ZMB Member Ivo Bendix
ZMB Member
Ivo Bendix
Next ZMB-Member
Prof. Dr. Ivo Bendix
Pediatrics Clinic I
University Hospital Essen
Hufelandstr. 55
45122 Essen
- +49 201 723 0
- Website
- Publications
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- ZMB Research Program
Molecular and Chemical Cell Biology
Research Overview
The questions of the experimental perinatal neurosciences are aimed at uncovering cellular and molecular mechanisms of typical diseases of premature babies and sick newborns, with the integrity of the central nervous system being the focus of research.
Publications
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Oxygen and HIF1α-dependent SDF1 expression in primary astrocytesIn: Developmental Neurobiology Vol. 84 (2024) Nr. 3, pp. 113 - 127Online Full Text: dx.doi.org/ (Open Access)
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Extracellular vesicles from immortalized mesenchymal stromal cells protect against neonatal hypoxic-ischemic brain injuryIn: Inflammation and Regeneration Vol. 43 (2023) Nr. 1, 24Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Growth-Restricted Fetuses and Offspring Reveal Adverse Sex-Specific Metabolic Responses in Preeclamptic Mice Expressing Human sFLT1In: International Journal of Molecular Sciences (IJMS) Vol. 24 (2023) Nr. 8, 6885Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Hypothermia combined with extracellular vesicles from clonally expanded immortalized mesenchymal stromal cells improves neurodevelopmental impairment in neonatal hypoxic-ischemic brain injuryIn: Journal of Neuroinflammation Vol. 20 (2023) Nr. 1, 280Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Perinatal Hyperoxia and Developmental Consequences on the Lung-Brain AxisIn: Oxidative Medicine and Cellular Longevity (2022) 5784146Online Full Text: dx.doi.org/ (Open Access)
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Peripheral immune cells and perinatal brain injury : A double-edged sword?In: Pediatric Research Vol. 91 (2022) Nr. 2, pp. 392 - 403Online Full Text: dx.doi.org/ (Open Access)
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Regulatory T Cells Contribute to Sexual Dimorphism in Neonatal Hypoxic-Ischemic Brain InjuryIn: Stroke Vol. 53 (2022) Nr. 2, pp. 381 - 390Online Full Text: dx.doi.org/ (Open Access)
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Systemic Maternal Human sFLT1 Overexpression Leads to an Impaired Foetal Brain Development of Growth-Restricted Foetuses upon Experimental PreeclampsiaIn: Oxidative Medicine and Cellular Longevity Vol. 2022 (2022) 3024032Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Taste-immune associative learning amplifies immunopharmacological effects and attenuates disease progression in a rat glioblastoma modelIn: Brain, Behavior and Immunity Vol. 106 (2022) pp. 270 - 279Online Full Text: dx.doi.org/ (Open Access)
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The Impact of Increased Maternal sFlt-1/PlGF Ratio on Motor Outcome of Preterm InfantsIn: Frontiers in Endocrinology Vol. 13 (2022) 913514Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Circulating Maternal sFLT1 (Soluble fms-Like Tyrosine Kinase-1) Is Sufficient to Impair Spiral Arterial Remodeling in a Preeclampsia Mouse ModelIn: Hypertension Vol. 78 (2021) Nr. 4, pp. 1067 - 1079Online Full Text: dx.doi.org/ (Open Access)
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Hyperoxia Leads to Transient Endocrine Alterations in the Neonatal Rat During Postnatal DevelopmentIn: Frontiers in Pediatrics Vol. 9 (2021) 723928Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Hypothermia modulates myeloid cell polarization in neonatal hypoxic–ischemic brain injuryIn: Journal of Neuroinflammation Vol. 18 (2021) Nr. 1, 266Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Neurobehavioral effects in rats with experimentally induced glioblastoma after treatment with the mTOR-inhibitor rapamycinIn: Neuropharmacology Vol. 184 (2021) 108424Online Full Text: dx.doi.org/
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Neutrophil dynamics, plasticity and function in acute neurodegeneration following neonatal hypoxia-ischemiaIn: Brain, Behavior and Immunity Vol. 92 (2021) pp. 234 - 244Online Full Text: dx.doi.org/ (Open Access)
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Treatment with the calcineurin inhibitor and immunosuppressant cyclosporine A impairs sensorimotor gating in Dark Agouti ratsIn: Psychopharmacology Vol. 238 (2021) Nr. 4, pp. 1047 - 1057Online Full Text: dx.doi.org/ (Open Access)
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Involvement of CXCL1/CXCR2 During Microglia Activation Following Inflammation-Sensitized Hypoxic-Ischemic Brain Injury in Neonatal RatsIn: Frontiers in Neurology Vol. 11 (2020) pp. 540878Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Mesenchymal Stromal Cell-Derived Extracellular Vesicles Reduce Neuroinflammation, Promote Neural Cell Proliferation and Improve Oligodendrocyte Maturation in Neonatal Hypoxic-Ischemic Brain InjuryIn: Frontiers in Cellular Neuroscience Vol. 14 (2020) pp. 601176Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Prevention of Oxygen-Induced Inflammatory Lung Injury by Caffeine in Neonatal RatsIn: Oxidative Medicine and Cellular Longevity (2020) pp. 3840124Online Full Text: dx.doi.org/ (Open Access)
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RNA interference therapeutics targeting angiotensinogen ameliorate preeclamptic phenotype in rodent modelsIn: The Journal of Clinical Investigation (JCI) Vol. 130 (2020) Nr. 6, pp. 2928 - 2942Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Repetitive Erythropoietin Treatment Improves Long-Term Neurocognitive Outcome by Attenuating Hyperoxia-Induced Hypomyelination in the Developing BrainIn: Frontiers in Neurology Vol. 11 (2020) pp. 804Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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White Matter Brain Development after Exposure to Circulating Cell-Free Hemoglobin and Hyperoxia in a Rat Pup ModelIn: Developmental Neuroscience Vol. 41 (2020) Nr. 3-4, pp. 234 - 246Online Full Text: dx.doi.org/ (Open Access)
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Adverse neuropsychiatric development following perinatal brain injury : from a preclinical perspectiveIn: Pediatric Research Vol. 85 (2019) Nr. 2, pp. 198 - 215Online Full Text: dx.doi.org/ (Open Access)
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Detrimental Impact of Energy Drink Compounds on Developing Oligodendrocytes and NeuronsIn: Cells Vol. 8 (2019) Nr. 11, pp. 1381Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Early pro-inflammatory microglia activation after inflammation-sensitized hypoxic-ischemic brain injury in neonatal ratsIn: Frontiers in Cellular Neuroscience Vol. 13 (2019) pp. 237Online Full Text: dx.doi.org/ (Open Access)
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Diabetes mellitus in pregnancy leads to growth restriction and epigenetic modification of the Srebf2 gene in rat fetusesIn: Hypertension Vol. 71 (2018) Nr. 5, pp. 911 - 920Online Full Text: dx.doi.org/ (Open Access)
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Interaction between hypothermia and delayed mesenchymal stem cell therapy in neonatal hypoxic-ischemic brain injuryIn: Brain, Behavior and Immunity Vol. 70 (2018) pp. 118 - 130Online Full Text: dx.doi.org/ (Open Access)
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Peripheral T cell depletion by FTY720 exacerbates hypoxic-ischemic brain injury in neonatal miceIn: Frontiers in Immunology Vol. 9 (2018) pp. 1696Online Full Text: dx.doi.org/ (Open Access)
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Protection of oligodendrocytes through neuronal overexpression of the small GTPase ras in hyperoxia-induced neonatal brain injuryIn: Frontiers in Neurology Vol. 9 (2018) pp. 175Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Repeated systemic treatment with rapamycin affects behavior and amygdala protein expression in ratsIn: The International Journal of Neuropsychopharmacology Vol. 21 (2018) Nr. 6, pp. 595 - 602Online Full Text: dx.doi.org/ (Open Access)
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Caffeine protects against anticonvulsant-induced neurotoxicity in the developing rat brainIn: Neurotoxicity Research Vol. 32 (2017) Nr. 3, pp. 460 - 472Online Full Text: dx.doi.org/
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Effects of Poly(ADP-Ribose) Polymerase-1 Inhibition in a Neonatal Rodent Model of Hypoxic-Ischemic InjuryIn: BioMed Research International (2017) 2924848Online Full Text: dx.doi.org/ (Open Access)
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Hyperoxia and the immature brainIn: Developmental Neuroscience Vol. 38 (2017) Nr. 5, pp. 311 - 330Online Full Text: dx.doi.org/ (Open Access)
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Mesenchymal stem cell-derived extracellular vesicles ameliorate inflammation-induced preterm brain injuryIn: Brain, Behavior and Immunity Vol. 60 (2017) pp. 220 - 232Online Full Text: dx.doi.org/ (Open Access)
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Sildenafil Enhances Quantity of Immature Neurons and Promotes Functional Recovery in the Developing Ischemic Mouse BrainIn: Developmental Neuroscience Vol. 39 (2017) Nr. 1-4, pp. 287 - 297Online Full Text: dx.doi.org/
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Dose-dependent effects of levetiracetam after hypoxia and hypothermia in the neonatal mouse brainIn: Brain Research Vol. 1646 (2016) pp. 116 - 124Online Full Text: dx.doi.org/
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ERK1 as a Therapeutic Target for Dendritic Cell Vaccination against High-Grade GliomasIn: Molecular Cancer Therapeutics Vol. 15 (2016) Nr. 8, pp. 1975 - 1987Online Full Text: dx.doi.org/ (Open Access)
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Endogenous hypothermic response to hypoxia reduces brain injury : Implications for modeling hypoxic-ischemic encephalopathy and therapeutic hypothermia in neonatal miceIn: Experimental Neurology Vol. 283, Part A (2016) pp. 264 - 275Online Full Text: dx.doi.org/ (Open Access)
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Erythropoietin Restores Long-Term Neurocognitive Function Involving Mechanisms of Neuronal Plasticity in a Model of Hyperoxia-Induced Preterm Brain InjuryIn: Oxidative Medicine and Cellular Longevity (2016) pp. 9247493Online Full Text: dx.doi.org/ (Open Access)
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Fingolimod protects against neonatal white matter damage and long-term cognitive deficits caused by hyperoxiaIn: Brain, Behavior and Immunity Vol. 52 (2016) pp. 106 - 119Online Full Text: dx.doi.org/ (Open Access)
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Transient inhibition of protein synthesis in the rat insular cortex delays extinction of conditioned taste aversion with cyclosporine AIn: Neurobiology of Learning and Memory Vol. 133 (2016) pp. 129 - 135Online Full Text: dx.doi.org/
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Tumor necrosis factor-inducible gene 6 protein : A novel neuroprotective factor against inflammation-induced developmental brain injuryIn: Experimental Neurology Vol. 279 (2016) pp. 283 - 289Online Full Text: dx.doi.org/ (Open Access)
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Neuroprotective Effect of Dexmedetomidine on Hyperoxia-Induced Toxicity in the Neonatal Rat BrainIn: Oxidative Medicine and Cellular Longevity Vol. 2015 (2015) pp. 530371Online Full Text: dx.doi.org/ (Open Access)
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Oxygen Sensitivity of Placental Trophoblast Connexins 43 and 46 : A Role in Preeclampsia?In: Journal of Cellular Biochemistry Vol. 116 (2015) Nr. 12, pp. 2924 - 2937Online Full Text: dx.doi.org/
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Regulatory T Cells Ameliorate Intrauterine Growth Retardation in a Transgenic Rat Model for PreeclampsiaIn: Hypertension Vol. 65 (2015) Nr. 6, pp. 1298 - 1306Online Full Text: dx.doi.org/ (Open Access)
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Inhibition of Acetylcholinesterase Modulates NMDA Receptor Antagonist Mediated Alterations in the Developing BrainIn: International Journal of Molecular Sciences (IJMS) Vol. 15 (2014) Nr. 3, pp. 3784 - 3798Online Full Text: dx.doi.org/ (Open Access)
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Modulation of Dendritic Cell Immunobiology via Inhibition of 3-Hydroxy-3-Methylglutaryl-CoA (HMG-CoA) ReductaseIn: PLoS ONE Vol. 9 (2014) Nr. 7, pp. e100871Online Full Text: dx.doi.org/ (Open Access)
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Neuroblastoma in dialog with its stroma : NTRK1 is a regulator of cellular cross-talk with Schwann cellsIn: OncoTarget Vol. 5 (2014) Nr. 22, pp. 11180 - 11192Online Full Text: dx.doi.org/ (Open Access)
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Sphingosin-1-phosphate-receptor modulation reduces hyperoxia mediated brain injuryIn: Journal of Neuroimmunology Vol. 275 (2014) Nr. 1-2, pp. 114Online Full Text: dx.doi.org/
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CEACAM1 Expression in Oligodendrocytes of the Developing Rat Brain Shows a Spatiotemporal Relation to Myelination and Is Altered in a Model of Encephalopathy of PrematurityIn: Developmental Neuroscience Vol. 35 (2013) Nr. 2-3, pp. 226 - 240Online Full Text: dx.doi.org/
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Effect of Propofol in the Immature Rat Brain on Short- and Long-Term Neurodevelopmental OutcomeIn: PLoS ONE Vol. 8 (2013) Nr. 5, pp. e64480Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Effects of repetitive exposure to pain and morphine treatment on the neonatal rat brainIn: Neonatology Vol. 103 (2013) Nr. 1, pp. 35 - 43Online Full Text: dx.doi.org/
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Oxygen toxicity is reduced by acetylcholinesterase inhibition in the developing rat brainIn: Developmental Neuroscience Vol. 35 (2013) Nr. 2-3, pp. 255 - 264Online Full Text: dx.doi.org/
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Strategies for repair of white matter: Influence of osmolarity and microglia on proliferation and apoptosis of oligodendrocyte precursor cells in different basal culture mediaIn: Frontiers in Cellular Neuroscience Vol. 7 (2013) pp. 277Online Full Text: dx.doi.org/
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Erythropoietin Modulates Autophagy Signaling in the Developing Rat Brain in an In Vivo Model of Oxygen-ToxicityIn: International Journal of Molecular Sciences (IJMS) Vol. 13 (2012) Nr. 10, pp. 12939 - 12951Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Hyperoxia changes the balance of the thioredoxin/peroxiredoxin system in the neonatal rat brainIn: Brain Research Vol. 1484 (2012) pp. 68 - 75Online Full Text: dx.doi.org/
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Interaction of Inflammation and Hyperoxia in a Rat Model of Neonatal White Matter DamageIn: PLoS ONE Vol. 7 (2012) Nr. 11, pp. e49023Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Interaction of inflammation and hyperoxia in a rat model of neonatal white matter damageIn: Journal of Neuroimmunology Vol. 253 (2012) Nr. 1-2, pp. 45 - 45
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Prevention of neonatal oxygen-induced brain damage by reduction of intrinsic apoptosisIn: Cell Death and Disease Vol. 3 (2012) Nr. 1, e250Online Full Text: dx.doi.org/ (Open Access)
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Impact of Experimental Neonatal Propofol Anaesthesia on Neurodevelopmental Short- and Long-Term OutcomeIn: Pediatric Research Vol. 70 (2011) pp. 31 - 31Online Full Text: dx.doi.org/
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111 Impact of the Caspase-2 Inhibitor Trp601 on Apoptotic Signaling in the Developing Brain During HyperoxiaIn: Pediatric Research Vol. 68 (2010) Nr. Suppl. 1, pp. 59 - 59Online Full Text: dx.doi.org/
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113 The Apoptotic Effect of Propofol in Immature Rat Brain and Possible Neuroprotection by ErythropoietinIn: Pediatric Research Vol. 68 (2010) Nr. Suppl. 1, pp. 60 - 60Online Full Text: dx.doi.org/
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Erythropoietin attenuates hyperoxia-induced oxidative stress in the developing rat brainIn: Brain, Behavior and Immunity Vol. 24 (2010) Nr. 5, pp. 792 - 799Online Full Text: dx.doi.org/
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MAPK3 deficiency drives autoimmunity via DC armingIn: European Journal of Immunology Vol. 40 (2010) Nr. 5, pp. 1486 - 1495Online Full Text: dx.doi.org/
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Neurotoxic effects of MDMA (Ecstasy) on the developing rodent brainIn: Developmental Neuroscience Vol. 32 (2010) Nr. 3, pp. 197 - 207Online Full Text: dx.doi.org/
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Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous systemIn: Nature Medicine Vol. 15 (2009) Nr. 7, pp. 788 - 793Online Full Text: dx.doi.org/
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Geranylgeranylation but not GTP-loading of Rho GTPases determines T cell functionIn: Science Signaling Vol. 1 (2008) Nr. 12,Online Full Text: dx.doi.org/
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Sirt1 contributes critically to the redox-dependent fate of neural progenitorsIn: Nature Cell Biology Vol. 10 (2008) Nr. 4, pp. 385 - 394Online Full Text: dx.doi.org/
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Geranylgeranylation but not GTP loading determines rho migratory function in T cellsIn: The Journal of Immunology Vol. 179 (2007) Nr. 9, pp. 6024 - 6032Online Full Text: dx.doi.org/