Fakultät für Biologie

Personenverzeichnis

Die Links zu den Personen führen zum zentralen Personenverzeichnis der UDE, das die Daten aus dem LSF ausliest. Persönliche Informationen können im LSF (nach Login mit der Uni-Kennung) selbst bearbeitet werden.

 

Dr. rer. nat. Johannes van den Boom

Fakultät Biologie

Anschrift
Universitätsstr. 5
45141 Essen
Raum
T03 R04 D04
Telefon
+49 201 183 2524
E-Mail
johannes.van-den-boom@uni-due.de
Webseite
https://www.uni-due.de/zmb/molecular-biology-meyer/group.php

Funktionen

  • Wissenschaftliche/r Mitarbeiter/in, Molekularbiologie I

Aktuelle Veranstaltungen

Keine aktuellen Veranstaltungen.

Vergangene Veranstaltungen (max. 10)

Keine vergangenen Veranstaltungen.

Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.

    Artikel in Zeitschriften

  • Reinders, Maike; Kravic, Bojana; Gahlot, Pinki; Koska, Sandra; van den Boom, Johannes; Schulze, Nina; Levantovsky, Sophie; Kleine, Stefan; Kaiser, Markus; Kulathu, Yogesh; Behrends, Christian; Meyer, Hemmo
    ATXN3 regulates lysosome regeneration after damage by targeting K48-K63-branched ubiquitin chains
    In: The EMBO Journal, Jg. 44, 2025, Nr. 18, S. 5086 – 5111
    DOI (Open Access)
  • Banerjee, Sudakshina; Cakil, Zeyneb Vildan; Gallant, Kai; van den Boom, Johannes; Palei, Shubhendu; Meyer, Hemmo; Gersch, Malte; Summerer, Daniel
    Light-Activatable Ubiquitin for Studying Linkage-Specific Ubiquitin Chain Formation Kinetics
    In: Advanced Science, Jg. 12, 2025, Nr. 6, 2406570
    DOI (Open Access)
  • Kirupakaran, Abbna; van den Boom, Johannes; Blueggel, Mike; Beuck, Christine; Niemeyer, Felix; Hayduk, Matthias; Balszuweit, Jan; Bayer, Peter; Voskuhl, Jens; Meyer, Hemmo; Schrader, Thomas
    Molecular Tweezers Block the Functional Pore of a Protein Machine
    In: Journal of the American Chemical Society: JACS, Jg. 147, 2025, Nr. 20, S. 16836 – 16849
    DOI (Open Access)
  • Huang, Jing; Jaekel, Andreas; van den Boom, Johannes; Podlesainski, David; Elnaggar, M.; Heuer-Jungemann, A.; Kaiser, Markus; Meyer, Hemmo; Saccà, Barbara
    A modular DNA origami nanocompartment for engineering a cell-free, protein unfolding and degradation pathway
    In: Nature Nanotechnology, Jg. 19, 2024, Nr. 10, S. 1521 – 1531
    DOI (Open Access)
  • Kück, Anja; van den Boom, Johannes; Koska, Sandra; Ron, David; Meyer, Hemmo
    Alternating binding and p97-mediated dissociation of SDS22 and I3 recycles active PP1 between holophosphatases
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS), Jg. 121, 2024, Nr. 36, e2408787121
    DOI (Open Access)
  • Gahlot, Pinki; Kravic, Bojana; Rota, Giulia; van den Boom, Johannes; Levantovsky, Sophie; Schulze, Nina; Maspero, Elena; Polo, Simona; Behrends, Christian; Meyer, Hemmo
    Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH
    In: Molecular Cell, 2024, S. 1556 – 1569.e10
    DOI, Online Volltext (Open Access)
  • Mirsanaye, Ann Schirin; Hoffmann, Saskia; Weisser, Melanie; Mund, Andreas; Lopez Mendez, Blanca; Typas, Dimitris; van den Boom, Johannes; Benedict, Bente; Hendriks, Ivo A.; Nielsen, Michael Lund; Meyer, Hemmo; Duxin, Julien P.; Montoya, Guillermo; Mailand, Niels
    VCF1 is a p97/VCP cofactor promoting recognition of ubiquitylated p97-UFD1-NPL4 substrates
    In: Nature Communications, Jg. 15, 2024, Nr. 1, 2459
    DOI (Open Access)
  • van den Boom, Johannes; Marini, Guendalina; Meyer, Hemmo; Saibil, Helen R
    Structural basis of ubiquitin-independent PP1 complex disassembly by p97
    In: The EMBO Journal, Jg. 42, 2023, Nr. 14, e113110
    DOI (Open Access)
  • Meyer, Hemmo; van den Boom, Johannes
    Targeting of client proteins to the VCP/p97/Cdc48 unfolding machine
    In: Frontiers in Molecular Biosciences, Jg. 10, 2023, 1142989
    DOI, Online Volltext (Open Access)
  • Blüggel, Mike; Kröning, Alexander; Kracht, Matthias; van den Boom, Johannes; Dabisch, Matthias; Göhring, Anna; Kaschani, Farnusch; Kaiser, Markus; Bayer, Peter; Meyer, Hemmo; Beuck, Christine
    The UBX domain in UBXD1 organizes ubiquitin binding at the C-terminus of the VCP/p97 AAA-ATPase
    In: Nature Communications, Jg. 14, 2023, Nr. 1, 3258
    DOI, Online Volltext (Open Access)
  • Kröning, Alexander; van den Boom, Johannes; Kracht, Matthias; Kück, Anja; Meyer, Hemmo
    Ubiquitin-directed AAA+ ATPase p97/VCP unfolds stable proteins crosslinked to DNA for proteolysis by SPRTN
    In: The Journal of Biological Chemistry (JBC), Jg. 298, 2022, Nr. 6, 101976
    DOI (Open Access)
  • van den Boom, Johannes; Kück, Anja; Kravic, Bojana; Müschenborn, Helen; Giesing, Maike; Pan, Dongqing; Kaschani, Farnusch; Kaiser, Markus; Musacchio, Andrea; Meyer, Hemmo
    Targeted substrate loop insertion by VCP/p97 during PP1 complex disassembly
    In: Nature Structural & Molecular Biology, Jg. 28, 2021, Nr. 12, S. 964 – 971
    DOI
  • Kracht, Matthias; van den Boom, Johannes; Seiler, Jonas; Kröning, Alexander; Kaschani, Farnusch; Kaiser, Markus; Meyer, Hemmo
    Protein Phosphatase-1 Complex Disassembly by p97 is Initiated through Multivalent Recognition of Catalytic and Regulatory Subunits by the p97 SEP-domain Adapters
    In: Journal of Molecular Biology (JMB), Jg. 432, 2020, Nr. 23, S. 6061 – 6074
    DOI
  • Iberahim, Nurul Aqilah; Sood, Neeraj; Pradhan, Pravata Kumar; van den Boom, Johannes; van West, Pieter; Trusch, Franziska
    The chaperone Lhs1 contributes to the virulence of the fish-pathogenic oomycete Aphanomyces invadans
    In: Fungal Biology, Jg. 124, 2020, Nr. 12, S. 1024 – 1031
    DOI
  • van den Boom, Johannes; Hensel, Astrid; Trusch, Franziska; Matena, Anja; Siemer, Svenja; Guel, Désirée; Docter, Dominic; Höing, Alexander; Bayer, Peter; Stauber, Roland H.; Knauer, Shirley
    The other side of the corona : Nanoparticles inhibit the protease taspase1 in a size-dependent manner
    In: Nanoscale, Jg. 12, 2020, Nr. 37, S. 19093 – 19103
    DOI
  • Blüggel, Mike; van den Boom, Johannes; Meyer, Hemmo; Bayer, Peter; Beuck, Christine
    Structure of the PUB Domain from Ubiquitin Regulatory X Domain Protein 1 (UBXD1) and Its Interaction with the p97 AAA+ ATPase
    In: Biomolecules, Jg. 9, 2019, Nr. 12, 876
    DOI, Online Volltext (Open Access)
  • Pöhler, Robert; Krahn, Jan; van den Boom, Johannes; Dobrynin, Grzegorz; Kaschani, Farnusch; Eggenweiler, Hans-Michael; Zenke, Frank T.; Kaiser, Markus; Meyer, Hemmo
    A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases
    In: Angewandte Chemie International Edition, Jg. 57, 2018, Nr. 6, S. 1576 – 1580
    DOI
  • Müller, Jonathan W.; Idkowiak, Jan; Gesteira, Tarsis F.; Vallet, Cecilia; Hardman, Rebecca; van den Boom, Johannes; Dhir, Vivek; Knauer, Shirley; Rosta, Edina; Arlt, Wiebke
    Human DHEA sulfation requires direct interaction between PAPS synthase 2 and DHEA sulfotransferase SULT2A1
    In: The Journal of Biological Chemistry (JBC), Jg. 293, 2018, Nr. 25, S. 9724 – 9735
    DOI (Open Access)
  • Weith, Matthias; Seiler, Jonas; van den Boom, Johannes; Kracht, Matthias; Hülsmann, Julia; Primorac, Ivana; Del Pino Garcia, Javier; Kaschani, Farnusch; Kaiser, Markus; Musacchio, Andrea; Bollen, Mathieu; Meyer, Hemmo
    Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation
    In: Molecular Cell, Jg. 72, 2018, Nr. 4, S. 766 – 777
    DOI (Open Access)
  • van den Boom, Johannes; Meyer, Hemmo
    VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling
    In: Molecular Cell, Jg. 69, 2018, Nr. 2, S. 182 – 194
    DOI (Open Access)
  • van den Boom, Johannes; Trusch, Franziska; Hoppstock, Lukas; Beuck, Christine; Bayer, Peter
    Structural Characterization of the Loop at the Alpha-Subunit C-Terminus of the Mixed Lineage Leukemia Protein Activating Protease Taspase1
    In: PLoS ONE, Jg. 11, 2016, Nr. 3, S. e0151431
    DOI, Online Volltext (Open Access)
  • Wünsch, Désirée; Angelina, Hahlbrock; Jung, Sascha; Schirmeister, Tanja; van den Boom, Johannes; Schilling, Oliver; Knauer, Shirley; Stauber, Roland H.
    Taspase1 : a 'misunderstood' protease with translational cancer relevance
    In: Oncogene, Jg. 35, 2016, Nr. 26, S. 3351 – 3364
    DOI
  • van den Boom, Johannes; Wolf, Markus; Weimann, Lena; Schulze, Nina; Li, Fanghua; Kaschani, Farnusch; Riemer, Anne; Zierhut, Christian; Kaiser, Markus; Iliakis, George; Funabiki, Hironori; Meyer, Hemmo
    VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair
    In: Molecular Cell, Jg. 64, 2016, Nr. 1, S. 189 – 198
    DOI (Open Access)
  • Roy Choudhury, Amrita; Sikorska, Emilia; van den Boom, Johannes; Bayer, Peter; Popenda, Lukasz; Szutkowski, Kosma; Jurga, Stefan; Bonomi, Massimiliano; Sali, Andrej; Zhukov, Igor; Passamonti, Sabina; Novič, Marjana
    Structural model of the bilitranslocase transmembrane domain supported by NMR and FRET data
    In: PLoS ONE, Jg. 10, 2015, Nr. 8, S. e0135455
    DOI (Open Access)
  • van den Boom, Johannes; Mamic, Marija; Baccelliere, Daniele; Zweerink, Susanne; Kaschani, Farnusch; Knauer, Shirley; Bayer, Peter; Kaiser, Markus
    Peptidyl succinimidyl peptides as taspase 1 inhibitors
    In: ChemBioChem, Jg. 15, 2014, Nr. 15, S. 2233 – 2237
    DOI
  • Matena, Anja; Sinnen, Christian; van den Boom, Johannes; Wilms, Christoph; Dybowski, Jan Nikolaj; Maltaner, Ricarda; Müller, Jonathan W.; Link, Nina M.; Hoffmann, Daniel; Bayer, Peter
    Transient domain interactions enhance the affinity of the mitotic regulator pin1 toward phosphorylated peptide ligands
    In: Structure, Jg. 21, 2013, Nr. 10, S. 1769 – 1777
    DOI (Open Access)
  • van den Boom, Johannes; Heider, Dominik; Martin, Stephen R; Pastore, Annalisa; Müller, Jonathan W.
    3'-Phosphoadenosine 5'-phosphosulfate (PAPS) synthases, naturally fragile enzymes specifically stabilized by nucleotide binding
    In: The Journal of Biological Chemistry (JBC), Jg. 2012, 2012, S. 17645 – 17655
    DOI
  • Lederer, Christoph; Heider, Dominik; van den Boom, Johannes; Hoffmann, Daniel; Müller, Jonathan W.; Bayer, Peter
    Single-Domain Parvulins Constitute a Specific Marker for Recently Proposed Deep-Branching Archaeal Subgroups
    In: Evolutionary Bioinformatics, Jg. 7, 2011, S. 135 – 148
    DOI, Online Volltext (Open Access)
  • Ohlig, Stefanie; Farshi, Pershang; Pickhinke, Ute; van den Boom, Johannes; Höing, Susanne; Jakuschev, Stanislav; Hoffmann, Daniel; Dreier, Rita; Schöler, Hans R.; Dierker, Tabea; Bordych, Christian; Grobe, Kay
    Sonic hedgehog shedding results in functional activation of the solubilized protein
    In: Developmental Cell, Jg. 20, 2011, Nr. 6, S. 764 – 774
    DOI (Open Access)
  • Grum, Daniel; van den Boom, Johannes; Neumann, Daniel; Matena, Anja; Link, Nina; Müller, Jonathan W.
    A Heterodimer of Human 3′-Phospho-Adenosine-5′-Phosphosulphate (PAPS) Synthases Is a New Sulphate Activating Complex
    In: Biochemical and Biophysical Research Communications (BBRC), Jg. 395, 2010, Nr. 3, S. 420 – 425
    DOI

    • Poster / Posterbeiträge

  • Jaekel, Andreas; Blüggel, Mike; Kracht, Matthias; van den Boom, Johannes; Hechler, Michelle; Bayer, Peter; Meyer, Hemmo; Sacca, Barbara
    Rationally designed DNA-origami hosts for protein guest
    Nantech2019, Nucleic Acid Nanotechnology: from algorithmic design to biochemical applications, Aalto University, Espoo, Finland May 27-29, 2019,
    2019