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https://www.uni-due.de/grk2989/opportunities.php

Cardiomyocytes are highly involved in reciprocal communication with other resident and non-resident cells in repAMI. Deleterious responses of surviving cardiomyocytes in the border and remote zones contribute to profound cardiac morphological changes and heart failure. The underlying mechanisms are not fully understood, but suggest a particular heterogeneity of LV cardiomyocytes and involvement of BCL2-family members.

To investigate how subtypes of cardiomyocytes and their spatiotemporal functional dynamics including cell-cell-communications determine the outcome in repAMI. The specific objectives are:

• Spatial and temporal heterogeneity of cardiomyocytes
• Functional network of cardiomyocytes
• Consequences of signaling of surviving cardiomyocytes
• Impact of BCL-2 family members​​

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Proteomics in cardiac compartments and restoration of heart function in repAMI
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repAMI-related differences in the BNIP3 molecular network

Principal Investigators

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