ZMB Member Erich Gulbins
ZMB Member
Erich Gulbins
Next ZMB-Member
Prof. Dr. Erich Gulbins
Director of:
Department of Molecular BiologyUniversity Hospital Essen
Hufelandstraße 55
45122 Essen
- +49 201 723 3118
- Website
- Selected Publications
- Publication Metrics
- ZMB Research Program
Oncology
Research Overview
- Regulation and function of sphingolipids in bacterial infections, in particular pneumonia
1.1. Role of ceramide and sphingosine in cystic fibrosis
1.2. Molecular mechanisms of anti-bacterial effects of sphingosine
1.3. Development of novel treatments of pneumonia with Pseudomonas aeruginosa and Staphylococcus aureus
1.4. Regulation and function of sphingolipids in systemic infections with S. aureus and mycobacteria. - Sphingolipids in tumor therapy, with a focus on the regulation and function of sphingolipids in the immune system of the tumor host.
- Regulation and function of acid sphingomyelinase/ceramide in auto-immune disorders, in particular multiple sclerosis.
- The acid sphingomyelinase-ceramide-acid ceramidase axis as target of antidepressants. Role of this system in the pathogenesis and treatment of major depressive disorder.
- Targeting the mitochondrial Kv1.3 channel with novel specific inhibitors to treat cancer.
Selected Publications
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Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer’s diseaseIn: Nature Communications Vol. 14 (2023) Nr. 1, 1631Online Full Text: dx.doi.org/ (Open Access)
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Comorbid medical conditions are a key factor to understand the relationship between psychiatric disorders and COVID-19-related mortality : Results from 49,089 COVID-19 inpatientsIn: Molecular Psychiatry Vol. 27 (2022) Nr. 3, pp. 1278 - 1280Online Full Text: dx.doi.org/ (Open Access)
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The acid sphingomyelinase/ceramide system in COVID-19In: Molecular Psychiatry Vol. 27 (2022) Nr. 1, pp. 307 - 314Online Full Text: dx.doi.org/ (Open Access)
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Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defectsIn: Molecular Psychiatry Vol. 26 (2021) Nr. 12, pp. 7403 - 7416Online Full Text: dx.doi.org/ (Open Access)
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Repurposing antidepressants inhibiting the sphingomyelinase acid/ceramide system against COVID-19 : Current evidence and potential mechanismsIn: Molecular Psychiatry Vol. 26 (2021) Nr. 12, pp. 7098 - 7099Online Full Text: dx.doi.org/ (Open Access)
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Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe diseaseIn: Nature Communications Vol. 11 (2020) Nr. 1, pp. 1338Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial CellsIn: Cell Reports Medicine Vol. 1 (2020) Nr. 8, pp. 100142Online Full Text: dx.doi.org/ (Open Access)
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Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramideIn: Molecular Psychiatry Vol. 23 (2018) Nr. 12, pp. 2324 - 2346Online Full Text: dx.doi.org/ (Open Access)
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Antidepressants regulate autophagy by targeting acid sphingomyelinaseIn: Molecular Psychiatry Vol. 23 (2018) Nr. 12, pp. 2251Online Full Text: dx.doi.org/
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Sphingolipids as targets for inhalation treatment of cystic fibrosisIn: Advanced Drug Delivery Reviews Vol. 133 (2018) pp. 66 - 75Online Full Text: dx.doi.org/
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Acid Sphingomyelinase Inhibition in Stored Erythrocytes Reduces Transfusion-Associated Lung InflammationIn: Annals of Surgery Vol. 265 (2017) Nr. 1, pp. 218 - 226Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Direct pharmacological targeting of a mitochondrial ion channel selectively kills tumor cells in vivoIn: Cancer Cell Vol. 31 (2017) Nr. 4, pp. 516 - 531.e10Online Full Text: dx.doi.org/ (Open Access)
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Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial functionIn: Nature Communications Vol. 8 (2017) pp. 480Online Full Text: dx.doi.org/ (Open Access)
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Paradoxical antidepressant effects of alcohol are related to acid sphingomyelinase and its control of sphingolipid homeostasisIn: Acta Neuropathologica Vol. 133 (2017) Nr. 3, pp. 463 - 483Online Full Text: dx.doi.org/ (Open Access)
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β1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingosine, Promoting Bacterial InfectionsIn: Cell Host & Microbe Vol. 21 (2017) Nr. 6, pp. 707 - 718.e8Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphateIn: Journal of Hepatology Vol. 64 (2016) Nr. 1, pp. 60 - 68Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in miceIn: Nature Biotechnology Vol. 33 (2015) Nr. 1, pp. 81 - 88Online Full Text: dx.doi.org/
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Regulation of hematogenous tumor metastasis by acid sphingomyelinaseIn: EMBO Molecular Medicine Vol. 7 (2015) Nr. 6, pp. 714 - 734Online Full Text: dx.doi.org/ (Open Access)
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Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosaIn: EMBO Molecular Medicine Vol. 6 (2014) Nr. 9, pp. 1205 - 1214Online Full Text: dx.doi.org/ (Open Access)
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Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugsIn: Nature Medicine Vol. 19 (2013) Nr. 7, pp. 934 - 938Online Full Text: dx.doi.org/
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Clofazimine, Psora-4 and PAP-1, inhibitors of the potassium channel Kv1.3, as a new and selective therapeutic strategy in chronic lymphocytic leukemiaIn: Leukemia Vol. 27 (2013) Nr. 8, pp. 1782 - 1785Online Full Text: dx.doi.org/
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It takes a CAD to kill a tumor cell with a LMPIn: Cancer Cell Vol. 24 (2013) Nr. 3, pp. 279 - 281Online Full Text: dx.doi.org/ (Open Access)
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Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cellsIn: EMBO Molecular Medicine Vol. 4 (2012) Nr. 7, pp. 577 - 593Online Full Text: dx.doi.org/ (Open Access)
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Kinase suppressor of Ras-1 protects against pulmonary Pseudomonas aeruginosa infectionsIn: Nature Medicine Vol. 17 (2011) Nr. 3, pp. 341 - 346Online Full Text: dx.doi.org/
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Lipids control mucus production in cystic fibrosisIn: Nature Medicine Vol. 16 (2010) Nr. 3, pp. 267 - 268Online Full Text: dx.doi.org/
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Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosisIn: Nature Medicine Vol. 14 (2008) Nr. 4, pp. 382 - 391Online Full Text: dx.doi.org/ (Open Access)