Publications
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Patents
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A modular DNA origami nanocompartment for engineering a cell-free, protein unfolding and degradation pathwayIn: Nature Nanotechnology Vol. 19 (2024) Nr. 10, pp. 1521 - 1531Online Full Text: dx.doi.org/ (Open Access)
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Activity-based proteomics uncovers suppressed hydrolases and a neo-functionalised antibacterial enzyme at the plant–pathogen interfaceIn: New Phytologist Vol. 241 (2024) Nr. 1, pp. 394 - 408Online Full Text: dx.doi.org/ (Open Access)
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Bioengineering of syrbactin megasynthetases for immunoproteasome inhibitor productionIn: Chem (2024) in pressOnline Full Text: dx.doi.org/ (Open Access)
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Characterization of 2-phenanthroate : CoA ligase from the sulfate-reducing, phenanthrene-degrading enrichment culture TRIPIn: Applied and Environmental Microbiology (2024) in pressOnline Full Text: dx.doi.org/ (Open Access)
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Differences in the Synovial Fluid Proteome of Septic and Aseptic Implant FailureIn: Antibiotics Vol. 13 (2024) Nr. 4, 346Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Discovery of active mouse, plant and fungal cytochrome P450s in endogenous proteomes and upon expression in plantaIn: Scientific Reports Vol. 14 (2024) Nr. 1, 10091Online Full Text: dx.doi.org/ (Open Access)
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Environmental activity-based protein profiling for function-driven enzyme discovery from natural communitiesIn: Environmental Microbiomes Vol. 19 (2024) Nr. 1, 36Online Full Text: dx.doi.org/ (Open Access)
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Extracellular plant subtilases dampen cold-shock peptide elicitor levelsIn: Nature Plants (2024) in pressOnline Full Text: dx.doi.org/ (Open Access)
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Factors governing attachment of Rhizobium leguminosarum to legume roots at acid, neutral, and alkaline pHsIn: mSystems Vol. 9 (2024) Nr. 9, e0042224Online Full Text: dx.doi.org/ (Open Access)
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Glutathione Transferase Photoaffinity Labeling Displays GST Induction by Safeners and Pathogen InfectionIn: Plant and Cell Physiology Vol. 65 (2024) Nr. 1, pp. 128 - 141Online Full Text: dx.doi.org/ (Open Access)
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High resolution analysis of proteolytic substrate processingIn: The Journal of Biological Chemistry (JBC) Vol. 300 (2024) Nr. 11, 107812Online Full Text: dx.doi.org/ (Open Access)
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Induced degradation of SNAP-fusion proteinsIn: RSC Chemical Biology (2024) in pressOnline Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ (Open Access)
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Microtubule end-on attachment maturation regulates Mps1 association with its kinetochore receptorIn: Current Biology Vol. 34 (2024) Nr. 11, pp. 2279 - 2293.e6Online Full Text: dx.doi.org/ (Open Access)
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Rational correction of pathogenic conformational defects in HTRA1In: Nature Communications Vol. 15 (2024) Nr. 1, 5944Online Full Text: dx.doi.org/ (Open Access)
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The anti-tubercular callyaerins target the Mycobacterium tuberculosis-specific non-essential membrane protein Rv2113In: Cell Chemical Biology (2024) in pressOnline Full Text: dx.doi.org/ (Open Access)
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The proteome of Nicotiana benthamiana is shaped by extensive protein processingIn: New Phytologist Vol. 243 (2024) Nr. 3, pp. 1034 - 1049Online Full Text: dx.doi.org/ (Open Access)
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TopBP1 utilises a bipartite GINS binding mode to support genome replicationIn: Nature Communications Vol. 15 (2024) Nr. 1, 1797Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ (Open Access)
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10q26 – The enigma in age-related macular degenerationIn: Progress in Retinal and Eye Research Vol. 96 (2023) 101154Online Full Text: dx.doi.org/ (Open Access)
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Chemoproteomics Reveals the Pan-HER Kinase Inhibitor Neratinib To Target an Arabidopsis Epoxide Hydrolase Related to Phytohormone SignalingIn: ACS Chemical Biology Vol. 18 (2023) Nr. 5, pp. 1076 - 1088Online Full Text: dx.doi.org/
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Clp-targeting BacPROTACs impair mycobacterial proteostasis and survivalIn: Cell Vol. 186 (2023) Nr. 10, pp. 2176 - 2192.e22Online Full Text: dx.doi.org/ (Open Access)
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Enhanced late blight resistance by engineering an EpiC2B-insensitive immune proteaseIn: Plant Biotechnology Journal Vol. 22 (2023) Nr. 2, pp. 284 - 286Online Full Text: dx.doi.org/ (Open Access)
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Facile Multicomponent Synthesis of Oxazolidinones from Primary Amines and Cesium (Hydrogen)CarbonateIn: European Journal of Organic Chemistry Vol. 26 (2023) Nr. 27, e202300135Online Full Text: dx.doi.org/ (Open Access)
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IFNα primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilizationIn: Cell Chemical Biology Vol. 30 (2023) Nr. 6, pp. 573 - 590.e6Online Full Text: dx.doi.org/
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The UBX domain in UBXD1 organizes ubiquitin binding at the C-terminus of the VCP/p97 AAA-ATPaseIn: Nature Communications Vol. 14 (2023) Nr. 1, 3258Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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The root pathogen Aphanomyces euteiches secretes modular proteases in pea apoplast during host infectionIn: Frontiers in Plant Science (FPLS) Vol. 14 (2023) 1140101Online Full Text: dx.doi.org/ (Open Access)
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Activity-Based Protein Profiling for the Identification of Novel Carbohydrate-Active Enzymes Involved in Xylan Degradation in the Hyperthermophilic Euryarchaeon Thermococcus sp. Strain 2319x1EIn: Frontiers in Microbiology Vol. 12 (2022) 734039Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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BacPROTACs mediate targeted protein degradation in bacteriaIn: Cell Vol. 185 (2022) Nr. 13, pp. 2338 - 2353.e18Online Full Text: dx.doi.org/ (Open Access)
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Chemoproteomics‐Enabled Identification of 4‐Oxo‐β‐Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9In: Angewandte Chemie International Edition Vol. 61 (2022) Nr. 47, e202210498Online Full Text: dx.doi.org/ (Open Access)
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Erratum: Author Correction: Identification of fungal lignocellulose-degrading biocatalysts secreted by Phanerochaete chrysosporium via activity-based protein profiling (Communications biology (2022) 5 1 (1254))In: Communications Biology Vol. 5 (2022) Nr. 1, pp. 1319Online Full Text: dx.doi.org/ (Open Access)
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Identification of fungal lignocellulose-degrading biocatalysts secreted by Phanerochaete chrysosporium via activity-based protein profilingIn: Communications Biology Vol. 5 (2022) Nr. 1, 1254Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Persister state-directed transitioning and vulnerability in melanomaIn: Nature Communications Vol. 13 (2022) Nr. 1, 3055Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Article leaf apoplast of field-grown potato analyzed by quantitative proteomics and activity-based protein profilingIn: International Journal of Molecular Sciences (IJMS) Vol. 22 (2021) Nr. 21, 12033Online Full Text: dx.doi.org/ (Open Access)
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Correction to : Natural brominated phenoxyphenols kill persistent and biofilm-incorporated cells of MRSA and other pathogenic bacteriaIn: Applied Microbiology and Biotechnology Vol. 105 (2021) Nr. 14-15, pp. 6119 - 6119Online Full Text: dx.doi.org/ (Open Access)
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Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasisIn: Cell Reports Vol. 37 (2021) Nr. 8, 110056Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Targeted substrate loop insertion by VCP/p97 during PP1 complex disassemblyIn: Nature Structural & Molecular Biology Vol. 28 (2021) Nr. 12, pp. 964 - 971Online Full Text: dx.doi.org/
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The chemical compound ‘Heatin’ stimulates hypocotyl elongation and interferes with the Arabidopsis NIT1-subfamily of nitrilasesIn: The Plant Journal Vol. 106 (2021) Nr. 6, pp. 1523 - 1540Online Full Text: dx.doi.org/ (Open Access)
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Accelerated trypsin autolysis by affinity polymer templatesIn: RSC Advances Vol. 10 (2020) Nr. 48, pp. 28711 - 28719Online Full Text: dx.doi.org/ (Open Access)
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Accelerated trypsin autolysis by affinity polymer templatesIn: RSC Advances Vol. 10 (2020) Nr. 48, pp. 28711 - 28719Online Full Text: dx.doi.org/ (Open Access)
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Activation by substoichiometric inhibitionIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 117 (2020) Nr. 3, pp. 1414 - 1418Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Discovering the RNA-binding proteome of plant leaves with an improved RNA interactome capture methodIn: Biomolecules Vol. 10 (2020) Nr. 4, 661Online Full Text: dx.doi.org/ (Open Access)
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From dolastatin 13 to cyanopeptolins, micropeptins, and lyngbyastatins : the chemical biology of Ahp-cyclodepsipeptidesIn: Natural Product Reports Vol. 37 (2020) Nr. 2, pp. 163 - 174Online Full Text: dx.doi.org/
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Natural brominated phenoxyphenols kill persistent and biofilm-incorporated cells of MRSA and other pathogenic bacteriaIn: Applied Microbiology and Biotechnology Vol. 104 (2020) Nr. 13, pp. 5985 - 5998Online Full Text: dx.doi.org/ (Open Access)
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Protein Phosphatase-1 Complex Disassembly by p97 is Initiated through Multivalent Recognition of Catalytic and Regulatory Subunits by the p97 SEP-domain AdaptersIn: Journal of Molecular Biology (JMB) Vol. 432 (2020) Nr. 23, pp. 6061 - 6074Online Full Text: dx.doi.org/
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Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactionsIn: Nature Communications Vol. 11 (2020) Nr. 1, pp. 3954Online Full Text: dx.doi.org/ (Open Access)
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Targeting of parvulin interactors by diazirine mediated cross-linking discloses a cellular role of human Par14/17 in actin polymerizationIn: Biological Chemistry Vol. 401 (2020) Nr. 8, pp. 955 - 968Online Full Text: dx.doi.org/ (Open Access)
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Using proteomics for an insight into the performance of activated sludge in a lab-scale WWTPIn: International Biodeterioration & Biodegradation Vol. 149 (2020) pp. 104934Online Full Text: dx.doi.org/
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Zelkovamycin is an OXPHOS Inhibitory Member of the Argyrin Natural Product FamilyIn: Chemistry - A European Journal Vol. 26 (2020) Nr. 39, pp. 8524 - 8531Online Full Text: dx.doi.org/ (Open Access)
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A homology-guided, genome-based proteome for improved proteomics in the alloploid Nicotiana benthamianaIn: BMC Genomics Vol. 20 (2019) Nr. 1, pp. 722Online Full Text: dx.doi.org/ (Open Access)
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Activity-based proteomics reveals nine target proteases for the recombinant protein-stabilizing inhibitor S/CYS8 in Nicotiana benthamianaIn: Plant Biotechnology Journal Vol. 17 (2019) Nr. 8, pp. 1670 - 1678Online Full Text: dx.doi.org/ (Open Access)
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Cathepsin L regulates metabolic networks controlling rapid cell growth and proliferationIn: Molecular and Cellular Proteomics (MCP) Vol. 18 (2019) Nr. 7, pp. 1330 - 1344Online Full Text: dx.doi.org/ (Open Access)
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Cathepsins Drive Anti-Inflammatory Activity by Regulating Autophagy and Mitochondrial Dynamics in Macrophage Foam CellsIn: Cellular Physiology and Biochemistry Vol. 53 (2019) Nr. 3, pp. 550 - 572Online Full Text: dx.doi.org/ (Open Access)
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Chemical Validation of DegS As a Target for the Development of Antibiotics with a Novel Mode of ActionIn: ChemMedChem Vol. 14 (2019) Nr. 11, pp. 1074 - 1078Online Full Text: dx.doi.org/
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Dynamic hydrolase labelling as a marker for seed quality in Arabidopsis seedsIn: Biochemical Journal Vol. 476 (2019) Nr. 5, pp. 843 - 857Online Full Text: dx.doi.org/ (Open Access)
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Glycosidase and glycan polymorphism control hydrolytic release of immunogenic flagellin peptidesIn: Science Vol. 364 (2019) Nr. 6436, eaav0748Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Metabolic reconstruction of the genome of candidate Desulfatiglans TRIP_1 and identification of key candidate enzymes for anaerobic phenanthrene degradationIn: Environmental Microbiology Vol. 21 (2019) Nr. 4, pp. 1267 - 1286Online Full Text: dx.doi.org/ (Open Access)
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Plant chemical genetics reveals colistin sulphate as a SA and NPR1-independent PR1 inducer functioning via a p38-like kinase pathwayIn: Scientific Reports Vol. 9 (2019) Nr. 1, pp. 11196Online Full Text: dx.doi.org/ (Open Access)
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Proteases underground : Analysis of the maize root apoplast identifies organ specific papain-like cysteine protease activityIn: Frontiers in Plant Science (FPLS) Vol. 10 (2019)Online Full Text: dx.doi.org/ (Open Access)
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Triazine probes target ascorbate peroxidases in plantsIn: Plant Physiology Vol. 180 (2019) Nr. 4, pp. 1848 - 1859Online Full Text: dx.doi.org/ (Open Access)
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A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPasesIn: Angewandte Chemie International Edition Vol. 57 (2018) Nr. 6, pp. 1576 - 1580Online Full Text: dx.doi.org/
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An apoplastic peptide activates salicylic acid signalling in maizeIn: Nature Plants Vol. 4 (2018) Nr. 3, pp. 172 - 180Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Fermentative Spirochaetes mediate necromass recycling in anoxic hydrocarbon-contaminated habitatsIn: ISME Journal Vol. 12 (2018) Nr. 8, pp. 2039 - 2050Online Full Text: dx.doi.org/ (Open Access)
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HTRA1-Dependent Cell Cycle ProteomicsIn: Journal of Proteome Research Vol. 17 (2018) Nr. 8, pp. 2679 - 2694Online Full Text: dx.doi.org/
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Identification of Noncatalytic Lysine Residues from Allosteric Circuits via Covalent ProbesIn: ACS Chemical Biology Vol. 13 (2018) Nr. 5, pp. 1307 - 1312Online Full Text: dx.doi.org/
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Identification of the Natural Product RotihibinA as a TOR Kinase Signaling Inhibitor by Unbiased Transcriptional ProfilingIn: Chemistry - A European Journal Vol. 24 (2018) Nr. 48, pp. 12500 - 12504Online Full Text: dx.doi.org/
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Low Protease Content in Medicago truncatula Cell Cultures Facilitates Recombinant Protein ProductionIn: Biotechnology Journal Vol. 13 (2018) Nr. 7, 1800050Online Full Text: dx.doi.org/
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Mono- and Bivalent 14-3-3 Inhibitors for Characterizing Supramolecular “Lysine Wrapping” of Oligoethylene Glycol (OEG) Moieties in ProteinsIn: Chemistry - A European Journal (2018)Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Multiplex Fluorescent, Activity-Based Protein Profiling Identifies Active α-Glycosidases and Other Hydrolases in PlantsIn: Plant Physiology Vol. 177 (2018) Nr. 1, pp. 24 - 37Online Full Text: dx.doi.org/ (Open Access)
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Protease Activities Triggered by Ralstonia solanacearum Infection in Susceptible and Tolerant Tomato LinesIn: Molecular and Cellular Proteomics (MCP) Vol. 17 (2018) Nr. 6, pp. 1112 - 1125Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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The transcriptome, extracellular proteome and active secretome of agroinfiltrated Nicotiana benthamiana uncover a large, diverse protease repertoireIn: Plant Biotechnology Journal Vol. 16 (2018) Nr. 5, pp. 1068 - 1084Online Full Text: dx.doi.org/ (Open Access)
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Three unrelated protease inhibitors enhance accumulation of pharmaceutical recombinant proteins in Nicotiana benthamianaIn: Plant Biotechnology Journal Vol. 16 (2018) Nr. 10, pp. 1797 - 1810Online Full Text: dx.doi.org/ (Open Access)
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Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme FormationIn: Molecular Cell Vol. 72 (2018) Nr. 4, pp. 766 - 777Online Full Text: dx.doi.org/ (Open Access)
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Utilities for Mass Spectrometry Analysis of Proteins (UMSAP) : Fast post-processing of mass spectrometry dataIn: Rapid Communications in Mass Spectrometry Vol. 32 (2018) Nr. 19, pp. 1659 - 1667Online Full Text: dx.doi.org/
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Activity-based protein profiling as a robust method for enzyme identification and screening in extremophilic ArchaeaIn: Nature Communications Vol. 8 (2017) pp. 15352Online Full Text: dx.doi.org/ (Open Access)
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Mesenchymal stem cell therapy protects lungs from radiation-induced endothelial cell loss by restoring superoxide dismutase 1 expressionIn: Antioxidants and Redox Signaling Vol. 26 (2017) Nr. 11, pp. 563 - 582Online Full Text: dx.doi.org/ (Open Access)
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Proteasome activity profiling uncovers alteration of catalytic β2 and β5 subunits of the stress-induced proteasome during salinity stress in tomato rootsIn: Frontiers in Plant Science (FPLS) Vol. 8 (2017) 107Online Full Text: dx.doi.org/ (Open Access)
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Quantitative proteomics reveals ecophysiological effects of light and silver stress on the mixotrophic protist Poterioochromonas malhamensisIn: PLoS ONE Vol. 12 (2017) Nr. 1, pp. e0168183Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Small Molecules from Deep within the GutIn: ChemBioChem Vol. 18 (2017) Nr. 11, pp. 967 - 968Online Full Text: dx.doi.org/
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Subunit-selective proteasome activity profiling uncovers uncoupled proteasome subunit activities during bacterial infectionsIn: The Plant Journal Vol. 90 (2017) Nr. 2, pp. 418 - 430Online Full Text: dx.doi.org/
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Tailored Ahp-cyclodepsipeptides as Potent Non-covalent Serine Protease InhibitorsIn: Angewandte Chemie International Edition Vol. 56 (2017) Nr. 29, Special Issue: 100th Anniversary of the Royal Australian Chemical Institute, pp. 8555 - 8558Online Full Text: dx.doi.org/
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The Root Growth-Regulating Brevicompanine Natural Products Modulate the Plant Circadian ClockIn: ACS Chemical Biology Vol. 12 (2017) Nr. 6, pp. 1466 - 1471Online Full Text: dx.doi.org/ (Open Access)
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Turning-ON ProteasomesIn: Cell Chemical Biology Vol. 24 (2017) Nr. 6, pp. 653 - 655Online Full Text: dx.doi.org/
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A novel quenched fluorescent activity-based probe reveals caspase-3 activity in the endoplasmic reticulum during apoptosisIn: Chemical Science Vol. 7 (2016) pp. 1322 - 1337Online Full Text: dx.doi.org/ (Open Access)
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Capture of endogenously biotinylated proteins from Pseudomonas aeruginosa displays unexpected downregulation of LiuD upon iron nutritionIn: Bioorganic and Medicinal Chemistry Vol. 24 (2016) Nr. 15, pp. 3330 - 3335Online Full Text: dx.doi.org/
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VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break RepairIn: Molecular Cell Vol. 64 (2016) Nr. 1, pp. 189 - 198Online Full Text: dx.doi.org/ (Open Access)
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Chemical proteomics versus LeishmaniasisIn: Chemistry and Biology Vol. 22 (2015) Nr. 3, pp. 309 - 310Online Full Text: dx.doi.org/ (Open Access)
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Chemoproteomic Evaluation of the Polyacetylene Callyspongynic AcidIn: Chemistry - A European Journal Vol. 21 (2015) Nr. 30, pp. 10721 - 10728Online Full Text: dx.doi.org/ (Open Access)
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Determinants of amyloid fibril degradation by the PDZ protease HTRA1In: Nature Chemical Biology Vol. 11 (2015) Nr. 11, pp. 862 - 869Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Functional divergence of two secreted immune proteases of tomatoIn: Current Biology Vol. 25 (2015) Nr. 17, pp. 2300 - 2306Online Full Text: dx.doi.org/ (Open Access)
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Identification of human telomerase assembly inhibitors enabled by a novel method to produce hTERTIn: Nucleic Acids Research Vol. 43 (2015) Nr. 15, art. no. e99Online Full Text: dx.doi.org/ (Open Access)
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Subfamily-specific fluorescent probes for cysteine proteases display dynamic protease activities during seed germinationIn: Plant Physiology Vol. 168 (2015) Nr. 4, pp. 1462 - 1475Online Full Text: dx.doi.org/
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Synthesis of a hexahydropyrrolo indole (HPI) compound libraryIn: Bioorganic and Medicinal Chemistry Vol. 23 (2015) Nr. 11, pp. 2636 - 2645Online Full Text: dx.doi.org/
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A chemical inhibitor of jasmonate signaling targets JAR1 in Arabidopsis thalianaIn: Nature Chemical Biology Vol. 10 (2014) Nr. 10, pp. 830 - 836Online Full Text: dx.doi.org/
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Building up a chemical proteomics network in Europe and beyondIn: ACS Chemical Biology Vol. 9 (2014) Nr. 8, pp. 1647 - 1648Online Full Text: dx.doi.org/
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Peptidyl succinimidyl peptides as taspase 1 inhibitorsIn: ChemBioChem Vol. 15 (2014) Nr. 15, pp. 2233 - 2237Online Full Text: dx.doi.org/
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Synthesis of the B-seco limonoid core scaffoldIn: Beilstein Journal of Organic Chemistry Vol. 10 (2014) pp. 194 - 208Online Full Text: dx.doi.org/ (Open Access)
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A substrate-inspired probe monitors translocation, activation, and subcellular targeting of bacterial type III effector protease AvrPphBIn: Chemistry and Biology Vol. 20 (2013) Nr. 2, pp. 168 - 176Online Full Text: dx.doi.org/
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Ahp cyclodepsipeptides: The impact of the ahp residue on the "Canonical Inhibition" of S1 serine proteasesIn: ChemBioChem Vol. 14 (2013) Nr. 11, pp. 1301 - 1308Online Full Text: dx.doi.org/
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Case studies of the synthesis of bioactive cyclodepsipeptide natural productsIn: Molecules: A Journal of Synthetic Chemistry and Natural Product Chemistry Vol. 18 (2013) Nr. 2, pp. 1337 - 1367Online Full Text: dx.doi.org/ (Open Access)
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Chemical proteomics with sulfonyl fluoride probes reveals selective labeling of functional tyrosines in glutathione transferasesIn: Chemistry and Biology Vol. 20 (2013) Nr. 4, pp. 541 - 548Online Full Text: dx.doi.org/ (Open Access)
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Diversity of allosteric regulation in proteasesIn: ACS Chemical Biology Vol. 8 (2013) Nr. 1, pp. 19 - 26Online Full Text: dx.doi.org/
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Profiling protein kinases and other ATP binding proteins in arabidopsis using acyl-ATP probesIn: Molecular and Cellular Proteomics (MCP) Vol. 12 (2013) Nr. 9, pp. 2481 - 2496Online Full Text: dx.doi.org/
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Pseudomonas syringae pv. syringae Uses Proteasome Inhibitor Syringolin A to Colonize from Wound Infection SitesIn: PLoS Pathogens Vol. 9 (2013) Nr. 3, pp. e1003281Online Full Text: dx.doi.org/ (Open Access)
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Streamlining chemical probe discovery : libraries of "fully functionalized" small molecules for phenotypic screeningIn: Angewandte Chemie International Edition Vol. 52 (2013) Nr. 5, pp. 1368 - 1370Online Full Text: dx.doi.org/
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A para-nitrophenol phosphonate probe labels distinct serine hydrolases of ArabidopsisIn: Bioorganic and Medicinal Chemistry Vol. 20 (2012) Nr. 2, pp. 601 - 606Online Full Text: dx.doi.org/
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Activity enhancement of the synthetic syrbactin proteasome inhibitor hybrid and biological evaluation in tumor cellsIn: Biochemistry Vol. 51 (2012) Nr. 34, pp. 6880 - 6888Online Full Text: dx.doi.org/
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Allosteric inhibition of Taspase1's pathobiological activity by enforced dimerization in vivoIn: The FASEB Journal Vol. 26 (2012) Nr. 8, pp. 3421 - 3429Online Full Text: dx.doi.org/
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Challenges in the syntheses of peptidic natural productsIn: Synthesis: Journal of Synthetic Organic Chemistry Vol. 44 (2012) Nr. 12, pp. 1755 - 1777Online Full Text: dx.doi.org/
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Chemical Biology Approaches Reveal Conserved Features of a C-Terminal Processing PDZ ProteaseIn: ChemBioChem Vol. 13 (2012) Nr. 3, pp. 402 - 408Online Full Text: dx.doi.org/
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Development of a Solid-Phase Approach to the Natural Product Class of Ahp-Containing CyclodepsipeptidesIn: European Journal of Organic Chemistry (2012) Nr. 8, pp. 1616 - 1625Online Full Text: dx.doi.org/
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Discovery of a potent and highly β1 specific proteasome inhibitor from a focused library of urea-containing peptide vinyl sulfones and peptide epoxyketonesIn: Organic and Biomolecular Chemistry Vol. 10 (2012) Nr. 1, pp. 181 - 194Online Full Text: dx.doi.org/
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E. coli LoiP (YggG), a metalloprotease hydrolyzing Phe–Phe bondsIn: Molecular BioSystems Vol. 8 (2012) Nr. 6, pp. 1775 - 1782Online Full Text: dx.doi.org/ Online Full Text
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Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregatesIn: The Journal of Biological Chemistry (JBC) Vol. 287 (2012) Nr. 25, pp. 20931 - 20941Online Full Text: dx.doi.org/
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Identification of a selective, activity-based probe for glyceraldehyde 3-phosphate dehydrogenasesIn: Angewandte Chemie International Edition Vol. 51 (2012) Nr. 21, pp. 5230 - 5233Online Full Text: dx.doi.org/
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In Silico Identification of an Interferon InhibitorIn: ChemMedChem Vol. 7 (2012) Nr. 4, pp. 555 - 557Online Full Text: dx.doi.org/
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One-shot NMR analysis of microbial secretions identifies highly potent proteasome inhibitorIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 109 (2012) Nr. 45, pp. 18367 - 18371Online Full Text: dx.doi.org/
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Probes for activity-based profiling of plant proteasesIn: Physiologia Plantarum Vol. 145 (2012) Nr. 1, Special Issue: Plant Proteases, pp. 18 - 27Online Full Text: dx.doi.org/
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Selective inhibition of plant serine hydrolases by agrochemicals revealed by competitive ABPPIn: Bioorganic and Medicinal Chemistry Vol. 20 (2012) Nr. 2, pp. 597 - 600Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Small-molecule stabilization of protein-protein interactions : An underestimated concept in drug discovery?In: Angewandte Chemie International Edition Vol. 51 (2012) Nr. 9, pp. 2012 - 2018Online Full Text: dx.doi.org/
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Sulfonyl Fluoride Analogues as Activity-Based Probes for Serine ProteasesIn: ChemBioChem Vol. 13 (2012) Nr. 16, pp. 2327 - 2330Online Full Text: dx.doi.org/
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The antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipainsIn: Chemistry and Biology Vol. 19 (2012) Nr. 12, pp. 1546 - 1555Online Full Text: dx.doi.org/
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The impact of plant-pathogen studies on medicinal drug discoveryIn: Chemical Society Reviews Vol. 41 (2012) Nr. 8, pp. 3168 - 3178Online Full Text: dx.doi.org/
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Enzymatic timing and tailoring of macrolactamization in syringolin biosynthesisIn: Organic Letters Vol. 13 (2011) Nr. 17, pp. 4518 - 4521Online Full Text: dx.doi.org/
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HTRA proteases : regulated proteolysis in protein quality controlIn: Nature Reviews Molecular Cell Biology Vol. 12 (2011) Nr. 3, pp. 152 - 162Online Full Text: dx.doi.org/
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Macrocyclic Proteasome InhibitorsIn: Current Medicinal Chemistry Vol. 18 (2011) Nr. 33, pp. 5052 - 5060Online Full Text: dx.doi.org/
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Mining the active proteome of Arabidopsis ThalianaIn: Frontiers in Plant Science (FPLS) Vol. 2 (2011) 89Online Full Text: dx.doi.org/ (Open Access)
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Proteasome activity imaging and profiling characterizes bacterial effector Syringolin AIn: Plant Physiology Vol. 155 (2011) Nr. 1, pp. 477 - 489Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Protein quality control in the bacterial periplasmIn: Annual Review of Microbiology Vol. 65 (2011) pp. 149 - 168Online Full Text: dx.doi.org/
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Substrate induced remodeling of the active site regulates human HtrA1 activityIn: Nature Structural & Molecular Biology Vol. 18 (2011) pp. 386 - 388Online Full Text: dx.doi.org/
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Synthesis of the B-seco limonoid scaffoldIn: Chemical Communications: ChemComm Vol. 47 (2011) Nr. 23, pp. 6545 - 6547Online Full Text: dx.doi.org/
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The chemistry and biology of syringolins, glidobactins and cepafungins (syrbactins)In: Natural Product Reports Vol. 28 (2011) Nr. 11, pp. 1854 - 1867Online Full Text: dx.doi.org/
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The natural product hybrid of Syringolin A and Glidobactin A synergizes proteasome inhibition potency with subsite selectivity.In: Chemical Communications: ChemComm Vol. 47 (2011) Nr. 1, pp. 385 - 387Online Full Text: dx.doi.org/
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The yeast three-hybrid system as an experimental platform to identify proteins interacting with small signaling molecules in plant cells : Potential and limitationsIn: Frontiers in Plant Science (FPLS) Vol. 2 (2011) Nr. DEC, 101Online Full Text: dx.doi.org/ (Open Access)
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A Scaffold-Tree-Merging Strategy for Prospective Bioactivity Annotation of γ-PyronesIn: Angewandte Chemie International Edition Vol. 49 (2010) Nr. 21, pp. 3666 - 3670Online Full Text: dx.doi.org/
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Activation Instead of Inhibition : Targeting Proenzymes for Small-Molecule InterventionIn: ChemBioChem Vol. 11 (2010) Nr. 5, pp. 637 - 639Online Full Text: dx.doi.org/ Online Full Text
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Convergent synthesis and biological evaluation of syringolin a and derivatives as eukaryotic 20S proteasome inhibitorsIn: European Journal of Organic Chemistry (2010) Nr. 21, pp. 3991 - 4003Online Full Text: dx.doi.org/
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Conversion of a regulatory into a degradative proteaseIn: Journal of Molecular Biology (JMB) Vol. 397 (2010) Nr. 4, pp. 957 - 966Online Full Text: dx.doi.org/
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Determinants of structural and functional plasticity of a widely conserved protease chaperone complexIn: Nature Structural & Molecular Biology Vol. 17 (2010) Nr. 7, pp. 837 - 843Online Full Text: dx.doi.org/
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Impaired Binding of 14-3-3 to C-RAF in Noonan Syndrome Suggests New Approaches in Diseases with Increased Ras SignalingIn: Molecular and Cellular Biology (MCB) Vol. 30 (2010) Nr. 19, pp. 4698 - 4711Online Full Text: dx.doi.org/
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LAP6/POLYKETIDE SYNTHASE A and LAP5/POLYKETIDE SYNTHASE B encode hydroxyalkyl α-pyrone synthases required for pollen development and sporopollenin biosynthesis in Arabidopsis thalianaIn: The Plant Cell Vol. 22 (2010) Nr. 12, pp. 4045 - 4066Online Full Text: dx.doi.org/ (Open Access)
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N-Acylation during glidobactin biosynthesis by the tridomain nonribosomal peptide synthetase module GlbFIn: Chemistry and Biology Vol. 17 (2010) Nr. 10, pp. 1077 - 1083Online Full Text: dx.doi.org/ Online Full Text (Open Access)
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Principles, implementation, and application of biology-oriented synthesis (BIOS).In: Biological Chemistry Vol. 391 (2010) Nr. 5, pp. 491 - 497
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Solid phase total synthesis of the 3-amino-6-hydroxy-2-piperidone (Ahp) cyclodepsipeptide and protease inhibitor Symplocamide AIn: Chemical Communications: ChemComm (2010) Nr. 46, pp. 8857 - 8859Online Full Text: dx.doi.org/
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Syrbactin class proteasome inhibitor-induced apoptosis and autophagy occurs in association with p53 accumulation and Akt/PKB activation in neuroblastomaIn: Biochemical Pharmacology Vol. 80 (2010) Nr. 2, pp. 170 - 178Online Full Text: dx.doi.org/
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The first small-molecule inhibitor of 14-3-3s : Modulating the master regulatorIn: ChemBioChem Vol. 11 (2010) Nr. 15, pp. 2085 - 2087Online Full Text: dx.doi.org/
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Biology-Oriented Combined Solid- and Solution-Phase Synthesis of a Macroline-Like Compound CollectionIn: Chemistry - A European Journal Vol. 15 (2009) Nr. 44, pp. 11976 - 11984Online Full Text: dx.doi.org/
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Minitags for small molecules: detecting targets of reactive small molecules in living plant tissues using ‘click chemistry’.In: The Plant Journal Vol. 57 (2009) Nr. 2, pp. 373 - 385
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Peptidic small molecule activators of the stress sensor DegSIn: Molecular BioSystems Vol. 5 (2009) Nr. 9, pp. 980 - 985Online Full Text: dx.doi.org/
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Purification, crystallization and preliminary X-ray diffraction analysis of a plant subtilase.In: Acta crystallographica, Section F, Structural biology and crystallization communications online Vol. 65 (2009) Nr. 5, pp. 522 - 525
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Selectivity profiling of DegP substrates and inhibitorsIn: Bioorganic and Medicinal Chemistry Vol. 17 (2009) Nr. 7, pp. 2920 - 2924Online Full Text: dx.doi.org/
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Structural basis for Ca2+-independence and activation by homodimerization of tomato subtilase 3In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 106 (2009) Nr. 40, pp. 17223 - 17228Online Full Text: dx.doi.org/
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Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coliIn: Research in Microbiology Vol. 160 (2009) Nr. 9, pp. 660 - 666Online Full Text: dx.doi.org/
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Synthetic and structural studies on Syringolin A and B reveal critical determinants for selectivity and potency of proteasome inhibitionIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 106 (2009) Nr. 16, pp. 6507 - 6512
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Syringolin A selectively labels the 20S proteasome in murine EL4 and wildtype and bortezomib adapted leukemic cell linesIn: ChemBioChem Vol. 10 (2009) Nr. 16, pp. 2638 - 2643Online Full Text: dx.doi.org/ Online Full Text
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The ras pathway modulator melophlin a targets dynaminsIn: Angewandte Chemie International Edition Vol. 48 (2009) Nr. 39, pp. 7240 - 7245Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/
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Traceless solid phase synthesis of natural product inspired cis-1,2-dehydrodecalinsIn: Chemical Communications: ChemComm (2009) Nr. 20, pp. 2923 - 2925Online Full Text: dx.doi.org/
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γ-Pyrone natural products – a privileged compound class provided by nature.In: Bioorganic & medicinal chemistry : a Tetrahedron publication for the rapid dissemination of full original research papers and critical reviews on biomolecular chemistry, medicinal chemistry and related disciplines Vol. 17 (2009) Nr. 6, pp. 2304 - 2309
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A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanismIn: Nature Vol. 452 (2008) pp. 755 - 758
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Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality controlIn: Angewandte Chemie International Edition Vol. 47 (2008) Nr. 7, pp. 1332 - 1334Online Full Text: dx.doi.org/
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Allosteric regulation of proteasesIn: ChemBioChem Vol. 9 (2008) Nr. 18, pp. 2920 - 2928Online Full Text: dx.doi.org/ Online Full Text
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Biology-inspired synthesis of compound librariesIn: Cellular and Molecular Life Sciences - CMLS Vol. 65 (2008) Nr. 7/8, pp. 1186 - 1201
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Discovery of a New Class of Inhibitors of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B by Biology-Oriented SynthesisIn: Angewandte Chemie International Edition Vol. 47 (2008) Nr. 32, pp. 5973 - 5977Online Full Text: dx.doi.org/
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Identification and characterization of a novel proteasome inhibitor with apoptotic properties in neuroblastoma.In: Proceedings : annual meeting of the American Association for Cancer Research. Vol. 49 (2008) pp. 773
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Identification of CNG trinucleotide repeat ligands with a FRET melting assayIn: ChemBioChem Vol. 9 (2008) Nr. 8, pp. 1229 - 1234Online Full Text: dx.doi.org/ Online Full Text
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On the molecular mechanism of hormone action: Hunting the jasmonate target(s)In: Current topics in phytochemistry Vol. 9 (2008) pp. 1 - 16
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β-lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana.In: Nature Chemical Biology Vol. 4 (2008) Nr. 9, pp. 557 - 563
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Fluorescence-based melting assays for studying quadruplex ligandsIn: Methods: A Companion to Methods in Enzymology Vol. 42 (2007) Nr. 2, pp. 183 - 195Online Full Text: dx.doi.org/
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Identification of inhibitors for mycobacterial protein tyrosine phosphatase B (MptpB) by biology-oriented synthesis (BIOS).In: Chemistry: An Asian Journal Vol. 2 (2007) Nr. 9, pp. 1109 - 1126
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Aminoglycoside-quinacridine conjugates : Towards recognition of the P6.1 element of Telomerase RNA.In: ChemBioChem Vol. 7 (2006) Nr. 2, pp. 321 - 329Online Full Text: dx.doi.org/ Online Full Text
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Neomycin-capped aromatic platforms : Quadruplex DNA recognition and telomerase inhibitionIn: Organic and Biomolecular Chemistry Vol. 4 (2006) Nr. 6, pp. 1049 - 1057Online Full Text: dx.doi.org/
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TMC-95-Based Inhibitor Design Provides Evidence for the Catalytic Versatility of the ProteasomeIn: Chemistry and Biology Vol. 13 (2006) Nr. 6, pp. 607 - 614
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Toward Semisynthetic Lipoproteins by Convergent Strategies Based on Click and Ligation ChemistryIn: ChemBioChem Vol. 6 (2005) Nr. 4, pp. 625 - 628Online Full Text: dx.doi.org/ Online Full Text
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Binding mode of TMC-95A analogues to eukaryotic 20S proteasomeIn: ChemBioChem Vol. 5 (2004) Nr. 9, pp. 1256 - 1266Online Full Text: dx.doi.org/
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TMC-95A analogues with endocyclic biphenyl ether group as proteasome inhibitors.In: Chemistry & biodiversity : CB ; an official journal of the Center for the Study of Biological Complexity Vol. 1 (2004) Nr. 1, pp. 161 - 173
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Synthesis of a TMC-95A ketomethylene analogue by cyclization via intramolecular Suzuki coupling.In: Organic Letters Vol. 5 (2003) Nr. 19, pp. 3435 - 3437
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Navigation inside a protease: Substrate selection and product exit in the tricorn protease from Thermoplasma acidophilumIn: Journal of Molecular Biology (JMB) Vol. 324 (2002) Nr. 5, pp. 1041 - 1050Online Full Text: dx.doi.org/
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Structural plasticity and non-covalent substrate binding in the GroEL apical domain: A study using electrospray ionisation mass spectrometry and fluorescence binding studiesIn: The Journal of Biological Chemistry (JBC) Vol. 277 (2002) Nr. 36, pp. 33115 - 33126
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Structure-based prediction of cyclization propensities of linear precursorsIn: International Journal of Peptide Research and Therapeutics Vol. 9 (2002) Nr. 2/3, pp. 65 - 70
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Synthesis of TMC-95A analogues. Structure-based prediction of cyclization propensities of linear precursorsIn: Letters in Peptide Science Vol. 9 (2002) Nr. 2-3, pp. 65 - 70Online Full Text: dx.doi.org/
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The Core Structure of TMC-95A Is a Promising Lead for Reversible Proteasome InhibitionIn: Angewandte Chemie International Edition Vol. 41 (2002) Nr. 5, pp. 780 - 783Online Full Text: dx.doi.org/
Journal articles
Patents
Groll M, Kaiser M, Huber R, Moroder L, Renner C, Kohno J. Crystals of a Proteasome-Inhibitor Complex. Patent WO02081501 (2002).
Kaiser M, Clerc J. Development of a synthesis of Syringolin A and B and derivatives thereof. Patent US 61/129,865 (2008).
Kaiser M, Clerc J. Derivatives of syringolin A. Patent EP09075018.3-2117 (2009).
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