ZMB Member Sebastian Bauer

ZMB Member
Sebastian Bauer

Next ZMB-Member
Sebastian Bauer
© UKE/S.Bauer

Prof. Dr. Sebastian Bauer

West German Cancer Center (WTZ)
University Hospital Essen
Hufelandstr. 55
45147 Essen

Research Overview

  1. Analysis of oncogenetic signalling pathways in soft-tissue sarcoma (esp. GIST)
  2. Evaluation of purposive, small molecular inhibitors of tyrosine kinases in soft-tissue sarcoma
  3. Development of soft-tissue sarcoma models (cell lines and Xenografts)
  4. Evaluation of preclinical diagnostic techniques/methods (in vitro/in vivo) for GIST and other soft-tissue sarcoma
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Selected Publications

    Journal articles

  • Teuber, A.; Schulz, T.; Fletcher, B.S.; Gontla, R.; Mühlenberg, Thomas; Zischinsky, M.-L.; Niggenaber, J.; Weisner, J.; Kleinbölting, S.B.; Lategahn, J.; Sievers, S.; Müller, M.P.; Bauer, Sebastian; Rauh, D.
    Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA
    In: Nature Communications Vol. 15 (2024) Nr. 1, 63
  • Heinrich, Michael C.; Zhang, Xinhua; Jones, Robin L.; George, Suzanne; Serrano, César; Deng, Yanhong; Bauer, Sebastian; Cai, Shirong; Wu, Xin; Zhou, Yongjian; Tao, Kaixiong; Zheng, Zhichao; Zhang, Jun; Cui, Yuehong; Cao, Hui; Wang, Meining; Hu, Jin; Yang, Jason; Li, Jian; Shen, Lin
    Clinical Benefit of Avapritinib in KIT-Mutant Gastrointestinal Stromal Tumors : A Post Hoc Analysis of the Phase I NAVIGATOR and Phase I/II CS3007-001 Studies
    In: Clinical Cancer Research Vol. 30 (2024) Nr. 4, pp. 719 - 728
  • Tretter, Celina; de Andrade Krätzig, Niklas; Pecoraro, Matteo; Lange, Sebastian; Seifert, Philipp; von Frankenberg, Clara; Untch, Johannes; Zuleger, Gabriela; Wilhelm, Mathias; Zolg, Daniel P.; Dreyer, Florian S.; Bräunlein, Eva; Engleitner, Thomas; Uhrig, Sebastian; Boxberg, Melanie; Steiger, Katja; Slotta-Huspenina, Julia; Ochsenreither, Sebastian; von Bubnoff, Nikolas; Bauer, Sebastian; Boerries, Melanie; Jost, Philipp J.; Schenck, Kristina; Dresing, Iska; Bassermann, Florian; Friess, Helmut; Reim, Daniel; Grützmann, Konrad; Pfütze, Katrin; Klink, Barbara; Schröck, Evelin; Haller, Bernhard; Kuster, Bernhard; Mann, Matthias; Weichert, Wilko; Fröhling, Stefan; Rad, Roland; Hiltensperger, Michael; Krackhardt, Angela M.
    Correction to: Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification
    In: Nature Communications Vol. 15 (2024) Nr. 1, 2364
  • Heinrich, Michael C.; Jones, Robin L.; George, Suzanne; Gelderblom, Hans; Schöffski, Patrick; von Mehren, Margaret; Zalcberg, John R.; Kang, Yoon-Koo; Razak, Albiruni Abdul; Trent, Jonathan; Attia, Steven; Le Cesne, Axel; Siontis, Brittany L.; Goldstein, David; Boye, Kjetil; Sanchez, Cesar; Steeghs, Neeltje; Rutkowski, Piotr; Druta, Mihaela; Serrano, César; Somaiah, Neeta; Chi, Ping; Reichmann, William; Sprott, Kam; Achour, Haroun; Sherman, Matthew L.; Ruiz-Soto, Rodrigo; Blay, Jean-Yves; Bauer, Sebastian
    Ripretinib versus sunitinib in gastrointestinal stromal tumor : ctDNA biomarker analysis of the phase 3 INTRIGUE trial
    In: Nature Medicine Vol. 30 (2024) Nr. 2, pp. 498 - 506
  • Joensuu, Heikki; Wardelmann, Eva; Eriksson, Mikael; Reichardt, Annette; Hall, Kirsten Sundby; Schütte, Jochen; Cameron, Silke; Hohenberger, Peter; Sihto, Harri; Jost, Philipp J.; Lindner, Lars H.; Bauer, Sebastian; Nilsson, Bengt; Kallio, Raija; Pesonen, Tommi; Reichardt, Peter
    KIT and PDGFRA Mutations and Survival of Gastrointestinal Stromal Tumor Patients Treated with Adjuvant Imatinib in a Randomized Trial
    In: Clinical Cancer Research Vol. 29 (2023) Nr. 17, pp. 3313 - 3319
  • Tretter, Celina; de Andrade Krätzig, Niklas; Pecoraro, Matteo; Lange, Sebastian; Seifert, Philipp; von Frankenberg, Clara; Untch, Johannes; Zuleger, Gabriela; Wilhelm, Mathias; Zolg, Daniel P.; Dreyer, Florian S.; Bräunlein, Eva; Engleitner, Thomas; Uhrig, Sebastian; Boxberg, Melanie; Steiger, Katja; Slotta-Huspenina, Julia; Ochsenreither, Sebastian; von Bubnoff, Nikolas; Bauer, Sebastian; Boerries, Melanie; Jost, Philipp J.; Schenck, Kristina; Dresing, Iska; Bassermann, Florian; Friess, Helmut; Reim, Daniel; Grützmann, Konrad; Pfütze, Katrin; Klink, Barbara; Schröck, Evelin; Haller, Bernhard; Kuster, Bernhard; Mann, Matthias; Weichert, Wilko; Fröhling, Stefan; Rad, Roland; Hiltensperger, Michael; Krackhardt, Angela M.
    Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification
    In: Nature Communications Vol. 14 (2023) Nr. 1, pp. 4632
  • Koch, Raphael; Haveman, Lianne; Ladenstein, Ruth; Brichard, Benedicte; Jürgens, Heribert; Cyprova, Sona; van den Berg, Henk; Hassenpflug, Wolf; Raciborska, Anna; Ek, Torben; Baumhoer, Daniel; Egerer, Gerlinde; Kager, Leo; Renard, Marleen; Hauser, Peter; Burdach, Stefan; Bovee, Judith V M G; Hong, Angela M.; Reichardt, Peter; Kruseova, Jarmila; Streitbürger, Arne; Kühne, Thomas; Kessler, Torsten; Bernkopf, Marie; Butterfaß-Bahloul, Trude; Dhooge, Catharina; Bauer, Sebastian; Kiss, János; Paulussen, Michael; Bonar, Fiona; Ranft, Andreas; Timmermann, Beate; Rascon, Jelena; Vieth, Volker; Kanerva, Jukka; Faldum, Andreas; Hartmann, Wolfgang; Hjorth, Lars; Bhadri, Vivek A.; Metzler, Markus; Gelderblom, Hans; Dirksen, Uta
    Zoledronic Acid Add-on Therapy for Standard-Risk Ewing Sarcoma Patients in the Ewing 2008R1 Trial
    In: Clinical Cancer Research Vol. 29 (2023) Nr. 24, pp. 5057 - 5068
  • Vincenzi, Bruno; Napolitano, Andrea; Fiocco, Marta; Mir, Olivier; Rutkowski, Piotr; Blay, Jean-Yves; Reichardt, Peter; Joensuu, Heikki; Fumagalli, Elena; Gennatas, Spyridon; Hindi, Nadia; Nannini, Margherita; Ceruso, Mariella Spalato; Italiano, Antoine; Grignani, Giovanni; Brunello, Antonella; Gasperoni, Silvia; De Pas, Tommaso; Badalamenti, Giuseppe; Pantaleo, Maria A.; Van Houdt, Winan J.; IJzerman, Nikki S.; Steeghs, Neeltje; Gelderblom, Hans; Desar, Ingrid M.E.; Falkenhorst, Johanna; Silletta, Marianna; Sbaraglia, Marta; Tonini, Giuseppe; Martin-Brot, Javier; Hohenberger, Peter; Le Cesne, Axel; Jones, Robin L.; Dei Tos, Angelo P.; Gronchi, Alessandro; Bauer, Sebastian; Casali, Paolo G.
    Adjuvant Imatinib in Patients with GIST Harboring Exon 9 KIT Mutations : Results from a Multi-institutional European Retrospective Study
    In: Clinical Cancer Research Vol. 28 (2022) Nr. 8, pp. 1672 - 1679
  • Abdul Razak, Albiruni R.; Bauer, Sebastian; Suarez, Cristina; Lin, Chia-Chi; Quek, Richard; Hütter-Krönke, Marie Luise; Cubedo, Ricardo; Ferretti, Stephane; Guerreiro, Nelson; Jullion, Astrid; Orlando, Elena J.; Clementi, Giorgia; Dejmek, Janna Sand; Halilovic, Ensar; Fabre, Claire; Blay, Jean-Yves; Italiano, Antoine; Sand Dejmek, Janna
    Co-Targeting of MDM2 and CDK4/6 with Siremadlin and Ribociclib for the Treatment of Patients with Well-Differentiated or Dedifferentiated Liposarcoma : Results from a Proof-of-Concept, Phase Ib Study
    In: Clinical Cancer Research Vol. 28 (2022) Nr. 6, pp. 1087 - 1097
  • Stein, Eytan M.; DeAngelo, Daniel J.; Chromik, Jörg; Chatterjee, Manik; Bauer, Sebastian; Lin, Chia-Chi; Suarez, Cristina; de Vos, Filip; Steeghs, Neeltje; Cassier, Philippe A.; Tai, David; Kiladjian, Jean-Jacques; Yamamoto, Noboru; Mous, Rogier; Esteve, Jordi; Minami, Hironobu; Ferretti, Stephane; Guerreiro, Nelson; Meille, Christophe; Radhakrishnan, Rajkumar; Pereira, Bernard; Mariconti, Luisa; Halilovic, Ensar; Fabre, Claire; Carpio, Cecilia; Cassier, Phillippe A.
    Results from a First-in-Human Phase I Study of Siremadlin (HDM201) in Patients with Advanced Wild-Type TP53 Solid Tumors and Acute Leukemia
    In: Clinical Cancer Research Vol. 28 (2022) Nr. 5, pp. 870 - 881
  • Fendler, Wolfgang; Pabst, Kim M.; Kessler, Lukas; Fragoso Costa, Pedro; Ferdinandus, Justin; Weber, Manuel; Lippert, Maria; Lückerath, Katharina; Umutlu, Lale; Kostbade, Karina; Mavroeidi, Ilektra A.; Schuler, Martin; Ahrens, Marit; Rischpler, Christoph; Bauer, Sebastian; Herrmann, Ken; Siveke, Jens; Hamacher, Rainer
    Safety and Efficacy of 90Y-FAPI-46 Radioligand Therapy in Patients with Advanced Sarcoma and Other Cancer Entities
    In: Clinical Cancer Research Vol. 28 (2022) Nr. 19, pp. 4346 - 4353
  • Bauer, Sebastian; Heinrich, Michael C.; George, Suzanne; Zalcberg, John R.; Serrano, César; Gelderblom, Hans; Jones, Robin L.; Attia, Steven; D'Amato, Gina; Chi, Ping; Reichardt, Peter; Meade, Julie; Su, Ying; Ruiz-Soto, Rodrigo; Blay, Jean-Yves; von Mehren, Margaret; Schöffski, Patrick
    Clinical Activity of Ripretinib in Patients with Advanced Gastrointestinal Stromal Tumor Harboring Heterogeneous KIT/PDGFRA Mutations in the Phase III INVICTUS Study
    In: Clinical Cancer Research Vol. 27 (2021) Nr. 23, pp. 6333 - 6342
  • Gröschel, Stefan; Hübschmann, Daniel; Raimondi, Francesco; Horak, Peter; Warsow, Gregor; Fröhlich, Martina; Klink, Barbara; Gieldon, Laura; Hutter, Barbara; Kleinheinz, Kortine; Bonekamp, David; Marschal, Oliver; Chudasama, Priya; Mika, Jagoda; Groth, Marie; Uhrig, Sebastian; Krämer, Stephen; Heining, Christoph; Heilig, Christoph E.; Richter, Daniela; Reisinger, Eva; Pfütze, Katrin; Eils, Roland; Wolf, Stephan; Kalle, Christof von; Brandts, Christian; Scholl, Claudia; Weichert, Wilko; Richter, Stephan; Bauer, Sebastian; Penzel, Roland; Schröck, Evelin; Stenzinger, Albrecht; Schlenk, Richard F.; Brors, Benedikt; Russell, Robert B.; Glimm, Hanno; Schlesner, Matthias; Fröhling, Stefan
    Defective homologous recombination DNA repair as therapeutic target in advanced chordoma
    In: Nature Communications Vol. 10 (2019) Nr. 1, pp. 1635
  • Chudasama, Priya; Mughal, Sadaf S.; Schröck, Evelin; Glimm, Hanno; Kleinheinz, Kortine; Klink, Barbara; Brors, Benedikt; Hlevnjak, Mario; Gröschel, Stefan; Wolf, Stephan; Omlor, Georg; Ernst, Aurélie; Ulrich, Alexis; Deeg, Katharina I.; Mechtersheimer, Gunhild; Schimmack, Simon; Eils, Roland; Egerer, Gerlinde; Kasper, Bernd; Wong, Siao-Han; von Kalle, Christof; Hohenberger, Peter; Lehner, Burkhard; Rippe, Karsten; Chung, Inn; Bauer, Sebastian; Scholl, Claudia; Sieverling, Lina; Sanders, Mathijs A.; Hübschmann, Daniel; Heilig, Christoph E.; Hutter, Barbara; Renner, Marcus; Weichert, Wilko; Stenzinger, Albrecht; Schlesner, Matthias; Hoogenboezem, Remco M.; Kopp, Hans-Georg; Rabe, Sophie; Zapatka, Marc; Fröhling, Stefan
    Integrative genomic and transcriptomic analysis of leiomyosarcoma
    In: Nature Communications Vol. 9 (2018) Nr. 1, pp. 144
  • Schaefer, Inga-Marie; Wang, Yuexiang; Liang, Cher-Wei; Bahri, Nacef; Quattrone, Anna; Doyle, Leona; Marinõ-Enríquez, Adrian; Lauria, Alexandra; Zhu, Meijun; Debiec-Rychter, Maria; Grunewald, Susanne; Hechtman, Jaclyn F.; Dufresne, Armelle; Antonescu, Cristina R.; Beadling, Carol; Sicinska, Ewa T.; Van De Rijn, Matt; Demetri, George D.; Ladanyi, Marc; Corless, Christopher L.; Heinrich, Michael C.; Raut, Chandrajit P.; Bauer, Sebastian; Fletcher, Jonathan A.
    MAX inactivation is an early event in GIST development that regulates p16 and cell proliferation
    In: Nature Communications Vol. 8 (2017) pp. 14674
  • Kim, Won Kyu; Yun, SeongJu; Park, Cheol Keun; Bauer, Sebastian; Kim, Jiyoon; Lee, Min Goo; Kim, Hoguen
    Sustained mutant KIT activation in the Golgi complex is mediated by PKC-θ in gastrointestinal stromal tumors
    In: Clinical Cancer Research Vol. 23 (2017) Nr. 3, pp. 845 - 856
  • Garner, Andrew P.; Gozgit, Joseph M.; Anjum, Rana; Vodala, Sadanand; Schrock, Alexa; Zhou, Tianjun; Serrano, César; Eilers, Grant; Zhu, Meijun; Ketzer, Julia; Wardwell, Scott D.; Ning, Yaoyu; Song, Youngchul; Kohlmann, Anna; Wang, Frank; Clackson, Tim P.; Heinrich, Michael C.; Fletcher, Jonathan A.; Bauer, Sebastian; Rivera, Víctor M.
    Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and shows therapeutic potential in heavily pretreated gastrointestinal stromal tumor (GIST) patients
    In: Clinical Cancer Research Vol. 20 (2014) Nr. 22, pp. 5745 - 5755
  • Mühlenberg, T.; Grunewald, S.; Schuler, Martin; Bauer, Sebastian
    Targeting glucose metabolism by 2-deoxyglucose in gastrointestinal stromal tumors
    In: Cancer Research Vol. 74 (2014) Nr. 19 Suppl.,
  • Simon, Susanne; Grabellus, Florian; Ferrera, Loretta; Galietta, Luis; Schwindenhammer, Benjamin; Mühlenberg, Thomas; Täger, Georg; Eilers, Grant; Treckmann, Jürgen-Walter; Breitenbücher, Frank; Schuler, Martin; Taguchi, Takahiro; Fletcher, Jonathan A.; Bauer, Sebastian
    DOG1 Regulates Growth and IGFBP5 in Gastrointestinal Stromal Tumors
    In: Cancer Research Vol. 73 (2013) Nr. 12, pp. 3661 - 3670
  • Demetri, G. D.; Jeffers, M.; Reichardt, P.; Kang, Y. K.; Blay, J. Y.; Rutkowski, P.; Gelderblom, H.; Hohenberger, P.; Leahy, M.; von Mehren, M.; Joensuu, H.; Badalamenti, G.; Blackstein, M.; Le Cesne, A.; Schoffski, P.; Maki, R. G.; Bauer, Sebastian; Nguyen, B. B.; Xu, J. M.; Nishida, T.; Chung, J.; Lathia, C. D.; Kappeler, C.; Kuss, I.; Laurent, D.; Casali, P. G.
    Detection of oncogenic kinase mutations in circulating plasma DNA and correlation with clinical benefit in the phase III GRID study of regorafenib vs placebo in TKI-refractory metastatic GIST
    In: Cancer Research Vol. 73 (2013) Nr. Suppl. 8,
  • Bauer, Sebastian; Parry, Joshua A.; Mühlenberg, Thomas; Brown, Matthew F.; Seneviratne, Danushka; Chatterjee, Payel; Chin, Anna; Rubin, Brian P.; Kuan, Shih-Fan; Fletcher, Jonathan A.; Duensing, Stefan; Duensing, Anette
    Proapoptotic activity of bortezomib in gastrointestinal stromal tumor cells
    In: Cancer Research Vol. 70 (2010) Nr. 1, pp. 150 - 159
  • Mühlenberg, Thomas; Zhang, Yixiang; Wagner, Andrew J.; Grabellus, Florian; Bradner, James; Täger, Georg; Lang, Hauke; Taguchi, Takahiro; Schuler, Martin; Fletcher, Jonathan A.; Bauer, Sebastian
    Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors
    In: Cancer Research Vol. 69 (2009) Nr. 17, pp. 6941 - 6950