Jadwiga Jablonska-Koch
ZMB Member
Jadwiga Jablonska-Koch
Next ZMB-Member
Prof. Dr. Jadwiga Jablonska-Koch
ENT Department
West German Cancer Center (WTZ)
German Cancer Research Center (DKFZ), Partnersite Essen/Düsseldorf
University Hospital Essen
45147 Essen
- +49 201 723 3190
- Website
- Selected Publications
- Publication Metrics
- ZMB Research Program
Oncology
Research Overview
We focus on the myeloid cell/ neutrophil-dependent immunoregulatory mechanisms that are responsible for the progression of cancerogenesis and inflammation. We study the molecular mechanisms involved in neutrophil polarization, mobilization and activation, but also complex interaction between regulatory myeloid cells, such as neutrophils, monocytes/macrophages and DCs.
Moreover, we are interested in overall neutrophil biology, i.e. development, differentiation, activation, migration and responses to various inflammatory stimuli in disease. We analyze the role of multiple cytokines (with focus on type I interferons) and growth factors (e.g. G-CSF) in the regulation of emergency myelopoiesis, and neutrophil polarization and homing.
Over the last years we have established and worked on the following main research themes:
- Neutrophil heterogeneity and immunoregulatory activity in disease
- Identification of intracellular factors/signaling pathways contributing to the tumorigenic transformation of neutrophils
- Neutrophil-mediated regulation of angiogenesis
- Type I interferons (IFNs) as immunomodulators
- Exosome-mediated suppression of immune responses in tumor
- The impact of tumor-mediated immunosuppression on the susceptibility to bacterial infections
Selected Publications
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Increased Risk for Infections and Allergic Disease in Hereditary Hemorrhagic TelangiectasiaIn: Journal of Clinical Medicine (JCM) Vol. 13 (2024) Nr. 13, 3752Online Full Text: dx.doi.org/ (Open Access)
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Neutrophils : Biology and diversityIn: Nephrology Dialysis Transplantation (NDT) (2024) in pressOnline Full Text: dx.doi.org/ (Open Access)
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Comparative transcriptomic and proteomic signature of lung alveolar macrophages reveals the integrin CD11b as a regulatory hub during pneumococcal pneumonia infectionIn: Frontiers in Immunology Vol. 14 (2023) 1227191Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Exosomes in Cancer Progression and Therapy Resistance : Molecular Insights and Therapeutic OpportunitiesIn: Life Vol. 13 (2023) Nr. 10, 2033Online Full Text: dx.doi.org/ (Open Access)
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Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanomaIn: Journal for ImmunoTherapy of Cancer Vol. 11 (2023) Nr. 4, e004150Online Full Text: dx.doi.org/ (Open Access)
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Nonfunctional TGF-β/ALK1/ENG signaling pathway supports neutrophil proangiogenic activity in hereditary hemorrhagic telangiectasiaIn: Journal of Leukocyte Biology (JLB) Vol. 114 (2023) Nr. 6, pp. 639 - 650Online Full Text: dx.doi.org/ (Open Access)
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Plasma-derived small extracellular vesicles unleash the angiogenic potential in head and neck cancer patientsIn: Molecular Medicine Vol. 29 (2023) Nr. 1, 69Online Full Text: dx.doi.org/ (Open Access)
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Sellhi neutrophils : A key to triumph in cancer therapyIn: Signal Transduction and Targeted Therapy Vol. 8 (2023) Nr. 1, 421Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Altered hypoxia inducible factor regulation in hereditary haemorrhagic telangiectasiaIn: Scientific Reports Vol. 12 (2022) Nr. 1, 5877Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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During early stages of cancer, neutrophils initiate anti-tumor immune responses in tumor-draining lymph nodesIn: Cell Reports Vol. 40 (2022) Nr. 7, 111171Online Full Text: dx.doi.org/ (Open Access)
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Efficient Small Extracellular Vesicles (EV) Isolation Method and Evaluation of EV-Associated DNA Role in Cell–Cell Communication in CancerIn: Cancers Vol. 14 (2022) Nr. 9, 2068Online Full Text: dx.doi.org/ (Open Access)
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Evaluation of Immunoregulatory Biomarkers on Plasma Small Extracellular Vesicles for Disease Progression and Early Therapeutic Response in Head and Neck CancerIn: Cells Vol. 11 (2022) Nr. 5, 902Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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IFNAR1 Deficiency Impairs Immunostimulatory Properties of Neutrophils in Tumor-Draining Lymph NodesIn: Frontiers in Immunology Vol. 13 (2022)Online Full Text: dx.doi.org/ (Open Access)
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PMN‐MDSC in newborns : Regulation of the regulatorsIn: Journal of Leukocyte Biology (JLB) Vol. 112 (2022) Nr. 5, pp. 949 - 950Online Full Text: dx.doi.org/ (Open Access)
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SIRT1‐mediated deacetylation of FOXO3a transcription factor supports pro‐angiogenic activity of interferon‐deficient tumor‐associated neutrophilsIn: International Journal of Cancer Vol. 150 (2022) Nr. 7, pp. 1198 - 1211Online Full Text: dx.doi.org/ (Open Access)
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TLR2-induced CD8⁺ T-cell deactivation shapes dendritic cell differentiation in the bone marrow during sepsisIn: Frontiers in Immunology Vol. 13 (2022) 945409Online Full Text: dx.doi.org/ (Open Access)
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The Good, the Bad, and the Ugly : Neutrophils, Angiogenesis, and CancerIn: Cancers Vol. 14 (2022) Nr. 3, 536Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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B-helper neutrophils in regional lymph nodes correlate with improved prognosis in patients with head and neck cancerIn: Cancers Vol. 13 (2021) Nr. 12, 3092Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Neutrophil dynamics, plasticity and function in acute neurodegeneration following neonatal hypoxia-ischemiaIn: Brain, Behavior and Immunity Vol. 92 (2021) pp. 234 - 244Online Full Text: dx.doi.org/ (Open Access)
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Das Mikrobiom bei Kopf-Hals-Tumoren – erste Erkenntnisse und AusblickIn: HNO Vol. 68 (2020) Nr. 12, pp. 905 - 910Online Full Text: dx.doi.org/
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Impaired Release of Neutrophil Extracellular Traps and Anemia-Associated T Cell Deficiency in Hereditary Hemorrhagic TelangiectasiaIn: Journal of Clinical Medicine (JCM) Vol. 9 (2020) Nr. 3, 767Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Neutrophile Granulozyten im Tumormikromilieu – Feind oder Freund?In: HNO (2020)Online Full Text: dx.doi.org/
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Oral Neutrophils : Underestimated Players in Oral CancerIn: Frontiers in Immunology Vol. 11 (2020) pp. 565683Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Challenges in the Isolation and Proteomic Analysis of Cancer Exosomes : Implications for Translational ResearchIn: Proteomes Vol. 7 (2019) Nr. 2, 22Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Detrimental Effect of Type I IFNs During Acute Lung Infection With Pseudomonas aeruginosa Is Mediated Through the Stimulation of Neutrophil NETosis.In: Frontiers in Immunology Vol. 10 (2019) pp. 2190Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Interactions among myeloid regulatory cells in cancerIn: Cancer Immunology, Immunotherapy Vol. 68 (2019) Nr. 4, pp. 645 - 660Online Full Text: dx.doi.org/
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NAMPT signaling is critical for the proangiogenic activity of tumor-associated neutrophilsIn: International Journal of Cancer Vol. 144 (2019) Nr. 1, pp. 136 - 149Online Full Text: dx.doi.org/ (Open Access)
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Neutrophil maturation and survival is controlled by IFN-dependent regulation of NAMPT signalingIn: International Journal of Molecular Sciences (IJMS) Vol. 20 (2019) Nr. 22, pp. 5584Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Prognostic Role of Blood NETosis in the Progression of Head and Neck CancerIn: Cells Vol. 8 (2019) Nr. 9, pp. 946Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Transfer of manipulated tumor-associated neutrophils into tumor-bearing mice to study their angiogenic potential in vivoIn: JoVE Vol. 2019 (2019) Nr. 149, pp. e59807Online Full Text: dx.doi.org/
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Drosophila Hsp67Bc hot-spot variants alter muscle structure and functionIn: Cellular and Molecular Life Sciences - CMLS Vol. 75 (2018) Nr. 23, pp. 4341 - 4356Online Full Text: dx.doi.org/ (Open Access)
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Neutrophil, quo vadis?In: Journal of Leukocyte Biology (JLB) Vol. 102 (2017) Nr. 3, pp. 685 - 688Online Full Text: dx.doi.org/
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The regulation of pre-metastatic niche formation by neutrophilsIn: OncoTarget Vol. 8 (2017) Nr. 67, pp. 112132 - 112144Online Full Text: dx.doi.org/ (Open Access)
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The regulatory effect of Type I IFNs on neutrophil angiogenic capability in tumor microenvironmentIn: European Journal of Immunology Vol. 47 (2017) Nr. S2, Special Issue: 47th Annual Meeting of the German Society for Immunology, 12–15 September, 2017, Erlangen, Germany, pp. 306Online Full Text: dx.doi.org/
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Growing tumors induce a local STING dependent Type I IFN response in dendritic cellsIn: International Journal of Cancer Vol. 139 (2016) Nr. 6, pp. 1350 - 1357Online Full Text: dx.doi.org/
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In Vivo Visualizing the IFN-β Response Required for Tumor Growth Control in a Therapeutic Model of Polyadenylic-Polyuridylic Acid AdministrationIn: The Journal of Immunology (JI) Vol. 196 (2016) Nr. 6, pp. 2860 - 2869Online Full Text: dx.doi.org/
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The Essential Role of Type I Interferons in Differentiation and Activation of Tumor-Associated NeutrophilsIn: Frontiers in Immunology Vol. 7 (2016) pp. 629Online Full Text: dx.doi.org/ (Open Access)
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Type i IFNs induce anti-tumor polarization of tumor associated neutrophils in mice and humanIn: International Journal of Cancer Vol. 138 (2016) Nr. 8, pp. 1982 - 1993Online Full Text: dx.doi.org/ (Open Access)
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The Mechanism of Type I Interferon-Mediated Polarization of Tumor-Associated Neutrophils in Mice and HumanIn: Blood Vol. 126 (2015) Nr. 23,