ZMB Member Karl Sebastian Lang
ZMB Member
Karl Sebastian Lang
Next ZMB-Member
Prof. Dr. Karl Sebastian Lang
Director of:
Institute of Immunology
University Hospital Essen
Hufelandstr. 55
45122 Essen
- +49 201 723 4273
- Website
- Selected Publications
- Publication Metrics
- ZMB Research Program
Immunology, Infectious Diseases and Transplantation
Research Overview
The group of Prof. Lang studies molecular and cellular immunological mechanisms which can influence the outcome of human disease. This includes immunopathology occurring during autoimmune disease, infectious disease, tumor disease and transplantation. Mainly immunological models are used for these studies.
The following models are currently used:
- Lmphocytic choriomeningitis virus (LCMV)
- Vesicular stomatitis Virus (VSV)
- Listeria monocytogenes
- RIP-GP model (Autoimmune diabetes)
- B16 melanoma model
Selected Publications
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BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor MicroenvironmentIn: Cancer Research Vol. 82 (2022) Nr. 2, pp. 264 - 277Online Full Text: dx.doi.org/ (Open Access)
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Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expressionIn: Nature Communications Vol. 13 (2022) Nr. 1, 156Online Full Text: dx.doi.org/ (Open Access)
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Protein Signatures of NK Cell–Mediated Melanoma Killing Predict Response to ImmunotherapiesIn: Cancer Research Vol. 81 (2021) Nr. 21, pp. 5540 - 5554Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus controlIn: Journal of Hepatology Vol. 72 (2020) Nr. 5, pp. 960 - 975Online Full Text: dx.doi.org/ (Open Access)
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Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injuryIn: Gut Vol. 69 (2020) Nr. 1, pp. 133 - 145Online Full Text: dx.doi.org/ (Open Access)
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Publisher Correction: Tumor-necrosis factor impairs CD4⁺ T cell–mediated immunological control in chronic viral infectionIn: Nature Immunology Vol. 21 (2020) Nr. 9, pp. 1135Online Full Text: dx.doi.org/ (Open Access)
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Reply [Letter to the Editor: Characterization of CD169+ Macrophages in Liver Regeneration: Tissue Distribution and Fate?]In: Hepatology Vol. 70 (2019) Nr. 3, pp. 1074 - 1075Online Full Text: dx.doi.org/ (Open Access)
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B Cell-Mediated Maintenance of Cluster of Differentiation 169–Positive Cells Is Critical for Liver RegenerationIn: Hepatology Vol. 68 (2018) Nr. 6, pp. 2348 - 2361Online Full Text: dx.doi.org/ (Open Access)
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CEACAM1 promotes CD8⁺ T cell responses and improves control of a chronic viral infectionIn: Nature Communications Vol. 9 (2018) 2561Online Full Text: dx.doi.org/ (Open Access)
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Carcinoembryonic antigen-related cell adhesion molecule 1 controls IL-2-dependent regulatory T-cell induction in immune-mediated hepatitis in miceIn: Hepatology Vol. 68 (2018) Nr. 1, pp. 200 - 214Online Full Text: dx.doi.org/
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Spatiotemporally restricted arenavirus replication induces immune surveillance and type i interferon-dependent tumour regressionIn: Nature Communications Vol. 8 (2017) pp. 14447Online Full Text: dx.doi.org/ (Open Access)
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Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infectionIn: Nature Immunology Vol. 17 (2016) Nr. 5, pp. 593 - 603Online Full Text: dx.doi.org/
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CEACAM1 induces B-cell survival and is essential for protective antiviral antibody productionIn: Nature Communications (2015) Nr. 6, pp. 6217Online Full Text: dx.doi.org/ (Open Access)
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Conjugated Bilirubin Triggers Anemia by Inducing Erythrocyte DeathIn: Hepatology Vol. 61 (2015) Nr. 1, pp. 275 - 284Online Full Text: dx.doi.org/ (Open Access)
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Immediate utility of two approved agents to target both the metabolic mevalonate pathway and its restorative feedback loopIn: Cancer Research Vol. 74 (2014) Nr. 17, pp. 4772 - 4782Online Full Text: dx.doi.org/
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Antiapoptotic function of Toso (Faim3) in death receptor signalingIn: Blood Vol. 119 (2012) Nr. 7, pp. 1790 - 1791Online Full Text: dx.doi.org/
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B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in miceIn: Blood Vol. 119 (2012) Nr. 12, pp. 2819 - 2828Online Full Text: dx.doi.org/
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Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virusIn: Nature Immunology Vol. 13 (2012) Nr. 1, pp. 51 - 57Online Full Text: dx.doi.org/
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iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPSIn: Science Vol. 335 (2012) Nr. 6065, pp. 229 - 232Online Full Text: dx.doi.org/
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IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathologyIn: Cell Vol. 144 (2011) Nr. 4, pp. 601 - 613Online Full Text: dx.doi.org/ (Open Access)
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Toso regulates the balance between apoptotic and nonapoptotic death receptor signaling by facilitating RIP1 ubiquitinationIn: Blood Vol. 118 (2011) Nr. 3, pp. 598 - 608Online Full Text: dx.doi.org/