CRC 1093 - Project Z3
Central Service Project Z3: NMR Spectroscopy
Prof. Dr. Peter Bayer
In project Z3 NMR spectroscopic methods will be offered for ligand optimization (STD), epitope identification (chemical shift perturbation) and structural characterization of protein-ligand complexes. Transferred NOE experiments will be employed in the case of weak interactions, while full structure determination of strong protein-ligand complexes will be attempted by a combination of classical 3D, 4D heteronuclear experiments and half-filtered NOESY experiments as well as by the use of residual dipolar coupling measurements and computational docking.
