Radiotherapy belongs to the three main therapy options for malignant tumors. To improve therapeutic gain of radiotherapy, researchers aim to develop effective strategies for a biology-based optimization of treatment protocols combining ionizing radiation and targeted drug therapy.

The research program of the GRK1739 aims to achieve a better mechanistic understanding of key molecules that determine the cellular response to ionizing radiation and thus radiation sensitivity with the goal of providing a scientific basis for effective response modulation. A major goal is to generate a profound understanding of the complex cellular and molecular processes that determine the cellular responses to ionizing radiation and the interaction of ionizing radiation with drug therapy.

The GRK 1739 will provide a comprehensive multidisciplinary training in basic, translational, and clinical research aspects in radiation sciences. Excellent scientific projects covering cutting-edge topics in radiation biology and experimental radiation oncology form the basis of a multidisciplinary education in the field. Project-oriented laboratory training is complemented with training in general and specific methods of radiation biology and related fields, and with lectures in radiation oncology and radiology, radiation biology, molecular, cellular, and tumor biology, and cell signaling. Additional courses will convey essential information in bioethics, good scientific practice, and will enhance other important soft skills useful for a scientific career. Students will be encouraged to participate in national and international meetings and to arrange internships to advance networking and mobility. The central goal of the GRK 1739 is to educate independent scientists that are optimally prepared for a future scientific career in the areas of radiation biology/radiation oncology and biomedical sciences.