P2: targeting cardiac macrophages

Targeting cardiac tissue-resident and monocyte-derived macrophages

This project is located at the Leibniz Institut für analytische Wissenschaften, ISAS Dortmund.

If you are interested in joining this project, please see our available positions at:
https://www.uni-due.de/grk2989/opportunities.php

Tissue-resident cardiac macrophages (MΦ) play essential roles in tissue repair, regeneration, and fibrosis in response to repAMI. Inflammatory-recruited monocyte and MΦ populations are not well defined yet. Unclear influence of the microenvironment on cell polarization and function. Niche-specific infiltration of different MΦ populations profile is affected by the MΦ migration inhibitory factor (MIF).

The specific objectives are:

  • Which MΦ populations are recruited to which inflammatory niches?
  • What are the individual underlying recruitment and polarization mechanisms?
  • How do the individual MΦ populations and their modulation via MIF affect tissue repair mechanisms in repAMI?
  • How does the fibroblast-like phenotype-switch affect MΦ-dependent repair mechanisms after repAMI?

 

​P2_1
Niche-specific MΦ subsets in repAMI
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Principal Investigators

​Grueneboom_Totzeck

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