Publications

2024

    Journal articles

  • Kück, Anja; van den Boom, Johannes; Koska, Sandra; Ron, David; Meyer, Hemmo
    Alternating binding and p97-mediated dissociation of SDS22 and I3 recycles active PP1 between holophosphatases
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 121 (2024) Nr. 36, e2408787121
    Online Full Text: dx.doi.org/ (Open Access)
  • Dobersalske, Celia; Rauschenbach, Laurèl; Hua, Yichao; Berliner, Christoph; Steinbach, Anita; Grüneboom, Anika; Kokkaliaris, Konstantinos D.; Heiland, Dieter H.; Berger, Pia; Langer, Sarah; Tan, Chin L.; Stenzel, Martin; Landolsi, Somaya; Weber, Flora; Darkwah Oppong, Marvin; Werner, Rudolf A.; Gull, Hanah; Schröder, Thomas; Linsenmann, Thomas; Buck, Andreas K.; Gunzer, Matthias; Stuschke, Martin; Keyvani, Kathy; Forsting, Michael; Glas, Martin; Kipnis, Jonathan; Steindler, Dennis A.; Reinhardt, Hans Christian; Green, Edward W.; Platten, Michael; Tasdogan, Alpaslan; Herrmann, Ken; Rambow, Florian; Cima, Igor; Sure, Ulrich; Scheffler, Björn
    Cranioencephalic functional lymphoid units in glioblastoma
    In: Nature Medicine (2024) in press
    Online Full Text: dx.doi.org/ (Open Access)
  • Pol, Savina Abraham; Liljenberg, Sara; Barr, Jack; Simon, Gina; Wong-Dilworth, Luis; Paterson, Danielle L.; Berishvili, Vladimir P.; Bottanelli, Francesca; Kaschani, Farnusch; Kaiser, Markus; Pettersson, Mariell; Hellerschmied, Doris
    Induced degradation of SNAP-fusion proteins
    In: RSC Chemical Biology (2024) in press
    Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ (Open Access)
  • Gahlot, Pinki; Kravic, Bojana; Rota, Giulia; van den Boom, Johannes; Levantovsky, Sophie; Schulze, Nina; Maspero, Elena; Polo, Simona; Behrends, Christian; Meyer, Hemmo
    Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH
    In: Molecular Cell (2024) pp. 1556 - 1569.e10
    Online Full Text: dx.doi.org/ (Open Access)
  • Pleuger, Richard; Cozma, Christian; Hohoff, Simone; Denkhaus, Christian; Dudziak, Alexander; Kaschani, Farnusch; Kaiser, Markus; Musacchio, Andrea; Vetter, Ingrid R.; Westermann, Stefan
    Microtubule end-on attachment maturation regulates Mps1 association with its kinetochore receptor
    In: Current Biology Vol. 34 (2024) Nr. 11, pp. 2279 - 2293.e6
    Online Full Text: dx.doi.org/ (Open Access)
  • Schmidt, Mirko; Grethe, Christian; Recknagel, Sarah; Kipka, Gian-Marvin; Klink, Nikolas; Gersch, Malte
    N-Cyanopiperazines as Specific Covalent Inhibitors of the Deubiquitinating Enzyme UCHL1
    In: Angewandte Chemie International Edition Vol. 63 (2024) Nr. 12, e202318849
    Online Full Text: dx.doi.org/ (Open Access)
  • Heger, Jan-Michel; d'Hargues, Yannick; Kleinert, Fanni; Mattlener, Julia; Weiss, Jonathan; Franzen, Fabian; Becker, Christian; Becker, Kerstin; Gödel, Philipp; Schmiel, Marcel; Meinel, Jörn; Flümann, Ruth; Simon, Florian; Reinhardt, Christian; Borchmann, Peter; Borchmann, Sven; Balke-Want, Hyatt; Knittel, Gero; von Tresckow, Bastian
    Noninvasive minimal residual disease assessment in relapsed/refractory large B-cell lymphoma using digital droplet PCR
    In: European Journal of Haematology Vol. 112 (2024) Nr. 6, pp. 957 - 963
    Online Full Text: dx.doi.org/ (Open Access)
  • Beaufort, Nathalie; Ingendahl, Linda; Merdanovic, Melisa; Schmidt, Andree; Podlesainski, David; Richter, Tim; Neumann, Thorben; Kuszner, Michael; Vetter, Ingrid R.; Stege, Patricia; Burston, Steven G.; Filipovic, Anto; Ruiz-Blanco, Yasser B.; Bravo Rodriguez, Kenny; Mieres-Perez, Joel; Beuck, Christine; Uebel, Stephan; Zobawa, Monika; Schillinger, Jasmin; Malik, Rainer; Todorov-Völgyi, Katalin; Rey, Juliana; Roberti, Annabell; Hagemeier, Birte; Wefers, Benedikt; Müller, Stephan A.; Wurst, Wolfgang; Sanchez-Garcia, Elsa; Zimmermann, Alexander; Hu, Xiao-Yu; Clausen, Tim; Huber, Robert; Lichtenthaler, Stefan F.; Schmuck, Carsten; Giese, Michael; Kaiser, Markus; Ehrmann, Michael; Dichgans, Martin
    Rational correction of pathogenic conformational defects in HTRA1
    In: Nature Communications Vol. 15 (2024) Nr. 1, 5944
    Online Full Text: dx.doi.org/ (Open Access)
  • Conti, Duccio; Verza, Arianna Esposito; Pesenti, Marion E.; Cmentowski, Verena; Vetter, Ingrid R.; Pan, Dongqing; Musacchio, Andrea
    Role of protein kinase PLK1 in the epigenetic maintenance of centromeres
    In: Science Vol. 385 (2024) Nr. 6713, pp. 1091 - 1097
    Online Full Text: dx.doi.org/
  • Polley, Soumitra; Raisch, Tobias; Ghetti, Sabrina; Körner, Marie; Terbeck, Melina; Gräter, Frauke; Raunser, Stefan; Aponte-Santamaría, Camilo; Vetter, Ingrid R.; Musacchio, Andrea
    Structure of the human KMN complex and implications for regulation of its assembly
    In: Nature Structural & Molecular Biology Vol. 31 (2024) Nr. 6, pp. 861 - 873
    Online Full Text: dx.doi.org/ (Open Access)
  • Meyer, Hemmo; Kravic, Bojana
    The Endo-Lysosomal Damage Response
    In: Annual Review of Biochemistry Vol. 93 (2024) Nr. 1, pp. 367 - 387
    Online Full Text: dx.doi.org/ (Open Access)
  • Musacchio, Andrea
    Thirty years of structural changes
    In: Nature Structural & Molecular Biology Vol. 31 (2024) Nr. 1, pp. 4 - 5
    Online Full Text: dx.doi.org/
  • Day, Matthew; Tetik, Bilal; Parlak, Milena; Almeida-Hernández, Yasser; Räschle, Markus; Kaschani, Farnusch; Siegert, Heike; Marko, Anika; Sanchez-Garcia, Elsa; Kaiser, Markus; Barker, Isabel A.; Pearl, Laurence H.; Oliver, Antony W.; Boos, Dominik
    TopBP1 utilises a bipartite GINS binding mode to support genome replication
    In: Nature Communications Vol. 15 (2024) Nr. 1, 1797
    Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ (Open Access)

    • Preprints

  • Blümke, Anika; Hagemeier, Birte; Ripkens, Kamilla; Schulze, Nina; Strzala, Michal; Koci, Michelle; Kaschani, Farnusch; Kaiser, Markus; Erkelenz, Michael; Schlücker, Sebastian; Merdanovic, Melisa; Poepsel, Simon; Hellerschmied-Jelinek, Doris; Burston, Steve; Ehrmann, Michael
    A non-autonomous protein quality control mechanism targeting tau aggregate propagation
    (2024)
    Online Full Text: dx.doi.org/ (Open Access)
  • Brenner, Joel Cyrille; Zirden, Linda; Almeida-Hernandez, Yasser; Kaschani, Farnusch; Kaiser, Markus; Sanchez-Garcia, Elsa; Poepsel, Simon; Hellerschmied-Jelinek, Doris
    Conformational plasticity of a BiP-GRP94 chaperone complex
    (2024)
    Online Full Text: dx.doi.org/ (Open Access)
  • Sethi, Suruchi; Piano, Valentina; Ghetti, Sabrina; Cmentowski, Verena; Stege, Patricia; Musacchio, Andrea
    Interplay of kinetochores and catalysts drives rapid assembly of the mitotic checkpoint complex
    (2024)
    Online Full Text: dx.doi.org/ (Open Access)

2023

    Journal articles

  • Sauer, Paul V.; Pavlenko, Egor; Cookis, Trinity; Zirden, Linda C.; Renn, Juliane; Singhal, Ankush; Hunold, Pascal; Hoehne, Michaela N.; van Ray, Olivia; Hänsel-Hertsch, Robert; Sanbonmatsu, Karissa Y.; Nogales, Eva; Poepsel, Simon
    Activation of automethylated PRC2 by dimerization on chromatin
    In: Molecular Cell Vol. 84 (2023) Nr. 20, pp. 3885 - 3898.e8
    Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ (Open Access)
  • Patwardhan, Rutuja; Nanda, Suchet; Wagner, Jessica; Stockter, Tom; Dehmelt, Leif; Nalbant, Perihan;
    Li, Rong (Eds.)
    Cdc42 activity in the trailing edge is required for persistent directional migration of keratinocytes
    In: Molecular Biology of the Cell Vol. 35 (2023) Nr. 1, br1
    Online Full Text: dx.doi.org/
  • Hoi, David M.; Junker, Sabryna; Junk, Lukas; Schwechel, Kristin; Fischel, Katharina; Podlesainski, David; Hawkins, Paige M.E.; van Geelen, Lasse; Kaschani, Farnusch; Leodolter, Julia; Morreale, Francesca Ester; Kleine, Stefan; Guha, Somraj; Rumpel, Klaus; Schmiedel, Volker M.; Weinstabl, Harald; Meinhart, Anton; Payne, Richard J.; Kaiser, Markus; Hartl, Markus; Boehmelt, Guido; Kazmaier, Uli; Kalscheuer, Rainer; Clausen, Tim
    Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival
    In: Cell Vol. 186 (2023) Nr. 10, pp. 2176 - 2192.e22
    Online Full Text: dx.doi.org/ (Open Access)
  • Flümann, Ruth; Hansen, Julia; Pelzer, Benedikt W.; Nieper, Pascal; Lohmann, Tim; Kisis, Ilmars; Riet, Tobias; Kohlhas, Viktoria; Nguyen, Phuong-Hien; Peifer, Martin; Abedpour, Nima; Bosco, Graziella; Thomas, Roman K.; Kochanek, Moritz; Knüfer, Jacqueline; Jonigkeit, Lorenz; Beleggia, Filippo; Holzem, Alessandra; Büttner, Reinhard; Lohneis, Philipp; Meinel, Jörn; Ortmann, Monika; Persigehl, Thorsten; Hallek, Michael; Calado, Dinis Pedro; Chmielewski, Markus; Klein, Sebastian; Göthert, Joachim R.; Chapuy, Bjoern; Zevnik, Branko; Wunderlich, F. Thomas; von Tresckow, Bastian; Jachimowicz, Ron D.; Melnick, Ari M.; Reinhardt, Christian; Knittel, Gero
    Distinct genetically-determined origins of Myd88/Bcl2-driven aggressive lymphoma rationalize targeted therapeutic intervention strategies
    In: Blood Cancer Discovery Vol. 4 (2023) Nr. 1, pp. 78 - 97
    Online Full Text: dx.doi.org/ (Open Access)
  • Fehr, Lorenz; Sewald, Leonard; Huber, Robert; Kaiser, Markus
    Facile Multicomponent Synthesis of Oxazolidinones from Primary Amines and Cesium (Hydrogen)Carbonate
    In: European Journal of Organic Chemistry Vol. 26 (2023) Nr. 27, e202300135
    Online Full Text: dx.doi.org/ (Open Access)
  • Stupia, Simone; Heeke, Christina; Brüggemann, Alicia; Zaremba-Montenari, Anne; Thier, Beatrice; Kretz, Julia; Sucker, Antje; Philip, Manuel; Zelinskyy, Gennadiy; Ferrone, Soldano; Rösch, Alexander; Horn, Susanne; Hadaschik, Eva; Schadendorf, Dirk; Trilling, Mirko; Dittmer, Ulf; Griewank, Klaus; Zhao, Fang; Paschen, Annette
    HLA class II loss and JAK1/2 deficiency coevolve in melanoma leading to CD4 T cell and IFNγ cross-resistance
    In: Clinical Cancer Research Vol. 29 (2023) Nr. 15, pp. 2894 - 2907
    Online Full Text: dx.doi.org/
  • Váraljai, Renáta; Zimmer, Lisa; Al-Matary, Yahya; Kaptein, Paulien; Albrecht, Lea J.; Shannan, Batool; Brase, Jan C.; Gusenleitner, Daniel; Amaral, Teresa; Wyss, Nina; Utikal, Jochen; Flatz, Lukas; Rambow, Florian; Reinhardt, Hans Christian; Dick, Jenny; Engel, Daniel R.; Horn, Susanne; Ugurel, Selma; Sondermann, Wiebke; Livingstone, Elisabeth; Sucker, Antje; Paschen, Annette; Zhao, Fang; Placke, Jan-Malte; Klose, Jasmin M.; Fendler, Wolfgang; Thommen, Daniela S.; Helfrich, Iris; Schadendorf, Dirk; Rösch, Alexander
    Interleukin 17 signaling supports clinical benefit of dual CTLA-4 and PD-1 checkpoint inhibition in melanoma
    In: Nature Cancer Vol. 4 (2023) Nr. 9, pp. 1292 - 1308
    Online Full Text: dx.doi.org/ (Open Access)
  • O’Dea, Rachel; Kazi, Nafizul; Hoffmann-Benito, Alicia; Zhao, Zhou; Recknagel, Sarah; Wendrich, Kim; Janning, Petra; Gersch, Malte
    Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36
    In: Nature Chemical Biology Vol. 19 (2023) Nr. 11, pp. 1394 - 1405
    Online Full Text: dx.doi.org/ (Open Access)
  • Cmentowski, Verena; Ciossani, Giuseppe; d'Amico, Ennio; Wohlgemuth, Sabine; Owa, Mikito; Dynlacht, Brian; Musacchio, Andrea
    RZZ‐Spindly and CENP‐E form an integrated platform to recruit dynein to the kinetochore corona
    In: The EMBO Journal Vol. 42 (2023) Nr. 24, e114838
    Online Full Text: dx.doi.org/ (Open Access)
  • van den Boom, Johannes; Marini, Guendalina; Meyer, Hemmo; Saibil, Helen R
    Structural basis of ubiquitin-independent PP1 complex disassembly by p97
    In: The EMBO Journal Vol. 42 (2023) Nr. 14, e113110
    Online Full Text: dx.doi.org/ (Open Access)
  • Rüttermann, Maximilian; Koci, Michelle; Lill, Pascal; Geladas, Ermis Dionysios; Kaschani, Farnusch; Klink, Björn Udo; Erdmann, Ralf; Gatsogiannis, Christos
    Structure of the peroxisomal Pex1/Pex6 ATPase complex bound to a substrate
    In: Nature Communications Vol. 14 (2023) Nr. 1, 5942
    Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ (Open Access)
  • Kornakov, Nikolay; Westermann, Stefan
    Systematic analysis of microtubule plus-end networks defines EB-cargo complexes critical for mitosis in budding yeast
    In: Molecular Biology of the Cell Vol. 34 (2023) Nr. 5, ar37
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Meyer, Hemmo; van den Boom, Johannes
    Targeting of client proteins to the VCP/p97/Cdc48 unfolding machine
    In: Frontiers in Molecular Biosciences Vol. 10 (2023) 1142989
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Blüggel, Mike; Kröning, Alexander; Kracht, Matthias; van den Boom, Johannes; Dabisch, Matthias; Göhring, Anna; Kaschani, Farnusch; Kaiser, Markus; Bayer, Peter; Meyer, Hemmo; Beuck, Christine
    The UBX domain in UBXD1 organizes ubiquitin binding at the C-terminus of the VCP/p97 AAA-ATPase
    In: Nature Communications Vol. 14 (2023) Nr. 1, 3258
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Schwalm, Martin P.; Knapp, Stefan; Rogov, Vladimir V.
    Toward effective Atg8-based ATTECs : Approaches and perspectives
    In: Journal of Cellular Biochemistry (2023) in press
    Online Full Text: dx.doi.org/ (Open Access)
  • Schwalm, Martin P.; Krämer, Andreas; Dölle, Anja; Weckesser, Janik; Yu, Xufen; Jin, Jian; Saxena, Krishna; Knapp, Stefan
    Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization
    In: Cell Chemical Biology Vol. 30 (2023) Nr. 7, pp. 753 - 765.e8
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Buzuk, Lana; Hellerschmied-Jelinek, Doris
    Ubiquitin-mediated degradation at the Golgi apparatus
    In: Frontiers in Molecular Biosciences Vol. 10 (2023) 1197921
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)

    • Preprints

  • Pleuger, Richard; Cozma, Christian; Hohoff, Simone; Denkhaus, Christian; Dudziak, Alexander; Kaschani, Farnusch; Musacchio, Andrea; Vetter, Ingrid R.; Westermann, Stefan
    Ipl1-controlled attachment maturation regulates Mps1 association with its kinetochore receptor
    (2023) 43 Seiten
    Online Full Text: dx.doi.org/ (Open Access)

2022

    Journal articles

  • Schwalm, Martin P.; Berger, Lena M.; Meuter, Maximilian N.; Vasta, James D.; Corona, Cesear R.; Röhm, Sandra; Berger, Benedict-Tilman; Farges, Frederic; Beinert, Sebastian M.; Preuss, Franziska; Morasch, Viktoria; Rogov, Vladimir V.; Mathea, Sebastian; Saxena, Krishna; Robers, Matthew B.; Müller, Susanne; Knapp, Stefan
    A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing Proteins
    In: Frontiers in Cell and Developmental Biology Vol. 10 (2022) 886537
    Online Full Text: dx.doi.org/ (Open Access)
  • Ruiz-Blanco, Yasser B.; Agüero-Chapin, Guillermin; Romero-Molina, Sandra; Antunes, Agostinho; Olari, Lia-Raluca; Spellerberg, Barbara; Münch, Jan; Sanchez-Garcia, Elsa
    ABP-Finder : A Tool to Identify Antibacterial Peptides and the Gram-Staining Type of Targeted Bacteria
    In: Antibiotics Vol. 11 (2022) Nr. 12, 1708
    Online Full Text: dx.doi.org/ (Open Access)
  • Rey, Juliana; Breiden, Maike; Lux, Vanda; Bluemke, Anika; Steindel, Maike; Ripkens, Kamilla; Möllers, Bastian; Bravo Rodriguez, Kenny; Boisguerin, Prisca; Volkmer, Rudolf; Mieres-Perez, Joel; Clausen, Tim; Sánchez-García, Elsa; Ehrmann, Michael
    An allosteric HTRA1-calpain 2 complex with restricted activation profile
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 119 (2022) Nr. 14, e2113520119
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Carvalho, Luís A. R.; Ross, Breyan; Fehr, Lorenz; Bolgi, Oguz; Wöhrle, Svenja; Lum, Kenneth M.; Podlesainski, David; Vieira, Andreia C.; Kiefersauer, Reiner; Félix, Rita; Rodrigues, Tiago; Lucas, Susana D.; Groß, Olaf; Geiss‐Friedlander, Ruth; Cravatt, Benjamin F.; Huber, Robert; Kaiser, Markus; Moreira, Rui
    Chemoproteomics‐Enabled Identification of 4‐Oxo‐β‐Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9
    In: Angewandte Chemie International Edition Vol. 61 (2022) Nr. 47, e202210498
    Online Full Text: dx.doi.org/ (Open Access)
  • d'Amico, Ennio A.; Ud Din Ahmad, Misbha; Cmentowski, Verena; Girbig, Mathias; Müller, Franziska; Wohlgemuth, Sabine; Brockmeyer, Andreas; Maffini, Stefano; Janning, Petra; Vetter, Ingrid R.; Carter, Andrew P.; Perrakis, Anastassis; Musacchio, Andrea
    Conformational transitions of the Spindly adaptor underlie its interaction with Dynein and Dynactin
    In: The Journal of Cell Biology (JCB) Vol. 221 (2022) Nr. 11, e202206131
    Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ (Open Access)
  • Harms, Mirja; Hansson, Rikke Fabech; Carmali, Sheiliza; Almeida-Hernández, Yasser; Sanchez-Garcia, Elsa; Münch, Jan; Zelikin, Alexander N.
    Dimerization of the Peptide CXCR4-Antagonist on Macromolecular and Supramolecular Protraction Arms Affords Increased Potency and Enhanced Plasma Stability
    In: Bioconjugate Chemistry Vol. 33 (2022) Nr. 4, pp. 594 - 607
    Online Full Text: dx.doi.org/
  • Pavlenko, Egor; Ruengeler, Till; Engel, Paulina; Poepsel, Simon
    Functions and Interactions of Mammalian KDM5 Demethylases
    In: Frontiers in Genetics Vol. 13 (2022)
    Online Full Text: dx.doi.org/ (Open Access)
  • Thier, Beatrice; Zhao, Fang; Stupia, Simone; Brüggemann, Alicia; Koch, Johannes; Schulze, Nina; Horn, Susanne; Coch, Christoph; Hartmann, Gunther; Sucker, Antje; Schadendorf, Dirk; Paschen, Annette
    Innate immune receptor signaling induces transient melanoma dedifferentiation while preserving immunogenicity
    In: Journal for ImmunoTherapy of Cancer Vol. 10 (2022) Nr. 6, e003863
    Online Full Text: dx.doi.org/ (Open Access)
  • Stejerean-Todoran, Ioana; Zimmermann, Katharina; Gibhardt, Christine S; Vultur, Adina; Ickes, Christian; Shannan, Batool; Bonilla del Rio, Zuriñe; Wölling, Anna; Cappello, Sabrina; Sung, Hsu-Min; Shumanska, Magdalena; Zhang, Xin; Nanadikar, Maithily; Latif, Muhammad U; Wittek, Anna; Lange, Felix; Waters, Andrea; Brafford, Patricia; Wilting, Jörg; Urlaub, Henning; Katschinski, Dörthe M; Rehling, Peter; Lenz, Christof; Jakobs, Stefan; Ellenrieder, Volker; Rösch, Alexander; Schön, Michael P; Herlyn, Meenhard; Stanisz, Hedwig; Bogeski, Ivan
    MCU controls melanoma progression through a redox-controlled phenotype switch
    In: EMBO Reports Vol. 23 (2022) Nr. 11, e54746
    Online Full Text: dx.doi.org/ (Open Access)
  • Bozilovic, Jelena; Eing, Lorenz; Berger, Benedict-Tilman; Adhikari, Bikash; Weckesser, Janik; Berner, Nicola B.; Wilhelm, Stephanie; Kuster, Bernhard; Wolf, Elmar; Knapp, Stefan
    Novel, highly potent PROTACs targeting AURORA-A kinase
    In: Current Research in Chemical Biology Vol. 2 (2022) 100032
    Online Full Text: dx.doi.org/ (Open Access)
  • Musacchio, Andrea
    On the role of phase separation in the biogenesis of membraneless compartments
    In: The EMBO Journal Vol. 41 (2022) Nr. 5, e109952
    Online Full Text: dx.doi.org/ (Open Access)
  • Romero-Molina, Sandra; Ruiz-Blanco, Yasser B.; Mieres-Perez, Joel; Harms, Mirja; Münch, Jan; Ehrmann, Michael; Sanchez-Garcia, Elsa
    PPI-Affinity : A Web Tool for the Prediction and Optimization of Protein-Peptide and Protein-Protein Binding Affinity
    In: Journal of Proteome Research Vol. 21 (2022) Nr. 8, pp. 1829 - 1841
    Online Full Text: dx.doi.org/ (Open Access)
  • Němec, Václav; Schwalm, Martin P.; Müller, Susanne; Knapp, Stefan
    PROTAC degraders as chemical probes for studying target biology and target validation
    In: Chemical Society Reviews Vol. 51 (2022) Nr. 18, pp. 7971 - 7993
    Online Full Text: dx.doi.org/
  • Chauvistré, Heike; Shannan, Batool; Daignault-Mill, Sheena M.; Ju, Robert J.; Picard, Daniel; Egetemaier, Stefanie; Váraljai, Renáta; Gibhardt, Christine S.; Sechi, Antonio; Kaschani, Farnusch; Keminer, Oliver; Stehbens, Samantha J.; Liu, Qin; Yin, Xiangfan; Jeyakumar, Kirujan; Vogel, Felix C. E.; Krepler, Clemens; Rebecca, Vito W.; Kubat, Linda; Lueong, Smiths S.; Forster, Jan; Horn, Susanne; Remke, Marc; Ehrmann, Michael; Paschen, Annette; Becker, Jürgen; Helfrich, Iris; Rauh, Daniel; Kaiser, Markus; Gul, Sheraz; Herlyn, Meenhard; Bogeski, Ivan; Rodríguez-López, José Neptuno; Haass, Nikolas K.; Schadendorf, Dirk; Rösch, Alexander;
    Persister state-directed transitioning and vulnerability in melanoma
    32. Deutscher Hautkrebskongress (ADO-Jahrestagung), 14.–17. September 2022, Hannover, Germany,
    In: Nature Communications Vol. 13 (2022) Nr. 1, pp. 35 - 36
    Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Grethe, Christian; Schmidt, Mirko; Kipka, Gian-Marvin; O’Dea, Rachel; Gallant, Kai; Janning, Petra; Gersch, Malte
    Structural basis for specific inhibition of the deubiquitinase UCHL1
    In: Nature Communications Vol. 13 (2022) Nr. 1, 5950
    Online Full Text: dx.doi.org/ (Open Access)
  • Raisch, Tobias; Ciossani, Giuseppe; d’Amico, Ennio; Cmentowski, Verena; Carmignani, Sara; Maffini, Stefano; Merino, Felipe; Wohlgemuth, Sabine; Vetter, Ingrid R.; Raunser, Stefan; Musacchio, Andrea
    Structure of the RZZ complex and molecular basis of Spindly‐driven corona assembly at human kinetochores
    In: The EMBO Journal Vol. 41 (2022) Nr. 9, e110411
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Kravić, Bojana; Bionda, Tihana; Siebert, Alexander; Gahlot, Pinki; Levantovsky, Sophie; Behrends, Christian; Meyer, Hemmo
    Ubiquitin profiling of lysophagy identifies actin stabilizer CNN2 as a target of VCP/p97 and uncovers a link to HSPB1
    In: Molecular Cell Vol. 82 (2022) Nr. 14, pp. 2633 - 2649.e7
    Online Full Text: dx.doi.org/ (Open Access)
  • Kröning, Alexander; van den Boom, Johannes; Kracht, Matthias; Kück, Anja; Meyer, Hemmo
    Ubiquitin-directed AAA+ ATPase p97/VCP unfolds stable proteins crosslinked to DNA for proteolysis by SPRTN
    In: The Journal of Biological Chemistry (JBC) Vol. 298 (2022) Nr. 6, 101976
    Online Full Text: dx.doi.org/ (Open Access)

    • Book articles / Proceedings papers

  • Schillinger, Jasmin; Hellerschmied-Jelinek, Doris
    Targeted Protein Unfolding at the Golgi Apparatus
    In: Golgi: Methods and Protocols / Wang, Yanzhuang; Lupashin, Vladimir V.; Graham, Todd R. (Eds.) 2022, pp. 645 - 659
    Online Full Text: dx.doi.org/

2021

    Journal articles

  • Böhm, Miriam; Killinger, Kerstin; Dudziak, Alexander; Pant, Pradeep; Jänen, Karolin; Hohoff, Simone; Mechtler, Karl; Örd, Mihkel; Loog, Mart; Sánchez-García, Elsa; Westermann, Stefan
    Cdc4 phospho-degrons allow differential regulation of ame1ceⁿp⁻u protein stability across the cell cycle
    In: eLife Vol. 10 (2021) e67390
    Online Full Text: dx.doi.org/ (Open Access)
  • Dudziak, Alexander; Engelhard, Lena; Bourque, Cole; Klink, Björn Udo; Rombaut, Pascaline; Kornakov, Nikolay; Jänen, Karolin; Herzog, Franz; Gatsogiannis, Christos; Westermann, Stefan
    Phospho-regulated Bim1/EB1 interactions trigger Dam1c ring assembly at the budding yeast outer kinetochore
    In: The EMBO Journal Vol. 40 (2021) Nr. 18, e108004
    Online Full Text: dx.doi.org/ (Open Access)
  • Dorsch, Madeleine; Kowalczyk, Manuela; Planque, Mélanie; Heilmann, Geronimo; Urban, Sebastian; Dujardin, Philip; Forster, Jan; Ueffing, Kristina; Nothdurft, Silke; Oeck, Sebastian; Paul, Annika; Liffers, Sven T.; Kaschani, Farnusch; Kaiser, Markus; Schramm, Alexander; Siveke, Jens; Winslow, Monte M.; Fendt, Sarah-Maria; Nalbant, Perihan; Grüner, Barbara M.
    Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis
    In: Cell Reports Vol. 37 (2021) Nr. 8, 110056
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)