Sven Brandau

ZMB Member
Sven Brandau

Next ZMB-Member
portrait photo of ZMB member Sven Brandau
© UKE/S.Brandau

Prof. Dr. Sven Brandau

Group

Otorhinolaryngology

West German Cancer Center (WTZ)
University Hospital Essen
Hufelandstr. 55
45147 Essen

Research Overview

We have a special interest in the immunological tumor-host interaction with a particular focus on neutrophils and myeloid-derived suppressor cells. A second research theme of the division aims at better understanding the immunoregulatory properties of so-called mesenchymal stromal cells. In the last ten years we have authored or co-authored over 130 peer-reviewed publications, some of which are highly cited.
Over the last ten years we have established and worked on the following three main research themes:

  1. Immunoregulatory mechanisms in tumor-host interaction
  2. Immunological and biological tumor therapy
  3. Immunobiology of mesenchymal stromal cells
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Selected Publications

    Journal articles

  • Mittmann, Laura A.; Haring, Florian; Schaubächer, Johanna B.; Hennel, Roman; Smiljanov, Bojan; Zuchtriegel, Gabriele; Canis, Martin; Gires, Olivier; Krombach, Fritz; Holdt, Lesca; Brandau, Sven; Vogl, Thomas; Lauber, Kirsten; Uhl, Bernd; Reichel, Christoph et al.
    Uncoupled biological and chronological aging of neutrophils in cancer promotes tumor progression
    In: Journal for ImmunoTherapy of Cancer Vol. 9 (2021) Nr. 12, e003495
    Online Full Text: dx.doi.org/ (Open Access)
  • Cassetta, Luca; Bruderek, Kirsten; Skrzeczynska-Moncznik, Joanna; Osiecka, Oktawia; Hu, Xiaoying; Rundgren, Ida Marie; Lin, Ang; Santegoets, Kim; Horzum, Utku; Godinho-Santos, Ana; Zelinskyy, Gennadiy; Garcia-Tellez, Thalia; Bjelica, Sunčica; Taciak, Bartł et al.
    Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation
    In: Journal for ImmunoTherapy of Cancer Vol. 8 (2020) Nr. 2, pp. e001223
    Online Full Text: dx.doi.org/ (Open Access)
  • Si, Yu; Merz, Simon F.; Jansen, Philipp; Wang, Baoxiao; Bruderek, Kirsten; Altenhoff, Petra; Mattheis, Stefan; Lang, Stephan; Gunzer, Matthias; Klode, Joachim; Squire, Anthony; Brandau, Sven.
    Multidimensional imaging provides evidence for down-regulation of T cell effector function by MDSC in human cancer tissue
    In: Science Immunology Vol. 4 (2019) Nr. 40,
    Online Full Text: dx.doi.org/
  • Lang, Stephan; Bruderek, Kirsten; Kaspar, Cordelia; Höing, Benedikt; Kanaan, Oliver; Dominas, Nina; Hussain, Timon; Droege, Freya; Eyth, Christian; Hadaschik, Boris; Brandau, Sven.
    Clinical Relevance and Suppressive Capacity of Human Myeloid-Derived Suppressor Cell Subsets
    In: Clinical Cancer Research Vol. 24 (2018) Nr. 19, pp. 4834 - 4844
    Online Full Text: dx.doi.org/ (Open Access)
  • Klein, Johanna C.; Moses, Katrin; Zelinskyy, Gennadiy; Sody, Simon; Buer, Jan; Lang, Stephan; Helfrich, Iris; Dittmer, Ulf; Kirschning, Carsten Jürgen; Brandau, Sven.
    Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth
    In: Nature Communications Vol. 8 (2017) pp. 14600
    Online Full Text: dx.doi.org/ (Open Access)
  • Brandau, Sven; Hartl, Dominik.
    Lost in neutrophil heterogeneity? : CD10!
    In: Blood Vol. 129 (2017) Nr. 10, pp. 1240 - 1241
    Online Full Text: dx.doi.org/ (Open Access)
  • Kansy, Benjamin A.; Concha-Benavente, Fernando; Srivastava, Raghvendra M.; Jie, Hyun-Bae; Shayan, Gulidanna; Lei, Yu; Moskovitz, Jessica; Moy, Jennifer; Li, Jing; Brandau, Sven; Lang, Stephan; Schmitt, Nicole C.; Freeman, Gordon J.; Gooding, William E.; Cl et al.
    PD-1 Status in CD8+ T Cells Associates with Survival and Anti-PD-1 Therapeutic Outcomes in Head and Neck Cancer
    In: Cancer Research Vol. 77 (2017) Nr. 22, pp. 6353 - 6364
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Kalkavan, Halime; Sharma, Piyush; Kasper, Stefan; Helfrich, Iris; Pandyra, Aleksandra A.; Gassa, Asmae; Virchow, Isabel; Flatz, Lukas; Brandenburg, Tim; Namineni, Sukumar; Heikenwalder, Mathias; Höchst, Bastian; Knolle, Percy A.; Wollmann, Guido; Von Laer, et al.
    Spatiotemporally restricted arenavirus replication induces immune surveillance and type i interferon-dependent tumour regression
    In: Nature Communications Vol. 8 (2017) pp. 14447
    Online Full Text: dx.doi.org/ (Open Access)
  • Bronte, Vincenzo; Brandau, Sven; Chen, Shu-Hsia; Colombo, Mario P; Frey, Alan B; Greten, Tim F; Mandruzzato, Susanna; Murray, Peter J; Ochoa, Augusto; Ostrand-Rosenberg, Suzanne; Rodriguez, Paulo C; Sica, Antonio; Umansky, Viktor; Vonderheide, Robert H; Ga et al.
    Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
    In: Nature Communications Vol. 7 (2016) pp. 12150
    Online Full Text: dx.doi.org/ (Open Access)
  • Hasenberg, Anja; Hasenberg, Mike; Männ, Linda; Neumann, Franziska; Borkenstein, Lars; Stecher, Manuel; Kraus, Andreas; Engel, Daniel Robert; Klingberg, Anika; Seddigh, Pegah; Abdullah, Zeinab; Klebow, Sabrina; Engelmann, Swen; Reinhold, Annegret; Brandau, et al.
    Catchup : a mouse model for imaging-based tracking and modulation of neutrophil granulocytes
    In: Nature Methods Vol. 12 (2015) Nr. 5, pp. 445 - 452
    Online Full Text: dx.doi.org/
  • Andzinski, Lisa; Harati, Mozhgan Dehghan; Zyla, Edyta; Kasnitz, Nadine; Stahnke, Stephanie; Wu, Ching-Fang; Gereke, Marcus; von Kockritz-Blickwede, Maren; Schilling, Bastian; Brandau, Sven; Kanz, Lothar; Welte, Karl; Weiss, Siegfried; Skokowa, Julia; Jablo et al.
    The Mechanism of Type I Interferon-Mediated Polarization of Tumor-Associated Neutrophils in Mice and Human
    In: Blood Vol. 126 (2015) Nr. 23,
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