; Roggendorf, Michael; Epple, Matthias; Krawczyk, Adalbert
    Induction of herpes simplex virus type 1 cell-to-cell spread inhibiting antibodies by a calcium phosphate nanoparticle-based vaccine
    In: Nanomedicine: Nanotechnology, Biology, and Medicine Jg. 16 (2019) S. 138 - 148
    Online Volltext: dx.doi.org/ (Open Access)
  • Karimzadeh, Hadi; Kiraithe, Muthamia M.; Oberhardt, Valerie; Salimi Alizei, Elahe; Bockmann, Jan; Schulze zur Wiesch, Julian; Budeus, Bettina; Hoffmann, Daniel; Wedemeyer, Heiner; Cornberg, Markus; Krawczyk, Adalbert; Rashidi-Alavijeh, Jassin; Rodríguez-Frías, Francisco; Casillas, Rosario; Buti, Maria; Smedile, Antonina; Alavian, Seyed Moayed; Heinold, Andreas; Emmerich, Florian; Panning, Marcus; Gostick, Emma; Price, David A.; Timm, Jörg; Hofmann, Maike; Raziorrouh, Bijan; Thimme, Robert; Protzer, Ulrike; Roggendorf, Michael; Neumann-Haefelin, Christoph
    Mutations in Hepatitis D Virus Allow It to Escape Detection by CD8⁺ T Cells and Evolve at the Population Level
    In: Gastroenterology Jg. 156 (2019) Nr. 6, S. 1820 - 1833
    Online Volltext: dx.doi.org/ (Open Access)
  • Krawczyk, Adalbert; Bazinet, Michel; Pantea, Victor; Cotler, Scott; Dahari, Harel; Shekhtman, Louis; Jimbei, Pavlina; Cojuhari, Lilia; Cebotarescu, Valentin; Uprichard, Susan; Vaillant, Andrew
    Understanding HDV and HBsAg kinetics during nucleic acid polymer REP 2139 mono-therapy in HBeAg-negative chronic HBV/HDV co-infected patients via mathematical modeling
    In: Journal of Hepatology Jg. 70 (2019) Nr. 1 Suppl., S. e463
    Online Volltext: dx.doi.org/

    • Bücher/Sammelwerke/Tagungsbände

  • Krawczyk, Adalbert
    Antivirale Interventionen
    Duisburg ; Essen (2019) 1 CD-ROM

    • 2018

    Artikel in Zeitschriften

  • Zinser, Elisabeth; Krawczyk, Adalbert; Mühl-Zürbes, Petra; Aufderhorst, Ulrich; Draßner, Christina; Stich, Lena; Zaja, Mirko; Strobl, Stefan; Steinkasserer, Alexander; Heilingloh, Christiane Silke
    A new promising candidate to overcome drug resistant herpes simplex virus infections
    In: Antiviral Research Jg. 149 (2018) S. 202 - 210
    Online Volltext: dx.doi.org/
  • Krawczyk, Adalbert; Ackermann, Jessica; Goitowski, Birgit; Trenschel, Rudolf; Ditschkowski, Markus; Timm, Jörg; Ottinger, Hellmut; Beelen, Dietrich; Grüner, Nico; Fiedler, Melanie
    Assessing the risk of CMV reactivation and reconstitution of antiviral immune response post bone marrow transplantation by the QuantiFERON-CMV-assay and real time PCR
    In: Journal of Clinical Virology Jg. 99-100 (2018) S. 61 - 66
    Online Volltext: dx.doi.org/ (Open Access)
  • Alt, Mira; Falk, Jessica; Eis-Hübinger, Anna Maria; Kropff, Barbara; Sinzger, Christian; Krawczyk, Adalbert
    Detection of antibody-secreting cells specific for the cytomegalovirus and herpes simplex virus surface antigens
    In: Journal of Immunological Methods Jg. 462 (2018) S. 13 - 22
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Krawczyk, Adalbert; et.al.
    Establishment of High Rates of Functional Control and Reversal of Fibrosis Following Treatment of Hbeag Negative Chronic HBV Infection with REP 2139-Mg / REP 2165-Mg, Tenofovir Disoproxil Fumarate and Pegylated Interferon Alpha-2a
    In: Hepatology Jg. 68 (2018) Nr. S1, S. 234A - 235A
    Online Volltext: dx.doi.org/
  • Falk, Jessica Julia; Winkelmann, Martina; Stöhr, Dagmar; Alt, Mira; Schrezenmeier, Hubert; Krawczyk, Adalbert; Lotfi, Ramin; Sinzger, Christian
    Identification of Elite Neutralizers With Broad and Potent Neutralizing Activity Against Human Cytomegalovirus (HCMV) in a Population of HCMV-Seropositive Blood Donors
    In: The Journal of Infectious Diseases (JID) Jg. 218 (2018) Nr. 6, S. 876 - 885
    Online Volltext: dx.doi.org/ (Open Access)
  • Falk, Jessica Julia; Winkelmann, Martina; Sampaio, Kerstin Laib; Paal, Caroline; Schrezenmeier, Hubert; Alt, Mira; Stanton, Richard; Krawczyk, Adalbert; Lotfi, Ramin; Sinzger, Christian
    Large-scale screening of HCMV-seropositive blood donors indicates that HCMV effectively escapes from antibodies by cell-associated spread
    In: Viruses Jg. 10 (2018) Nr. 9, S. 500
    Online Volltext: dx.doi.org/ (Open Access)
  • Gliga, Smaranda; Korth, Johannes; Krawczyk, Adalbert; Wilde, Benjamin; Horn, Peter; Witzke, Oliver; Lindemann, Monika; Fiedler, Melanie
    T-Track-CMV and QuantiFERON-CMV assays for prediction of protection from CMV reactivation in kidney transplant recipients
    In: Journal of Clinical Virology Jg. 105 (2018) S. 91 - 96
    Online Volltext: dx.doi.org/

    • Abstracts

  • Turan, A.; Krawczyk, Adalbert; Grosche, L.; Muehl-Zuerbes, P.; Drassner, C.; Hasenberg, Mike; Voortmann, S.; Jastrow, Holger; Kraner, M.; Döhner, K.; Sodeik, B.; Heilingloh, C.; Steinkasserer, A.
    Autophagy-Mediated Breakdown of the nuclear lamina facilitates nuclear egress of HSV-1 capsids and thus generation of progeny virus in dendritic cells
    In: European Journal of Immunology Jg. 48 (2018) Nr. Suppl. 1, S. 21 - 22
    Online Volltext: dx.doi.org/ (Open Access)
  • Bazinet, M.; Pantea, V.; Placinta, G.; Moscalu, I.; Cebotarescu, V.; Cojuhari, L.; Jimbei, P.; Iarovoi, L.; Smesnoi, V.; Musteata, T.; Jucov, A.; Krawczyk, Adalbert; Vaillant, A.
    Updated Follow-up Analysis in the REP 401 Protocol : Treatment of HBeAg Negative Chronic HBV Infection with REP 2139 or REP 2165, Tenofovir Disoproxil Fumarate and Pegylated Interferon α-2a
    In: Journal of Viral Hepatitis Jg. 25 (2018) Nr. Suppl. 2, S. 14
    Online Volltext: dx.doi.org/
  • Vaillant, Andrew; Bazinet, Michel; Pantea, Victor; Placinta, Gheorghe; Moscalu, Iurie; Cebotarescu, Valentin; Cojuhari, Lilia; Jimbei, Pavlina; Iarovoi, Liviu; Smesnoi, Valentina; Musteata, Tatiana; Jucov, Alina; Krawczyk, Adalbert
    Updated follow-up analysis in the REP 401 protocol : Treatment HBeAg negative chronic hepatitis B infection with REP 2139 or REP 2165, tenofovir disoproxil fumarate and pegylated interferon alfa-2a
    In: Journal of Hepatology Jg. 68 (2018) Nr. Suppl. 1, S. 517
    Online Volltext: dx.doi.org/

    • 2017

    Artikel in Zeitschriften

  • Bauer, Dirk; Alt, Mira; Dirks, Miriam; Buch, Anna; Heilingloh, Christiane S.; Dittmer, Ulf; Giebel, Bernd; Görgens, André; Palapys, Vivien; Kasper, Maren; Eis-Hübinger, Anna M.; Sodeik, Beate; Heiligenhaus, Arnd; Roggendorf, Michael; Krawczyk, Adalbert
    A therapeutic antiviral antibody inhibits the anterograde directed neuron-to-cell spread of herpes simplex virus and protects against ocular disease
    In: Frontiers in Microbiology Jg. 8 (2017) S. 2115
    Online Volltext: dx.doi.org/ (Open Access)
  • Bauer, Dirk; Keller, Jessica; Alt, Mira; Schubert, Axel; Aufderhorst, Ulrich Wilhelm; Palapys, Vivien; Kasper, Maren; Heilingloh, Christiane Silke; Dittmer, Ulf; Laffer, Björn; Eis-Hübinger, Anna Maria; Verjans, Georges M.; Heiligenhaus, Arnd; Roggendorf, Michael; Krawczyk, Adalbert
    Antibody-based immunotherapy of aciclovir resistant ocular herpes simplex virus infections
    In: Virology Jg. 512 (2017) S. 194 - 200
    Online Volltext: dx.doi.org/ (Open Access)
  • Gliga, S.; Fiedler, Melanie; Herzer, Kerstin; Witzke, Oliver; Krawczyk, Adalbert; Korth, Johannes; Horn, Peter; Dittmer, Ulf; Lindemann, Monika
    CMV elispot assays are superior to the quantiferon CMV assay to predict protection from CMV reactivation in kidney ans liver transplant recipients
    In: HLA: Immune Response Genetics (Human Leukocyte Antigens) Jg. 89 (2017) Nr. 6, S. 375
    Online Volltext: dx.doi.org/
  • Cojuhari, L.; Cebotarescu, V.; Krawczyk, Adalbert; Bazinet, M.; Pantea, V.; Vaillant, A.; Jimbei, P.
    One year follow-up and HBV RNA / HBcrAg analysis in the REP 301 Trial : REP 2139 and pegylated interferon alpha-2a in Caucasian patients with chronic HBV / HDV co-infection
    In: Journal of Hepatology Jg. 66 (2017) Nr. 1, S. S96 - S97
    Online Volltext: dx.doi.org/
  • Heilingloh, Christiane S.; Krawczyk, Adalbert
    Role of L-particles during Herpes Simplex virus infection
    In: Frontiers in Microbiology Jg. 8 (2017) S. 2565
    Online Volltext: dx.doi.org/ (Open Access)
  • Bazinet, Michel; Pântea, Victor; Cebotarescu, Valentin; Cojuhari, Lilia; Jimbei, Pavlina; Albrecht, Jeffrey; Schmid, Peter; Le Gal, Frédéric; Gordien, Emmanuel; Krawczyk, Adalbert; Mijočević, Hrvoje; Karimzadeh, Hadi; Roggendorf, Michael; Vaillant, Andrew
    Safety and efficacy of REP 2139 and pegylated interferon alfa-2a for treatment-naive patients with chronic hepatitis B virus and hepatitis D virus co-infection (REP 301 and REP 301-LTF) : a non-randomised, open-label, phase 2 trial
    In: The Lancet Gastroenterology & Hepatology Jg. 2 (2017) Nr. 12, S. 877 - 889
    Online Volltext: dx.doi.org/
  • Smesnoi, V.; Vaillant, A.; Pantea, V.; Cebotarescu, V.; Iarovoi, L.; Placinta, G.; Moscalu, I.; Krawczyk, Adalbert; Jimbei, P.; Bazinet, M.; Musteata, T.; Jucov, A.; Cojuhari, L.
    Update on safety and efficacy in the REP 401 protocol : REP 2139-Mg or REP 2165-Mg used in combination with tenofovir disoproxil fumarate and pegylated Interferon alpha-2a in treatment naïve caucasian patients with chronic HBeAg negative HBV infection
    In: Journal of Hepatology Jg. 66 (2017) Nr. 1, S. S256 - S257
    Online Volltext: dx.doi.org/

    • 2016

    Artikel in Zeitschriften

  • Le-Trilling, Vu Thuy Khanh; Megger, Dominik A.; Katschinski, Benjamin; Landsberg, Christine D.; Rückborn, Meike U.; Tao, Sha; Krawczyk, Adalbert; Bayer, Wibke; Drexler, Ingo; Tenbusch, Matthias; Sitek, Barbara; Trilling, Mirko
    Broad and potent antiviral activity of the NAE inhibitor MLN4924
    In: Scientific Reports Jg. 6 (2016) 19977
    Online Volltext: dx.doi.org/ (Open Access)

    • Abstracts

  • Bazinet, M.; Pantea, V.; Cebotarescu, V.; Cojuhari, L.; Jimbei, P.; Albrecht, J.; Schmid, P.; Krawczyk, Adalbert; Karimzadeh, H.; Roggendorf, Michael; Vaillant, A.
    Update on the safety and efficacy of REP 2139 monotherapy and subsequent combination therapy with pegylated interferon Alpha-2A in caucasian patients with chronic HBV/HDV co-infection
    In: Journal of Hepatology Jg. 64 (2016) Nr. 2, Suppl., S. S584 - S585
    Online Volltext: dx.doi.org/

    • 2015

    Artikel in Zeitschriften

  • Goergens, Andre; Ludwig, Anna-Krist; Moellmann, Michael; Krawczyk, Adalbert; Dürig, Jan; Hanenberg, Helmut; Horn, Peter A.; Giebel, Bernd
    Multipotent Hematopoietic Progenitors Divide Asymmetrically to Create Progenitors of the Lymphomyeloid and Erythromyeloid Lineages
    In: Stem Cell Reports Jg. 5 (2015) Nr. 1, S. 154 - 155
    Online Volltext: dx.doi.org/ (Open Access)
  • Krawczyk, Adalbert; Dirks, Miriam; Kasper, Maren; Buch, Anna; Dittmer, Ulf; Giebel, Bernd; Wildschütz, Lena; Busch, Martin; Goergens, Andre; Schneweis, Karl E.; Eis-Hübinger, Anna M.; Sodeik, Beate; Heiligenhaus, Arnd; Roggendorf, Michael; Bauer, Dirk C.
    Prevention of herpes simplex virus induced stromal keratitis by a glycoprotein B-specific monoclonal antibody
    In: PLoS ONE Jg. 10 (2015) Nr. 1, S. e0116800
    Online Volltext: dx.doi.org/ (Open Access)

    • 2014

    Artikel in Zeitschriften

  • Krawczyk, Adalbert; Hintze, Christian; Ackermann, Jessica; Goitowski, Birgit; Trippler, Martin; Grüner, Nico; Neumann-Fraune, Maria; Verheyen, Jens; Fiedler, Melanie
    Clinical performance of the novel DiaSorin LIAISON® XL murex : HBsAg Quant, HCV-Ab, HIV-Ab/Ag assays
    In: Journal of Clinical Virology Jg. 59 (2014) Nr. 1, S. 44 - 49
    Online Volltext: dx.doi.org/
  • Krawczyk, Adalbert; Ludwig, Charlotte; Jochum, Christoph; Fiedler, Melanie; Heinemann, Falko M.; Shouval, Daniel; Roggendorf, Michael; Roggendorf, Hedwig; Lindemann, Monika
    Induction of a robust T- and B-cell immune response in non- and low-responders to conventional vaccination against hepatitis B by using a third generation PreS/S vaccine
    In: Vaccine Jg. 32 (2014) Nr. 39, S. 5077 - 5082
    Online Volltext: dx.doi.org/
  • Gorgens, A.; Ludwig, A. K.; Mollmann, M.; Krawczyk, Adalbert; Dürig, Jan; Hanenberg, H.; Horn, Peter; Giebel, Bernd
    Multipotent hematopoietic progenitors divide asymmetrically to create progenitors of the lymphomyeloid and erythromyeloid lineages
    In: Stem Cell Reports Jg. 3 (2014) Nr. 6, S. 1058 - 1072
    Online Volltext: dx.doi.org/ (Open Access)

    • 2013

    Artikel in Zeitschriften

  • Krawczyk, Adalbert; Arndt, Michaela A.E.; Grosse-Hovest, Ludger; Weichert, Wilko; Giebel, Bernd; Dittmer, Ulf; Hengel, Hartmut; Jäger, Dirk; Schneweis, Karl E.; Eis-Hübinger, Anna M.; Roggendorf, Michael; Krauss, Jürgen
    Overcoming drug-resistant herpes simplex virus (HSV) infection by a humanized antibody
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Jg. 110 (2013) Nr. 17, S. 6760 - 6765
    Online Volltext: dx.doi.org/
  • Krawczyk, Adalbert; Roggendorf, Hedwig; Ludwig, Charlotte; Herzer, Kerstin; Gerken, Guido; Horn, Peter; Roggendorf, Michael; Lindemann, Monika
    Therapeutic vaccination of a liver transplant recipient suffering from fulminant hepatitis B during pregnancy
    In: Liver Transplantation Jg. 19 (2013) Nr. 12, S. 1411 - 1412
    Online Volltext: dx.doi.org/

    • 2011

    Artikel in Zeitschriften

  • Krawczyk, Adalbert; Krauss, Jürgen; Eis-Hübinger, Anna M.; Däumer, Martin P.; Schwarzenbacher, Robert; Dittmer, Ulf; Schneweis, Karl E.; Jäger, Dirk; Roggendorf, Michael; Arndt, Michaela A. E.
    Impact of Valency of a Glycoprotein B-Specific Monoclonal Antibody on Neutralization of Herpes Simplex Virus
    In: Journal of Virology Jg. 85 (2011) Nr. 4, S. 1793 - 1803
    Online Volltext: dx.doi.org/

    • 2010

    Dissertation

  • Krawczyk, Adalbert;
    Humanisierung und funktionelle Charakterisierung eines gegen Herpes Simplex Viren Typ-1 und Typ-2 (HSV-1 und HSV-2) gerichteten murinen monoklonalen Antikörpers
    Duisburg, Essen (2010) 164 Bl.
    Online Volltext

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