CRC1093 Member Laura Hartmann
Macromolecular Chemistry Research
The research of Laura Hartmann focuses on the use of polymers as biomimetic molecules. She applies solid phase synthesis techniques in combination with classical polymer chemistry to create monodisperse, sequence-controlled oligo- and polymers. These so-called precision macromolecules can then be used for the controlled presentation of ligands such as sugars or peptides and lead to novel bioactive polymers for biotechnological and biomedical applications. Within the CRC, Laura Hartmann and her team will combine their synthetic platform with supramolecular binding motifs from the CRC and design novel multivalent, supramolecular ligands to target specific protein binding.
Curriculum Vitae
Professional career
| 2014-today | Full Professor (W3) of Macromolecular Chemistry, Heinrich-Heine University Düsseldorf |
| 2009-2014 | Emmy-Noether groupleader, Max-Planck-Insitute of Colloids and Interfaces in the Department for Biomolecular Systems |
| 2007-2009 | Postdoctoral Researcher with Prof. Dr. Curtis W. Frank and Prof. Dr. Christopher Ta at Stanford University, CA, USA |
Scientific education and degrees
| 2014 | Habilitation and Venia legendi (Macromolecular Chemistry) at the Freie Universität Berlin, Mentors: Prof. Dr. Peter H. Seeberger and Prof. Dr. Rainer Haag |
| 2004-2007 | Ph.D. at the Max-Planck-Insitute of Colloids and Interfaces with Prof. Dr. Hans G. Börner and Prof. Dr. Markus Antonietti |
| 1998-2004 | Study of Chemistry (Dipl.) at the Albert-Ludwigs-University Freiburg, Diploma thesis with Prof. Dr. Jörg Tiller and Prof. Dr. Rolf Mülhaupt |
Selected Publications
F. Broecker, J. Hanske, C. E. Martin, J. Y. Baek, A. Wahlbrink, F. Wojcik, L. Hartmann, C. Rademacher, C. Anish, P. H. Seeberger: Multivalent display of minimal Clostridium difficile glycan epitopes mimics antigenic properties of larger glycan. Nat. Commun. 2016, 7: 11224.
M. F. Ebbesen, C. Gerke, P. Hartwig and L. Hartmann: Biodegradable poly(amidoamine)s with uniform degradation fragments via sequence-controlled macromonomers. Polym. Chem. 2016, 7, 7086-7093.
S. Mosca, J. Keller, N. Azzouz, S. Wagner, A. Titz, P. H. Seeberger, G. Brezesinski, L. Hartmann: Amphiphilic Cationic β3R3-Peptides: Membrane Active Peptidomimetics and Their Potential as Antimicrobial Agents. Biomacromolecules. 2014, 15 (5), 1687–1695.
D. Ponader, P. Maffre, J. Aretz, D. Pussak, N. M. Ninnemann, S. Schmidt, P. H. Seeberger, C. Rademacher, G. U. Nienhaus, L. Hartmann: Carbohydrate-Lectin Recognition of Sequence-Defined Heteromultivalent Glycooligomers. J. Am. Chem. Soc., 2014, 136, 2008−2016.
M. Behra, N. Azzouz, S. Mosca, M. Chanana, P. H. Seeberger, L. Hartmann: Magnetic Porous Sugar-Functionalized PEG Microgels for Efficient Isolation and Removal of Bacteria from Solution. Biomacromolecules. 2013, 14: 1927-1935.
D. Pussak, D. Ponader, S. Mosca, S. Vargas Ruiz, L. Hartmann, S. Schmidt: Mechanical Carbohydrate Sensors based on Soft Hydrogel Particles. Angew. Chem. Int. Ed. 2013, 52: 6084-6087.
F. Wojcik, A. G. O'Brien, S. Götze, P. H. Seeberger, L. Hartmann: Synthesis of Carbohydrate-Functionalised Sequence-Defined Oligo(amidoamine)s by Photochemical Thiol-Ene Coupling in a Continous Flow Reactor. Chem. Eur. J. 2013, 19: 3090-3098.
D. Ponader, F. Wojcik, F. Beceren-Braun, J. Demedde, L. Hartmann: Sequence-Defined Glycopolymer Segments Presenting Mannose: Synthesis and Lectin Binding Affinity. Biomacromolecules. 2012, 13: 1845-1852.
L. Hartmann, H. G. Boerner: Precision Polymers: Monodisperse, Monomer-Sequence-Defined Segments to Target Future Demands of Polymers in Medicine. Adv. Mater. 2007, 21: 3425-3431.
L. Hartmann, E. Krause, M. Antonietti, H. G. Börner: Solid-Phase Supported Polymer Synthesis of Sequence-Defined, Multifunctional Poly(amidoamines). Biomacromolecules. 2006, 7: 1239-1244.
