ZMB Member Christian Reinhardt
ZMB Member
Christian Reinhardt
Next ZMB-Member
Prof. Dr. Christian Reinhardt
Director of:
Clinic for Hematology and Stem Cell TransplantationWest German Cancer Centre (WTZ)
University Hospital Essen
Hufelandstraße 55
45147 Essen
- +49 201 723 3136
- Website
- Selected Publications
- Publication Metrics
- ZMB Research Program
Oncology
Research Overview
- B cell lymphomas
- Lung Cancer
- Functional Genomics
- DNA Damage
- Transcription factor p53
Selected Publications
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Entirely noninvasive outcome prediction in central nervous system lymphomas using circulating tumor DNAIn: Blood Vol. 143 (2024) Nr. 6, pp. 522 - 534Online Full Text: dx.doi.org/
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Data-driven grading of acute graft-versus-host diseaseIn: Nature Communications Vol. 14 (2023) Nr. 1, 7799Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Germ line variant GFI1-36N affects DNA repair and sensitizes AML cells to DNA damage and repair therapyIn: Blood Vol. 142 (2023) Nr. 25, pp. 2175 - 2191Online Full Text: dx.doi.org/ (Open Access)
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Impact of TP53 on outcome of patients with myelofibrosis undergoing hematopoietic stem cell transplantationIn: Blood Vol. 141 (2023) Nr. 23, pp. 2901 - 2911Online Full Text: dx.doi.org/
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Aberrant expansion of spontaneous splenic germinal centers induced by hallmark genetic lesions of aggressive lymphomaIn: Blood Vol. 140 (2022) Nr. 10, pp. 1119 - 1131Online Full Text: dx.doi.org/ (Open Access)
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Deregulation and epigenetic modification of BCL2-family genes cause resistance to venetoclax in hematologic malignanciesIn: Blood Vol. 140 (2022) Nr. 20, pp. 2113 - 2126Online Full Text: dx.doi.org/ (Open Access)
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Extracellular vesicles and PD-L1 suppress macrophages, inducing therapy resistance in TP53-deficient B-cell malignanciesIn: Blood Vol. 139 (2022) Nr. 25, pp. 3617 - 3629Online Full Text: dx.doi.org/ (Open Access)
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SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphomaIn: Blood Vol. 139 (2022) Nr. 4, pp. 538 - 553Online Full Text: dx.doi.org/ (Open Access)
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Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1In: Blood Vol. 137 (2021) Nr. 5, pp. 646 - 660Online Full Text: dx.doi.org/ (Open Access)
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Adaptive T-cell immunity controls senescence-prone MyD88- or CARD11-mutant B-cell lymphomasIn: Blood Vol. 137 (2021) Nr. 20, pp. 2785 - 2799Online Full Text: dx.doi.org/ (Open Access)
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An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular VulnerabilitiesIn: Cancer Discovery Vol. 2 (2021) Nr. 1, pp. 70 - 91Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypesIn: Nature Communications Vol. 12 (2021) Nr. 1, pp. 2048Online Full Text: dx.doi.org/ (Open Access)
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mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerabilityIn: Nature Communications Vol. 11 (2020) Nr. 1, pp. 4684Online Full Text: dx.doi.org/ (Open Access)
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UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive TumorsIn: Cell Vol. 176 (2019) Nr. 3, pp. 505 - 519.e22Online Full Text: dx.doi.org/ (Open Access)
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Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemiaIn: Nature Communications Vol. 8 (2017) Nr. 1, pp. 153Online Full Text: dx.doi.org/ (Open Access)
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B-cell-specific conditional expression of Myd88p.L²⁵²P leads to the development of diffuse large B-cell lymphoma in miceIn: Blood Vol. 127 (2016) Nr. 22, pp. 2732 - 2741Online Full Text: dx.doi.org/ (Open Access)
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A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant CancerIn: Cell Vol. 162 (2015) Nr. 1, pp. 146 - 159Online Full Text: dx.doi.org/ (Open Access)
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Comprehensive genomic profiles of small cell lung cancerIn: Nature Vol. 524 (2015) Nr. 7563, pp. 47 - 53Online Full Text: dx.doi.org/ (Open Access)
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Erratum: A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant CancerIn: Cell Vol. 162 (2015) Nr. 5, pp. 1169Online Full Text: dx.doi.org/ (Open Access)
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A functional cancer genomics screen identifies a druggable synthetic lethal interaction between MSH3 and PRKDCIn: Cancer Discovery Vol. 4 (2014) Nr. 5, pp. 592 - 605Online Full Text: dx.doi.org/ (Open Access)
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Cytokine-Induced Signaling Networks Prioritize Dynamic Range over Signal StrengthIn: Cell Vol. 135 (2008) Nr. 2, pp. 343 - 354Online Full Text: dx.doi.org/ (Open Access)
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14-3-3σ controls mitotic translation to facilitate cytokinesisIn: Nature Vol. 446 (2007) Nr. 7133, pp. 329 - 332Online Full Text: dx.doi.org/
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p53-Deficient Cells Rely on ATM- and ATR-Mediated Checkpoint Signaling through the p38MAPK/MK2 Pathway for Survival after DNA DamageIn: Cancer Cell Vol. 11 (2007) Nr. 2, pp. 175 - 189Online Full Text: dx.doi.org/ (Open Access)