ZMB Member Ralf Küppers

ZMB Member
Ralf Küppers

Next ZMB-Member
Ralf Küppers portrait
© UKE/Küppers

Prof. Dr. Ralf Küppers

Director of:

Institute of Cell Biology (Tumor Research)

University Hospital Essen
Virchowstr. 173
45122 Essen

Research Overview

B lymphocytes represent the white blood cells that produce antibodies and that play an important role in immune responses against foreign antigens (e.g. bacteria). In rare instances, B lymphocytes may undergo malignant transformation and become tumour cells. Such tumours are called B cell lymphomas or leukemias. The main research topics of the group are:

  • Investigation of B cell differentiation and function in the human
  • The interplay of B cells with viruses (EBV, HCV, HIV)
  • Pathogenesis of human B cell lymphomas, in particular Hodgkin lymphoma

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Selected Publications

    Journal articles

  • Weischenfeldt, Joachim; Beroukhim, Rameen; Martincorena, Iñigo; Küppers, Ralf; Schadendorf, Dirk
    Analyses of non-coding somatic drivers in 2,658 cancer whole genomes
    In: Nature Vol. 578 (2023) Nr. 7793, pp. 102 - 111
    Online Full Text: dx.doi.org/
  • Weischenfeldt, Joachim; Beroukhim, Rameen; Campbell, Peter J.; Küppers, Ralf; Schadendorf, Dirk
    Author Correction : Patterns of somatic structural variation in human cancer genomes
    In: Nature Vol. 614 (2023) Nr. 7948, pp. E38
    Online Full Text: dx.doi.org/ (Open Access)
  • Calabrese, Claudia; Brazma, Alvis; Brooks, Angela N.; Rätsch, Gunnar; Küppers, Ralf; Schadendorf, Dirk
    Author Correction : Genomic basis for RNA alterations in cancer
    In: Nature Vol. 614 (2023) Nr. 7948, pp. E37
    Online Full Text: dx.doi.org/
  • Gerstung, Moritz; Jolly, Clemency; Leshchiner, Ignaty; Küppers, Ralf; Schadendorf, Dirk
    Author Correction : The evolutionary history of 2,658 cancers
    In: Nature Vol. 614 (2023) pp. E42
    Online Full Text: dx.doi.org/
  • Weischenfeldt, Joachim; Beroukhim, Rameen; Martincorena, Iñigo; Küppers, Ralf
    Author Correction : Analyses of non-coding somatic drivers in 2,658 cancer whole genomes
    In: Nature Vol. 614 (2023) pp. E40
    Online Full Text: dx.doi.org/ (Open Access)
  • Yakneen, Sergei; M. Waszak, Sebastian; Korbel, Jan O.; Küppers, Ralf; Schadendorf, Dirk
    Author Correction : Butler enables rapid cloud-based analysis of thousands of human genomes
    In: Nature Biotechnology Vol. 41 (2023) Nr. 4, pp. 577
    Online Full Text: dx.doi.org/
  • Alexandrov, Ludmil B.; Kim, Jaegil; Haradhvala, Nicholas J.; Rozen, Steven G.; Stratton, Michael R.; Küppers, Ralf; Schadendorf, Dirk
    Author Correction: : The repertoire of mutational signatures in human cancer
    In: Nature Vol. 614 (2023) pp. E41
    Online Full Text: dx.doi.org/ (Open Access)
  • Cortés-Ciriano, Isidro; Küppers, Ralf; Schadendorf, Dirk; Park, Peter J.
    Author Correction: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing
    In: Nature Genetics Vol. 55 (2023) Nr. 6, 1076
    Online Full Text: dx.doi.org/ (Open Access)
  • Yuan, Yuan; Küppers, Ralf; Schadendorf, Dirk; Park, Keunchil; Campbell, Peter J.; Liang, Han
    Author Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers
    In: Nature Genetics Vol. 55 (2023) Nr. 6, pp. 1078
    Online Full Text: dx.doi.org/ (Open Access)
  • Akdemir, Kadir C.; Küppers, Ralf; Schadendorf, Dirk; Futreal, P. Andrew
    Author Correction: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer
    In: Nature Genetics Vol. 55 (2023) Nr. 6, pp. 1079
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium, et.al.
    Author Correction: Pan-cancer analysis of whole genomes
    In: Nature Vol. 614 (2023) Nr. 7948, pp. E39
    Online Full Text: dx.doi.org/ (Open Access)
  • Rodriguez-Martin, Bernardo; Schadendorf, Dirk; Küppers, Ralf; Campbell, Peter J.
    Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition
    In: Nature Genetics Vol. 55 (2023) Nr. 6, 1080
    Online Full Text: dx.doi.org/ (Open Access)
  • Cortés-Ciriano, Isidro; Küppers, Ralf; Schadendorf, Dirk; Park, Peter J.
    Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing
    In: Nature Genetics Vol. 52 (2023) pp. 331 - 341
    Online Full Text: dx.doi.org/ (Open Access)
  • Yuan, Yuan; Küppers, Ralf; Schadendorf, Dirk; Park, Keunchil; Campbell, Peter J.; Liang, Han
    Comprehensive molecular characterization of mitochondrial genomes in human cancers
    In: Nature Genetics Vol. 52 (2023) pp. 342 - 352
    Online Full Text: dx.doi.org/ (Open Access)
  • Akdemir, Kadir C.; Küppers, Ralf; Schadendorf, Dirk; Futreal, P. Andrew
    Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer
    In: Nature Genetics Vol. 52 (2023) Nr. 3, pp. 294 - 305
    Online Full Text: dx.doi.org/ (Open Access)
  • Calabrese, Claudia; Brazma, Alvis; Brooks, Angela N.; Rätsch, Gunnar; Küppers, Ralf; Schadendorf, Dirk
    Genomic basis for RNA alterations in cancer
    In: Nature Vol. 578 (2023) Nr. 7793, pp. 129 - 136
    Online Full Text: dx.doi.org/
  • Rodriguez-Martin, Bernardo; Schadendorf, Dirk; Küppers, Ralf; Campbell, Peter J.
    Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition
    In: Nature Genetics Vol. 52 (2023) Nr. 3, pp. 306 - 319
    Online Full Text: dx.doi.org/ (Open Access)
  • Weischenfeldt, Joachim; Beroukhim, Rameen; Campbell, Peter J.; Küppers, Ralf; Schadendorf, Dirk
    Patterns of somatic structural variation in human cancer genomes
    In: Nature Vol. 578 (2023) Nr. 7793, pp. 112 - 121
    Online Full Text: dx.doi.org/
  • Zapatka, Marc; Küppers, Ralf; Schadendorf, Dirk; Lichter, Peter
    The landscape of viral associations in human cancers
    In: Nature Genetics (2023) Nr. 52, pp. 320 - 330
    Online Full Text: dx.doi.org/ (Open Access)
  • Alexandrov, Ludmil B.; Kim, Jaegil; Haradhvala, Nicholas J.; Rozen, Steven G.; Stratton, Michael R.; Küppers, Ralf; Schadendorf, Dirk
    The repertoire of mutational signatures in human cancer
    In: Nature Vol. 578 (2023) Nr. 7793, pp. 94 - 101
    Online Full Text: dx.doi.org/ (Open Access)
  • Schleussner, Nikolai; Cauchy, Pierre; Franke, Vedran; Giefing, Maciej; Fornes, Oriol; Vankadari, Naveen; Assi, Salam A.; Costanza, Mariantonia; Weniger, Marc A.; Akalin, Altuna; Anagnostopoulos, Ioannis; Bukur, Thomas; Casarotto, Marco G.; Damm, Frederik; Daumke, Oliver; Edginton-White, Benjamin; Gebhardt, J. Christof M.; Grau, Michael; Grunwald, Stephan; Hansmann, Martin-Leo; Hartmann, Sylvia; Huber, Lionel; Kärgel, Eva; Lusatis, Simone; Noerenberg, Daniel; Obier, Nadine; Pannicke, Ulrich; Fischer, Anja; Reisser, Anja; Rosenwald, Andreas; Schwarz, Klaus; Sundararaj, Srinivasan; Weilemann, Andre; Winkler, Wiebke; Xu, Wendan; Lenz, Georg; Rajewsky, Klaus; Wasserman, Wyeth W.; Cockerill, Peter N.; Scheidereit, Claus; Siebert, Reiner; Küppers, Ralf; Grosschedl, Rudolf; Janz, Martin; Bonifer, Constanze; Mathas, Stephan
    Transcriptional reprogramming by mutated IRF4 in lymphoma
    In: Nature Communications Vol. 14 (2023) Nr. 1, 6947
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Reimand, Jüri; PCAWG Drivers and Functional Interpretation Working Group; PCAWG Consortium
    Author Correction : Integrative pathway enrichment analysis of multivariate omics data
    In: Nature Communications Vol. 13 (2022) 7570
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Feuerbach, Lars; PCAWG Consortium
    Author Correction : Genomic footprints of activated telomere maintenance mechanisms in cancer
    In: Nature Communications Vol. 13 (2022) 7574
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Macintyre, Geoff; PCAWG Consortium
    Author Correction : Inferring structural variant cancer cell fraction
    In: Nature Communications Vol. 13 (2022) 7568
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Stein, Lincoln D.; PCAWG Consortium
    Author Correction : A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns
    In: Nature Communications Vol. 13 (2022) 7573
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Bristow, Robert G.; Boutros, Paul C.; PCAWG Consortium
    Author Correction : Divergent mutational processes distinguish hypoxic and normoxic tumours
    In: Nature Communications Vol. 13 (2022) 7569
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Shuai, Shimin; Stein, Lincoln D.; PCAWG Drivers and Functional Interpretation Working Group; PCAWG Consortium
    Author Correction : Combined burden and functional impact tests for cancer driver discovery using DriverPower
    In: Nature Communications Vol. 13 (2022) 7571
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Creighton, Chad J.; PCAWG Consortium
    Author Correction : High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations
    In: Nature Communications Vol. 13 (2022) 7572
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Reimand, Jüri; PCAWG Consortium
    Author Correction : Pathway and network analysis of more than 2500 whole cancer genomes
    In: Nature Communications Vol. 13 (2022) 7566
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Morris, Quaid D.; PCAWG Consortium
    Author Correction : Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig
    In: Nature Communications Vol. 13 (2022) 7567
    Online Full Text: dx.doi.org/ (Open Access)
  • Johansson, Patricia; Eckstein, Anja; Küppers, Ralf
    The Biology of Ocular Adnexal Marginal Zone Lymphomas
    In: Cancers Vol. 14 (2022) Nr. 5, 1264
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Montesinos-Rongen, Manuel; Brunn, Anna; Sanchez-Ruiz, Monica; Küppers, Ralf; Siebert, Reiner; Deckert, Martina
    Impact of a faulty germinal center reaction on the pathogenesis of primary diffuse large b cell lymphoma of the central nervous system
    In: Cancers Vol. 13 (2021) Nr. 24, 6334
    Online Full Text: dx.doi.org/ (Open Access)
  • Weniger, Marc; Küppers, Ralf
    Molecular biology of Hodgkin lymphoma
    In: Leukemia Vol. 35 (2021) Nr. 4, pp. 968 - 981
    Online Full Text: dx.doi.org/ (Open Access)
  • Hübschmann, Daniel; Kleinheinz, Kortine; Wagener, Rabea; Bernhart, Stephan H.; López, Cristina; Toprak, Umut H.; Sungalee, Stephanie; Ishaque, Naveed; Kretzmer, Helene; Kreuz, Markus; Waszak, Sebastian M.; Paramasivam, Nagarajan; Ammerpohl, Ole; Aukema, Sietse M.; Beekman, Renée; Bergmann, Anke K.; Bieg, Matthias; Binder, Hans; Borkhardt, Arndt; Borst, Christoph; Brors, Benedikt; Bruns, Philipp; Carrillo de Santa Pau, Enrique; Claviez, Alexander; Doose, Gero; Haake, Andrea; Karsch, Dennis; Haas, Siegfried; Hansmann, Martin-Leo; Hoell, Jessica I.; Hovestadt, Volker; Huang, Bingding; Hummel, Michael; Jäger-Schmidt, Christina; Kerssemakers, Jules N. A.; Korbel, Jan O.; Kube, Dieter; Lawerenz, Chris; Lenze, Dido; Martens, Joost H. A.; Ott, German; Radlwimmer, Bernhard; Reisinger, Eva; Richter, Julia; Rico, Daniel; Rosenstiel, Philip; Rosenwald, Andreas; Schillhabel, Markus; Stilgenbauer, Stephan; Stadler, Peter F.; Martín-Subero, José I.; Szczepanowski, Monika; Warsow, Gregor; Weniger, Marc; Zapatka, Marc; Valencia, Alfonso; Stunnenberg, Hendrik G.; Lichter, Peter; Möller, Peter; Loeffler, Markus; Eils, Roland; Klapper, Wolfram; Hoffmann, Steve; Trümper, Lorenz; Küppers, Ralf; Schlesner, Matthias; Siebert, Reiner
    Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas
    In: Leukemia Vol. 35 (2021) pp. 2002 - 2016
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf
    Sugar-modified B-cell receptors in DLBCL
    In: Blood Vol. 138 (2021) Nr. 17, pp. 1512 - 1514
    Online Full Text: dx.doi.org/ (Open Access)
  • Cao, Yingying; Kitanovski, Simo; Küppers, Ralf; Hoffmann, Daniel
    UMI or not UMI, that is the question for scRNA-seq zero-inflation
    In: Nature Biotechnology Vol. 39 (2021) Nr. 2, pp. 158 - 159
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Stein, Lincoln D.; PCAWG Consortium
    A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns
    In: Nature Communications Vol. 11 (2020) 728
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk
    Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
    In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 6232
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Shuai, Shimin; Stein, Lincoln D.
    Combined burden and functional impact tests for cancer driver discovery using DriverPower
    In: Nature Communications Vol. 11 (2020) 734
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Bristow, Robert G.; Boutros, Paul C.; PCAWG Consortium
    Divergent mutational processes distinguish hypoxic and normoxic tumours
    In: Nature Communications Vol. 11 (2020) 737
    Online Full Text: dx.doi.org/ (Open Access)
  • Nadeu, Ferran; Martin-Garcia, David; Clot, Guillem; Díaz-Navarro, Ander; Duran-Ferrer, Martí; Navarro, Alba; Vilarrasa-Blasi, Roser; Kulis, Marta; Royo, Romina; Gutiérrez-Abril, Jesús; Valdés-Mas, Rafael; López, Cristina; Chapaprieta, Vicente; Puiggros, Montserrat; Castellano, Giancarlo; Costa, Dolors; Aymerich, Marta; Jares, Pedro; Espinet, Blanca; Muntañola, Ana; Ribera-Cortada, Inmaculada; Siebert, Reiner; Colomer, Dolors; Torrents, David; Gine, Eva; López-Guillermo, Armando; Küppers, Ralf; Martin-Subero, Jose I.; Puente, Xose S.; Beà, Sílvia; Campo, Elias
    Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypes
    In: Blood Vol. 136 (2020) Nr. 12, pp. 1419 - 1432
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Feuerbach, Lars; PCAWG Consortium
    Genomic footprints of activated telomere maintenance mechanisms in cancer
    In: Nature Communications Vol. 11 (2020) 733
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Creighton, Chad J.; PCAWG Consortium
    High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations
    In: Nature Communications Vol. 11 (2020) 736
    Online Full Text: dx.doi.org/ (Open Access)
  • Johansson, Patricia; Klein-Hitpaß, Ludger; Budeus, Bettina; Kuhn, Matthias; Lauber, Chris; Seifert, Michael; Roeder, Ingo; Pförtner, Roman; Stuschke, Martin; Dührsen, Ulrich; Eckstein, Anja; Dürig, Jan; Küppers, Ralf
    Identifying genetic lesions in ocular adnexal extranodal marginal zone lymphomas of the malt subtype by whole genome, whole exome and targeted sequencing
    In: Cancers Vol. 12 (2020) Nr. 4, pp. 986
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Cmero, Marek; Macintyre, Geoff; PCAWG Consortium
    Inferring structural variant cancer cell fraction
    In: Nature Communications Vol. 11 (2020) 730
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Reimand, Jüri; PCAWG Drivers and Functional Interpretation Working Group; PCAWG Consortium
    Integrative pathway enrichment analysis of multivariate omics data
    In: Nature Communications Vol. 11 (2020) 735
    Online Full Text: dx.doi.org/ (Open Access)
  • Thurner, Lorenz; Hartmann, Sylvia; Fadle, Natalie; Regitz, Evi; Kemele, Maria; Kim, Yoo-Jin; Bohle, Rainer Maria; Nimmesgern, Anna; von Müller, Lutz; Kempf, Volkhard A. J.; Weniger, Marc; Neumann, Frank; Schneider, Nadine; Vornanen, Martine; Sundström, Christer; de Leval, Laurence; Engert, Andreas; Eichenauer, Dennis A.; Küppers, Ralf; Preuss, Klaus-Dieter; Hansmann, Martin-Leo; Pfreundschuh, Michael
    Lymphocyte predominant cells detect Moraxella catarrhalis-derived antigens in nodular lymphocyte-predominant Hodgkin lymphoma
    In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 2465
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium; et al.
    Pan-cancer analysis of whole genomes
    In: Nature Vol. 578 (2020) Nr. 7793, pp. 82 - 93
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk
    Pathway and network analysis of more than 2500 whole cancer genomes
    In: Nature Communications Vol. 11 (2020) 729
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; Morris, Quaid D.; PCAWG Consortium
    Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig
    In: Nature Communications Vol. 11 (2020) 731
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk
    Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
    In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 4748
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Schadendorf, Dirk; PCAWG Tumour Subtypes and Clinical Translation; PCAWG Consortium
    Sex differences in oncogenic mutational processes
    In: Nature Communications Vol. 11 (2020) Nr. 1, pp. 4330
    Online Full Text: dx.doi.org/ (Open Access)
  • Bankov, Katrin; Döring, Claudia; Ustaszewski, Adam; Giefing, Maciej; Herling, Marco; Cencioni, Chiara; Spallotta, Francesco; Gaetano, Carlo; Küppers, Ralf; Hansmann, Martin-Leo; Hartmann, Sylvia
    Fibroblasts in nodular sclerosing classical Hodgkin lymphoma are defined by a specific phenotype and protect tumor cells from brentuximab-Vedotin induced injury
    In: Cancers Vol. 11 (2019) Nr. 11, Article-No: 1687
    Online Full Text: dx.doi.org/ (Open Access)
  • López, Cristina; Kleinheinz, Kortine; Aukema, Sietse M.; Rohde, Marius; Bernhart, Stephan H.; Hübschmann, Daniel; Wagener, Rabea; Toprak, Umut H.; Raimondi, Francesco; Kreuz, Markus; Waszak, Sebastian M.; Huang, Zhiqin; Sieverling, Lina; Paramasivam, Nagarajan; Seufert, Julian; Sungalee, Stephanie; Russell, Robert B.; Bausinger, Julia; Kretzmer, Helene; Ammerpohl, Ole; Bergmann, Anke K.; Binder, Hans; Borkhardt, Arndt; Brors, Benedikt; Claviez, Alexander; Doose, Gero; Feuerbach, Lars; Haake, Andrea; Hansmann, Martin-Leo; Hoell, Jessica; Hummel, Michael; Korbel, Jan O.; Lawerenz, Chris; Lenze, Dido; Radlwimmer, Bernhard; Richter, Julia; Rosenstiel, Philip; Rosenwald, Andreas; Schilhabel, Markus B.; Stein, Harald; Stilgenbauer, Stephan; Stadler, Peter F.; Szczepanowski, Monika; Weniger, Marc; Zapatka, Marc; Eils, Roland; Lichter, Peter; Loeffler, Markus; Möller, Peter; Trümper, Lorenz; Klapper, Wolfram; Wagner, Susanne; Richter, Gesine; Eils, Jürgen; Kerssemakers, Jules; Jaeger-Schmidt, Christina; Scholz, Ingrid; Borst, Christoph; Braulke, Friederike; Dreyling, Martin; Eberth, Sonja; Einsele, Hermann; Frickhofen, Norbert; Haas, Siegfried; Karsch, Dennis; Klepl, Nicole; Kneba, Michael; Lisfeld, Jasmin; Mantovani-Löffler, Luisa; Ott, German; Stadler, Christina; Staib, Peter; Zenz, Thorsten; Kube, Dieter; Kostezka, Ulrike; Binder, Vera; Leich, Ellen; Nagel, Inga; Pischimariov, Jordan; Schreiber, Stefan; Vater, Inga; Hopp, Lydia; Langenberger, David; Rosolowski, Maciej; Hoffmann, Steve; Küppers, Ralf; Burkhardt, Birgit; Schlesner, Matthias; Siebert, Reiner
    Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma
    In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 1459
    Online Full Text: dx.doi.org/ (Open Access)
  • Hüllein, Jennifer; Słabicki, Mikołaj; Rosolowski, Maciej; Jethwa, Alexander; Habringer, Stefan; Tomska, Katarzyna; Kurilov, Roma; Lu, Junyan; Scheinost, Sebastian; Wagener, Rabea; Huang, Zhiqin; Lukas, Marina; Yavorska, Olena; Helfrich, Hanne; Scholtysik, René; Bonneau, Kyle; Tedesco, Donato; Küppers, Ralf; Klapper, Wolfram; Pott, Christiane; Stilgenbauer, Stephan; Burkhardt, Birgit; Löffler, Markus; Trümper, Lorenz H.; Hummel, Michael; Brors, Benedikt; Zapatka, Marc; Siebert, Reiner; Kreuz, Markus; Keller, Ulrich; Huber, Wolfgang; Zenz, Thorsten
    MDM4 Is Targeted by 1q Gain and Drives Disease in Burkitt Lymphoma
    In: Cancer Research Vol. 79 (2019) Nr. 12, pp. 3125 - 3138
    Online Full Text: dx.doi.org/ (Open Access)
  • Goncharova, Olga; Flinner, Nadine; Bein, Julia; Döring, Claudia; Donnadieu, Emmanuel; Rikirsch, Sandy; Herling, Marco; Küppers, Ralf; Hansmann, Martin-Leo; Hartmann, Sylvia
    Migration properties distinguish tumor cells of classical hodgkin lymphoma from anaplastic large cell lymphoma cells
    In: Cancers Vol. 11 (2019) Nr. 10, pp. 1484
    Online Full Text: dx.doi.org/ (Open Access)
  • Lollies, Anna; Hartmann, Sylvia; Schneider, Markus; Bracht, Thilo; Weiß, A.L.; Arnolds, Judith; Klein-Hitpaß, Ludger; Sitek, Barbara; Hansmann, Martin Leo; Küppers, Ralf; Weniger, Marc
    An oncogenic axis of STAT-mediated BATF3 upregulation causing MYC activity in classical Hodgkin lymphoma and anaplastic large cell lymphoma
    In: Leukemia Vol. 32 (2018) Nr. 1, pp. 92 - 101
    Online Full Text: dx.doi.org/
  • Tucci, Felicia A.; Kitanovski, Simo; Johansson, Patricia; Klein-Hitpaß, Ludger; Kahraman, Alisan; Dürig, Jan; Hoffmann, Daniel; Küppers, Ralf
    Biased IGH VDJ gene repertoire and clonal expansions in B cells of chronically hepatitis C virus–infected individuals
    In: Blood Vol. 131 (2018) Nr. 5, pp. 546 - 557
    Online Full Text: dx.doi.org/ (Open Access)
  • Küppers, Ralf; Stevenson, Freda K.
    Critical influences on the pathogenesis of follicular lymphoma
    In: Blood Vol. 131 (2018) Nr. 21, pp. 2297 - 2306
    Online Full Text: dx.doi.org/ (Open Access)
  • Wagener, Rabea; López, Cristina; Kleinheinz, Kortine; Bausinger, Julia; Aukema, Sietse M.; Nagel, Inga; Toprak, Umut H.; Seufert, Julian; Altmüller, Janine; Thiele, Holger; Schneider, Christof; Kolarova, Julia; Park, Jeongbin; Hübschmann, Daniel; Murga Penas, Eva M.; Drexler, Hans G.; Attarbaschi, Andishe; Hovland, Randi; Kjeldsen, Eigil; Kneba, Michael; Kontny, Udo; de Leval, Laurence; Nürnberg, Peter; Oschlies, Ilske; Oscier, David; Schlegelberger, Brigitte; Stilgenbauer, Stephan; Wössmann, Wilhelm; Schlesner, Matthias; Burkhardt, Birgit; Klapper, Wolfram; Jaffe, Elaine S.; Küppers, Ralf; Siebert, Reiner
    IG-MYC⁺ neoplasms with precursor B-cell phenotype are molecularly distinct from Burkitt lymphomas
    In: Blood Vol. 132 (2018) Nr. 21, pp. 2280 - 2285
    Online Full Text: dx.doi.org/ (Open Access)
  • Oakes, Christopher C; Seifert, Marc; Assenov, Yassen; Gu, Lei; Przekopowitz, Martina; Ruppert, Amy S; Wang, Qi; Imbusch, Charles D; Serva, Andrius; Koser, Sandra D; Brocks, David; Lipka, Daniel B; Bogatyrova, Olga; Weichenhan, Dieter; Brors, Benedikt; Rassenti, Laura; Kipps, Thomas J; Mertens, Daniel; Zapatka, Marc; Lichter, Peter; Döhner, Hartmut; Küppers, Ralf; Zenz, Thorsten; Stilgenbauer, Stephan; Byrd, John C; Plass, Christoph
    DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia
    In: Nature Genetics Vol. 48 (2016) Nr. 3, pp. 253 - 264
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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    Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma
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    Highly recurrent mutations of SGK1, DUSP2 and JUNB in nodular lymphocyte predominant Hodgkin lymphoma
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    Human memory B cells
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    The International Human Epigenome Consortium : A Blueprint for Scientific Collaboration and Discovery
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    DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control
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    Genomic and epigenomic co-evolution in follicular lymphomas
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    Progressive Epigenetic Programming during B Cell Maturation Is Reflected in a Continuum of Epigenetic Disease Phenotypes in Chronic Lymphocytic Leukemia
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    Whole-genome fingerprint of the DNA methylome during human B cell differentiation
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    A microRNA involved in the germinal center reaction
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    A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphoma
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    Characterization of the DNA Methylome during Human B-Cell Differentiation
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    Pathogenesis, diagnosis, and treatment of composite lymphomas
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    The PRDX2 gene is transcriptionally silenced and de novo methylated in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma
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    Role of early B-cell factor 1 (EBF1) in Hodgkin lymphoma
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    Analyzing primary Hodgkin and Reed-Sternberg cells to capture the molecular and cellular pathogenesis of classical Hodgkin lymphoma
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    Array-based DNA methylation analysis in classical Hodgkin lymphoma reveals new insights into the mechanisms underlying silencing of B cell-specific genes
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    BLUEPRINT to decode the epigenetic signature written in blood
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    Combined SNP Microarray Based Genomic Mapping and Next Generation Transcriptome Sequencing Confirms the Presence of Somatic STAT3 Mutations and Identifies Novel Chromosomal Imbalances and Candidate Genes in T Large Granular Lymphocytic Leukemia (T-LGL)
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    Dysregulation of global microRNA expression in splenic marginal zone lymphoma and influence of chronic hepatitis C virus infection
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    Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing
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    CCR7 & lymphotoxin in lymphoma niche
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    Modern concepts in the biology, diagnosis, differential diagnosis and treatment of primary central nervous system lymphoma
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    NPAT mutations in Hodgkin lymphoma
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    Translocations activating IRF4 identify a subtype of germinal center-derived B-cell lymphoma affecting predominantly children and young adults
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  • Zenz, Thorsten; Mertens, Daniel; Küppers, Ralf; Döhner, Hartmut; Stilgenbauer, Stephan
    From pathogenesis to treatment of chronic lymphocytic leukaemia
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    Genomic imbalances in Hodgkin lymphoma
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  • Stanelle, Jens; Döring, Claudia; Hansmann, Martin-Leo; Küppers, Ralf
    Mechanisms of aberrant GATA3 expression in classical Hodgkin lymphoma and its consequences for the cytokine profile of Hodgkin and Reed/Sternberg cells
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  • Montesinos-Rongen, Manuel; Schmitz, Roland; Brunn, Anna; Gesk, Stefan; Richter, Julia; Hong, Ke; Wiestler, Otmar D.; Siebert, Reiner; Küppers, Ralf; Deckert, Martina
    Mutations of CARD11 but not TNFAIP3 may activate the NF-κB pathway in primary CNS lymphoma
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  • Nückel, Holger; Switala, Magdalena; Sellmann, Ludger; Horn, Peter; Dürig, Jan; Dührsen, Ulrich; Küppers, Ralf; Grosse-Wilde, Hans; Rebmann, Vera
    The prognostic significance of soluble NKG2D ligands in B-cell chronic lymphocytic leukemia
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