ZMB Member Ralf Küppers
ZMB Member
Ralf Küppers
Next ZMB-Member
Prof. Dr. Ralf Küppers
Director of:
Institute of Cell Biology (Tumor Research)
University Hospital Essen
Virchowstr. 173
45122 Essen
- +49 201 723 3384
- Website
- Selected Publications
- Publication Metrics
- ZMB Research Program
Oncology
Research Overview
B lymphocytes represent the white blood cells that produce antibodies and that play an important role in immune responses against foreign antigens (e.g. bacteria). In rare instances, B lymphocytes may undergo malignant transformation and become tumour cells. Such tumours are called B cell lymphomas or leukemias. The main research topics of the group are:
- Investigation of B cell differentiation and function in the human
- The interplay of B cells with viruses (EBV, HCV, HIV)
- Pathogenesis of human B cell lymphomas, in particular Hodgkin lymphoma
Selected Publications
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Analyses of non-coding somatic drivers in 2,658 cancer whole genomesIn: Nature Vol. 578 (2023) Nr. 7793, pp. 102 - 111Online Full Text: dx.doi.org/
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Author Correction : The evolutionary history of 2,658 cancersIn: Nature Vol. 614 (2023) pp. E42Online Full Text: dx.doi.org/
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Author Correction : Genomic basis for RNA alterations in cancerIn: Nature Vol. 614 (2023) Nr. 7948, pp. E37Online Full Text: dx.doi.org/
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Author Correction : Patterns of somatic structural variation in human cancer genomesIn: Nature Vol. 614 (2023) Nr. 7948, pp. E38Online Full Text: dx.doi.org/ (Open Access)
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Author Correction : Analyses of non-coding somatic drivers in 2,658 cancer whole genomesIn: Nature Vol. 614 (2023) pp. E40Online Full Text: dx.doi.org/ (Open Access)
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Author Correction : Butler enables rapid cloud-based analysis of thousands of human genomesIn: Nature Biotechnology Vol. 41 (2023) Nr. 4, pp. 577Online Full Text: dx.doi.org/
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Author Correction: : The repertoire of mutational signatures in human cancerIn: Nature Vol. 614 (2023) pp. E41Online Full Text: dx.doi.org/ (Open Access)
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Author Correction: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencingIn: Nature Genetics Vol. 55 (2023) Nr. 6, 1076Online Full Text: dx.doi.org/ (Open Access)
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Author Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancersIn: Nature Genetics Vol. 55 (2023) Nr. 6, pp. 1078Online Full Text: dx.doi.org/ (Open Access)
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Author Correction: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancerIn: Nature Genetics Vol. 55 (2023) Nr. 6, pp. 1079Online Full Text: dx.doi.org/ (Open Access)
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Author Correction: Pan-cancer analysis of whole genomesIn: Nature Vol. 614 (2023) Nr. 7948, pp. E39Online Full Text: dx.doi.org/ (Open Access)
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Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotranspositionIn: Nature Genetics Vol. 55 (2023) Nr. 6, 1080Online Full Text: dx.doi.org/ (Open Access)
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Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencingIn: Nature Genetics Vol. 52 (2023) pp. 331 - 341Online Full Text: dx.doi.org/ (Open Access)
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Comprehensive molecular characterization of mitochondrial genomes in human cancersIn: Nature Genetics Vol. 52 (2023) pp. 342 - 352Online Full Text: dx.doi.org/ (Open Access)
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Disruption of chromatin folding domains by somatic genomic rearrangements in human cancerIn: Nature Genetics Vol. 52 (2023) Nr. 3, pp. 294 - 305Online Full Text: dx.doi.org/ (Open Access)
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Genomic basis for RNA alterations in cancerIn: Nature Vol. 578 (2023) Nr. 7793, pp. 129 - 136Online Full Text: dx.doi.org/
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Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotranspositionIn: Nature Genetics Vol. 52 (2023) Nr. 3, pp. 306 - 319Online Full Text: dx.doi.org/ (Open Access)
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Patterns of somatic structural variation in human cancer genomesIn: Nature Vol. 578 (2023) Nr. 7793, pp. 112 - 121Online Full Text: dx.doi.org/
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The landscape of viral associations in human cancersIn: Nature Genetics (2023) Nr. 52, pp. 320 - 330Online Full Text: dx.doi.org/ (Open Access)
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The repertoire of mutational signatures in human cancerIn: Nature Vol. 578 (2023) Nr. 7793, pp. 94 - 101Online Full Text: dx.doi.org/ (Open Access)
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Transcriptional reprogramming by mutated IRF4 in lymphomaIn: Nature Communications Vol. 14 (2023) Nr. 1, 6947Online Full Text: dx.doi.org/ (Open Access)
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Author Correction : Genomic footprints of activated telomere maintenance mechanisms in cancerIn: Nature Communications Vol. 13 (2022) 7574Online Full Text: dx.doi.org/ (Open Access)
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Author Correction : Combined burden and functional impact tests for cancer driver discovery using DriverPowerIn: Nature Communications Vol. 13 (2022) 7571Online Full Text: dx.doi.org/ (Open Access)
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Author Correction : Inferring structural variant cancer cell fractionIn: Nature Communications Vol. 13 (2022) 7568Online Full Text: dx.doi.org/ (Open Access)
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Author Correction : Pathway and network analysis of more than 2500 whole cancer genomesIn: Nature Communications Vol. 13 (2022) 7566Online Full Text: dx.doi.org/ (Open Access)
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Author Correction : Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSigIn: Nature Communications Vol. 13 (2022) 7567Online Full Text: dx.doi.org/ (Open Access)
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Author Correction : Integrative pathway enrichment analysis of multivariate omics dataIn: Nature Communications Vol. 13 (2022) 7570Online Full Text: dx.doi.org/ (Open Access)
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Author Correction : Divergent mutational processes distinguish hypoxic and normoxic tumoursIn: Nature Communications Vol. 13 (2022) 7569Online Full Text: dx.doi.org/ (Open Access)
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Author Correction : High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterationsIn: Nature Communications Vol. 13 (2022) 7572Online Full Text: dx.doi.org/ (Open Access)
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Author Correction : A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patternsIn: Nature Communications Vol. 13 (2022) 7573Online Full Text: dx.doi.org/ (Open Access)
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The Biology of Ocular Adnexal Marginal Zone LymphomasIn: Cancers Vol. 14 (2022) Nr. 5, 1264Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Impact of a faulty germinal center reaction on the pathogenesis of primary diffuse large b cell lymphoma of the central nervous systemIn: Cancers Vol. 13 (2021) Nr. 24, 6334Online Full Text: dx.doi.org/ (Open Access)
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Molecular biology of Hodgkin lymphomaIn: Leukemia Vol. 35 (2021) Nr. 4, pp. 968 - 981Online Full Text: dx.doi.org/ (Open Access)
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Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomasIn: Leukemia Vol. 35 (2021) pp. 2002 - 2016Online Full Text: dx.doi.org/ (Open Access)
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Sugar-modified B-cell receptors in DLBCLIn: Blood Vol. 138 (2021) Nr. 17, pp. 1512 - 1514Online Full Text: dx.doi.org/ (Open Access)
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UMI or not UMI, that is the question for scRNA-seq zero-inflationIn: Nature Biotechnology Vol. 39 (2021) Nr. 2, pp. 158 - 159Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patternsIn: Nature Communications Vol. 11 (2020) 728Online Full Text: dx.doi.org/ (Open Access)
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Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samplesIn: Nature Communications Vol. 11 (2020) Nr. 1, pp. 6232Online Full Text: dx.doi.org/ (Open Access)
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Combined burden and functional impact tests for cancer driver discovery using DriverPowerIn: Nature Communications Vol. 11 (2020) 734Online Full Text: dx.doi.org/ (Open Access)
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Divergent mutational processes distinguish hypoxic and normoxic tumoursIn: Nature Communications Vol. 11 (2020) 737Online Full Text: dx.doi.org/ (Open Access)
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Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypesIn: Blood Vol. 136 (2020) Nr. 12, pp. 1419 - 1432Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Genomic footprints of activated telomere maintenance mechanisms in cancerIn: Nature Communications Vol. 11 (2020) 733Online Full Text: dx.doi.org/ (Open Access)
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High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterationsIn: Nature Communications Vol. 11 (2020) 736Online Full Text: dx.doi.org/ (Open Access)
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Identifying genetic lesions in ocular adnexal extranodal marginal zone lymphomas of the malt subtype by whole genome, whole exome and targeted sequencingIn: Cancers Vol. 12 (2020) Nr. 4, pp. 986Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Inferring structural variant cancer cell fractionIn: Nature Communications Vol. 11 (2020) 730Online Full Text: dx.doi.org/ (Open Access)
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Integrative pathway enrichment analysis of multivariate omics dataIn: Nature Communications Vol. 11 (2020) 735Online Full Text: dx.doi.org/ (Open Access)
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Lymphocyte predominant cells detect Moraxella catarrhalis-derived antigens in nodular lymphocyte-predominant Hodgkin lymphomaIn: Nature Communications Vol. 11 (2020) Nr. 1, pp. 2465Online Full Text: dx.doi.org/ (Open Access)
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Pan-cancer analysis of whole genomesIn: Nature Vol. 578 (2020) Nr. 7793, pp. 82 - 93Online Full Text: dx.doi.org/ (Open Access)
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Pathway and network analysis of more than 2500 whole cancer genomesIn: Nature Communications Vol. 11 (2020) 729Online Full Text: dx.doi.org/ (Open Access)
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Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSigIn: Nature Communications Vol. 11 (2020) 731Online Full Text: dx.doi.org/ (Open Access)
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Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samplesIn: Nature Communications Vol. 11 (2020) Nr. 1, pp. 4748Online Full Text: dx.doi.org/ (Open Access)
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Sex differences in oncogenic mutational processesIn: Nature Communications Vol. 11 (2020) Nr. 1, pp. 4330Online Full Text: dx.doi.org/ (Open Access)
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Fibroblasts in nodular sclerosing classical Hodgkin lymphoma are defined by a specific phenotype and protect tumor cells from brentuximab-Vedotin induced injuryIn: Cancers Vol. 11 (2019) Nr. 11, Article-No: 1687Online Full Text: dx.doi.org/ (Open Access)
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Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphomaIn: Nature Communications Vol. 10 (2019) Nr. 1, pp. 1459Online Full Text: dx.doi.org/ (Open Access)
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MDM4 Is Targeted by 1q Gain and Drives Disease in Burkitt LymphomaIn: Cancer Research Vol. 79 (2019) Nr. 12, pp. 3125 - 3138Online Full Text: dx.doi.org/ (Open Access)
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Migration properties distinguish tumor cells of classical hodgkin lymphoma from anaplastic large cell lymphoma cellsIn: Cancers Vol. 11 (2019) Nr. 10, pp. 1484Online Full Text: dx.doi.org/ (Open Access)
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An oncogenic axis of STAT-mediated BATF3 upregulation causing MYC activity in classical Hodgkin lymphoma and anaplastic large cell lymphomaIn: Leukemia Vol. 32 (2018) Nr. 1, pp. 92 - 101Online Full Text: dx.doi.org/
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Biased IGH VDJ gene repertoire and clonal expansions in B cells of chronically hepatitis C virus–infected individualsIn: Blood Vol. 131 (2018) Nr. 5, pp. 546 - 557Online Full Text: dx.doi.org/ (Open Access)
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Critical influences on the pathogenesis of follicular lymphomaIn: Blood Vol. 131 (2018) Nr. 21, pp. 2297 - 2306Online Full Text: dx.doi.org/ (Open Access)
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IG-MYC⁺ neoplasms with precursor B-cell phenotype are molecularly distinct from Burkitt lymphomasIn: Blood Vol. 132 (2018) Nr. 21, pp. 2280 - 2285Online Full Text: dx.doi.org/ (Open Access)
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DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemiaIn: Nature Genetics Vol. 48 (2016) Nr. 3, pp. 253 - 264Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphomaIn: Blood Vol. 128 (2016) Nr. 23, pp. 2666 - 2670Online Full Text: dx.doi.org/ (Open Access)
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Highly recurrent mutations of SGK1, DUSP2 and JUNB in nodular lymphocyte predominant Hodgkin lymphomaIn: Leukemia Vol. 30 (2016) Nr. 4, pp. 844 - 853Online Full Text: dx.doi.org/
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Human memory B cellsIn: Leukemia Vol. 30 (2016) Nr. 12, pp. 2283 - 2292Online Full Text: dx.doi.org/
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The International Human Epigenome Consortium : A Blueprint for Scientific Collaboration and DiscoveryIn: Cell Vol. 167 (2016) Nr. 5, pp. 1145 - 1149Online Full Text: dx.doi.org/ (Open Access)
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DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional controlIn: Nature Genetics Vol. 47 (2015) Nr. 11, pp. 1316 - 1325Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Genomic and epigenomic co-evolution in follicular lymphomasIn: Leukemia Vol. 29 (2015) Nr. 2, pp. 456 - 463Online Full Text: dx.doi.org/
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Progressive Epigenetic Programming during B Cell Maturation Is Reflected in a Continuum of Epigenetic Disease Phenotypes in Chronic Lymphocytic LeukemiaIn: Blood Vol. 126 (2015) Nr. 23, pp. 2436Online Full Text: dx.doi.org/
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Whole-genome fingerprint of the DNA methylome during human B cell differentiationIn: Nature Genetics Vol. 47 (2015) Nr. 7, pp. 746 - 756Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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A microRNA involved in the germinal center reactionIn: Blood Vol. 124 (2014) Nr. 2, pp. 158 - 159Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphomaIn: Blood Vol. 123 (2014) Nr. 8, pp. 1187 - 1198Online Full Text: dx.doi.org/
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Characterization of the DNA Methylome during Human B-Cell DifferentiationIn: Blood Vol. 124 (2014) Nr. 21, pp. 4346
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Pathogenesis, diagnosis, and treatment of composite lymphomasIn: The Lancet Oncology Vol. 15 (2014) Nr. 10, pp. e435 - 46Online Full Text: dx.doi.org/
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The PRDX2 gene is transcriptionally silenced and de novo methylated in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphomaIn: Blood Vol. 123 (2014) Nr. 23, pp. 3672 - 3674Online Full Text: dx.doi.org/
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Role of early B-cell factor 1 (EBF1) in Hodgkin lymphomaIn: Leukemia Vol. 27 (2013) Nr. 3, pp. 671 - 679Online Full Text: dx.doi.org/
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Analyzing primary Hodgkin and Reed-Sternberg cells to capture the molecular and cellular pathogenesis of classical Hodgkin lymphomaIn: Blood Vol. 120 (2012) Nr. 23, pp. 4609 - 4620Online Full Text: dx.doi.org/
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Array-based DNA methylation analysis in classical Hodgkin lymphoma reveals new insights into the mechanisms underlying silencing of B cell-specific genesIn: Leukemia Vol. 26 (2012) Nr. 1, pp. 185 - 188Online Full Text: dx.doi.org/
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BLUEPRINT to decode the epigenetic signature written in bloodIn: Nature Biotechnology Vol. 30 (2012) Nr. 3, pp. 224 - 226Online Full Text: dx.doi.org/
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Combined SNP Microarray Based Genomic Mapping and Next Generation Transcriptome Sequencing Confirms the Presence of Somatic STAT3 Mutations and Identifies Novel Chromosomal Imbalances and Candidate Genes in T Large Granular Lymphocytic Leukemia (T-LGL)In: Blood Vol. 120 (2012) Nr. 21, pp. 3512Online Full Text: dx.doi.org/
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Dysregulation of global microRNA expression in splenic marginal zone lymphoma and influence of chronic hepatitis C virus infectionIn: Leukemia Vol. 26 (2012) Nr. 7, pp. 1654 - 1662Online Full Text: dx.doi.org/
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Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencingIn: Nature Genetics Vol. 44 (2012) Nr. 12, pp. 1316 - 1320Online Full Text: dx.doi.org/
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CCR7 & lymphotoxin in lymphoma nicheIn: Blood Vol. 118 (2011) Nr. 4, pp. 831 - 832Online Full Text: dx.doi.org/
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Modern concepts in the biology, diagnosis, differential diagnosis and treatment of primary central nervous system lymphomaIn: Leukemia Vol. 25 (2011) Nr. 12, pp. 1797 - 1807Online Full Text: dx.doi.org/
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NPAT mutations in Hodgkin lymphomaIn: Blood Vol. 118 (2011) Nr. 3, pp. 484 - 485Online Full Text: dx.doi.org/
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Translocations activating IRF4 identify a subtype of germinal center-derived B-cell lymphoma affecting predominantly children and young adultsIn: Blood Vol. 118 (2011) Nr. 1, pp. 139 - 147Online Full Text: dx.doi.org/
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From pathogenesis to treatment of chronic lymphocytic leukaemiaIn: Nature Reviews Cancer Vol. 10 (2010) Nr. 1, pp. 37 - 50Online Full Text: dx.doi.org/
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Genomic imbalances in Hodgkin lymphomaIn: Blood Vol. 116 (2010) Nr. 3, pp. 309 - 311Online Full Text: dx.doi.org/ (Open Access)
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Mechanisms of aberrant GATA3 expression in classical Hodgkin lymphoma and its consequences for the cytokine profile of Hodgkin and Reed/Sternberg cellsIn: Blood Vol. 116 (2010) Nr. 20, pp. 4202 - 4211Online Full Text: dx.doi.org/ (Open Access)
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Mutations of CARD11 but not TNFAIP3 may activate the NF-κB pathway in primary CNS lymphomaIn: Acta Neuropathologica Vol. 120 (2010) Nr. 4, pp. 529 - 535Online Full Text: dx.doi.org/
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The prognostic significance of soluble NKG2D ligands in B-cell chronic lymphocytic leukemiaIn: Leukemia Vol. 24 (2010) Nr. 6, pp. 1152 - 1159Online Full Text: dx.doi.org/