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ZMB Member Astrid Westendorf

ZMB Member
Astrid Westendorf

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portrait picture Astrid Westendorf
© UDE/ Vladimir Unkovic

Prof. Dr. Astrid Westendorf

Group

Infection Immunology

Institute of Medical Microbiology
University Hospital Essen
Hufelandstr. 55
45147 Essen

Research Overview

  • Role of interleukin-33 during intestinal Citrobacter rodentium infection
  • Modulation of the mucosal immune system for the treatment of chronic inflammatory bowel diseases
  • Importance of immune cells in the induction and rejection of colitis-mediated
    • colon cancer
  • Influence of helminth infection on the course of colitis-related colon cancer
  • Role of sphingolipids in inflammatory bowel disease
  • Development of new nanoparticle-based strategies for modulating the immune system
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Selected Publications

    Journal articles

  • Sokolova, V.; Loza, Kateryna; Ebel, J.F.; Buer, Jan; Westendorf, Astrid; Epple, Matthias.
    Barium sulphate microparticles are taken up by three different cell types: HeLa, THP-1, and hMSC
    In: Acta Biomaterialia Vol. 164 (2023) pp. 577 - 587
    Online Full Text: dx.doi.org/
  • Adamczyk, Alexandra; Pastille, Eva; Kehrmann, Jan; Vu, Vivian P.; Geffers, Robert; Wasmer, Marie-Hélène; Kasper, Stefan; Schuler, Martin; Lange, Christian; Muggli, Beat; Rau, Tilman T.; Klein, Diana; Hansen, Wiebke; Krebs, Philippe; Buer, Jan; Westendorf, et al.
    GPR15 facilitates recruitment of regulatory T cells to promote colorectal cancer
    In: Cancer Research Vol. 81 (2021) Nr. 11, pp. 2970 - 2982
    Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ (Open Access)
  • Kehrmann, Jan; Effenberg, Laura; Wilk, Camilla; Schoemer, Davina; Ngo Thi Phuong, Nhi; Adamczyk, Alexandra; Pastille, Eva; Scholtysik, René; Klein-Hitpaß, Ludger; Klopfleisch, Robert; Westendorf, Astrid; Buer, Jan.
    Depletion of Foxp3⁺ regulatory T cells is accompanied by an increase in the relative abundance of Firmicutes in the murine gut microbiome
    In: Immunology Vol. 159 (2020) Nr. 3, pp. 344 - 353
    Online Full Text: dx.doi.org/ (Open Access)
  • Kollenda, Sebastian; Klose, Jasmin; Knuschke, Torben; Sokolova, Viktoriya; Schmitz, Jochen; Staniszewska, Magdalena; Costa, Pedro Fragoso; Herrmann, Ken; Westendorf, Astrid; Fendler, Wolfgang; Epple, Matthias.
    In vivo biodistribution of calcium phosphate nanoparticles after intravascular, intramuscular, intratumoral, and soft tissue administration in mice investigated by small animal PET/CT
    In: Acta Biomaterialia Vol. 109 (2020) pp. 244 - 253
    Online Full Text: dx.doi.org/
  • Grüneboom, Anika; Hawwari, Ibrahim; Weidner, Daniela; Culemann, Stephan; Müller, Sylvia; Henneberg, Sophie; Brenzel, Alexandra; Merz, Simon; Bornemann, Lea; Zec, Kristina; Wülling, Manuela; Kling, Lasse; Hasenberg, Mike; Voortmann, Sylvia; Lang, Stefanie; et al.
    A network of trans-cortical capillaries as mainstay for blood circulation in long bones
    In: Nature Metabolism Vol. 1 (2019) Nr. 2, pp. 236 - 250
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Sokolova, Viktoriya; Loza, Kateryna; Knuschke, Torben; Heinen-Weiler, J.; Jastrow, Holger; Hasenberg, Mike; Buer, Jan; Westendorf, Astrid; Gunzer, Matthias; Epple, Matthias.
    A systematic electron microscopic study on the uptake of barium sulphate nano-, submicro-, microparticles by bone marrow-derived phagocytosing cells
    In: Acta Biomaterialia Vol. 80 (2018) pp. 352 - 363
    Online Full Text: dx.doi.org/
  • Khairnar, Vishal; Duhan, Vikas; Patil, Ashwini M.; Zhou, Fan; Bhat, Hilal; Thoens, Christine; Sharma, Piyush; Adomati, Tom; Friendrich, Sarah-Kim; Bezgovsek, Judith; Dreesen, Janine D.; Wennemuth, Gunther; Westendorf, Astrid; Zelinskyy, Gennadiy; Dittmer, et al.
    CEACAM1 promotes CD8⁺ T cell responses and improves control of a chronic viral infection
    In: Nature Communications Vol. 9 (2018) 2561
    Online Full Text: dx.doi.org/ (Open Access)
  • Sucker, Antje; Zhao, Fang; Pieper, Natalia; Heeke, Christina; Maltaner, Raffaela; Stadtler, Nadine; Real, Birgit; Bielefeld, Nicola; Howe, Sebastian; Weide, Benjamin; Gutzmer, Ralf; Utikal, Jochen; Loquai, Carmen; Gogas, Helen; Klein-Hitpaß, Ludger; Zeschn et al.
    Acquired IFNγ 3 resistance impairs anti-Tumor immunity and gives rise to T-cell-resistant melanoma lesions
    In: Nature Communications Vol. 8 (2017) 15440
    Online Full Text: dx.doi.org/ (Open Access)
  • van der Meer, Selina; Knuschke, Torben; Frede, Annika; Schulze, Nina; Westendorf, Astrid; Epple, Matthias.
    Avidin-conjugated calcium phosphate nanoparticles as a modular targeting system for the attachment of biotinylated molecules in vitro and in vivo
    In: Acta Biomaterialia Vol. 57 (2017) pp. 414 - 425
    Online Full Text: dx.doi.org/
  • Sokolova, Viktoriya; Shi, Zou; Huang, Shunmei; Du, Yanqin; Kopp, Mathis; Frede, Annika; Knuschke, Torben; Buer, Jan; Yang, Dongliang; Wu, Jun; Westendorf, Astrid; Epple, Matthias.
    Delivery of the TLR ligand poly(I:C) to liver cells in vitro and in vivo by calcium phosphate nanoparticles leads to a pronounced immunostimulation
    In: Acta Biomaterialia Vol. 64 (2017) pp. 401 - 410
    Online Full Text: dx.doi.org/
  • Wirsdörfer, Florian; de Leve, Simone; Cappuccini, Federica; Eldh, Therese; Meyer, Alina V; Gau, Eva; Thompson, Linda F; Chen, Ning-Yuan; Karmouty-Quintana, Harry; Fischer, Ute; Kasper, Michael; Klein, Diana; Ritchey, Jerry W; Blackburn, Michael R; Westendo et al.
    Extracellular Adenosine Production by ecto-5'-Nucleotidase (CD73) Enhances Radiation-Induced Lung Fibrosis
    In: Cancer Research Vol. 76 (2016) Nr. 10, pp. 3045 - 3056
    Online Full Text: dx.doi.org/ (Open Access)
  • Abel, Simone; Hansen, Wiebke; Buer, Jan; Westendorf, Astrid; Kehrmann, Jan; Matuschewski, Kai; Hose, Matthias; Hutzler, Marina; Tatura, Roman; Ueffing, Kristina.
    Plasmodium yoelii infection of BALB/c mice results in expansion rather than induction of CD4+ Foxp3+ regulatory T cells
    In: Immunology Vol. 148 (2016) Nr. 2, pp. 197 - 205
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Khairnar, Vishal; Duhan, Vikas; Kumar Maney, Sathish; Seifert, Marc; Kirschning, Carsten; Westendorf, Astrid M.; Dittmer, Ulf; Küppers, Ralf; Scheffrahn, Inka; Göthert, Joachim R.; Singer, Bernhard B.; Lang, Karl S.; et al.
    CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production
    In: Nature Communications Vol. 6 (2015) 6217
    Online Full Text: dx.doi.org/ (Open Access)
  • Tatura, Roman; Zeschnigk, Michael; Hansen, Wiebke; Steinmann, Jörg; Goncalves Vidigal, Pedrina; Hutzler, Marina; Pastille, Eva; Westendorf, Astrid; Buer, Jan; Kehrmann, Jan.
    Relevance of Foxp3+ regulatory T cells for early and late phases of murine sepsis
    In: Immunology Vol. 146 (2015) Nr. 1, pp. 144 - 156
    Online Full Text: dx.doi.org/ (Open Access)
  • Pastille, Eva; Bardini, Katrin; Fleissner, Diana; Adamczyk, Alexandra; Frede, Annika; Wadwa, Munisch; Smolinski, Dorthe von; Kasper, Stefan; Sparwasser, Tim; Gruber, Achim D.; Schuler, Martin; Sakaguchi, Shimon; Roers, Axel; Müller, Werner; Hansen, Wiebke; et al.
    Transient ablation of regulatory T cells improves antitumor immunity in colitis-associated colon cancer
    In: Cancer Research Vol. 74 (2014) Nr. 16, pp. 4258 - 4269
    Online Full Text: dx.doi.org/
  • Sokolova, Viktoriya; Kozlova, Diana; Knuschke, Torben; Buer, Jan; Westendorf, Astrid; Epple, Matthias.
    Mechanism of the uptake of cationic and anionic calcium phosphate nanoparticles by cells
    In: Acta Biomaterialia Vol. 9 (2013) Nr. 7, pp. 7527 - 7535
    Online Full Text: dx.doi.org/
  • Fleissner, Diana; Frede, Annika; Knott, Markus; Knuschke, Torben; Geffers, Robert; Hansen, Wiebke; Dobos, Gustav; Langhorst, Jost; Buer, Jan; Westendorf, Astrid.
    Generation and function of immunosuppressive human and murine CD8⁺ T cells by transforming growth factor-β and retinoic acid
    In: Immunology Vol. 134 (2011) Nr. 1, pp. 82 - 92
    Online Full Text: dx.doi.org/ (Open Access)
  • Sokolova, Viktoriya; Knuschke, Torben; Buer, Jan; Westendorf, Astrid; Epple, Matthias.
    Quantitative determination of the composition of multi-shell calcium phosphate-oligonucleotide nanoparticles and their application for the activation of dendritic cells
    In: Acta Biomaterialia Vol. 7 (2011) Nr. 11, pp. 4029 - 4036
    Online Full Text: dx.doi.org/
  • Veldhoen, M.; Hirota, K.; Stockinger, B.; Westendorf, Astrid; Buer, Jan; Renauld, J.C.; Dumoutier, L:.
    The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
    In: Nature Vol. 453 (2008) Nr. 7191, pp. 106 - 109
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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