Z02

Project Area Z - Central Services
Dr. Nina Schulze
Imaging Center Campus Essen (ICCE)
University of Duisburg-Essen
Phone: +49 201 183 2622
Email
Detection and modulation of cell state transitions using advanced light microscopy
To investigate and fully understand the molecular triggers and cell signaling events underlying dynamic cell state transitions, many projects within the CRC1430 will utilize imaging-based acute perturbation and detection as key methodological strategies. Project Z02 will serve as a central platform for imaging-based detection via advanced light microscopy, supporting all members of the CRC in developing and optimizing customized protocols for their specific applications and with image analysis. Utilizing a variety of different imaging techniques in combination with a diverse set of sample materials ranging from cell populations to individual molecules will allow us to study dynamic switches over different scales in time and space.
Z02 is organized by the Imaging Center Campus Essen (ICCE) at the Center of Medical Biotechnology (ZMB), which, in addition to its high-level expertise in these topics, provides access to a variety of state-of-the-art microscope systems.
Project Members
Dr. Johannes Koch
Dr. Kristina Mrug
Publications
-
Lysosomal damage sensing and lysophagy initiation by SPG20-ITCHIn: Molecular Cell (2024) pp. 1556 - 1569.e10Online Full Text: dx.doi.org/ (Open Access)
-
Innate immune receptor signaling induces transient melanoma dedifferentiation while preserving immunogenicityIn: Journal for ImmunoTherapy of Cancer Vol. 10 (2022) Nr. 6, e003863Online Full Text: dx.doi.org/ (Open Access)
-
A non-autonomous protein quality control mechanism targeting tau aggregate propagation(2024)Online Full Text: dx.doi.org/ (Open Access)