ZMB Member Elisabeth Littwitz-Salomon

ZMB Member
Elisabeth Littwitz-Salomon

Next Member
Elisabeth Littwitz-Salomon
© E. Littwitz-Salomon

Jun.-Prof. Dr. Elisabeth Littwitz-Salomon

Group

Immune Metabolism in Infection and Cancer

Institute for The Research on HIV and AIDS-associated Diseases
University Hospital Essen
Robert Koch Haus 179
45147 Essen

Research Overview

Despite intensive research, the cure of infections with retroviruses, e.g. the immunodeficiency virus (HIV), is still impossible with the strategies currently used. New ways of strengthening the body's own immunity and improving antiviral functions are therefore of outstanding interest. Natural killer (NK) cells are an important cell type of innate immunity that fights infection until adaptive immunity takes over. For their activity, NK cells undergo metabolic reprogramming to meet their increased demand for nutrients and energy. We have shown that metabolism plays an essential role in the cytotoxic function of antiviral NK cells.

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Publications

    Journal articles

  • Mittermüller, Daniela; Otto, Lucas; Kilian, Annika Loredana; Schnormeier, Ann-Kathrin; Littwitz-Salomon, Elisabeth; Hasenberg, Anja; Dittmer, Ulf; Gunzer, Matthias
    PD-1 knockout on cytotoxic primary murine CD8+ T cells improves their motility in retrovirus infected mice
    In: Frontiers in Immunology Vol. 15 (2024) 1338218
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Picard, Lea Katharina; Niemann, Jens Alexander; Littwitz-Salomon, Elisabeth; Waldmann, Herbert; Watzl, Carsten
    Restriction of Glycolysis Increases Serial Killing Capacity of Natural Killer Cells
    In: International Journal of Molecular Sciences (IJMS) Vol. 25 (2024) Nr. 5, 2917
    Online Full Text: dx.doi.org/ (Open Access)
  • Schimmer, Simone; Mittermüller, Daniela; Werner, Tanja; Görs, Paul E.; Meckelmann, Sven; Finlay, David K.; Dittmer, Ulf; Littwitz-Salomon, Elisabeth
    Fatty acids are crucial to fuel NK cells upon acute retrovirus infection
    In: Frontiers in Immunology Vol. 14 (2023) 1296355
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Schild, Yves; Bosserhoff, Jonah; Droege, Freya; Littwitz-Salomon, Elisabeth; Fandrey, Joachim; Wrobeln, Anna
    Hypoxia-Inducible Factor–Prolyl Hydroxylase Inhibitor Improves Leukocyte Energy Metabolism in Hereditary Hemorrhagic Telangiectasia
    In: Life Vol. 13 (2023) Nr. 8, 1708
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Picard, Lea Katharina; Littwitz-Salomon, Elisabeth; Waldmann, Herbert; Watzl, Carsten
    Inhibition of Glucose Uptake Blocks Proliferation but Not Cytotoxic Activity of NK Cells
    In: Cells Vol. 11 (2022) Nr. 21, 3489
    Online Full Text: dx.doi.org/ (Open Access)
  • Schmitz, Yasmin; Schwerdtfeger, Mara; Westmeier, Jaana; Littwitz-Salomon, Elisabeth; Alt, Mira; Brochhagen, Leonie; Krawczyk, Adalbert; Sutter, Kathrin
    Superior antiviral activity of IFNβ in genital HSV-1 infection
    In: Frontiers in Cellular and Infection Microbiology Vol. 12 (2022) 949036
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Littwitz-Salomon, Elisabeth; Moreira, Diana; Frost, Joe N.; Choi, Chloe; Liou, Kevin T.; Ahern, David K.; O’Shaughnessy, Simon; Wagner, Bernd; Biron, Christine A.; Drakesmith, Hal; Dittmer, Ulf; Finlay, David K.
    Metabolic requirements of NK cells during the acute response against retroviral infection
    In: Nature Communications Vol. 12 (2021) Nr. 1, 5376
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Zou, Shi; Du, Yanqin; Huang, Shunmei; Chen, Mingfa; Yang, Xiaoli; Li, Sumeng; Chen, Yingshan; Han, Meihong; Li, Jia; Yu, Qing; Littwitz-Salomon, Elisabeth; Huang, Hongming; Trilling, Mirko; Liu, Shi; Pei, Rongjuan; Liu, Jia; Wang, Baoju; Zheng, Xin; Lu, Mengji; Dittmer, Ulf; Sun, Shuilin; Yang, Dongliang; Wu, Jun
    Simultaneous or Prior Activation of Intrahepatic Type I Interferon Signaling Leads to Hepatitis B Virus Persistence in a Mouse Model
    In: Journal of Virology Vol. 95 (2021) Nr. 24, e00034-21
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Malyshkina, Anna; Littwitz-Salomon, Elisabeth; Sutter, Kathrin; Ross, Jean Alexander; Paschen, Annette; Windmann, Sonja; Schimmer, Simone; Dittmer, Ulf
    Chronic retroviral infection of mice promotes tumor development, but CD137 agonist therapy restores effective tumor immune surveillance
    In: Cancer Immunology, Immunotherapy Vol. 68 (2019) Nr. 3, pp. 479 - 488
    Online Full Text: dx.doi.org/
  • Moore, Tyler C.; Messer, Ronald J.; Gonzaga, Lorena M.; Mather, Jennifer M.; Carmody, Aaron B.; Bayer, Wibke; Littwitz-Salomon, Elisabeth; Dittmer, Ulf; Hasenkrug, Kim J.
    Effects of Friend Virus Infection and Regulatory T Cells on the Antigen Presentation Function of B Cells
    In: mBio Vol. 10 (2019) Nr. 1, pp. e02578 - 18
    Online Full Text: dx.doi.org/ (Open Access)
  • Hotter, Dominik; Bosso, Matteo; Jønsson, Kasper L.; Krapp, Christian; Stürzel, Christina M.; Das, Atze; Littwitz-Salomon, Elisabeth; Berkhout, Ben; Russ, Alina; Wittmann, Sabine; Gramberg, Thomas; Zheng, Yue; Martins, Laura J.; Planelles, Vicente; Jakobsen, Martin R.; Hahn, Beatrice H.; Dittmer, Ulf; Sauter, Daniel; Kirchhoff, Frank
    IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation
    In: Cell Host & Microbe Vol. 25 (2019) Nr. 6, pp. 858 - 872.e13
    Online Full Text: dx.doi.org/ (Open Access)
  • Kedia-Mehta, Nidhi; Choi, Chloe; McCrudden, Aisling; Littwitz-Salomon, Elisabeth; Fox, Proinnsias G.; Gardiner, Clair M.; Finlay, David K.
    Natural Killer Cells Integrate Signals Received from Tumour Interactions and IL2 to Induce Robust and Prolonged Anti-Tumour and Metabolic Responses
    In: Immunometabolism Vol. 1 (2019) pp. e190014
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Littwitz-Salomon, Elisabeth; Nguyen, Thanh; Schimmer, Simone; Dittmer, Ulf
    Friend retrovirus infection induces the development of memory-like natural killer cells 11 Medical and Health Sciences 1107 Immunology
    In: Retrovirology Vol. 15 (2018) Nr. 1, 68
    Online Full Text: dx.doi.org/ (Open Access)
  • Malyshkina, Anna; Littwitz-Salomon, Elisabeth; Dittmer, Ulf; Schimmer, Simone
    The Cytotoxic Activity of Natural Killer Cells Is Suppressed by IL-10⁺ Regulatory T Cells During Acute Retroviral Infection
    In: Frontiers in Immunology Vol. 9 (2018) pp. 1947
    Online Full Text: dx.doi.org/ (Open Access)
  • Littwitz-Salomon, Elisabeth; Schimmer, Simone; Dittmer, Ulf
    Dose of retroviral infection determines induction of antiviral NK cell responses
    In: Journal of Virology Vol. 91 (2017) Nr. 22, pp. e01122 15 Seiten - 17
    Online Full Text: dx.doi.org/ (Open Access)
  • Malyshkina, Anna; Littwitz-Salomon, Elisabeth; Sutter, Kathrin; Zelinskyy, Gennadiy; Windmann, Sonja; Schimmer, Simone; Paschen, Annette; Streeck, Hendrik; Hasenkrug, Kim J; Dittmer, Ulf
    Fas Ligand-mediated cytotoxicity of CD4+ T cells during chronic retrovirus infection
    In: Scientific Reports Vol. 7 (2017) pp. 7785
    Online Full Text: dx.doi.org/ (Open Access)
  • Littwitz-Salomon, Elisabeth; Schimmer, Simone; Dittmer, Ulf
    Natural killer T cells contribute to the control of acute retroviral infection
    In: Retrovirology Vol. 14 (2017) Nr. 1, 5
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Akhmetzyanova, Ilseyar; Dittmer, Ulf; Brandau, Sven; Streeck, Hendrik; Dietze, Kirsten; Malyshkina, Anna; Littwitz-Salomon, Elisabeth; Zelinskyy, Gennadiy
    CD137 agonist therapy can reprogram regulatory T cells into cytotoxic CD4+ T cells with antitumor activity
    In: The Journal of Immunology (JI) Vol. 196 (2016) Nr. 1, pp. 484 - 492
    Online Full Text: dx.doi.org/ (Open Access)
  • Littwitz-Salomon, Elisabeth; Dittmer, Ulf; Sutter, Kathrin
    Insufficient natural killer cell responses against retroviruses : How to improve NK cell killing of retrovirus-infected cells
    In: Retrovirology Vol. 13 (2016) Nr. 1, 77
    Online Full Text: dx.doi.org/ (Open Access)
  • Littwitz-Salomon, Elisabeth; Akhmetzyanova, Ilseyar; Vallet, Cecilia; Francois, Sandra; Dittmer, Ulf; Gibbert, Kathrin
    Activated regulatory T cells suppress effector NK cell responses by an IL-2-mediated mechanism during an acute retroviral infection
    In: Retrovirology Vol. 12 (2015) Nr. 1, 66
    Online Full Text: dx.doi.org/ (Open Access)
  • Littwitz-Salomon, Elisabeth; Francois, Sandra; Dittmer, Ulf; Gibbert, Kathrin
    Distinct roles of NK cells in viral immunity during different phases of acute Friend retrovirus infection
    In: Retrovirology Vol. 10 (2013) Nr. 1, 127
    Online Full Text: dx.doi.org/ (Open Access)
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