ZMB Member Joachim Fandrey
ZMB Member
Joachim Fandrey
Next ZMB-Member
Prof. Dr. Joachim Fandrey
Director of:
Institute of PhysiologyUniversity Hospital Essen
Virchowstr. 171
45147 Essen
- +49 201 723 4600
- Website
- Selected Publications
- Publication Metrics
- ZMB Research Program
Molecular and Chemical Cell Biology
Research Overview
- Oxygen-dependent Gene Expression
Activation of the transcription factor complex hypoxia-inducible factor-1 (HIF-1) - Mechanisms of Inflammatory Reactions Role of HIF-1 Complexes
Non-hypoxic activation of hypoxia-inducible factor-1 by inflammatory cytokines and signalling molecules
Role of reactive oxygen and nitrogen species for the function of cellular oxygen sensors
Cross-talk of hypoxic and proinflammatory cytokine-mediated activation of genes important for angiogenesis and vascular permeability
Pathophysiology of erythropoietin production in chronic inflammatory and malignant diseases - Role of HIF-1 Complexes in Muscle Trauma
Activation of HIF-1 in traumatized tissue
Role of HIF-1 activation for the severity of tissue trauma
Influence of reactive oxygen and nitrogen species for regeneration processes in skeletal muscle
Selected Publications
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Exposure to normobaric hypoxia shapes the acute inflammatory response in human whole blood cells in vivoIn: Pflügers Archiv: European Journal of Physiology (2024) in pressOnline Full Text: dx.doi.org/ (Open Access)
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Endogenous myoglobin expression in mouse models of mammary carcinoma reduces hypoxia and metastasis in PyMT miceIn: Scientific Reports Vol. 13 (2023) Nr. 1, 7530Online Full Text: dx.doi.org/ (Open Access)
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Altered hypoxia inducible factor regulation in hereditary haemorrhagic telangiectasiaIn: Scientific Reports Vol. 12 (2022) Nr. 1, 5877Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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(H)IF applicable: promotion of neurogenesis by induced HIF-2 signalling after ischaemiaIn: Pflügers Archiv: European Journal of Physiology Vol. 473 (2021) Nr. 8, pp. 1287 - 1299Online Full Text: dx.doi.org/ (Open Access)
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NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defenceIn: Nature Communications Vol. 12 (2021) Nr. 1, 4700Online Full Text: dx.doi.org/ (Open Access)
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Albumin-derived perfluorocarbon-based artificial oxygen carriers can avoid hypoxic tissue damage in massive hemodilutionIn: Scientific Reports Vol. 10 (2020) Nr. 1, pp. 11950Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Carotid body type I cells engage flavoprotein and Pin1 for oxygen sensingIn: American Journal of Physiology: Cell Physiology Vol. 318 (2020) Nr. 4, pp. C719 - C731Online Full Text: dx.doi.org/ (Open Access)
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Hypoxia-inducible factor-2α is crucial for proper brain developmentIn: Scientific Reports Vol. 10 (2020) Nr. 1, 19146Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Prolyl hydroxylase domain 2 reduction enhances skeletal muscle tissue regeneration after soft tissue trauma in miceIn: PLoS ONE Vol. 15 (2020) Nr. 5, pp. e0233261Online Full Text: dx.doi.org/ (Open Access)
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Effect of HIV infection and antiretroviral therapy on immune cellular functionsIn: JCI Insight Vol. 4 (2019) Nr. 12, :e126675Online Full Text: dx.doi.org/ (Open Access)
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Now a Nobel gas : oxygenIn: Pflügers Archiv: European Journal of Physiology Vol. 471 (2019) Nr. 11/12, pp. 1343 - 1358Online Full Text: dx.doi.org/
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Hypoxia-inducible factor 1α is essential for macrophage-mediated erythroblast proliferation in acute friend retrovirus infectionIn: Scientific Reports Vol. 7 (2017) art. no. 17236Online Full Text: dx.doi.org/ (Open Access)
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Knockdown of myeloid cell hypoxia-inducible factor-1α ameliorates the acute pathology in DSS-induced colitisIn: PLoS ONE Vol. 12 (2017) Nr. 12, pp. e0190074Online Full Text: dx.doi.org/ (Open Access)
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Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis.In: Nature Communications Vol. 8 (2017) pp. 1597Online Full Text: dx.doi.org/ (Open Access)
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Oxygen sensing in intestinal mucosal inflammationIn: Pflügers Archiv: European Journal of Physiology Vol. 468 (2016) Nr. 1, pp. 77 - 84Online Full Text: dx.doi.org/
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Targeting VEGF-A in myeloid cells enhances natural killer cell responses to chemotherapy and ameliorates cachexiaIn: Nature Communications Vol. 7 (2016) pp. 12528Online Full Text: dx.doi.org/ (Open Access)
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Hypoxia-induced p38 MAPK activation reduces Mcl-1 expression and facilitates sensitivity towards BH3 mimetics in chronic lymphocytic leukemiaIn: Leukemia Vol. 29 (2015) Nr. 4, pp. 981 - 984Online Full Text: dx.doi.org/
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Novel antibodies directed against the human erythropoietin receptor : Creating a basis for clinical implementationIn: British Journal of Haematology Vol. 168 (2015) Nr. 3, pp. 429 - 442Online Full Text: dx.doi.org/
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Resolution of liver fibrosis requires myeloid cell-driven sinusoidal angiogenesisIn: Hepatology Vol. 61 (2015) Nr. 6, pp. 2042 - 2055Online Full Text: dx.doi.org/ (Open Access)
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Severe Blunt Muscle Trauma in Rats : Only Marginal Hypoxia in the Injured AreaIn: PLoS ONE Vol. 9 (2014) Nr. 10, pp. e111151Online Full Text: dx.doi.org/ (Open Access)
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HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesisIn: Blood Vol. 121 (2013) Nr. 8, pp. 1436 - 1445Online Full Text: dx.doi.org/
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Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosisIn: Blood Vol. 119 (2012) Nr. 24, pp. 5931 - 5942Online Full Text: dx.doi.org/
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Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signalingIn: Nucleic Acids Research Vol. 40 (2012) Nr. 5, pp. 1928 - 1943Online Full Text: dx.doi.org/ (Open Access)
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Why not the liver instead of the kidney?In: Blood Vol. 120 (2012) Nr. 9, pp. 1760 - 1761Online Full Text: dx.doi.org/ (Open Access)
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Multifocal animated imaging of changes in cellular oxygen and calcium concentrations and membrane potential within the intact adult mouse carotid body ex vivoIn: American Journal of Physiology: Cell Physiology Vol. 301 (2011) Nr. 2, pp. C266 - 71Online Full Text: dx.doi.org/
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Oxygen-regulated expression of the erythropoietin gene in the human renal cell line REPCIn: Blood Vol. 117 (2011) Nr. 18, pp. 4905 - 4914Online Full Text: dx.doi.org/ (Open Access)
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The Function of Hypoxia-Inducible Factor (HIF) Is Independent of the Endoplasmic Reticulum Protein OS-9In: PLoS ONE Vol. 6 (2011) Nr. 4, pp. e19151Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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ZAP-70 expression is a prognostic factor in chronic lymphocytic leukemiaIn: Leukemia Vol. 17 (2003) Nr. 12, pp. 2426 - 2434Online Full Text: dx.doi.org/
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Hypoxia-inducible erythropoietin gene expression in human neuroblastoma cellsIn: Blood Vol. 100 (2002) Nr. 7, pp. 2623 - 2628Online Full Text: dx.doi.org/