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ZMB Member Kathrin Thedieck

ZMB Member
Kathrin Thedieck

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Kathrin Thedieck portrait
© UDE

Prof. Dr. Kathrin Thedieck

Group

Metabolism, Senescence and Autophagy

Research Center One Health Ruhr
University Alliance Ruhr
University Hospital Essen
Hufelandstrasse 55
45147 Essen

Research Overview

The Lab for Metabolic Signaling studies the control of metabolic homeostasis through kinase signaling networks converging on the metabolic master regulator mTOR (mammalian / mechanistic target of rapamycin) in health and disease. We adopt biochemistry, cell biology, proteomics, metabolomics and systems modelling approaches.

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Press Releases

Kathrin Thedieck portrait
© UDE/Bettina Engel-Albustin
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uni-due.de | Presse release

UA Ruhr Berufung: Kathrin Thedieck Stoffwechselsignale eröffnen neue Ansätze für Krebsforschung und seltene Erkrankungen

[07.01.2025] Stress gilt allgemein als ungesund. Wie er sich auf den menschlichen Stoffwechsel auswirkt untersucht Prof. Dr. Kathrin Thedieck, neu berufene Professorin für Metabolismus, Seneszenz und Autophagie an der Fakultät für Medizin der UDE. Dafür forscht sie am Research Center One Health der Universitätsallianz Ruhr zur Kontrolle des Stoffwechsels in Tumorzellen.
ZMB Member: Prof. Dr. Kathrin Thedieck

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Selected Publications

    Journal articles

  • Gollowitzer, André; Pein, Helmut; Rao, Zhigang; Waltl, Lorenz; Bereuter, Leonhard; Loeser, Konstantin; Meyer, Tobias; Jafari, Vajiheh; Witt, Finja; Winkler, René; Su, Fengting; Große, Silke; Thürmer, Maria; Grander, Julia; Hotze, Madlen; Harder, Sönke; Esp et al.
    Attenuated growth factor signaling during cell death initiation sensitizes membranes towards peroxidation
    In: Nature Communications Vol. 16 (2025) Nr. 1, 1774
    Online Full Text: dx.doi.org/ (Open Access)
  • Sharma, Suraj; Sauter, Roland; Hotze, Madlen; Prowatke, Aaron Marcellus Paul; Niere, Marc; Kipura, Tobias; Egger, Anna-Sophia; Thedieck, Kathrin; Kwiatkowski, Marcel; Ziegler, Mathias; Heiland, Ines.
    GEMCAT : A new algorithm for gene expression-based prediction of metabolic alterations
    In: NAR Genomics and Bioinformatics Vol. 7 (2025) Nr. 1, lqaf003
    Online Full Text: dx.doi.org/ (Open Access)
  • Kipura, Tobias; Hotze, Madlen; Hofer, Alexa; Egger, Anna-Sophia; Timpen, Lea E.; Opitz, Christiane A.; Townsend, Paul A.; Gethings, Lee A.; Thedieck, Kathrin; Kwiatkowski, Marcel.
    Automated Liquid Handling Extraction and Rapid Quantification of Underivatized Amino Acids and Tryptophan Metabolites from Human Serum and Plasma Using Dual-Column U(H)PLC-MRM-MS and Its Application to Prostate Cancer Study
    In: Metabolites Vol. 14 (2024) Nr. 7, 370
    Online Full Text: dx.doi.org/ (Open Access)
  • Braeuning, Albert; Balaguer, Patrick; Bourguet, William; Carreras-Puigvert, Jordi; Feiertag, Katreece; Kamstra, Jorke H.; Knapen, Dries; Lichtenstein, Dajana; Marx-Stoelting, Philip; Rietdijk, Jonne; Schubert, Kristin; Spjuth, Ola; Stinckens, Evelyn; Thedi et al.
    Development of new approach methods for the identification and characterization of endocrine metabolic disruptors : A PARC project
    In: Frontiers in Toxicology Vol. 5 (2023) 1212509
    Online Full Text: dx.doi.org/ (Open Access)
  • Alpsoy, Lokman; Sedeky, Abanoub Selim; Rehbein, Ulrike; Thedieck, Kathrin; Brandstetter, Thomas; Rühe, Jürgen.
    Particle ID : A Multiplexed Hydrogel Bead Platform for Biomedical Applications
    In: ACS Applied Materials & Interfaces Vol. 15 (2023) Nr. 48, pp. 55346 - 55357
    Online Full Text: dx.doi.org/ (Open Access)
  • Fricke, Anna L.; Mühlhäuser, Wignand W. D.; Reimann, Lena; Zimmermann, Johannes P.; Reichenbach, Christa; Knapp, Bettina; Peikert, Christian D.; Heberle, Alexander M.; Faessler, Erik; Schäuble, Sascha; Hahn, Udo; Thedieck, Kathrin; Radziwill, Gerald; Warsc et al.
    Phosphoproteomics Profiling Defines a Target Landscape of the Basophilic Protein Kinases AKT, S6K, and RSK in Skeletal Myotubes
    In: Journal of Proteome Research Vol. 22 (2023) Nr. 3, pp. 768 - 789
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • van Pijkeren, Alienke; Egger, Anna-Sophia; Hotze, Madlen; Zimmermann, Elisabeth; Kipura, Tobias; Grander, Julia; Gollowitzer, André; Koeberle, Andreas; Bischoff, Rainer; Thedieck, Kathrin; Kwiatkowski, Marcel.
    Proteome Coverage after Simultaneous Proteo-Metabolome Liquid-Liquid Extraction
    In: Journal of Proteome Research Vol. 22 (2023) Nr. 3, pp. 951 - 966
    Online Full Text: dx.doi.org/ (Open Access)
  • Ling, Catriona; Versloot, Christian J.; Arvidsson Kvissberg, Matilda E.; Hu, Guanlan; Swain, Nathan; Horcas-Nieto, José M.; Miraglia, Emily; Thind, Mehakpreet K.; Farooqui, Amber; Gerding, Albert; van Eunen, Karen; Koster, Mirjam H.; Kloosterhuis, Niels J. et al.
    Rebalancing of mitochondrial homeostasis through an NAD⁺-SIRT1 pathway preserves intestinal barrier function in severe malnutrition
    In: eBioMedicine Vol. 96 (2023) 104809
    Online Full Text: dx.doi.org/ (Open Access)
  • Abdellatif, Mahmoud; Eisenberg, Tobias; Heberle, Alexander Martin; Thedieck, Kathrin; Kroemer, Guido; Sedej, Simon.
    Cardiac PI3K p110a attenuation delays aging and extends lifespan
    In: Cell Stress: The Journal of the European Research Institute for Integrated Cellular Pathology Vol. 6 (2022) Nr. 8, pp. 72 - 75
    Online Full Text: dx.doi.org/ (Open Access)
  • Zhang, Yang; Dreyer, Benjamin; Govorukhina, Natalia; Heberle, Alexander M.; Končarević, Saša; Krisp, Christoph; Opitz, Christiane A.; Pfänder, Pauline; Bischoff, Rainer; Schlüter, Hartmut; Kwiatkowski, Marcel; Thedieck, Kathrin; Horvatovich, Peter L.
    Comparative Assessment of Quantification Methods for Tumor Tissue Phosphoproteomics
    In: Analytical Chemistry Vol. 94 (2022) Nr. 31, pp. 10893 - 10906
    Online Full Text: dx.doi.org/ (Open Access)
  • Abdellatif, Mahmoud; Trummer-Herbst, Viktoria; Heberle, Alexander Martin; Humnig, Alina; Pendl, Tobias; Durand, Sylvère; Cerrato, Giulia; Hofer, Sebastian J.; Islam, Moydul; Voglhuber, Julia; Ramos Pittol, José Miguel; Kepp, Oliver; Hoefler, Gerald; Schmid et al.
    Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity
    In: Circulation Vol. 145 (2022) Nr. 25, pp. 1853 - 1866
    Online Full Text: dx.doi.org/ (Open Access)
  • Thürmer, Maria; Gollowitzer, André; Pein, Helmut; Neukirch, Konstantin; Gelmez, Elif; Waltl, Lorenz; Wielsch, Natalie; Winkler, René; Löser, Konstantin; Grander, Julia; Hotze, Madlen; Harder, Sönke; Döding, Annika; Meßner, Martina; Troisi, Fabiana; Ardelt, et al.
    PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling
    In: Nature Communications Vol. 13 (2022) Nr. 1, 2982
    Online Full Text: dx.doi.org/ (Open Access)
  • van Pijkeren, Alienke; Dietze, Jörn; Brotons, Alejandro Sánchez; Egger, Anna-Sophia; Lijster, Tim; Barcaru, Andrei; Hotze, Madlen; Kobler, Philipp; Dekker, Frank J.; Horvatovich, Peter; Melgert, Barbro N.; Ziegler, Mathias; Thedieck, Kathrin; Heiland, Ines et al.
    Combined Metabolic and Chemical (CoMetChem) Labeling Using Stable Isotopes : a Strategy to Reveal Site-Specific Histone Acetylation and Deacetylation Rates by LC-MS
    In: Analytical Chemistry Vol. 93 (2021) Nr. 38, pp. 12872 - 12880
    Online Full Text: dx.doi.org/ (Open Access)
  • Heberle, Alexander Martin; Rehbein, Ulrike; Peiris, Maria Rodríguez; Thedieck, Kathrin; Rodríguez Peiris, Maria.
    Finding new edges: Systems approaches to MTOR signaling
    In: Biochemical Society Transactions Vol. 49 (2021) Nr. 1, pp. 41 - 54
    Online Full Text: dx.doi.org/ (Open Access)
  • Prentzell, Mirja Tamara; Rehbein, Ulrike; Cadena Sandoval, Marti; De Meulemeester, Ann-Sofie; Baumeister, Ralf; Brohée, Laura; Berdel, Bianca; Bockwoldt, Mathias; Carroll, Bernadette; Chowdhury, Suvagata Roy; von Deimling, Andreas; Demetriades, Constantino et al.
    G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling
    In: Cell Vol. 184 (2021) Nr. 3, pp. 655 - 674.e27
    Online Full Text: dx.doi.org/ (Open Access)
  • Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Sara, Abdelfatah; Thedieck, Kathrin; Tong, Chun-Kit.
    Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)¹
    In: Autophagy Vol. 17 (2021) Nr. 1, pp. 1 - 382
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Rehbein, Ulrike; Prentzell, Mirja Tamara; Cadena Sandoval, Marti; Heberle, Alexander Martin; Henske, Elizabeth P.; Opitz, Christiane A.; Thedieck, Kathrin.
    The TSC Complex-mTORC1 Axis : From Lysosomes to Stress Granules and Back
    In: Frontiers in Cell and Developmental Biology Vol. 9 (2021) 751892
    Online Full Text: dx.doi.org/ (Open Access)
  • Cattelani, Cecilia; Lesiak, Dominik; Liebscher, Gudrun; Singer, Isabel I.; Stasyk, Taras; Wallnöfer, Moritz H.; Heberle, Alexander M.; Corti, Corrado; Hess, Michael W.; Pfaller, Kristian; Kwiatkowski, Marcel; Pramstaller, Peter P.; Hicks, Andrew A.; Thedie et al.
    The szt2 interactome unravels new functions of the kicstor complex
    In: Cells Vol. 10 (2021) Nr. 10, 2711
    Online Full Text: dx.doi.org/ (Open Access)
  • Cadena Sandoval, Marti; Heberle, Alexander Martin; Rehbein, Ulrike; Barile, Cecilia; Ramos Pittol, José Miguel; Thedieck, Kathrin.
    mTORC1 Crosstalk With Stress Granules in Aging and Age-Related Diseases
    In: Frontiers in Aging Vol. 2 (2021) 761333
    Online Full Text: dx.doi.org/ (Open Access)
  • Metzler, Lukas; Rehbein, Ulrike; Schönberg, Jan-Niklas; Brandstetter, Thomas; Thedieck, Kathrin; Rühe, Jürgen.
    Breaking the Interface : Efficient Extraction of Magnetic Beads from Nanoliter Droplets for Automated Sequential Immunoassays
    In: Analytical Chemistry Vol. 92 (2020) Nr. 15, pp. 10283 - 10290
    Online Full Text: dx.doi.org/ (Open Access)
  • Sadik, Ahmed; Somarribas Patterson, Luis F.; Öztürk, Selcen; Mohapatra, Soumya R.; Panitz, Verena; Secker, Philipp F.; Pfänder, Pauline; Loth, Stefanie; Salem, Heba; Prentzell, Mirja Tamara; Berdel, Bianca; Iskar, Murat; Faessler, Erik; Reuter, Friederike; et al.
    IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression
    In: Cell Vol. 182 (2020) Nr. 5, pp. 1252 - 1270.e34
    Online Full Text: dx.doi.org/ (Open Access)
  • Bork, Tillmann; Liang, Wei; Yamahara, Kosuke; Lee, Philipp; Tian, Zhejia; Liu, Shuya; Schell, Christoph; Thedieck, Kathrin; Hartleben, Bjoern; Patel, Ketan; Tharaux, Pierre-Louis; Lenoir, Olivia; Huber, Tobias B.
    Podocytes maintain high basal levels of autophagy independent of mtor signaling
    In: Autophagy Vol. 16 (2020) Nr. 11, pp. 1932 - 1948
    Online Full Text: dx.doi.org/ (Open Access)
  • Shafiee Kamalabad, Mahdi; Heberle, Alexander Martin; Thedieck, Kathrin; Grzegorczyk, Marco.
    Partially non-homogeneous dynamic Bayesian networks based on Bayesian regression models with partitioned design matrices
    In: Bioinformatics Vol. 35 (2019) Nr. 12, pp. 2108 - 2117
    Online Full Text: dx.doi.org/ (Open Access)
  • Heberle, Alexander Martin; Navas, Patricia Razquin; Langelaar-Makkinje, Miriam; Kasack, Katharina; Sadik, Ahmed; Faessler, Erik; Hahn, Udo; Marx-Stoelting, Philip; Opitz, Christiane A.; Sers, Christine; Heiland, Ines; Schäuble, Sascha; Thedieck, Kathrin.
    The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner
    In: Life Science Alliance Vol. 2 (2019) Nr. 2, e201800257
    Online Full Text: dx.doi.org/ (Open Access)
  • Diosa-Toro, Mayra; Troost, Berit; van de Pol, Denise; Heberle, Alexander Martin; Urcuqui-Inchima, Silvio; Thedieck, Kathrin; Smit, Jolanda M.
    Tomatidine, a novel antiviral compound towards dengue virus
    In: Antiviral Research Vol. 161 (2019) pp. 90 - 99
    Online Full Text: dx.doi.org/ (Open Access)
  • Li, Yujie; Finkbeiner, Sandra; Ganner, Athina; Gerber, Julia; Klein, Marinella; Grafe, Manuel; Kandzia, Jakob; Thien, Antje; Thedieck, Kathrin; Breves, Gerhard; Jank, Thomas; Baumeister, Ralf; Walz, Gerd; Neumann-Haefelin, Elke.
    CGEF-1 regulates mTORC1 signaling during adult longevity and stress response in C. elegans
    In: OncoTarget Vol. 9 (2018) Nr. 11, pp. 9581 - 9595
    Online Full Text: dx.doi.org/ (Open Access)
  • Weise, Stefan Christopher; Villarreal, Alejandro; Heidrich, Stefanie; Dehghanian, Fariba; Schachtrup, Christian; Nestel, Sigrun; Schwarz, Jennifer; Thedieck, Kathrin; Vogel, Tanja.
    TGFβ-signaling and FOXG1-expression are a hallmark of astrocyte lineage diversity in the murine ventral and dorsal forebrain
    In: Frontiers in Cellular Neuroscience Vol. 12 (2018) 448
    Online Full Text: dx.doi.org/ (Open Access)
  • Adam, Isabell; Dewi, Dyah L.; Mooiweer, Joram; Sadik, Ahmed; Mohapatra, Soumya R.; Berdel, Bianca; Keil, Melanie; Sonner, Jana K.; Thedieck, Kathrin; Rose, Adam J.; Platten, Michael; Heiland, Ines; Trump, Saskia; Opitz, Christiane A.
    Upregulation of tryptophanyl-tRNA synthethase adapts human cancer cells to nutritional stress caused by tryptophan degradation
    In: OncoImmunology Vol. 7 (2018) Nr. 12, e1486353
    Online Full Text: dx.doi.org/ (Open Access)
  • Navas, Patricia Razquin; Thedieck, Kathrin.
    Differential control of ageing and lifespan by isoforms and splice variants across the mTOR network
    In: Essays in Biochemistry Vol. 61 (2017) Nr. 3, pp. 349 - 368
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Riemer, Pamela; Rydenfelt, Mattias; Marks, Matthias; van Eunen, Karen; Thedieck, Kathrin; Herrmann, Bernhard G.; Blüthgen, Nils; Sers, Christine; Morkel, Markus.
    Oncogenic β-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids
    In: The Journal of Cell Biology (JCB) Vol. 216 (2017) Nr. 6, pp. 1567 - 1577
    Online Full Text: dx.doi.org/ (Open Access)
  • Ruf, Stefanie; Heberle, Alexander Martin; Langelaar-Makkinje, Miriam; Gelino, Sara; Wilkinson, Deepti; Gerbeth, Carolin; Schwarz, Jennifer Jasmin; Holzwarth, Birgit; Warscheid, Bettina; Meisinger, Chris; van Vugt, Marcel A. T. M.; Baumeister, Ralf; Hansen, et al.
    PLK1 (polo like kinase 1) inhibits MTOR complex 1 and promotes autophagy
    In: Autophagy Vol. 13 (2017) Nr. 3, pp. 486 - 505
    Online Full Text: dx.doi.org/ (Open Access)
  • Pezze, Piero Dalle; Ruf, Stefanie; Sonntag, Annika G.; Langelaar-Makkinje, Miriam; Hall, Philip; Heberle, Alexander M.; Navas, Patricia Razquin; Van Eunen, Karen; Tölle, Regine C.; Schwarz, Jennifer J.; Wiese, Heike; Warscheid, Bettina; Deitersen, Jana; St et al.
    A systems study reveals concurrent activation of AMPK and mTOR by amino acids
    In: Nature Communications Vol. 7 (2016) 13254
    Online Full Text: dx.doi.org/ (Open Access)
  • Clark, Curtis A.; Gupta, Harshita B.; Sareddy, Gangadhara; Pandeswara, Srilakshmi; Lao, Shunhua; Yuan, Bin; Drerup, Justin M.; Padron, Alvaro; Conejo-Garcia, José; Murthy, Kruthi; Liu, Yang; Turk, Mary Jo; Thedieck, Kathrin; Hurez, Vincent; Li, Rong; Vadla et al.
    Tumor-intrinsic PD-L1 signals regulate cell growth, pathogenesis, and autophagy in ovarian cancer and melanoma
    In: Cancer Research Vol. 76 (2016) Nr. 23, pp. 6964 - 6974
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Schwarz, Jennifer Jasmin; Wiese, Heike; Tölle, Regine Charlotte; Zarei, Mostafa; Dengjel, Jörn; Warscheid, Bettina; Thedieck, Kathrin.
    Functional proteomics identifies acinus L as a direct insulin- and amino acid-dependent mammalian target of rapamycin complex 1 (mTORC1) substrate
    In: Molecular and Cellular Proteomics (MCP) Vol. 14 (2015) Nr. 8, pp. 2042 - 2055
    Online Full Text: dx.doi.org/ (Open Access)
  • Heberle, Alexander Martin; Prentzell, Mirja Tamara; van Eunen, Karen; Bakker, Barbara Marleen; Grellscheid, Sushma Nagaraja; Thedieck, Kathrin.
    Molecular mechanisms of mTOR regulation by stress
    In: Molecular and Cellular Oncology Vol. 2 (2015) Nr. 2, e970489
    Online Full Text: dx.doi.org/ (Open Access)
  • Heiland, I.; Thedieck, Kathrin.
    Nutrigenomics: Toward a cross-disciplinary understanding of nutrient-driven networks in health and disease : What can we learn from the study of cross-talk in complex protein kinase and metabolic networks?
    In: Aktuelle Ernährungsmedizin Vol. 40 (2015) Nr. 2, pp. 88 - 92
    Online Full Text: dx.doi.org/
  • Thien, Antje; Prentzell, Mirja Tamara; Holzwarth, Birgit; Kläsener, Kathrin; Kuper, Ineke; Boehlke, Christopher; Sonntag, Annika G.; Ruf, Stefanie; Maerz, Lars; Nitschke, Roland; Grellscheid, Sushma-Nagaraja; Reth, Michael; Walz, Gerd; Baumeister, Ralf; Ne et al.
    TSC1 Activates TGF-β-Smad2/3 Signaling in Growth Arrest and Epithelial-to-Mesenchymal Transition
    In: Developmental Cell Vol. 32 (2015) Nr. 5, pp. 617 - 630
    Online Full Text: dx.doi.org/ (Open Access)
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