ZMB Member Alpaslan Tasdogan
ZMB Member
Alpaslan Tasdogan
Next ZMB-Member
Prof. Dr. Dr. Alpaslan Tasdogan
Group
Tumor MetabolismClinic for Dermatology
University Hospital Essen
Hufelandstraße 55
45147 Essen
- +49 201 723 85356
- Website
- Publications
- Publication Metrics
- ZMB Research Program
Oncology
Research Overview
- Better understanding the molecular regulators of cancer metastasis
- Developing novel metabolic tools to study cancer metabolism in vivo
- Applying state-of-the art metabolic technologies to study melanoma metabolism in patient
- Discovering new metabolic vulnerabilities in melanoma metastasis
Publications
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Case report: : Durable complete response of a mucosal melanoma of the rectum after neoadjuvant immunotherapy with ipilimumab plus nivolumabIn: Frontiers in Immunology Vol. 15 (2024) 1369190Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Comparison of visual diagnostic accuracy of dermatologists practicing in Germany in patients with light skin and skin of colorIn: Scientific Reports Vol. 14 (2024) Nr. 1, 8740Online Full Text: dx.doi.org/ (Open Access)
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Cranioencephalic functional lymphoid units in glioblastomaIn: Nature Medicine (2024) in pressOnline Full Text: dx.doi.org/ (Open Access)
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De novo and salvage purine synthesis pathways across tissues and tumorsIn: Cell Vol. 187 (2024) Nr. 14, pp. 3602 - 3618.e20Online Full Text: dx.doi.org/
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Diätetische Ansätze in der TumortherapieIn: TumorDiagnostik & Therapie Vol. 45 (2024) Nr. 3, pp. 186 - 194Online Full Text: dx.doi.org/
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Early versus late response to PD-1-based immunotherapy in metastatic melanomaIn: European Journal of Cancer (EJC) Vol. 210 (2024) 114295Online Full Text: dx.doi.org/ (Open Access)
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Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activationIn: Nature Cancer Vol. 5 (2024) Nr. 3, pp. 433 - 447Online Full Text: dx.doi.org/
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Multilokuläres Pyoderma gangraenosum durch Levamisol-gestrecktes KokainIn: Die Dermatologie Vol. 75 (2024) Nr. 8, pp. 640Online Full Text: dx.doi.org/ (Open Access)
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Pathogenic mitochondrial DNA mutations inhibit melanoma metastasisIn: Science Advances Vol. 10 (2024) Nr. 44, eadk8801Online Full Text: dx.doi.org/ (Open Access)
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Retrotransposons are co-opted to activate hematopoietic stem cells and erythropoiesisIn: Science Vol. 386 (2024) Nr. 6722, pp. eado6836Online Full Text: dx.doi.org/
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Short-term post-fast refeeding enhances intestinal stemness via polyaminesIn: Nature (2024) in pressOnline Full Text: dx.doi.org/
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The Interplay between Metabolic Adaptations and Diet in Cancer ImmunotherapyIn: Clinical Cancer Research Vol. 30 (2024) Nr. 15, pp. 3117 - 3127Online Full Text: dx.doi.org/
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Advancements in melanoma cancer metastasis modelsIn: Pigment Cell and Melanoma Research Vol. 36 (2023) Nr. 2, pp. 206 - 223Online Full Text: dx.doi.org/ (Open Access)
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Characterisation and outcome of RAC1 mutated melanomaIn: European Journal of Cancer (EJC) Vol. 183 (2023) pp. 1 - 10Online Full Text: dx.doi.org/
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Combined immunotherapy with ipilimumab plus nivolumab in metastatic PD-1/PD-L1-refractory Merkel cell carcinoma : a case reportIn: International Journal of Dermatology Vol. 63 (2023) Nr. 2, pp. e69 - e71Online Full Text: dx.doi.org/
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Correlation of tumor PD-L1 expression in different tissue types and outcome of PD-1-based immunotherapy in metastatic melanoma ADOREG/TRIM : Analysis of the DeCOG prospective multicenter cohort studyIn: EBioMedicine Vol. 96 (2023) 104774Online Full Text: dx.doi.org/ (Open Access)
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Diätetische Ansätze in der TumortherapieIn: Aktuelle Dermatologie Vol. 49 (2023) Nr. 12, pp. 556 - 564Online Full Text: dx.doi.org/
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Ekzeme der Wundumgebung : Genese, Diagnostik und TherapieIn: Zeitschrift für Gerontologie und Geriatrie Vol. 56 (2023) Nr. 6, pp. 505 - 515Online Full Text: dx.doi.org/
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Leptin receptor⁺ cells promote bone marrow innervation and regeneration by synthesizing nerve growth factorIn: Nature Cell Biology Vol. 25 (2023) Nr. 12, pp. 1746 - 1757Online Full Text: dx.doi.org/ (Open Access)
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Multi-omics approaches to study platelet mechanismsIn: Current Opinion in Chemical Biology Vol. 73 (2023) 102253Online Full Text: dx.doi.org/ (Open Access)
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Multispectral optoacoustic tomography to differentiate between lymph node metastases and coronavirus-19 vaccine-associated lymphadenopathyIn: Journal of the European Academy of Dermatology and Venereology Vol. 37 (2023) Nr. 5: Special issue on melanoma: Immune check point and BRAF‐MEK inhibitors in melanoma, pp. 907 - 913Online Full Text: dx.doi.org/ (Open Access)
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Prognostic factors in the primary care of patients with Merkel cell carcinoma : A monocentric cohort study of 108 patients from a tertiary referral centreIn: JEADV Clinical Practice Vol. 2 (2023) Nr. 4, pp. 810 - 818Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Compartmentalized metabolism supports midgestation mammalian developmentIn: Nature Vol. 604 (2022) Nr. 7905, pp. 349 - 353Online Full Text: dx.doi.org/ (Open Access)
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Emerging metabolomic tools to study cancer metastasisIn: Trends in Cancer Vol. 8 (2022) Nr. 12, pp. 988 - 1001Online Full Text: dx.doi.org/ (Open Access)
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In vivo isotope tracing reveals a requirement for the electron transport chain in glucose and glutamine metabolism by tumorsIn: Science Advances Vol. 8 (2022) Nr. 35, eabn9550Online Full Text: dx.doi.org/ (Open Access)
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Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone massIn: eLife Vol. 8 (2022) pp. e42274Online Full Text: dx.doi.org/ (Open Access)
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Loss of glucose 6-phosphate dehydrogenase function increases oxidative stress and glutaminolysis in metastasizing melanoma cellsIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 119 (2022) Nr. 6, e2120617119Online Full Text: dx.doi.org/ (Open Access)
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Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathwayIn: Nature Communications Vol. 13 (2022) Nr. 1, 2698Online Full Text: dx.doi.org/ (Open Access)
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A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesisIn: Nature Vol. 591 (2021) Nr. 7850, pp. 438 - 444Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Isotope tracing reveals glycolysis and oxidative metabolism in childhood tumors of multiple histologiesIn: Med Vol. 2 (2021) Nr. 4, pp. 395 - 410.e4Online Full Text: dx.doi.org/ (Open Access)
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Metabolomic profiling of rare cell populations isolated by flow cytometry from tissuesIn: eLife Vol. 10 (2021) e61980Online Full Text: dx.doi.org/ (Open Access)
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Redox regulation in cancer cells during metastasisIn: Cancer Discovery Vol. 11 (2021) Nr. 11, pp. 2682 - 2692Online Full Text: dx.doi.org/ (Open Access)
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Stable isotope tracing to assess tumor metabolism in vivoIn: Nature Protocols Vol. 16 (2021) Nr. 11, pp. 5123 - 5145Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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The effect of parathyroid hormone on osteogenesis is mediated partly by osteolectinIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 118 (2021) Nr. 25, e2026176118Online Full Text: dx.doi.org/ (Open Access)
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U-RT1 : A new model for Richter transformationIn: Neoplasia: An International Journal for Oncology Research Vol. 23 (2021) Nr. 1, pp. 140 - 148Online Full Text: dx.doi.org/ (Open Access)
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Lymph protects metastasizing melanoma cells from ferroptosisIn: Nature Vol. 585 (2020) Nr. 7823, pp. 113 - 118Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Metabolic heterogeneity confers differences in melanoma metastatic potentialIn: Nature Vol. 577 (2020) Nr. 7788, pp. 115 - 120Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Mitochondrial DNA Haplotypes as Genetic Modifiers of CancerIn: Trends in Cancer Vol. 6 (2020) Nr. 12, pp. 1044 - 1058Online Full Text: dx.doi.org/
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Loss of EZH2 reprograms BCAA metabolism to drive leukemic transformationIn: Cancer Discovery Vol. 9 (2019) Nr. 9, pp. 1228 - 1247Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 SignalingIn: Cell Reports Vol. 28 (2019) Nr. 9, pp. 2293 - 2305.e9Online Full Text: dx.doi.org/ (Open Access)
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9-cis-Retinoic acid induces a distinct regulatory dendritic cell phenotype that modulates murine delayed-type allergyIn: Contact Dermatitis Vol. 78 (2018) Nr. 1, pp. 41 - 54Online Full Text: dx.doi.org/
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NF-κB activation in astrocytes drives a stage-specific beneficial neuroimmunological response in ALSIn: The EMBO Journal Vol. 37 (2018) Nr. 16, e98697Online Full Text: dx.doi.org/ (Open Access)
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The H3K4 methyltransferase setd1b is essential for hematopoietic stem and progenitor cell homeostasis in miceIn: eLife Vol. 7 (2018) e27157Online Full Text: dx.doi.org/ (Open Access)
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Die PD-L1-Expression im Tumor prognostiziert je nach Art des untersuchten Gewebes das Outcome einer Anti-PD-1-basierten Immuntherapie bei metastasiertem Melanom
33. Deutscher Hautkrebskongress (ADO-Jahrestagung) ; 06.–09. September 2023, Hamburg, Germany,In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) Vol. 21 (2023) Nr. S4, Special Issue: Abstractband anlässlich des 33. Deutschen Hautkrebskongresses (ADO‐Jahrestagung) 06.–09. September 2023 Hamburg, pp. 27 - 28Online Full Text: dx.doi.org/ (Open Access) -
Predictors of long-term survival of Stage IV melanoma patients: a multicenter DeCOG study on 395 patients from the prospective skin cancer registry ADOREG
52. Tagung der Deutschen Dermatologischen Gesellschaft, Vereinigung Deutschsprachiger Dermatologen e. V., 26.-29.04.2023, Berlin,In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) Vol. 21 (2023) Nr. S1, Special Issue: Abstractband anlässlich der 52. Tagung der Deutschen Dermatologischen Gesellschaft, Vereinigung Deutschsprachiger Dermatologen e. V. 26. bis 29. April 2023, Berlin, pp. 9 - 27Online Full Text: dx.doi.org/ (Open Access) -
Predictors of long-term survival of stage IV melanoma patients : a multicenter DeCOG study on 539 patients from the prospective skin cancer registry ADOREG
32. Deutscher Hautkrebskongress (ADO-Jahrestagung), 14.–17. September 2022, Hannover, Germany,In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) Vol. 20 (2022) Nr. S3, pp. 16 - 17Online Full Text: dx.doi.org/ -
Tumor PD-L1 predicts the outcome of PD-1-based immunotherapy in metastatic melanoma depending on the type of tissue examined
ESMO Congress 2023 ; 20 - 24 October 2023, Madrid, Spain,In: Annals of Oncology Vol. 34 (2023) Nr. Supplement 2: Abstract Book of the ESMO Congress 2023, 20 - 24 October 2023, pp. S695Online Full Text: dx.doi.org/