ZMB Member Kathrin Sutter
ZMB Member
Kathrin Sutter
Next Member
PD Dr. Kathrin Sutter
TRR60 Junior Research Group
Interferon-alpha Subtypes in chronic viral infectionsInstitute of Virology
University Hospital Essen
Hufelandstr. 55
45147 Essen
- +49 201 723 83250
- Website
- Publications
- Publication Metrics
- ZMB Research Program
Immunology, Infectious Diseases and Transplantation
Research Overview
- Interferon-alpha subtypes
- Modulation of immune cells
- Immunotherapies
- Chronic viral infections (HIV, HBV)
- IFN-stimulated genes
- NK cells
Publications
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Divergent autoantibody and cytokine levels in COVID-19 sepsis patients influence survivalIn: Journal of Medical Virology Vol. 96 (2024) Nr. 10, e29935Online Full Text: dx.doi.org/ (Open Access)
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IFNα Subtypes in HIV Infection and ImmunityIn: Viruses Vol. 16 (2024) Nr. 3, 364Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Identification of nitrile-containing isoquinoline-related natural product derivatives as coronavirus entry inhibitors in silico and in vitroIn: Biomedicine & Pharmacotherapy Vol. 180 (2024) 117517Online Full Text: dx.doi.org/ (Open Access)
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Influenza virus infection enhances tumour-specific CD8+ T-cell immunity, facilitating tumour controlIn: PLoS Pathogens Vol. 20 (2024) Nr. 1, e1011982Online Full Text: dx.doi.org/ (Open Access)
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Receptor transfer between immune cells by autoantibody-enhanced, CD32-driven trogocytosis is hijacked by HIV-1 to infect resting CD4 T cellsIn: Cell Reports Medicine Vol. 5 (2024) Nr. 4, 101483Online Full Text: dx.doi.org/ (Open Access)
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Reduced vacuolar ATPase protects mice from Friend virus infection – an unintended but instructive effect in Hif-2afl miceIn: Journal of Cell Science Vol. 137 (2024) Nr. 12, jcs261893Online Full Text: dx.doi.org/
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The interferon-regulated host factor hnRNPA0 modulates HIV-1 production by interference with LTR activity, mRNA trafficking, and programmed ribosomal frameshiftingIn: Journal of Virology Vol. 98 (2024) Nr. 7, e0053424Online Full Text: dx.doi.org/
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A systematic comparison reveals dynamic differences in early adaptive immune responses of acute-resolving versus chronic HBV replicationIn: Journal of Medical Virology Vol. 95 (2023) Nr. 3, e28670Online Full Text: dx.doi.org/ (Open Access)
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Immunotherapy-induced cytotoxic T follicular helper cells reduce numbers of retrovirus-infected reservoir cells in B cell folliclesIn: PLoS Pathogens Vol. 19 (2023) Nr. 10, e1011725Online Full Text: dx.doi.org/ (Open Access)
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Macrophage migration inhibitory factor receptor CD74 expression is associated with expansion and differentiation of effector T cells in COVID-19 patientsIn: Frontiers in Immunology Vol. 14 (2023) 1236374Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infectionIn: Virologica Sinica Vol. 38 (2023) Nr. 4, pp. 606 - 619Online Full Text: dx.doi.org/ (Open Access)
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Targeted mutations in IFNα2 improve its antiviral activity against various virusesIn: mBio Vol. 14 (2023) Nr. 6, e02357-23Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Tg1.4HBV-s-rec mice, a crossbred hepatitis B virus-transgenic model, develop mild hepatitisIn: Scientific Reports Vol. 13 (2023) Nr. 1, 22829Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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A ribavirin-induced ORF2 single-nucleotide variant produces defective hepatitis E virus particles with immune decoy functionIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 119 (2022) Nr. 34, e2202653119Online Full Text: dx.doi.org/ (Open Access)
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CD47 restricts antiviral function of alveolar macrophages during influenza virus infectionIn: iScience Vol. 25 (2022) Nr. 12, 105540Online Full Text: dx.doi.org/
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Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infectionIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 119 (2022) Nr. 8, e2111600119Online Full Text: dx.doi.org/ (Open Access)
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Distinct Type I Interferon Subtypes Differentially Stimulate T Cell Responses in HIV-1-Infected IndividualsIn: Frontiers in Immunology Vol. 13 (2022) 936918Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Distinct effects of treatment with two different interferon-alpha subtypes on HIV-1-associated T-cell activation and dysfunction in humanized miceIn: AIDS Vol. 36 (2022) Nr. 3, pp. 325 - 336Online Full Text: dx.doi.org/
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IFNAR1 Deficiency Impairs Immunostimulatory Properties of Neutrophils in Tumor-Draining Lymph NodesIn: Frontiers in Immunology Vol. 13 (2022)Online Full Text: dx.doi.org/ (Open Access)
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IFNα subtype-specific susceptibility of HBV in the course of chronic infectionIn: Frontiers in Immunology Vol. 13 (2022) 1017753Online Full Text: dx.doi.org/ (Open Access)
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Immunotherapy With Interferon α11, But Not Interferon Beta, Controls Persistent Retroviral InfectionIn: Frontiers in Immunology Vol. 12 (2022) 809774Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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SRSF1 acts as an IFN-I-regulated cellular dependency factor decisively affecting HIV-1 post-integration stepsIn: Frontiers in Immunology Vol. 13 (2022) 935800Online Full Text: dx.doi.org/ (Open Access)
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Superior antiviral activity of IFNβ in genital HSV-1 infectionIn: Frontiers in Cellular and Infection Microbiology Vol. 12 (2022) 949036Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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The Bovine Seminal Plasma Protein PDC-109 Possesses Pan-Antiviral ActivityIn: Viruses Vol. 14 (2022) Nr. 9, 2031Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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The Role of the Inhibitory Ligand HVEM and Its Receptors CD160 and BTLA in the Regulation of Anti-retroviral T Cell ResponsesIn: Frontiers in Virology Vol. 2 (2022) 836291Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Analysis of the long-term impact on cellular immunity in COVID-19-recovered individuals reveals a profound nkt cell impairmentIn: mBio Vol. 12 (2021) Nr. 2, pp. e00085 - 21Online Full Text: dx.doi.org/ (Open Access)
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Characterization of SARS-CoV-2-Specific Humoral and Cellular Immune Responses Induced by Inactivated COVID-19 Vaccines in a Real-World SettingIn: Frontiers in Immunology Vol. 12 (2021) 802858Online Full Text: dx.doi.org/ (Open Access)
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Functional Comparison of Interferon-α Subtypes Reveals Potent Hepatitis B Virus Suppression by a Concerted Action of Interferon-α and Interferon-γ SignalingIn: Hepatology Vol. 73 (2021) Nr. 2, pp. 486 - 502Online Full Text: dx.doi.org/
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Longitudinal characterization of phenotypic profile of T cells in chronic hepatitis B identifies immune markers associated with HBsAg lossIn: EBioMedicine Vol. 69 (2021) 103464Online Full Text: dx.doi.org/ (Open Access)
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TLR4 Transactivates CD8⁺ T Lymphocytes upon Acute Sterile Tissue InjuryIn: ImmunoHorizons Vol. 5 (2021) Nr. 5, pp. 298 - 306Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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A Crowned Killer’s Résumé : Genome, Structure, Receptors, and Origin of SARS-CoV-2In: Virologica Sinica (2020)Online Full Text: dx.doi.org/ (Open Access)
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Die Einmischer: Interferone : Wie sie die Immunantwort beeinflussen, um Viren effektiv zu bekämpfenIn: Unikate: Berichte aus Forschung und Lehre (2020) Nr. 54: Medizin: Infektionskrankheiten - ein globales Problem, pp. 18 - 27Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Erratum for Westmeier et al., "Impaired Cytotoxic CD8⁺ T Cell Response in Elderly COVID-19 Patients"In: mBio Vol. 11 (2020) Nr. 5, pp. 02243 - 02220Online Full Text: dx.doi.org/ (Open Access)
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HIV infection does not alter interferon α/β receptor 2 expression on mucosal immune cellsIn: PLoS ONE Vol. 15 (2020) Nr. 1, pp. e0218905Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Impaired cytotoxic CD8⁺ T cell response in elderly COVID-19 patientsIn: mBio Vol. 11 (2020) Nr. 5, pp. e02243 - 20Online Full Text: dx.doi.org/ (Open Access)
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Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoVIn: Journal of Medical Virology Vol. 92 (2020) Nr. 5, pp. 491 - 494Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Qualitative differences between the IFNα subtypes and IFNβ influence chronic mucosal HIV-1 pathogenesisIn: PLoS Pathogens Vol. 16 (2020) Nr. 10, pp. 1008986Online Full Text: dx.doi.org/ (Open Access)
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SERINC5 Is an Unconventional HIV Restriction Factor That Is Upregulated during Myeloid Cell DifferentiationIn: Journal of Innate Immunity Vol. 12 (2020) Nr. 5, pp. 399 - 409Online Full Text: dx.doi.org/ (Open Access)
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Susceptibility of SARS-CoV-2 to UV irradiationIn: American Journal of Infection Control Vol. 48 (2020) Nr. 10, pp. 1273 - 1275Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Antiviral potential of human IFN-α subtypes against influenza A H3N2 infection in human lung explants reveals subtype-specific activitiesIn: Emerging Microbes & Infections Vol. 8 (2019) Nr. 1, pp. 1763 - 1776Online Full Text: dx.doi.org/ (Open Access)
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Characterization of Endogenous SERINC5 Protein as Anti-HIV-1 FactorIn: Journal of Virology Vol. 93 (2019) Nr. 24, pp. e01221 - 19Online Full Text: dx.doi.org/ (Open Access)
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Chronic retroviral infection of mice promotes tumor development, but CD137 agonist therapy restores effective tumor immune surveillanceIn: Cancer Immunology, Immunotherapy Vol. 68 (2019) Nr. 3, pp. 479 - 488Online Full Text: dx.doi.org/
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Concurrent administration of IFNα14 and cART in TKO-BLT mice enhances suppression of HIV-1 viremia but does not eliminate the latent reservoirIn: Scientific Reports Vol. 9 (2019) pp. 18089Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Different Biological Activities of Specific Interferon Alpha SubtypesIn: mSphere Vol. 4 (2019) Nr. 4, e00127 - 19Online Full Text: dx.doi.org/ (Open Access)
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Diverse immunomodulatory effects of individual IFNα subtypes on virus-specific CD8⁺ T cell responsesIn: Frontiers in Immunology Vol. 10 (2019) 2255Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunityIn: FEMS Microbiology Reviews Vol. 43 (2019) Nr. 5, pp. 435 - 456Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope ProteinsIn: Cell Reports Vol. 27 (2019) Nr. 7, pp. 2092 - 2104.e10Online Full Text: dx.doi.org/ (Open Access)
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PASylated interferon α efficiently suppresses hepatitis B virus and induces anti-HBs seroconversion in HBV-transgenic miceIn: Antiviral Research Vol. 161 (2019) pp. 134 - 143Online Full Text: dx.doi.org/
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Plasmacytoid dendritic cells respond to Epstein-Barr virus infection with a distinct type I interferon subtype profileIn: Blood Advances Vol. 3 (2019) Nr. 7, pp. 1129 - 1144Online Full Text: dx.doi.org/ (Open Access)
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An advanced BLT-humanized mouse model for extended HIV-1 cure studiesIn: AIDS Vol. 32 (2018) Nr. 1, pp. 1 - 10Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Hepatitis B virus sensitivity to interferon-α in hepatocytes is more associated with cellular interferon response than with viral genotypeIn: Hepatology Vol. 67 (2018) Nr. 4, pp. 1237 - 1252Online Full Text: dx.doi.org/ (Open Access)
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Impact of immune suppressive agents on the BK-Polyomavirus non coding control regionIn: Antiviral Research Vol. 159 (2018) pp. 68 - 76Online Full Text: dx.doi.org/
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Induction of Type I Interferons by Therapeutic Nanoparticle-Based Vaccination Is Indispensable to Reinforce Cytotoxic CD8+ T Cell Responses During Chronic Retroviral InfectionIn: Frontiers in Immunology Vol. 9 (2018) 614Online Full Text: dx.doi.org/ (Open Access)
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Interferon α subtypes in HIV infectionIn: Cytokine & Growth Factor Reviews Vol. 40 (2018) pp. 13 - 18Online Full Text: dx.doi.org/
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Different antiviral effects of IFNα and IFNβ in an HBV mouse modelIn: Immunobiology Vol. 222 (2017) Nr. 3, pp. 562 - 570Online Full Text: dx.doi.org/
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Different antiviral effects of IFNα subtypes in a mouse model of HBV infectionIn: Scientific Reports Vol. 7 (2017) Nr. 1, pp. 334Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Expression pattern of individual IFNA subtypes in chronic HIV infectionIn: Journal of Interferon & Cytokine Research Vol. 37 (2017) Nr. 12, pp. 541 - 549Online Full Text: dx.doi.org/
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Fas Ligand-mediated cytotoxicity of CD4+ T cells during chronic retrovirus infectionIn: Scientific Reports Vol. 7 (2017) pp. 7785Online Full Text: dx.doi.org/ (Open Access)
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Human pDCs display sex-specific differences in type I interferon subtypes and interferon α/β receptor expressionIn: European Journal of Immunology Vol. 47 (2017) Nr. 2, pp. 251 - 256Online Full Text: dx.doi.org/
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Hypoxia-inducible factor 1α is essential for macrophage-mediated erythroblast proliferation in acute friend retrovirus infectionIn: Scientific Reports Vol. 7 (2017) art. no. 17236Online Full Text: dx.doi.org/ (Open Access)
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Inhibition of catecholamine degradation ameliorates while chemical sympathectomy aggravates the severity of acute Friend retrovirus infection in miceIn: Brain, Behavior and Immunity Vol. 54 (2016) pp. 252 - 259Online Full Text: dx.doi.org/
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Insufficient natural killer cell responses against retroviruses : How to improve NK cell killing of retrovirus-infected cellsIn: Retrovirology Vol. 13 (2016) Nr. 1, 77Online Full Text: dx.doi.org/ (Open Access)
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Interferon alpha subtype-specific suppression of HIV-1 infection in vivoIn: Journal of Virology Vol. 90 (2016) Nr. 13, pp. 6001 - 6013Online Full Text: dx.doi.org/ (Open Access)
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Activated regulatory T cells suppress effector NK cell responses by an IL-2-mediated mechanism during an acute retroviral infectionIn: Retrovirology Vol. 12 (2015) Nr. 1, 66Online Full Text: dx.doi.org/ (Open Access)
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Interferon-α subtypes in an ex vivo model of acute HIV-1 infection : expression, potency and effector mechanismsIn: PLoS Pathogens Vol. 11 (2015) Nr. 11, pp. e1005254Online Full Text: dx.doi.org/ (Open Access)
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TLR ligand induced IL-6 counter-regulates the anti-viral CD8+ T cell response during an acute retrovirus infectionIn: Scientific Reports Vol. 5 (2015) pp. 10501Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Chemical modifications on siRNAs avoid Toll-like-receptor-mediated activation of the hepatic immune system in vivo and in vitroIn: International Immunology Vol. 26 (2014) Nr. 1, pp. 35 - 46Online Full Text: dx.doi.org/
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Distinct roles of NK cells in viral immunity during different phases of acute Friend retrovirus infectionIn: Retrovirology Vol. 10 (2013) Nr. 1, 127Online Full Text: dx.doi.org/ (Open Access)
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IFN-α subtypes : Distinct biological activities in anti-viral therapyIn: British Journal of Pharmacology (BJP) Vol. 168 (2013) Nr. 5, pp. 1048 - 1058Online Full Text: dx.doi.org/ (Open Access)
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IFN-α treatment inhibits acute friend retrovirus replication primarily through the antiviral effector molecule Apobec3In: The Journal of Immunology (JI) Vol. 190 (2013) Nr. 4, pp. 1583 - 1590Online Full Text: dx.doi.org/
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Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral responseIn: Cell Reports Vol. 4 (2013) Nr. 4, pp. 689 - 696Online Full Text: dx.doi.org/ (Open Access)
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Role of hypoxia inducible factor-1 α for interferon synthesis in mouse dendritic cellsIn: Biological Chemistry Vol. 394 (2013) Nr. 4, pp. 495 - 505Online Full Text: dx.doi.org/
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Interferon-alpha Subtype 11 Activates NK Cells and Enables Control of Retroviral InfectionIn: PLoS Pathogens Vol. 8 (2012) Nr. 8, pp. e1002868Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Distinct antiviral activities of IFN-α subtypesIn: Immunotherapy Vol. 3 (2011) Nr. 7, pp. 813 - 816Online Full Text: dx.doi.org/
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Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8⁺ T cells and reduces chronic retroviral set pointsIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 108 (2011) Nr. 6, pp. 2420 - 2425Online Full Text: dx.doi.org/ (Open Access)
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Virus-Specific CD8+ T Cells Upregulate Programmed Death-1 Expression during Acute Friend Retrovirus Infection but Are Highly Cytotoxic and Control Virus ReplicationIn: The Journal of Immunology (JI) Vol. 187 (2011) Nr. 7, pp. 3730 - 3737Online Full Text: dx.doi.org/
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CD40 ligand-triggered human dendritic cells mount interleukin-23 responses that are further enhanced by danger signalsIn: Molecular Immunology Vol. 47 (2010) Nr. 6, pp. 1255 - 1261Online Full Text: dx.doi.org/
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Polyinosinic-polycytidylic acid treatment of Friend retrovirus-infected mice improves functional properties of virus-specific T cells and prevents virus-induced diseaseIn: The Journal of Immunology (JI) Vol. 185 (2010) Nr. 10, pp. 6179 - 6189Online Full Text: dx.doi.org/ (Open Access)