Fakultät für Biologie

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Prof. Dr. Stefan Westermann

Biologie

Anschrift
Universitätsstr. 5
D-45141 Essen
Raum
S05 R01 H75
Telefon
+49 201 183 2733
Telefax
+49 201 183 4397
E-Mail
stefan.westermann@uni-due.de
Webseite
https://www.uni-due.de/zmb/molecular-genetics-westermann/index.php

Funktionen

  • Gruppe der Professorinnen und Professoren, Fakultätsrat Biologie

  • Vorsitzender, Promotionsausschuss Fakultät Biologie

  • Professor/in, Molekulare Genetik I

Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.

    Artikel in Zeitschriften

  • Cozma, Christian; Westermann, Stefan
    Kinetochores get a grip!
    In: The Journal of Cell Biology (JCB) Jg. 224 (2025) Nr. 1, e202411040
    Online Volltext: dx.doi.org/
  • Pleuger, Richard; Cozma, Christian; Hohoff, Simone; Denkhaus, Christian; Dudziak, Alexander; Kaschani, Farnusch; Kaiser, Markus; Musacchio, Andrea; Vetter, Ingrid R.; Westermann, Stefan
    Microtubule end-on attachment maturation regulates Mps1 association with its kinetochore receptor
    In: Current Biology Jg. 34 (2024) Nr. 11, S. 2279 - 2293.e6
    Online Volltext: dx.doi.org/ (Open Access)
  • Neblik, Jonas; Kirupakaran, Abbna; Beuck, Christine; Mieres-Perez, Joel; Niemeyer, Felix; Le, My-Hue; Telgheder, Ursula; Schmuck, Jessica Felice; Dudziak, Alexander; Bayer, Peter; Sanchez-Garcia, Elsa; Westermann, Stefan; Schrader, Thomas
    Multivalent Molecular Tweezers Disrupt the Essential NDC80 Interaction with Microtubules
    In: Journal of the American Chemical Society: JACS Jg. 145 (2023) Nr. 28, S. 15251 - 15264
    Online Volltext: dx.doi.org/
  • Kornakov, Nikolay; Westermann, Stefan
    Systematic analysis of microtubule plus-end networks defines EB-cargo complexes critical for mitosis in budding yeast
    In: Molecular Biology of the Cell Jg. 34 (2023) Nr. 5, ar37
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Böhm, Miriam; Killinger, Kerstin; Dudziak, Alexander; Pant, Pradeep; Jänen, Karolin; Hohoff, Simone; Mechtler, Karl; Örd, Mihkel; Loog, Mart; Sánchez-García, Elsa; Westermann, Stefan
    Cdc4 phospho-degrons allow differential regulation of ame1ceⁿp⁻u protein stability across the cell cycle
    In: eLife Jg. 10 (2021) e67390
    Online Volltext: dx.doi.org/ (Open Access)
  • Dudziak, Alexander; Engelhard, Lena; Bourque, Cole; Klink, Björn Udo; Rombaut, Pascaline; Kornakov, Nikolay; Jänen, Karolin; Herzog, Franz; Gatsogiannis, Christos; Westermann, Stefan
    Phospho-regulated Bim1/EB1 interactions trigger Dam1c ring assembly at the budding yeast outer kinetochore
    In: The EMBO Journal Jg. 40 (2021) Nr. 18, e108004
    Online Volltext: dx.doi.org/ (Open Access)
  • Killinger, Kerstin; Böhm, Miriam; Steinbach, Philine; Hagemann, Götz; Blüggel, Mike; Jänen, Karolin; Hohoff, Simone; Bayer, Peter; Herzog, Franz; Westermann, Stefan
    Auto-inhibition of Mif2/CENP-C ensures centromere-dependent kinetochore assembly in budding yeast
    In: The EMBO Journal Jg. 39 (2020) Nr. 14, S. e102938
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Kornakov, Nikolay; Möllers, Bastian; Westermann, Stefan
    The EB1-Kinesin-14 complex is required for efficient metaphase spindle assembly and kinetochore bi-orientation
    In: The Journal of Cell Biology (JCB) Jg. 219 (2020) Nr. 12, 202003072
    Online Volltext: dx.doi.org/ (Open Access)
  • Schmitzberger, Florian; Richter, Magdalena M; Gordiyenko, Yuliya; Robinson, Carol V; Dadlez, Michał; Westermann, Stefan
    Molecular basis for inner kinetochore configuration through RWD domain–peptide interactions
    In: The EMBO Journal Jg. 36 (2017) Nr. 23, S. 3458 - 3482
    Online Volltext: dx.doi.org/ (Open Access)
  • Howes, Stuart C.; Geyer, Elisabeth A.; LaFrance, Benjamin; Zhang, Rui; Kellogg, Elizabeth H.; Westermann, Stefan; Rice, Luke M.; Nogales, Eva
    Structural differences between yeast and mammalian microtubules revealed by cryo-EM
    In: The Journal of Cell Biology (JCB) Jg. 216 (2017) Nr. 9, S. 2669 - 2677
    Online Volltext: dx.doi.org/ (Open Access)
  • van der Vaart, Babet; Fischböck, Josef; Mieck, Christine; Pichler, Peter; Mechtler, Karl; Medema, René H.; Westermann, Stefan
    TORC1 signaling exerts spatial control over microtubule dynamics by promoting nuclear export of Stu2
    In: The Journal of Cell Biology (JCB) Jg. 216 (2017) Nr. 11, S. 3471 - 3484
    Online Volltext: dx.doi.org/ (Open Access)
  • Molodtsov, Maxim I.; Mieck, Christine; Dobbelaere, Jeroen; Dammermann, Alexander; Westermann, Stefan; Vaziri, Alipasha
    A Force-Induced Directional Switch of a Molecular Motor Enables Parallel Microtubule Bundle Formation
    In: Cell Jg. 167 (2016) Nr. 2, S. 539 - 552.e14
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Weissmann, Florian; Peters, Jan-Michael; Schulman, Brenda A.; Westermann, Stefan; Lampert, Fabienne; Stark, Holger; Huis in 't Veld, Pim J.; VanderLinden, Ryan; Petzold, Georg
    BiGBac enables rapid gene assembly for the expression of large multisubunit protein complexes
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Jg. 113 (2016) Nr. 19, S. E2564 - E2569
    Online Volltext: dx.doi.org/ (Open Access)
  • Pekgöz Altunkaya, Gülsah; Malvezzi, Francesca; Demianova, Zuzana; Zimniak, Tomasz; Litos, Gabriele; Weissmann, Florian; Mechtler, Karl; Herzog, Franz; Westermann, Stefan
    CCAN Assembly Configures Composite Binding Interfaces to Promote Cross-Linking of Ndc80 Complexes at the Kinetochore
    In: Current Biology Jg. 26 (2016) Nr. 17, S. 2370 - 2378
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Mieck, Christine; Molodtsov, Maxim I.; Drzewicka, Katarzyna; van der Vaart, Babet; Litos, Gabriele; Schmauss, Gerald; Vaziri, Alipasha; Westermann, Stefan
    Non-catalytic motor domains enable processive movement and functional diversification of the kinesin-14 Kar3
    In: eLife Jg. 4 (2015) S. e04489
    Online Volltext: dx.doi.org/ (Open Access)
  • Hornung, Peter; Troc, Paulina; Malvezzi, Francesca; Maier, Michael; Demianova, Zuzana; Zimniak, Tomasz; Litos, Gabriele; Lampert, Fabienne; Schleiffer, Alexander; Brunner, Matthias; Mechtler, Karl; Herzog, Franz; Marlovits, Thomas C.; Westermann, Stefan
    A cooperative mechanism drives budding yeast kinetochore assembly downstream of CENP-A
    In: The Journal of Cell Biology (JCB) Jg. 206 (2014) Nr. 4, S. 506 - 524
    Online Volltext: dx.doi.org/ (Open Access)
  • Malvezzi, Francesca; Westermann, Stefan
    “Uno, nessuno e centomila” : the different faces of the budding yeast kinetochore
    In: Chromosoma Jg. 123 (2014) Nr. 5, S. 447 - 457
    Online Volltext: dx.doi.org/
  • Malvezzi, Francesca; Litos, Gabriele; Schleiffer, Alexander; Heuck, Alexander; Mechtler, Karl; Clausen, Tim; Westermann, Stefan
    A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors
    In: The EMBO Journal Jg. 32 (2013) Nr. 3, S. 409 - 423
    Online Volltext: dx.doi.org/
  • Earnshaw, William C.; Allshire, Robin C.; Black, Ben E.; Bloom, Kerry; Brinkley, Bill R.; Brown, William; Cheeseman, Iain M.; Choo, Kong H. A.; Copenhaver, Gregory P.; DeLuca, Jennifer G.; Desai, Arshad; Diekmann, Stephan; Erhardt, Sylvia; Fitzgerald-Hayes, Molly; Foltz, Daniel; Fukagawa, Tatsuo; Gassmann, Reto; Gerlich, Daniel W.; Glover, David M.; Gorbsky, Gary J.; Harrison, Stephen C.; Heun, Patrick; Hirota, Toru; Jansen, Lars E. T.; Karpen, Gary; Kops, Geert J. P. L.; Lampson, Michael A.; Lens, Susanne M.; Losada, Ana; Luger, Karolin; Maiato, Helder; Maddox, Paul S.; Margolis, Robert L.; Masumoto, Hiroshi; McAinsh, Andrew D.; Mellone, Barbara G.; Meraldi, Patrick; Musacchio, Andrea; Oegema, Karen; O'Neill, Rachel J.; Salmon, Edward D.; Scott, Kristin C.; Straight, Aaron F.; Stukenberg, Peter T.; Sullivan, Beth A.; Sullivan, Kevin F.; Sunkel, Claudio E.; Swedlow, Jason R.; Walczak, Claire E.; Warburton, Peter E.; Westermann, Stefan; Willard, Huntington F.; Wordeman, Linda; Yanagida, Mitsuhiro; Yen, Tim J.; Yoda, Kinya; Cleveland, Don W.
    Esperanto for histones : CENP-A, not CenH3, is the centromeric histone H3 variant
    In: Chromosome Research Jg. 21 (2013) Nr. 2, S. 101 - 106
    Online Volltext: dx.doi.org/
  • Lampert, Fabienne; Mieck, Christine; Alushin, Gregory M.; Nogales, Eva; Westermann, Stefan
    Molecular requirements for the formation of a kinetochore–microtubule interface by Dam1 and Ndc80 complexes
    In: The Journal of Cell Biology (JCB) Jg. 200 (2013) Nr. 1, S. 21 - 30
    Online Volltext: dx.doi.org/
  • Schleiffer, Alexander; Maier, Michael; Litos, Gabriele; Lampert, Fabienne; Hornung, Peter; Mechtler, Karl; Westermann, Stefan
    CENP-T proteins are conserved centromere receptors of the Ndc80 complex
    In: Nature Cell Biology Jg. 14 (2012) Nr. 6, S. 604 - 613
    Online Volltext: dx.doi.org/
  • Westermann, Stefan; Schleiffer, Alexander
    Family matters: structural and functional conservation of centromere-associated proteins from yeast to humans
    In: Trends in Cell Biology Jg. 23 (2012) Nr. 6, S. 260 - 269
    Online Volltext: dx.doi.org/
  • Zimniak, Tomasz; Fitz, Veronika; Zhou, Hongwen; Lampert, Fabienne; Opravil, Susanne; Mechtler, Karl; Stolt-Bergner, Peggy; Westermann, Stefan
    Spatiotemporal regulation of Ipl1/Aurora activity by direct Cdk1 phosphorylation
    In: Current Biology Jg. 22 (2012) Nr. 9, S. 787 - 793
    Online Volltext: dx.doi.org/
  • Lampert, Fabienne; Westermann, Stefan
    A blueprint for kinetochores - new insights into the molecular mechanics of cell division
    In: Nature reviews. Molecular cell biology Jg. 12 (2011) Nr. 7, S. 407 - 412
    Online Volltext: dx.doi.org/
  • Hornung, Peter; Maier, Michael; Alushin, Gregory M.; Lander, Gabriel C.; Nogales, Eva; Westermann, Stefan
    Molecular architecture and connectivity of the budding yeast Mtw1 kinetochore complex
    In: Journal of Molecular Biology (JMB) Jg. 405 (2011) Nr. 2, S. 548 - 559
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Lampert, Fabienne; Hornung, Peter; Westermann, Stefan
    The Dam1 complex confers microtubule plus end–tracking activity to the Ndc80 kinetochore complex
    In: The Journal of Cell Biology (JCB) Jg. 189 (2010) Nr. 4, S. 641 - 649
    Online Volltext: dx.doi.org/
  • Kiermaier, Eva; Woehrer, Sophie; Peng, Yutian; Mechtler, Karl; Westermann, Stefan
    A Dam1-based artificial kinetochore is sufficient to promote chromosome segregation in budding yeast
    In: Nature Cell Biology Jg. 11 (2009) Nr. 9, S. 1109 - 1115
    Online Volltext: dx.doi.org/
  • Zimniak, Tomasz; Stengl, Katharina; Mechtler, Karl; Westermann, Stefan
    Phosphoregulation of the budding yeast EB1 homologue Bim1p by Aurora/Ipl1p
    In: The Journal of Cell Biology (JCB) Jg. 186 (2009) Nr. 3, S. 379 - 391
    Online Volltext: dx.doi.org/
  • Wang, Hong-Wei; Long, Sydney; Ciferri, Claudio; Westermann, Stefan; Drubin, David G.; Barnes, Georjana; Nogales, Eva
    Architecture and flexibility of the yeast Ndc80 kinetochore complex
    In: Journal of Molecular Biology (JMB) Jg. 383 (2008) Nr. 4, S. 894 - 903
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Grishchuk, Ekaterina L.; Spiridonov, Ilia S.; Volkov, Vladimir A.; Efremov, Artem K.; Westermann, Stefan; Drubin, David G.; Barnes, Georjana; Ataullakhanov, Fazly I.; McIntosh, J. Richard
    Different assemblies of the DAM1 complex follow shortening microtubules by distinct mechanisms
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Jg. 105 (2008) Nr. 19, S. 6918 - 6923
    Online Volltext: dx.doi.org/
  • Grishchuk, Ekaterina L.; Efremov, Artem K.; Volkov, Vladimir A.; Spiridonov, Ilia S.; Gudimchuk, Nikita; Westermann, Stefan; Drubin, David G.; Barnes, Georjana; McIntosh, J. Richard; Ataullakhanov, Fazly I.
    The Dam1 ring binds microtubules strongly enough to be a processive as well as energy-efficient coupler for chromosome motion
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Jg. 105 (2008) Nr. 40, S. 15423 - 15428
    Online Volltext: dx.doi.org/
  • Wong, Jonathan; Nakajima, Yuko; Westermann, Stefan; Shang, Ching; Kang, Jung-seog; Goodner, Crystal; Houshmand, Pantea; Fields, Stanley; Chan, Clarence S. M.; Drubin, David G.; Barnes, Georjana; Hazbun, Tony
    A protein interaction map of the mitotic spindle
    In: Molecular Biology of the Cell (MBoC) Jg. 18 (2007) Nr. 10, S. 3800 - 3809
    Online Volltext: dx.doi.org/
  • Wang, Hong-Wei; Ramey, Vincent H.; Westermann, Stefan; Leschziner, Andres E.; Welburn, Julie P. I.; Nakajima, Yuko; Drubin, David G.; Barnes, Georjana; Nogales, Eva
    Architecture of the Dam1 kinetochore ring complex and implications for microtubule-driven assembly and force-coupling mechanisms
    In: Nature Structural & Molecular Biology Jg. 14 (2007) Nr. 8, S. 721 - 726
    Online Volltext: dx.doi.org/
  • Westermann, Stefan; Drubin, David G.; Barnes, Georjana
    Structures and functions of yeast kinetochore complexes
    In: Annual Review of Biochemistry Jg. 76 (2007) S. 563 - 591
    Online Volltext: dx.doi.org/
  • Westermann, Stefan; Wang, Hong-Wei; Avila-Sakar, Augustin; Drubin, David G.; Nogales, Eva; Barnes, Georjana
    The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends
    In: Nature Jg. 440 (2006) Nr. 7083, S. 565 - 569
    Online Volltext: dx.doi.org/
  • Westermann, Stefan; Avila-Sakar, Augustin; Wang, Hong-Wei; Niederstrasser, Hanspeter; Wong, Jonathan; Drubin, David G.; Nogales, Eva; Barnes, Georjana
    Formation of a dynamic kinetochore-microtubule interface through assembly of the Dam1 ring complex
    In: Molecular Cell Jg. 17 (2005) Nr. 2, S. 277 - 290
    Online Volltext: dx.doi.org/
  • Westermann, Stefan; Cheeseman, Iain M.; Anderson, Scott; Yates, John R.; Drubin, David G.; Barnes, Georjana
    Architecture of the budding yeast kinetochore reveals a conserved molecular core
    In: The Journal of Cell Biology (JCB) Jg. 163 (2003) Nr. 2, S. 215 - 222
    Online Volltext: dx.doi.org/

    • Preprints

  • Dudziak, Alexander; Schmidt, Jasmin; Hamm, Frederik; Tendulkar, Sharvari; Jänen, Karolin; Vetter, Ingrid R.; Singh, Sylvia; Fischböck, Josef; Herzog, Franz; Westermann, Stefan
    The Spc105Knl1/Kre28Zwint complex promotes mitotic error correction by outer kinetochore recruitment of the Ipl1Aurora B kinase
    (2024)
    Online Volltext: dx.doi.org/ (Open Access)
  • Pleuger, Richard; Cozma, Christian; Hohoff, Simone; Denkhaus, Christian; Dudziak, Alexander; Kaschani, Farnusch; Musacchio, Andrea; Vetter, Ingrid R.; Westermann, Stefan
    Ipl1-controlled attachment maturation regulates Mps1 association with its kinetochore receptor
    (2023) 43 Seiten
    Online Volltext: dx.doi.org/ (Open Access)