ZMB Member Sebastian Schlücker
ZMB Member
Sebastian Schlücker
Next ZMB-Member
Prof. Dr. Sebastian Schlücker
Physical Chemistry
Faculty of Chemistry
University of Duisburg-Essen
Universitätsstr. 2
45141 Essen
- +49 201 183 6843
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- Selected Publications
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- ZMB Research Program
Molecular and Chemical Cell Biology
Research Overview
The Schluecker group is working in the field of Bio- and Nano-Photonics. The rational design and chemical synthesis of tailor-made functionalized metal colloids for bioanalytical and biomedical applications (assays, immunohistochemistry) in combination with optical detection is one focus of our research.
In cooperation with pathologists, we aim at establishing a methodology for highly differentiated, individualized and predictive tumor diagnostics based on a quantitative multi-parameter detection of tumor-relevant biomarkers, in particular for biomarkers in tissues employing in-situ optical imaging approaches. Various methods of optical microscopy and spectroscopy in combination with electron microscopy are employed for the characterization of the physical and chemical properties of our novel nanoparticle-based agents.
The interplay between theory/simulation and experiments is important to us: Starting from the physical description and computation of the optical properties of single gold and silver nanoparticles as well as clusters thereof, we follow a theory-guided approach to rationally design and synthesize functionalized colloids with tailor-made physical and chemical properties. Experiments at the single-particle level are performed in order to unambiguously characterize the physical and chemical properties as well as to establish correlations between structure/morphology and the corresponding properties/optical spectra.
A second line of research is the use of laser spectroscopic techniques for monitoring molecular recognition processes. Data from molecular vibrational spectroscopies are analyzed by multivariate/chemometric techniques and compared with results from computational chemistry. In fundamental methodological work, we have demonstrated that vibrational Raman and mid infrared spectroscopy are ideally suited for quantitative and label-free monitoring of the molecular recognition between small peptides and rationally designed artificial receptors (Schmuck group, organic chemistry, UDE).
Future work aims at quantitative, label-free and in particular site-specific probing of molecular recognition processes between small rationally designed supramolecular ligands and proteins.
Selected Publications
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Convergence of Surface-Enhanced Raman Scattering with Molecular Diagnostics: A Perspective on Future DirectionsIn: ACS Nano Vol. 18 (2024) Nr. 8, pp. 5998 - 6007Online Full Text: dx.doi.org/
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Impact of Surface Enhanced Raman Spectroscopy in CatalysisIn: ACS Nano (2024) in pressOnline Full Text: dx.doi.org/ (Open Access)
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Impact of bimetallic interface design on heat generation in plasmonic Au/Pd nanostructures studied by single-particle thermometryIn: Nature Communications Vol. 14 (2023) Nr. 1, 3813Online Full Text: dx.doi.org/ (Open Access)
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Tuning the Electronic Properties of Platinum in Hybrid-Nanoparticle Assemblies for use in Hydrogen Evolution ReactionIn: Angewandte Chemie International Edition Vol. 62 (2023) Nr. 25, e202301065Online Full Text: dx.doi.org/ (Open Access)
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Gold Nanorods Induce Endoplasmic Reticulum Stress and Autocrine Inflammatory Activation in Human NeutrophilsIn: ACS Nano Vol. 16 (2022) Nr. 7, pp. 11011 - 11026Online Full Text: dx.doi.org/
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Particle Size-Dependent Onset of the Tunneling Regime in Ideal Dimers of Gold NanospheresIn: ACS Nano Vol. 16 (2022) Nr. 12, pp. 21377 - 21387Online Full Text: dx.doi.org/
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In situ photothermal response of single gold nanoparticles through hyperspectral imaging anti-stokes thermometryIn: ACS Nano Vol. 15 (2021) Nr. 2, pp. 2458 - 2467Online Full Text: dx.doi.org/ (Open Access)
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6-Color/1-Target Immuno-SERS Microscopy on the Same Single Cancer CellIn: ACS Applied Materials & Interfaces Vol. 12 (2020) Nr. 29, pp. 32321 - 32327Online Full Text: dx.doi.org/ (Open Access)
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Present and Future of Surface-Enhanced Raman ScatteringIn: ACS Nano Vol. 14 (2020) Nr. 1, pp. 28 - 117Online Full Text: dx.doi.org/ (Open Access)
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Towards Reliable and Quantitative Surface-Enhanced Raman Scattering (SERS) : From Key Parameters to Good Analytical PracticeIn: Angewandte Chemie International Edition Vol. 59 (2020) pp. 5454 - 5462Online Full Text: dx.doi.org/ (Open Access)
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Rapid, Quantitative, and Ultrasensitive Point-of-Care Testing : A Portable SERS Reader for Lateral Flow Assays in Clinical ChemistryIn: Angewandte Chemie International Edition Vol. 58 (2019) Nr. 2, pp. 442 - 446Online Full Text: dx.doi.org/ (Open Access)
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Plasmonic hot electron transport drives nano-localized chemistryIn: Nature Communications Vol. 8 (2017) 14880Online Full Text: dx.doi.org/ (Open Access)
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Metal Nanoparticle-Catalyzed Reduction Using Borohydride in Aqueous Media : A Kinetic Analysis of the Surface Reaction by Microfluidic SERSIn: Angewandte Chemie International Edition Vol. 55 (2016) Nr. 44, pp. 13729 - 13733Online Full Text: dx.doi.org/
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Towards quantitative multi-color nanodiagnostics : spectral multiplexing with six silica-encapsulated SERS labelsIn: Angewandte Chemie International Edition Vol. 47 (2016) Nr. 9, pp. 1012 - 1016Online Full Text: dx.doi.org/
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Hot electron-induced reduction of small molecules on photorecycling metal surfacesIn: Nature Communications Vol. 6 (2015) 7570Online Full Text: dx.doi.org/ (Open Access)
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Surface-Enhanced Raman Spectroscopy : Concepts and Chemical ApplicationsIn: Angewandte Chemie International Edition Vol. 53 (2014) Nr. 19, pp. 4756 - 4795Online Full Text: dx.doi.org/
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Unveiling the Correlation between Nanometer-Thick Molecular Monolayer Sensitivity and Near-Field Enhancement and Localization in Coupled Plasmonic OligomersIn: ACS Nano Vol. 8 (2014) Nr. 9, pp. 9188 - 9198Online Full Text: dx.doi.org/ (Open Access)
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SERS labels for red laser excitation: silica-encapsulated SAMs on tunable gold/silver nanoshellsIn: Angewandte Chemie International Edition Vol. 48 (2009) Nr. 11, pp. 1950 - 1953Online Full Text: dx.doi.org/
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Direct and label-free detection of solid-phase-bound compounds by using surface-enhanced raman scattering microspectroscopyIn: Angewandte Chemie International Edition Vol. 46 (2007) Nr. 25, pp. 4786 - 4789Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/