ZMB Member Dietmar Lohmann

ZMB Member
Dietmar Lohmann

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Dietmar Lohmann portrait
© D.Lohmann

Prof. Dr. Dietmar Lohmann

Group

Ophthalmic Oncology and Genetics

Institute of Human Genetics
University Hospital Essen
Hufelandstr. 55
45122 Essen

Research Overview

Retinoblastoma

  • Determining the genetic architecture underlying predisposition to retinoblastoma
  • Identification of risk factors for development of extraocular neoplasms in patients with retinoblastoma
  • Analysis of changes of the genetic landscape during retinoblastoma progression

 

Uveal Melanoma

  • Identification of heritable genetic alterations that alter the risk for uveal melanoma
  • Development of prognostic and predictive biomarkers
  • Determining somatic genetic alterations linked to metastasizing uveal melanoma

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Selected Publications

    Journal articles

  • Grümme, Lea; Biewald, Eva; Reschke, Madlen; Fischhuber, Karen; Hanbücken, Anna; Schlüter, Sabrina; Müller, Bert; Kiefer, Tobias; Göricke, Sophia Luise; Geismar, Dirk; Ryl, Tatsiana; Sirin, Selma; Wieland, Regina; Timmermann, Beate; Lohmann, Dietmar; Ebinge et al.
    Comparing efficacy and side effects of two systemic chemotherapy regimens for eye-preserving therapy in children with retinoblastoma
    In: Pediatric Blood and Cancer Vol. 69 (2022) Nr. 2, e29362
    Online Full Text: dx.doi.org/ (Open Access)
  • Kanber, Deniz; Woestefeld, Julia; Döpper, Hannah; Bozet, Morgane; Brenzel, Alexandra; Altmüller, Janine; Kilpert, Fabian; Lohmann, Dietmar; Pommerenke, Claudia; Steenpass, Laura.
    RB1-Negative Retinal Organoids Display Proliferation of Cone Photoreceptors and Loss of Retinal Differentiation
    In: Cancers Vol. 14 (2022) Nr. 9, 2166
    Online Full Text: dx.doi.org/ (Open Access)
  • Busch, Maike; Haase, André; Miroschnikov, Natalia; Doege, Annika; Biewald, Eva; Bechrakis, Nikolaos E.; Beier, Manfred; Kanber, Deniz; Lohmann, Dietmar; Metz, Klaus; Dünker, Nicole.
    TFF1 in Aqueous Humor : A Potential New Biomarker for Retinoblastoma
    In: Cancers Vol. 14 (2022) Nr. 3, 677
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Reschke, Madlen; Biewald, Eva; Bronstein, Leo; Brecht, Ines B.; Dittner-Moormann, Sabine; Driever, Frank; Ebinger, Martin; Fleischhack, Gudrun; Grabow, Desiree; Geismar, Dirk; Göricke, Sophia Luise; Guberina, Maja; Le Guin, Claudia; Kiefer, Tobias; Kratz, et al.
    Eye tumors in childhood as first sign of tumor predisposition syndromes : Insights from an observational study conducted in Germany and Austria
    In: Cancers Vol. 13 (2021) Nr. 8, pp. 1876
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Hülsenbeck, Isabel; Frank, Mirjam; Biewald, Eva; Kanber, Deniz; Lohmann, Dietmar; Ketteler, Petra.
    Introduction of a variant classification system for analysis of genotype-phenotype relationships in heritable retinoblastoma
    In: Cancers Vol. 13 (2021) Nr. 7, pp. 1605
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Pfaff, Elke; Aichmüller, Christian; Sill, Martin; Stichel, Damian; Snuderl, Matija; Karajannis, Matthias A.; Schuhmann, Martin U.; Schittenhelm, Jens; Hasselblatt, Martin; Thomas, Christian; Korshunov, Andrey; Rhizova, Marina; Wittmann, Andrea; Kaufhold, A et al.
    Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations
    In: Acta Neuropathologica Vol. 139 (2020) Nr. 2, pp. 243 - 257
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Römer, Tristan; Temming, Petra; Lohmann, Dietmar; Sturm, Dominik; von Deimling, Andreas; Sellhaus, Bernd; Mull, Michael; Kontny, Udo; Moser, Olga.
    Ectopic intracranial retinoblastoma in a 3.5-month-old infant without eye involvement and without evidence of heritability
    In: Pediatric Blood and Cancer Vol. 66 (2019) Nr. 5, e27599
    Online Full Text: dx.doi.org/
  • Le Guin, Claudia Helga Dorothee; Metz, Klaus; Kreis, Stefan Horst; Bechrakis, Nikolaos E.; Bornfeld, Norbert; Zeschnigk, Michael; Lohmann, Dietmar.
    GNAQ Q209R Mutations Are Highly Specific for Circumscribed Choroidal Hemangioma
    In: Cancers Vol. 11 (2019) Nr. 7, pp. 1031
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Hofer, Silvia; Diebold, Joachim; Temming, Petra; Lohmann, Dietmar; Howell, Jeremy; Moulin, Alexandre P.; Beck-Popovic, Maja; Sahm, Felix; Milde, Till; Ecker, Jonas.
    Retinoblastoma with late metastatic spread : a case report
    In: Pediatric Blood and Cancer Vol. 66 (2019) Nr. 6, e27656
    Online Full Text: dx.doi.org/
  • Capper, David; Jones, David T. W.; Sill, Martin; Hovestadt, Volker; Schrimpf, Daniel; Sturm, Dominik; Koelsche, Christian; Sahm, Felix; Chavez, Lukas; Reuss, David E.; Kratz, Annekathrin; Wefers, Annika K.; Huang, Kristin; Pajtler, Kristian; Schweizer, Leo et al.
    DNA methylation-based classification of central nervous system tumours
    In: Nature Vol. 555 (2018) Nr. 7697, pp. 469 - 474
    Online Full Text: dx.doi.org/ (Open Access)
  • Gröbner, Susanne N.; Worst, Barbara C.; Weischenfeldt, Joachim; Buchhalter, Ivo; Kleinheinz, Kortine; Rudneva, Vasilisa A.; Johann, Pascal D.; Balasubramanian, Gnana Prakash; Segura-Wang, Maia; Brabetz, Sebastian; Bender, Sebastian; Hutter, Barbara; Sturm, et al.
    The landscape of genomic alterations across childhood cancers
    In: Nature Vol. 555 (2018) Nr. 7696, pp. 321 - 327
    Online Full Text: dx.doi.org/ (Open Access)
  • Temming, Petra; Arendt, Marina; Viehmann, Anja; Eisele, Lewin; Le Guin, Claudia H. D.; Schündeln, Michael; Biewald, Eva; Astrahantseff, Kathy; Wieland, Regina; Bornfeld, Norbert; Sauerwein, Wolfgang; Eggert, Angelika; Jöckel, Karl-Heinz; Lohmann, Dietmar.
    Incidence of second cancers after radiotherapy and systemic chemotherapy in heritable retinoblastoma survivors : a report from the German reference center
    In: Pediatric Blood and Cancer Vol. 64 (2017) Nr. 1, pp. 71 - 80
    Online Full Text: dx.doi.org/
  • Temming, Petra; Viehmann, Anja; Arendt, Marina; Eisele, Lewin; Spix, Claudia; Bornfeld, Norbert; Sauerwein, Wolfgang; Jöckel, Karl-Heinz; Lohmann, Dietmar.
    Pediatric second primary malignancies after retinoblastoma treatment
    In: Pediatric Blood and Cancer Vol. 62 (2015) Nr. 10, pp. 1799 - 1804
    Online Full Text: dx.doi.org/ (Open Access)
  • Rushlow, Diane E.; Mol, Berber M.; Kennett, Jennifer Y.; Yee, Stephanie; Pajovic, Sanja; Thériault, Brigitte L.; Prigoda-Lee, Nadia L.; Spencer, Clarellen; Dimaras, Helen; Corson, Timothy W.; Pang, Renée; Massey, Christine; Godbout, Roseline; Jiang, Zhe; Z et al.
    Characterisation of retinoblastomas without RB1 mutations: Genomic, gene expression, and clinical studies
    In: The Lancet Oncology Vol. 14 (2013) Nr. 4, pp. 327 - 334
    Online Full Text: dx.doi.org/
  • Martin, Marcel; Maßhöfer, Lars; Temming, Petra; Rahmann, Sven; Metz, Claudia; Bornfeld, Norbert; van de Nes, Johannes; Klein-Hitpaß, Ludger; Hinnebusch, Alan G.; Horsthemke, Bernhard; Lohmann, Dietmar; Zeschnigk, Michael.
    Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3
    In: Nature Genetics Vol. 45 (2013) Nr. 8, pp. 933 - 936
    Online Full Text: dx.doi.org/
  • Temming, Petra; Bornfeld, Norbert; Lohmann, Dietmar;.
    Sporadic unilateral retinoblastoma or first sign of bilateral disease?
    44th Congress of the International Society of Paediatric Oncology (SIOP) 2012, 5th–8th October, 2012, London, UK,
    In: Pediatric Blood and Cancer Vol. 59 (2012) Nr. 6, pp. 1064 - 1064
    Online Full Text: dx.doi.org/
  • Pall, P.; Aina, T.; Stone, D. A.; Stott, P. A.; Nozawa, T.; Hilberts, A. G.; Lohmann, Dietmar; Allen, M. R.
    Anthropogenic greenhouse gas contribution to flood risk in England and Wales in autumn 2000
    In: Nature Vol. 470 (2011) Nr. 7334, pp. 382 - 385
    Online Full Text: dx.doi.org/
  • Dauwerse, Johannes G.; Dixon, Jill; Seland, Saskia; Ruivenkamp, Claudia A. L.; Van Haeringen, Arie; Hoefsloot, Lies H.; Peters, Dorien J. M.; Clement-de Boers, Agnes; Daumer-Haas, Cornelia; Maiwald, Robert; Zweier, Christiane; Kerr, Bronwyn; Cobo, Ana M.; et al.
    Mutations in genes encoding subunits of RNA polymerases I and III cause Treacher Collins syndrome
    In: Nature Genetics Vol. 43 (2011) Nr. 1, pp. 20 - 22
    Online Full Text: dx.doi.org/
  • Khandanpour, Cyrus; Thiede, Christian; Valk, Peter J.; Sharif-Askari, Ehssan; Nückel, Holger; Lohmann, Dietmar; Horsthemke, Bernhard; Siffert, Winfried; Neubauer, Andreas; Grzeschik, Karl-Heinz; Bloomfield, Clara D.; Marcucci, Guido; Maharry, Kati; Slovak et al.
    A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia
    In: Blood Vol. 115 (2010) Nr. 12, pp. 2462 - 2472
    Online Full Text: dx.doi.org/
  • Stephan, Harald; Zakrzewski, Johannes L.; Bölöni, Reka; Grasemann, Corinna; Lohmann, Dietmar; Eggert, Angelika.
    Neurotrophin receptor expression in human primary retinoblastomas and retinoblastoma cell lines
    In: Pediatric Blood and Cancer Vol. 50 (2008) Nr. 2, pp. 218 - 222
    Online Full Text: dx.doi.org/
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