AG Zelinskyy

Forschungsschwerpunkte

  • Zytotoxische Virus-spezifische T-Zellen
  • Regulation von Virus-spezifischen T-Zellen
  • Checkpoint-Rezeptoren 
  • Regulatorische T-Zellen
  • Immuntherapie gegen retrovirale Infektionen und Virus-induzierte Tumoren

Aktivierte zytotoxische T-Zellen sind für die erfolgreiche Eliminierung Virus-infizierter Zellen und Tumoren erforderlich. Andererseits können zytotoxische Zellen gefährlich sein und immunvermittelte Pathologien verursachen. Verschiedene Regulationsmechanismen steuern gleichzeitig die Expansion und Aktivierung dieser Effektorzellen, um Virus-infizierte Zellen oder Tumorzellen zu eliminieren und dabei den Schaden in dem infizierten Organ zu minimieren.

Checkpoint-Rezeptoren, regulatorische T-Zellen (Treg) und MDSC (myeloid-derived suppressor cells) beeinflussen gleichzeitig die Expansion und die Funktionalität von zytotoxischen T-Zellen. Eine Entschlüsselung der Effekte einzelner regulatorischer Mechanismen ist nur in einem Tiermodell möglich. Daten von mit dem „Friend Murine Leukemia Virus“ (FV) infizierten Mäusen erlauben einen tiefen Einblick in verschiedene regulatorische Mechanismen bei akuten und chronischen antiviralen Antworten. Diese Kenntnisse liefern die Grundlagen für eine erfolgreiche antivirale Immuntherapie ähnlich den sehr erfolgreichen Behandlungen von Melanomen, Lungenkrebs und anderen malignen Erkrankungen mit auf Checkpoint-Rezeptoren gerichteten Therapien.

Arbeitsgruppe

Leiter

​​​Dr. rer. nat. Gennadiy Zelinskyy
Tel.: +49 (0)201 723 3541
E-Mail: gennadiy.zelinskyy@uni-due.de

Tanja Werner, BTA
Tel.: +49 (0)201 723 3583
E-Mail: tanja.werner@uni-due.de

Publikationen

    2023

    Artikel in Zeitschriften

  • Stupia, Simone; Heeke, Christina; Brüggemann, Alicia; Zaremba-Montenari, Anne; Thier, Beatrice; Kretz, Julia; Sucker, Antje; Philip, Manuel; Zelinskyy, Gennadiy; Ferrone, Soldano; Rösch, Alexander; Horn, Susanne; Hadaschik, Eva; Schadendorf, Dirk; Trilling, Mirko; Dittmer, Ulf; Griewank, Klaus; Zhao, Fang; Paschen, Annette
    HLA class II loss and JAK1/2 deficiency coevolve in melanoma leading to CD4 T cell and IFNγ cross-resistance
    In: Clinical Cancer Research Jg. 29 (2023) Nr. 15, S. 2894 - 2907
    Online Volltext: dx.doi.org/
  • Westmeier, Jaana; Brochtrup, Annika; Paniskaki, Krystallenia; Karakoese, Zehra; Werner, Tanja; Sutter, Kathrin; Dolff, Sebastian; Limmer, Andreas; Mittermüller, Daniela; Liu, Jia; Zheng, Xin; Koval, Tetiana; Kaidashev, Igor; Berger, Marc Moritz; Herbstreit, Frank; Brenner, Thorsten; Witzke, Oliver; Trilling, Mirko; Lu, Mengji; Yang, Dongliang; Babel, Nina; Westhoff, Timm; Dittmer, Ulf; Zelinskyy, Gennadiy
    Macrophage migration inhibitory factor receptor CD74 expression is associated with expansion and differentiation of effector T cells in COVID-19 patients
    In: Frontiers in Immunology Jg. 14 (2023) 1236374
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Limmer, Andreas; Engler, Andrea; Kattner, Simone; Gregorius, Jonas; Pattberg, Kevin Thomas; Schulz, Rebecca; Schwab, Jansje; Roth, Johannes; Vogl, Thomas; Krawczyk, Adalbert; Witzke, Oliver; Zelinskyy, Gennadiy; Dittmer, Ulf; Brenner, Thorsten; Berger, Marc
    Patients with SARS-CoV-2-Induced Viral Sepsis Simultaneously Show Immune Activation, Impaired Immune Function and a Procoagulatory Disease State
    In: Vaccines Jg. 11 (2023) Nr. 2, 435
    Online Volltext: dx.doi.org/ (Open Access)
  • Izmailova, Olga; Shlykova, Oksana; Kabaliei, Alina; Vatsenko, Anastasia; Ivashchenko, Dmytro; Dudchenko, Maksym; Volianskyi, Andrii; Zelinskyy, Gennadiy; Koval, Tetiana; Dittmer, Ulf; Kaidashev, Igor
    Polymorphism of tmprss2 (rs12329760) and severity of COVID-19 in the Ukrainian population : Response
    In: Acta Biomedica Jg. 94 (2023) Nr. 2, e2023109
    Online Volltext: dx.doi.org/
  • Izmailova, Olga; Shlykova, Oksana; Kabaliei, Alina; Vatsenko, Anastasia; Ivashchenko, Dmytro; Dudchenko, Maksym; Volianskyi, Andrii; Zelinskyy, Gennadiy; Koval, Tetiana; Dittmer, Ulf; Kaidashev, Igor
    Polymorphism of tmprss2 (rs12329760) but not ace2 (rs4240157), tmprss11a (rs353163) and cd147 (rs8259) is associated with the severity of COVID-19 in the Ukrainian population
    In: Acta Biomedica Jg. 94 (2023) Nr. 1, e2023030
    Online Volltext: dx.doi.org/ (Open Access)
  • Mittermüller, Daniela; Otto, Lucas; Long, Zoë; Kraus, Andreas; Beer, Alexander; Hasenberg, Anja; Zelinskyy, Gennadiy; Westmeier, Jaana; Hasenkrug, Kim J.; Dittmer, Ulf; Gunzer, Matthias
    Regulatory T cells suppress the motility of cytotoxic T cells in Friend retrovirus-infected mice
    In: JCI Insight Jg. 8 (2023) Nr. 13, e167482
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Li, Ziwei; Xiang, Tiandan; Liang, Boyun; Liu, Jing; Deng, Hui; Yang, Xuecheng; Wang, Hua; Feng, Xuemei; Zelinskyy, Gennadiy; Trilling, Mirko; Sutter, Kathrin; Lu, Mengji; Dittmer, Ulf; Wang, Baoju; Yang, Dongliang; Zheng, Xin; Liu, Jia
    SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infection
    In: Virologica Sinica Jg. 38 (2023) Nr. 4, S. 606 - 619
    Online Volltext: dx.doi.org/ (Open Access)

    • 2022

    Artikel in Zeitschriften

  • David, Paul; Westmeier, Jaana; Drabczyk-Pluta, Malgorzata; Werner, Tanja; Ickler, Julia; Francois, Sandra; Bayer, Wibke; Sutter, Kathrin; Del Rio, Maria Luisa; Rodriguez-Barbosa, Jose-Ignacio; Dittmer, Ulf; Zelinskyy, Gennadiy
    The Role of the Inhibitory Ligand HVEM and Its Receptors CD160 and BTLA in the Regulation of Anti-retroviral T Cell Responses
    In: Frontiers in Virology Jg. 2 (2022) 836291
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)

    • 2021

    Artikel in Zeitschriften

  • Knuschke, Torben; Kollenda, Sebastian; Wenzek, Christina; Zelinskyy, Gennadiy; Steinbach, Philine; Dittmer, Ulf; Buer, Jan; Epple, Matthias; Westendorf, Astrid
    A combination of anti-pd-l1 treatment and therapeutic vaccination facilitates improved retroviral clearance via reactivation of highly exhausted t cells
    In: mBio Jg. 12 (2021) Nr. 1, S. e02121 - 20
    Online Volltext: dx.doi.org/ (Open Access)
  • Liu, Jia; Yang, Xuecheng; Wang, Hua; Li, Ziwei; Deng, Hui; Liu, Jing; Xiong, Shue; He, Junyi; Feng, Xuemei; Guo, Chunxia; Wang, Weixian; Zelinskyy, Gennadiy; Trilling, Mirko; Sutter, Kathrin; Senff, Tina; Menne, Christopher; Timm, Jörg; Zhang, Yanfang; Deng, Fei; Lu, Yinping; Wu, Jun; Lu, Mengji; Yang, Dongliang; Dittmer, Ulf; Wang, Baoju; Zheng, Xin
    Analysis of the long-term impact on cellular immunity in COVID-19-recovered individuals reveals a profound nkt cell impairment
    In: mBio Jg. 12 (2021) Nr. 2, S. e00085 - 21
    Online Volltext: dx.doi.org/ (Open Access)
  • Li, Ziwei; Xiang, Tiandan; Liang, Boyun; Deng, Hui; Wang, Hua; Feng, Xuemei; Quan, Xufeng; Wang, Xiaoyan; Li, Sumeng; Lu, Sihong; Yang, Xuecheng; Wang, Baoju; Zelinskyy, Gennadiy; Trilling, Mirko; Sutter, Kathrin; Lu, Mengji; Dittmer, Ulf; Yang, Dongliang; Zheng, Xin; Liu, Jia
    Characterization of SARS-CoV-2-Specific Humoral and Cellular Immune Responses Induced by Inactivated COVID-19 Vaccines in a Real-World Setting
    In: Frontiers in Immunology Jg. 12 (2021) 802858
    Online Volltext: dx.doi.org/ (Open Access)

    • 2020

    Artikel in Zeitschriften

  • David, Paul; Drabczyk-Pluta, Malgorzata; Pastille, Eva; Knuschke, Torben; Werner, Tanja; Honke, Nadine; Megger, Dominik A.; Akhmetzyanova, Ilseyar; Shaabani, Namir; Eyking-Singer, Annette; Cario, Elke; Kershaw, Olivia; Gruber, Achim D.; Tenbusch, Matthias; Dietze, Kirsten; Trilling, Mirko; Liu, Jia; Schadendorf, Dirk; Streeck, Hendrik; Lang, Karl S.; Xie, Youhua; Zimmer, Lisa; Sitek, Barbara; Paschen, Annette; Westendorf, Astrid; Dittmer, Ulf; Zelinskyy, Gennadiy
    Combination immunotherapy with anti-PD-L1 antibody and depletion of regulatory T cells during acute viral infections results in improved virus control but lethal immunopathology
    In: PLoS Pathogens Jg. 16 (2020) Nr. 3, e1008340
    Online Volltext: dx.doi.org/ (Open Access)
  • Rodriguez-Barbosa, Jose-Ignacio; Azuma, Miyuki; Zelinskyy, Gennadiy; Perez-Simon, Jose-Antonio; del Rio, Maria-Luisa
    Critical role of PD-L1 expression on non-tumor cells rather than on tumor cells for effective anti-PD-L1 immunotherapy in a transplantable mouse hematopoietic tumor model
    In: Cancer Immunology, Immunotherapy (2020)
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Cassetta, Luca; Bruderek, Kirsten; Skrzeczynska-Moncznik, Joanna; Osiecka, Oktawia; Hu, Xiaoying; Rundgren, Ida Marie; Lin, Ang; Santegoets, Kim; Horzum, Utku; Godinho-Santos, Ana; Zelinskyy, Gennadiy; Garcia-Tellez, Thalia; Bjelica, Sunčica; Taciak, Bartłomiej; Kittang, Astrid Olsnes; Höing, Benedikt; Lang, Stephan; Dixon, Michael; Müller, Verena; Utikal, Jochen Sven; Karakoç, Derya; Yilmaz, Kerim Bora; Górka, Emilia; Bodnar, Lubomir; Anastasiou, Olympia Evdoxia; Bourgeois, Christine; Badura, Robert; Kapinska-Mrowiecka, Monika; Gotic, Mirjana; Ter Laan, Mark; Kers-Rebel, Esther; Król, Magdalena; Santibañez, Juan Francisco; Müller-Trutwin, Michaela; Dittmer, Ulf; De Sousa, Ana Espada; Esendaǧli, Güneş; Adema, Gosse; Loré, Karin; Ersvær, Elisabeth; Umansky, Viktor; Pollard, Jeffrey W.; Cichy, Joanna; Brandau, Sven
    Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation
    In: Journal for ImmunoTherapy of Cancer Jg. 8 (2020) Nr. 2, S. e001223
    Online Volltext: dx.doi.org/ (Open Access)
  • Westmeier, Jaana; Paniskaki, Krystallenia; Karaköse, Zehra; Werner, Tanja; Sutter, Kathrin; Dolff, Sebastian; Overbeck, Marvin; Limmer, Andreas; Liu, Jia; Zheng, Xin; Brenner, Thorsten; Berger, Marc; Witzke, Oliver; Trilling, Mirko; Lu, Mengji; Yang, Dongliang; Babel, Nina; Westhoff, Timm; Dittmer, Ulf; Zelinskyy, Gennadiy
    Erratum for Westmeier et al., "Impaired Cytotoxic CD8⁺ T Cell Response in Elderly COVID-19 Patients"
    In: mBio Jg. 11 (2020) Nr. 5, S. 02243 - 02220
    Online Volltext: dx.doi.org/ (Open Access)
  • Westmeier, Jaana; Paniskaki, Krystallenia; Karaköse, Zehra; Werner, Tanja; Sutter, Kathrin; Dolff, Sebastian; Overbeck, Marvin; Limmer, Andreas; Liu, Jia; Zheng, Xin; Brenner, Thorsten; Berger, Marc; Witzke, Oliver; Trilling, Mirko; Lu, Mengji; Yang, Dongliang; Babel, Nina; Westhoff, Timm; Dittmer, Ulf; Zelinskyy, Gennadiy
    Impaired cytotoxic CD8⁺ T cell response in elderly COVID-19 patients
    In: mBio Jg. 11 (2020) Nr. 5, S. e02243 - 20
    Online Volltext: dx.doi.org/ (Open Access)
  • Gu, Chenjian; Ming, Lijun; Fang, Yili; Liu, Xuejing; Zhang, Junqi; Zelinskyy, Gennadiy; Deng, Qiang; Liu, Jing; Xie, Youhua
    Restriction of exogenous DNA expression by SAMHD1
    In: Science Bulletin Jg. 65 (2020) Nr. 7, S. 573 - 586
    Online Volltext: dx.doi.org/ Online Volltext

    • 2019

    Artikel in Zeitschriften

  • Dittmer, Ulf; Sutter, Kathrin; Kassiotis, George; Zelinskyy, Gennadiy; Bánki, Zoltán; Stoiber, Heribert; Santiago, Mario L.; Hasenkrug, Kim J.
    Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity
    In: FEMS Microbiology Reviews Jg. 43 (2019) Nr. 5, S. 435 - 456
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Dorhoi, Anca; Glaría, Estibaliz; Garcia-Tellez, Thalia; Nieuwenhuizen, Natalie E.; Zelinskyy, Gennadiy; Favier, Benoit; Singh, Anurag; Ehrchen, Jan; Gujer, Cornelia; Münz, Christian; Saraiva, Margarida; Sohrabi, Yahya; Sousa, Ana E.; Delputte, Peter; Müller-Trutwin, Michaela; Valledor, Annabel F.
    MDSCs in infectious diseases: regulation, roles, and readjustment
    In: Cancer Immunology, Immunotherapy Jg. 68 (2019) Nr. 4, S. 673 - 685
    Online Volltext: dx.doi.org/ (Open Access)
  • David, Paul; Megger, Dominik A.; Kaiser, Tamara; Werner, Tanja; Liu, Jia; Chen, Lieping; Sitek, Barbara; Dittmer, Ulf; Zelinskyy, Gennadiy
    The PD-1/PD-L1 Pathway Affects the Expansion and Function of Cytotoxic CD8⁺ T Cells During an Acute Retroviral Infection
    In: Frontiers in Immunology Jg. 10 (2019) 54
    Online Volltext: dx.doi.org/ (Open Access)

    • 2018

    Artikel in Zeitschriften

  • Khairnar, Vishal; Duhan, Vikas; Patil, Ashwini M.; Zhou, Fan; Bhat, Hilal; Thoens, Christine; Sharma, Piyush; Adomati, Tom; Friendrich, Sarah-Kim; Bezgovsek, Judith; Dreesen, Janine D.; Wennemuth, Gunther; Westendorf, Astrid; Zelinskyy, Gennadiy; Dittmer, Ulf; Hardt, Cornelia; Timm, Jörg; Göthert, Joachim Rudolf; Lang, Philipp A.; Singer, Bernhard B.; Lang, Karl S.
    CEACAM1 promotes CD8⁺ T cell responses and improves control of a chronic viral infection
    In: Nature Communications Jg. 9 (2018) 2561
    Online Volltext: dx.doi.org/ (Open Access)
  • Otto, Lucas; Zelinskyy, Gennadiy; Schuster, Marc; Dittmer, Ulf; Gunzer, Matthias
    Imaging of cytotoxic antiviral immunity while considering the 3R principle of animal research
    In: Journal of Molecular Medicine Jg. 96 (2018) Nr. 3-4, S. 349 - 360
    Online Volltext: dx.doi.org/

    • 2017

    Artikel in Zeitschriften

  • Klein, Johanna C.; Moses, Katrin; Zelinskyy, Gennadiy; Sody, Simon; Buer, Jan; Lang, Stephan; Helfrich, Iris; Dittmer, Ulf; Kirschning, Carsten Jürgen; Brandau, Sven
    Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth
    In: Nature Communications Jg. 8 (2017) S. 14600
    Online Volltext: dx.doi.org/ (Open Access)
  • Teigler, Jeffrey E.; Zelinskyy, Gennadiy; Eller, Michael A.; Bolton, Diane L.; Marovich, Mary; Gordon, Alexander D.; Alrubayyi, Aljawharah; Alter, Galit; Robb, Merlin L.; Martin, Jeffrey N.; Deeks, Steven G.; Michael, Nelson L.; Dittmer, Ulf; Streeck, Hendrik
    Differential inhibitory receptor expression on T cells delineates functional capacities in chronic viral infection
    In: Journal of Virology Jg. 91 (2017) Nr. 23, S. e01263 - 17
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Malyshkina, Anna; Littwitz-Salomon, Elisabeth; Sutter, Kathrin; Zelinskyy, Gennadiy; Windmann, Sonja; Schimmer, Simone; Paschen, Annette; Streeck, Hendrik; Hasenkrug, Kim J; Dittmer, Ulf
    Fas Ligand-mediated cytotoxicity of CD4+ T cells during chronic retrovirus infection
    In: Scientific Reports Jg. 7 (2017) S. 7785
    Online Volltext: dx.doi.org/ (Open Access)
  • Drabczyk-Pluta, Malgorzata; Werner, Tanja; Hoffmann, Daniel; Leng, Qibin; Chen, Lieping; Dittmer, Ulf; Zelinskyy, Gennadiy
    Granulocytic myeloid-derived suppressor cells suppress virus-specific CD8+ T cell responses during acute Friend retrovirus infection
    In: Retrovirology Jg. 14 (2017) 42
    Online Volltext: dx.doi.org/ (Open Access)
  • Ma, Zhiyong; Liu, Jia; Wu, Weimin; Zhang, Ejuan; Zhang, Xiaoyong; Li, Qian; Zelinskyy, Gennadiy; Buer, Jan; Dittmer, Ulf; Kirschning, Carsten Jürgen; Lu, Mengji
    The IL-1R/TLR signaling pathway is essential for efficient CD8+ T-cell responses against hepatitis B virus in the hydrodynamic injection mouse model
    In: Cellular & Molecular Immunology Jg. 14 (2017) Nr. 12, S. 997 - 1008
    Online Volltext: dx.doi.org/ (Open Access)

    • 2016

    Artikel in Zeitschriften

  • Akhmetzyanova, Ilseyar; Dittmer, Ulf; Brandau, Sven; Streeck, Hendrik; Dietze, Kirsten; Malyshkina, Anna; Littwitz-Salomon, Elisabeth; Zelinskyy, Gennadiy
    CD137 agonist therapy can reprogram regulatory T cells into cytotoxic CD4+ T cells with antitumor activity
    In: The Journal of Immunology (JI) Jg. 196 (2016) Nr. 1, S. 484 - 492
    Online Volltext: dx.doi.org/ (Open Access)
  • Shaabani, Namir; Duhan, Vikas; Khairnar, Vishal; Gassa, Asmae; Ferrer-Tur, Rita; Häussinger, Dieter; Recher, Mike; Zelinskyy, Gennadiy; Liu, Jia; Dittmer, Ulf; Trilling, Mirko; Scheu, Stefanie; Hardt, Cornelia; Lang, Philipp A; Honke, Nadine; Lang, Karl S.
    CD169+ macrophages regulate PD-L1 expression via type I interferon and thereby prevent severe immunopathology after LCMV infection
    In: Cell Death and Disease Jg. 7 (2016) Nr. 11, e2446
    Online Volltext: dx.doi.org/ (Open Access)

    • 2015

    Artikel in Zeitschriften

  • Akhmetzyanova, Ilseyar; Drabczyk, Malgorzata; Neff, C Preston; Gibbert, Kathrin; Dietze, Kirsten; Werner, Tanja; Liu, Jia; Chen, Lieping; Lang, Karl S.; Palmer, Brent E; Dittmer, Ulf; Zelinskyy, Gennadiy
    Correction: PD-L1 Expression on Retrovirus-Infected Cells Mediates Immune Escape from CD8+ T Cell Killing
    In: PLoS Pathogens Jg. 11 (2015) Nr. 12, e1005364
    Online Volltext: dx.doi.org/ (Open Access)
  • Akhmetzyanova, Ilseyar; Drabczyk, Malgorzata; Neff, C Preston; Gibbert, Kathrin; Dietze, Kirsten; Werner, Tanja; Liu, Jia; Chen, Lieping; Lang, Karl S.; Palmer, Brent E; Dittmer, Ulf; Zelinskyy, Gennadiy
    PD-L1 Expression on Retrovirus-Infected Cells Mediates Immune Escape from CD8+ T Cell Killing
    In: PLoS Pathogens Jg. 11 (2015) Nr. 10, e1005224
    Online Volltext: dx.doi.org/ (Open Access)

    • 2014

    Artikel in Zeitschriften

  • Joedicke, Jara J.; Zelinskyy, Gennadiy; Dittmer, Ulf; Hasenkrug, Kim J.
    CD8+ T Cells Are Essential for Controlling Acute Friend Retrovirus Infection in C57BL/6 Mice
    In: Journal of Virology Jg. 88 (2014) Nr. 9, S. 5200 - 5201
    Online Volltext: dx.doi.org/
  • Joedicke, Jara J.; Dietze, Kirsten; Zelinskyy, Gennadiy; Dittmer, Ulf
    The phenotype and activation status of regulatory T cells during Friend retrovirus infection
    In: Virologica Sinica Jg. 29 (2014) Nr. 1, S. 48 - 60
    Online Volltext: dx.doi.org/

    • 2013

    Artikel in Zeitschriften

  • Manzke, Nora; Akhmetzyanova, Ilseyar; Hasenkrug, Kim J.; Trilling, Mirko; Zelinskyy, Gennadiy; Dittmer, Ulf
    CD4⁺ T cells develop antiretroviral cytotoxic activity in the absence of regulatory T cells and CD8⁺ T cells
    In: Journal of Virology Jg. 87 (2013) Nr. 11, S. 6306 - 6313
    Online Volltext: dx.doi.org/ Online Volltext
  • Dietze, Kirsten Katrin; Zelinskyy, Gennadiy; Liu, Jia; Kretschmer, Freya; Schimmer, Simone; Dittmer, Ulf
    Combining Regulatory T Cell Depletion and Inhibitory Receptor Blockade Improves Reactivation of Exhausted Virus-Specific CD8+ T Cells and Efficiently Reduces Chronic Retroviral Loads
    In: PLoS Pathogens Jg. 9 (2013) Nr. 12, S. e1003798
    Online Volltext: dx.doi.org/ (Open Access)
  • Zelinskyy, Gennadiy; Werner, Tanja; Dittmer, Ulf
    Natural regulatory T cells inhibit production of cytotoxic molecules in CD8+ T cells during low-level Friend retrovirus infection
    In: Retrovirology Jg. 10 (2013) Nr. 1, 109
    Online Volltext: dx.doi.org/ (Open Access)
  • Liu, Jia; Jiang, Min; Ma, Zhiyong; Dietze, Kirsten; Zelinskyy, Gennadiy; Yang, Dongliang; Dittmer, Ulf; Schlaak, Jörg Friedrich; Roggendorf, Michael; Lu, Mengji
    TLR1/2 ligand-stimulated mouse liver endothelial cells secrete IL-12 and trigger CD8+ T cell immunity in vitro
    In: The Journal of Immunology (JI) Jg. 191 (2013) Nr. 12, S. 6178 - 6190
    Online Volltext: dx.doi.org/
  • Akhmetzyanova, Ilseyar; Zelinskyy, Gennadiy; Schimmer, Simone; Brandau, Sven; Altenhoff, Petra; Sparwasser, Tim; Dittmer, Ulf
    Tumor-specific CD4+ T cells develop cytotoxic activity and eliminate virus-induced tumor cells in the absence of regulatory T cells
    In: Cancer Immunology, Immunotherapy Jg. 62 (2013) Nr. 2, S. 257 - 271
    Online Volltext: dx.doi.org/

    • 2011

    Artikel in Zeitschriften

  • Dietze, Kirsten; Zelinskyy, Gennadiy; Gibbert, Kathrin; Schimmer, Simone; Francois, Sandra; Myers, Lara; Sparwasser, Tim; Hasenkrug, Kim J.; Dittmer, Ulf
    Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8⁺ T cells and reduces chronic retroviral set points
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Jg. 108 (2011) Nr. 6, S. 2420 - 2425
    Online Volltext: dx.doi.org/ (Open Access)
  • Zelinskyy, Gennadiy; Myers, Lara; Dietze, Kirsten; Gibbert, Kathrin; Roggendorf, Michael; Liu, Jia; Lu, Mengji; Kraft, Anke R.; Teichgräber, Volker; Hasenkrug, Kim J.; Dittmer, Ulf
    Virus-Specific CD8+ T Cells Upregulate Programmed Death-1 Expression during Acute Friend Retrovirus Infection but Are Highly Cytotoxic and Control Virus Replication
    In: The Journal of Immunology (JI) Jg. 187 (2011) Nr. 7, S. 3730 - 3737
    Online Volltext: dx.doi.org/

    • 2010

    Artikel in Zeitschriften

  • Nair, Savita R.; Zelinskyy, Gennadiy; Shimmer, Simone; Gerlach, Nicole; Kassiotis, George; Dittmer, Ulf; Schimmer, S.
    Mechanisms of control of acute Friend virus infection by CD4⁺ T helper cells and their functional impairment by regulatory T cells
    In: Journal of General Virology Jg. 91 (2010) Nr. 2, S. 440 - 451
    Online Volltext: dx.doi.org/
  • Gibbert, Kathrin; Dietze, Kirsten; Zelinskyy, Gennadiy; Lang, Karl S.; Barchet, Winfried; Kirschning, Carsten Jürgen; Dittmer, Ulf
    Polyinosinic-polycytidylic acid treatment of Friend retrovirus-infected mice improves functional properties of virus-specific T cells and prevents virus-induced disease
    In: The Journal of Immunology (JI) Jg. 185 (2010) Nr. 10, S. 6179 - 6189
    Online Volltext: dx.doi.org/ (Open Access)

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