2024

• Early CYP3A5 genotype-based adjustment of Tacrolimus dosage reduces risk of de novo donor-specific HLA antibodies and rejection among CYP3A5-expressing renal transplant patients. Diagnostics 2024, Sep 26; 14. Schönfelder K, Möhlendick B, Eisenberger U, Kribben A, Siffert W, Heinemann FM, Gäckler A, Wilde B, Friebus-Kardash J.
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• Acute liver failure during deferasirox therapy and the potential role of pharmacogenetics. Front. Pharmacol. Sep 23 2024; 15:1477755. García-Fariña B, Rink L, Santarini V, Westkemper M, Dohna-Schwake C, Möhlendick B. 
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• Current progress in genomic and genetic research on human viral diseases. Front. Genet. Apr 15 2024;15:1407559. Ji H, Möhlendick B, Gao X, Liang B.
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• The single nucleotide polymorphism rs4986790 (c.896A>G) in the gene TLR4 as a protective factor in corona virus disease 2019 (COVID-19). Front. Immunol. 2024 Jan 29;15:1355193. Zacher C, Schönfelder K, Rohn H, Siffert W, Möhlendick B.
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2023

• Single-Nucleotide Polymorphism in Genes Encoding G Protein Subunits GNB3 and GNAQ Increase the Risk of Cardiovascular Morbiditiy among Patients Undergoing Renal Replacement Therapy. Int. J. Mol. Sci. 2023, 24 (20), 15260. Birkner S, Möhlendick B, Wilde B, Schoenfelder K, Boss K, Siffert W, Kribben A, Friebus-Kardash J.
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• Influence of the Single Nucleotide Polymorphisms rs12252 and rs34481144 in IFITM3 on the Antibody Response after Vaccination against COVID-19. Vaccines. 2023 Jul 19, 11 (7),1257. Ciuciulkaite I, Siffert W, Elsner C, Dittmer U, Wichert M, Wagner B, Volbracht L, Mosel F, Möhlendick B.
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• Characteristics and Long-Term Outcome of 535 Patients with Autoimmune Hepatitis - The 20-Year Experience of a High-Volume Tertiary Center. J. Clin. Med. 2023, 12(13),4192. Buechter M, Dorn D, Möhlendick B, Siffert W, Baba HA, Gerken G, Kahraman A.
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• Durability of immune response after application of a third dose of SARS-CoV-2 vaccination in liver transplant recipients. Vaccines 2023 Mar 2;11(3):572. Passenberg M, Authorsen-Grundmann R, Frey A, Korth J, Zmudzinski J, Anastasiou OE, Möhlendick B, Schmidt H, Rashidi-Alavijeh J, Willuweit K.
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• Antibody responses elicited by mRNA vaccination in firefighters persist six months and correlate inversly with age and directly with BMI. Heliyon 2022, Dec 30. Holtkamp C, Schöler L, Anastasiou OE, Brune B, Fessmann K, Elsner C, Möhlendick B, Ciuciulkaite I, Dudda M, Trilling M, Dittmer U, Spors J, Le-Trilling VTK. 
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2022

• CC Genotype of GNAS c.393C>T (rs7121) Polymorphism has a Protective Effect against Development of BK Viremia and BKV-Associated Nephropathy after Renal Transplant. Pathogens 2022, 11(10), 1138. Peitz T, Möhlendick B, Eisenberger U, Siffert W, Heinemann FM, Kribben A, Friebus-Kardash J.
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• GNB3 c.825C>T (rs5443) polymorphism and risk of acute cardiovascular events after renal allograft transplant. Int. J. Mol. Sci. 2022, 23 (17), 9783. Peitz T, Möhlendick B, Siffert W, Heinemann FM, Kribben A, Eisenberger U, Friebus-Kardash J.
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• GNB3 c.825C>T polymorphism influences T-cell but not antibody response following vaccination with mRNA-1273 vaccine.
  Front. Genet. 2022 August 1; 932043. Ciuciulkaite I, Möhlendick B, Thümmler L, Fisenkci N, Elsner C, Dittmer U, Siffert W, Lindemann M.
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• The GNB3 c.825C>T (rs5443) polymorphism and protection against fatal outcome of corona virus disease 2019 (COVID-19).
  Front. Genet. 2022 July 15; 960731. Möhlendick B, Schönfelder K, Zacher C, Elsner C, Rohn H, Konik MJ, Thümmler L, Rebmann V, Lindemann M, Jöckel KH, Siffert W.
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• Individuals with weaker antibody responses after booster vaccination are prone to Omicron breakthrough infections. Front. Immunol. 2022 May 27;13:907343. Möhlendick B, Ciuciulkaite I, Elsner C, Anastasiou OE, Trilling M, Wagner B, Zwanziger D, Jöckel KH, Dittmer U, Siffert W.
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• Antibody responses elicted by mRNA vaccination in firefighters persist six months and correlate inversely with age and directly with BMI. Heliyon. 2022 Apr 23. Holtkamp C, Schöler L, Anastasiou OE, Brune B, Fessmann K, Elsner C, Möhlendick B, Ciuciulkaite I, Dudda M, Trilling M, Dittmer U, Spors J, Le-Trilling VTK.
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• Characterization of the promoter of the human farnesyltransferase beta subunit and the impact of the transcription factor OCT-1 on its expression. Genomics. 2022 Mar;114 (2). Verhasselt H, Stelmach P, Domin M, Jung D, Hagemann A, Manthey I, Bachmachn HS. 
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• Patients with Liver Cirrhosis Show High Immunogenicity upon COVID-19 Vaccination but Develop Premature Deterioration of Antibody Titers. Vaccines. 2022 February 28. Willuweit K, Frey A, Passenberg M, Korth J, Saka N, Anastasiou OE, Möhlendick B, Schütte A, Schmidt H, Rashidi-Alavijeh J. 
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• FNTB promoter polymorphisms are independent predictors of survival in patients with triple negative breast cancer. Cancers. 2022 Jan 18;14 (3): 468. Bachmann HS, Jung D, Link T, Arnold A, Kantelhardt E, Thomssen C, Wimberger P, Vetter M, Kuhlmann JD.
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2021

• Development of de novo donor-specific HLA antibodies and ABMR in renal transplant patients depends on CYP3A5 genotype. Transplantation. 2021 July 1. Friebus-Kardash J, Nela E, Möhlendick B, Kribben A, Siffert W, Heinemann F, Eisenberger U. 
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• ACE2 polymorphism and susceptibility for SARS-CoV-2 infection and severity of COVID-19. Pharmacogenet Genomics. 2021 May 14. Möhlendick B, Schönfelder K, Breuckmann K, Elsner C, Babel N, Balfanz P, Dahl E, Dreher M, Fistera D, Herbstreit F, Hölzer B, Koch M, Kohnle M, Marx N, Risse J, Schmidt K, Skrzypczyk S, Sutharsan S, Taube C, Westhoff TH, Jöckel KH, Dittmer U, Siffert W, Kribben A. 
  Zum PubMed Artikel

• Transmembrane serine protease 2 Polymorphisms and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Type 2 Infection: A German Case-Control Study. Front. Genet. 2021 Apr 21;12:667231. Schönfelder K, Breuckmann K, Elsner C, Dittmer U, Fistera D, Herbstreit F, Risse J, Schmidt K, Sutharsan S, Taube C, Jöckel KH, Siffert W, Kribben A, Möhlendick B. 
  Zum PubMed Artikel

• The influence of IFITM3 polymorphisms on susceptibility to SARS-CoV-2 infection and severity of COVID-19. Cytokine. 2021 Mar 6. Schönfelder K, Breuckmann K, Elsner C, Dittmer U, Fistera D, Herbstreit F, Risse J, Schmidt K, Sutharsan S, Taube C, Jöckel KH, Siffert W, Kribben A, Möhlendick B.
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• NAT2 polymorphisms as a cause of metamizole-induced agranulocytosis. Pharmacogenet. Genom. 2021 Mar 5. Radulovic I, Dogan B, Dohna-Schwake C, Schündeln MM, Siffert W, Möhlendick B.
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• Characterization of the G protein-coupled receptor kinase 6 promoter reveals a functional CREB binding site. PLoS One. 2021 Feb 18; 16 (2). Stegen M, Engler A, Ochsenfarth C, Manthey I, Peters J, Siffert W, Frey UH.
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2020

• Lack of association of common polymorphisms linked to empathic behavior with self-reported trait empathy in healthy volunteers. Horm Behav. 2020;104841. Hütter FK, Möhlendick B, Knop D, Siffert W.
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• Major Adverse Kidney Events Are Associated with the Aquaporin 5 -1364A/C Promoter Polymorphism in Sepsis: A Prospective Validation Study. Cells. 2020;9(4):904. Bergmann L, Nowak H, Siffert W, Peters J, Adamzik M, Koos, B, Rahmel T.
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• Genetic variations in G-protein signal pathways influence progression of coronary artery calcification: Results from the Heinz Nixdorf Recall study. Atherosclerosis. 2020;S0021-9150(20)30344-0. Klenke S, Lehmann N, Erbel R, Jöckel KH, Siffert W, Frey UH, Peters J.
  Zum PubMed Artikel

2019

• DNA methylation of Nf-κB binding site in the aquaporin 5 promoter impacts mortality in sepsis. Sci Rep. 2019 Dec 6; 9(1):18511. Rump K, Unterberg M, Dahlke A, Nowak H, Koos B, Bergmann L, Siffert W, Schäfer ST, Peters J, Adamzik M, Rahmel T.
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• Association of caspase 8 polymorphisms -652 6N InsDel and Asp302His with progression-free survival and tumor infiltrating lymphocytes in early breast cancer. Sci Rep. 2019 Aug 29; 9(1): 12594. Kuhlmann JD, Bachmann HS, Link T, Wimberger P, Kröber E, Thomssen C, Mallé B, Bethmann D, Vetter M, Kantelhardt EJ.
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• The GNAS SNP c.393C>T (rs7121) as a marker for disease progression and survival in cancer. Pharmacogenomics. 2019 May; 20(6):553-562. Möhlendick B, Schmid KW, Siffert S.
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• BRAF(V600E) mutation: A promising target in colorectal neuroendocrine carcinoma. Int J Cancer. 2019 Mar 15; 144(6):1379-1390. Dizdar L, Werner TA, Drusenheimer JC, Möhlendick B, Raba K, Boeck I, Anlauf M,
  Schott M, Göring W, Esposito I, Stoecklein NH, Knoefel WT, Krieg A.
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• The small molecule Bcl-2/Mcl-1 inhibitor TW-37 shows single-agent cytotoxicity in neuroblastoma cell lines. BMC Cancer. 2019 Mar 18; 19(1):243. Klenke S, Akdeli N, Stelmach P, Heukamp L, Schulte JH, Bachmann HS.
  Zum PubMed Artikel

• Severe reduction in tacrolimus concentrations with concomitant metamizole (dipyrone) therapy in transplant patients. Eur J Clin Pharmacol. 2019 Jan 29. Sigaroudi A, Jetter A, Mueller TF, Kullak-Ublick G, Weiler S.
  Zum PubMed Artikel

2018

• The aquaporin 5 -1364A/C promoter polymorphism impacts on resolution of acute kidney injury in pneumonia evoked ARDS. PLoS One. 2018 Dec 5;13 (12):e0208582. Rahmel T, Nowak H, Rump K, Siffert W, Peters J, Adamzik M.
  Zum PubMed Artikel

• The GRK2 promoter is regulated by early-growth response transcription factor EGR-1. Basic Clin Pharmacol Toxicol. 2018 Dec; 123(6):660-669. Klenke S, Engler A, Ecker D, Ochsenfarth C, Danowski N, Peters J, Siffert W, Frey UH.
  Zum PubMed Artikel

• Sex-specific association of a common GNAS polymorphism with self-reported cognitive empathy in healthy volunteers. PLoS One. 2018 Oct 26;13(10):e0206114. Huetter FK, Horn PA, Siffert W.
  Zum PubMed Artikel

• The prognostic impact of UDP-glucuronyltransferase 1A1*1 (UGT1A1*1) polymorphism in patients with advanced colorectal and non-colorectal cancer treated with irinotecan-based systemic chemotherapies. Oncol Res & Treat. 2018 Sep 28;41 Suppl 4: 122-123. Stein G, Stelmach P, Kasper S, Paul A, Wedemeyer HH, Schmid KW, Schumacher B, Markus P, Siffert W, Schuler M, Bachmann HS, Virchow I.
  Zum PubMed Artikel

• CHRM3 rs2165870 polymorphism is independently associated with postoperative nausea and vomitting, but combined prophylaxis is effective. Br J Anaesth. 2018 Jul; 121(1):58-65. Klenke S, de Vries GJ, Schiefer L, Seyffert N, Bachmann HS, Peters J, Frey UH.
  Zum PubMed Artikel

• ACGH detects distinct genomic alterations of primary intrahepatic cholangiocarcinomas and matched lymph node metastases and identifies a poor prognosis subclass. Sci Rep. 2018 Jul 13;8(1):10637. Jansen R, Möhlendick B, Bartenhagen C, Tóth C, Lehwald N, Stoecklein NH, Knoefel WT, Lachenmayer A.
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• Association of Caspase 8 polymorphisms with TILs and disease-free survival in primary breast cancer patients. JCO. 2018 May 20 36;4: doi:10.1200/JCO.2018.36.15_suppl.e24258. Wimberger P, Bachmann HS, Kuhlmann JD, Link T, Kroeber E, Thomssen C.
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2017

• A single intraperitoneal injection of bovine fetuin-A attenuates bone resorption in a murine calvarial model of particle-induced osteolysis.
  Bone. 2017 Dec;105:262-268. doi: 10.1016/j.bone.2017.09.006. Epub 2017 Sep 21. Jablonski H, Polan C, Wedemeyer C, Hilken G, Schlepper R, Bachmann HS, Grabellus F, Dudda M, Jäger M, Kauther MD.
  Zum PubMed Artikel

• Exploring the putative self-binding property of the human farnesyltransferase alpha-subunit.
  FEBS Lett. 2017 Nov;591(21):3637-3648. doi: 10.1002/1873-3468.12862. Epub 2017 Oct 11. Hagemann A, Müller G, Manthey I, Bachmann HS.
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• Relationship between GNAS1 T393C polymorphism and aseptic loosening after total hip arthroplasty.
  Eur J Med Res. 2017 Aug 23;22(1):29. doi: 10.1186/s40001-017-0271-z. Stelmach P, Kauther MD, Fuest L, Kurscheid G, Gehrke T, Klenke S, Jäger M, Wedemeyer C, Bachmann HS.
  Zum PubMed Artikel

• GNAQ TT(-695/-694)GC Polymorphism Is Associated with Increased Gq Expression, Vascular Reactivity, and Myocardial Injury after Coronary Artery Bypass Surgery.
  Anesthesiology. 2017 Jul;127(1):70-77. doi: 10.1097/ALN.0000000000001642. Frey UH, Klenke S, Mitchell A, Knüfermann T, Jakob H, Thielmann M, Siffert W, Peters J.
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• Hypoxia Inducible Factor-2 Alpha and Prolinhydroxylase 2 Polymorphisms in Patients with Acute Respiratory Distress Syndrome (ARDS).
  Int J Mol Sci. 2017 Jun 14;18(6). pii: E1266. doi: 10.3390/ijms18061266. Dötsch A, Eisele L, Rabeling M, Rump K, Walstein K, Bick A, Cox L, Engler A, Bachmann HS, Jöckel KH, Adamzik M, Peters J, Schäfer ST.
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• Impact of BCL2 polymorphisms on survival in transitional cell carcinoma of the bladder.
  J Cancer Res Clin Oncol. 2017 Apr 17. doi: 10.1007/s00432-017-2404-8. Hess J, Stelmach P, Eisenhardt A, Rübben H, Reis H, Schmid KW, Bachmann HS.
  Zum PubMed Artikel

2016

• Polymorphisms in the GNAS Gene as Predictors of Ventricular Tachyarrhythmias and Sudden Cardiac Death: Results From the DISCOVERY Trial and Oregon Sudden Unexpected Death Study.
  J Am Heart Assoc. 2016 Nov 28;5(12). pii: e003905. Wieneke H, Svendsen JH, Lande J, Spencker S, Martinez JG, Strohmer B, Toivonen L, Le Marec H, Garcia-Fernandez FJ, Corrado D, Huertas-Vazquez A, Uy-Evanado A, Rusinaru C, Reinier K, Foldesi C, Hulak W, Chugh SS, Siffert W.
  Zum PubMed Artikel

• AQP5-1364A/C polymorphism and the AQP5 expression influence sepsis survival and immune cell migration: a prospective laboratory and patient study.
  J Transl Med. 2016 Nov 21;14(1):321. Rump K, Unterberg M, Bergmann L, Bankfalvi A, Menon A, Schäfer S, Scherag A, Bazzi Z, Siffert W, Peters J, Adamzik M.
  Zum PubMed Artikel

• A Single Dose of the Anti-Resorptive Peptide Human Calcitonin Paradoxically Augments Particle- and Endotoxin-Mediated Pro-Inflammatory Cytokine Production In Vitro.
  Horm Metab Res. 2016 Sep;48(9):607-12. doi: 10.1055/s-0042-108338. Epub 2016 Jun 3. Jablonski H, Wedemeyer C, Bachmann HS, Schlagkamp M, Bernstein A, Jäger M, Kauther MD.

  Zum PubMed Artikel

• Hypoxia inducible factor-1 alpha and prolinhydroxlase 2 polymorphisms in patients with severe sepsis: a prospective observational trial.
  BMC Anesthesiol. 2016 Aug 11;16(1):61. doi: 10.1186/s12871-016-0225-y. Höcker A, Rabeling M, Bick A, Cox L, Kreuzer M, Engler A, Walstein K, Bachmann HS, Jöckel KH, Eisele L, Adamzik M, Peters J, Schäfer ST.
  Zum PubMed Artikel

• Prognostic relevance of caspase 8 -652 6N InsDel and Asp302His polymorphisms for breast cancer.
  BMC Cancer. 2016 Aug 9;16:618. doi: 10.1186/s12885-016-2662-x. Kuhlmann JD, Bankfalvi A, Schmid KW, Callies R, Kimmig R, Wimberger P, Siffert W, Bachmann HS.
  Zum PubMed Artikel

• Association of a Common Oxytocin Receptor Gene Polymorphism with Self-Reported 'Empathic Concern' in a Large Population of Healthy Volunteers.
  PLoS One. 2016 Jul 28;11(7):e0160059. doi: 10.1371/journal.pone.0160059. eCollection 2016. Huetter FK, Bachmann HS, Reinders A, Siffert D, Stelmach P, Knop D, Horn PA, Siffert W.
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• The Transcription Factor NMP4 Binds to the AQP5 Promoter and Is a Novel Transcriptional Regulator of the AQP5 Gene.
  DNA Cell Biol. 2016 Jul;35(7):322-7. doi: 10.1089/dna.2015.3110. Epub 2016 Apr 8. Rump K, Siffert W, Peters J, Adamzik M.
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• A suggested vital function for eIF-5A and dhs genes during murine malaria blood-stage infection.
  FEBS Open Bio. 2016 Jun 23;6(8):860-72. doi:10.1002/2211-5463.12093. eCollection 2016 Aug. Kersting D, Krüger M, Sattler JM, Mueller AK, Kaiser A.
  Zum PubMed Artikel

• The BCL2 -938C>A Promoter Polymorphism Is Associated with Risk for and Time to Aseptic Loosening of Total Hip Arthroplasty.
  PLoS One. 2016 Feb 16;11(2):e0149528. doi: 10.1371/journal.pone.0149528. eCollection 2016. Stelmach P, Wedemeyer C, Fuest L, Kurscheid G, Gehrke T, Klenke S, Jäger M, Kauther MD, Bachmann HS.
  Zum PubMed Artikel

2015

• Single nucleotide polymorphisms of the EpCAM-coding gene TACSTD1 in patients with ovarian cancer and their potential translational aspects.
  Arch Gynecol Obstet. 2015 Dec;292(6):1367-72. doi: 10.1007/s00404-015-3802-2. Epub 2015 Jun 27. Heubner M, Wimberger P, Kasimir-Bauer S, Singer BB, Ruf P, Kimmig R, Siffert W.
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• Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging.
  Sci Transl Med. 2015 Dec 9;7(317):317ra199. doi: 10.1126/scitranslmed.aad1278. Stoffels I, Morscher S, Helfrich I, Hillen U, Leyh J, Burton NC, Sardella TC, Claussen J, Poeppel TD, Bachmann HS, Roesch A, Griewank K, Schadendorf D, Gunzer M, Klode J.
  Zum PubMed Artikel

• The FNTB promoter polymorphism rs11623866 as a potential predictive biomarker for lonafarnib treatment of ovarian cancer patients.
  Br J Clin Pharmacol. 2015 Nov;80(5):1139-48. doi: 10.1111/bcp.12688. Epub 2015 Jul 22. Bachmann HS, Meier W, du Bois A, Kimmig R, Kuhlmann JD, Siffert W, Sehouli J, Wollschlaeger K, Huober J, Hillemanns P, Burges A, Schmalfeldt B, Aminossadati B, Wimberger P.
  Zum PubMed Artikel

• Absence of telomerase reverse transcriptase promoter mutations in neuroblastoma.
  Biomed Rep. 2015 Jul;3(4):443-446. Epub 2015 May 13.
  Lindner S, Bachmann HS, Odersky A, Schaefers S, Klein-Hitpass L, Hero B, Fischer M, Eggert A, Schramm A, Schulte JH.
  Zum PubMed Artikel

• New insights into novel inhibitors against deoxyhypusine hydroxylase from plasmodium falciparum: compounds with an iron chelating potential.
  Amino Acids. 2015 Jun;47(6):1155-66. doi: 10.1007/s00726-015-1943-z. Epub 2015 Feb 26. von Koschitzky I, Gerhardt H, Lämmerhofer M, Kohout M, Gehringer M, Laufer S, Pink M, Schmitz-Spanke S, Strube C, Kaiser A.
  Zum PubMed Artikel

• AQP1, AQP5, Bcl-2 and p16 in pharyngeal squamous cell carcinoma.
  J Laryngol Otol. 2015 Jun;129(6):580-6. doi: 10.1017/S002221511500119X. Lehnerdt GF, Bachmann HS, Adamzik M, Panic A, Köksal E, Weller P, Lang S, Schmid KW, Siffert W, Bankfalvi A.
  Zum PubMed Artikel

• Calcitonin Gene-Related Peptide Modulates the Production of Pro-Inflammatory Cytokines Associated with Periprosthetic Osteolysis by THP-1 Macrophage-Like Cells.
  Neuroimmunomodulation. 2015;22(3):152-65. doi: 10.1159/000360988. Epub 2014 May 14. Jablonski H, Kauther MD, Bachmann HS, Jäger M, Wedemeyer C.
  Zum PubMed Artikel

2014

• GNB3 gene 825 TT variant predicts hard coronary events in the population-based Heinz Nixdorf Recall study. 
  Atherosclerosis 2014 Dec; 237(2);437-42.doi: 10.1016/j.artherosclerosis. 2014.08.025. Epub 2014 Aug 28. Frey UH, Moebus S, Möhlenkamp S, Kälsch H, Bauer M, Lehmann N, Nöthen M, Mühleisen TW, Stang A, Erbel R, Jöckel KH, Peters J, Siffert W.
  Zum PubMed Artikel

• Characterization of the PLCB1 promoter and regulation by early growth response transcription factor EGR-1.
  Eur J Pharmacol. 2014 Nov 5;742:8-14. doi: 10.1016/j.ejphar.2014.08.026. Epub 2014 Sep 1. Klenke S, Rump K,Buschkamp K, Engler A, Peters J, Siffert W, Frey UH.
  Zum PubMed Artikel

• Hydrocortisone fails to abolish NF-?B1 protein nuclear translocation in deletion allele carriers of the NFKB1 promoter polymorphism (-94ins/delATTG) and is associated with increased 30-day mortality in septic shock.
  PLoS One. 2014 Aug 18;9(8):e104953. doi 10. 1371/journal.pone.0104953. eCollection 2014. Schäfer ST, Gessner S, Scherag A, Rump K, Frey UH, Siffert W, Westendorf AM, Peters J, Adamzik M.
  Zum PubMed Artikel

• Homozygous GNAS 393C-Allele Carriers with Locally Advanced Esophageal Cancer Fail to Benefit from Platinum-Based Preoperative Chemoradiotherapy.
  Ann Surg Oncol. 2014 Dec;21(13):4375-82. doi: 10. 1245/s10434-014-3843-y. Epub 2014 Jul 2. Alakus H, Bollschweiler E, Hölscher AH, Warnecke-Eberz U, Frazer KA, Harismendy O, Lowy AM, Mönig SP, Eberz PM, Maus M, Drebber U, Siffert W, Metzger R.
  Zum PubMed Artikel

• The haplotype of three polymorphisms in the SATB1 promoter region impacts survival in breast cancer patients.
  Oncol. Lett. 2014;7(6):2007-2012. Epub 2014 Mar 20. Heubner M, Kimmig R, Aktas B, Siffert W, Frey UH.
  Zum PubMed Artikel

• A 3'UTR polymorphism modulates mRNA stability of the oncogene and drug target Polo-like Kinase 1. 
  Mol Cancer 2014 Apr. 26; 13:87 doi: 10.1186/1476-4598-13-87. Akdeli N, Riemann K, Westphal J, Hess J, Siffert W, Bachmann HS.
  Zum PubMed Artikel

• Target evaluation of deoxyhypusine synthase from Theileria parva the neglected animal parasite and its relationship to Plasmodium.
  BIorg Med chem. 2014; Aug 1;22(15):4338-46. doi: 10.1016/j.bmc. 2014.04.007. Epub 2014 May 21. Njuguna JT, von Koschitzky I, Gerhardt H, Lämmerhofer M, Choucry A, Pink M, Schmitz-Spahnke S, Bakheit MA, Strube C, Kaiser A.
  Zum PubMed Artikel
• RNAi in Plasmodium. 
  Curr Pharm des. 2014;20(2):278-83. Mueller AK, Hammerschmidt-Kamper C, Kaiser A.
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2013

• Chemical profiling of deoxyhypusine hydroxylase inhibitors for antimalarial therapy.
  Amino Acids. 2013;45(5): 1047-53. von Koschitzky I, Kaiser A. 
  Zum PubMed Artikel

• The NFKB1 promoter polymorphism (-94ins/delATTG) alters nuclear translocation of NF-?B1 in monocytes after lipopolysaccharide stimulation and is associated with increased mortality in sepsis.
  Anesthesiology. 2013; 118(1): 123-33. Adamzik M, Schäfer S, Frey UH, Becker A, Kreuzer M, Winning S, Frede S, Steinmann J, Fandrey J, Zacharowski K, Siffert W, Peters J, Hartmann M.
  Zum PubMed Artikel

• Correlation of aquaporin-1 water channel protein expression with tumor angiogenesis in human astrocytoma. 
  Anticancer Res. 2013; 33(2): 609-13. El Hindy N, Bankfalvi A, Herring A, Adamzik M, Lambertz N, Zhu Y, Siffert W, Sure U, Sandalcioglu IE.
  Zum PubMed Artikel

• Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic Plasmodium falciparum parasites.
  Antimicrob Agents Chemother. 2013 57(6):2874-7. Niemand J, Burger P, Verlinden BK, Reader J, Joubert AM, Kaiser A, Louw AI, Kirk K, Phanstiel O 4th, Birkholtz LM.
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• The BCL2-938 C > A promoter polymorphism is associated with risk group classification in children with acute lymphoblastic leukemia.
  BMC Cancer. 2013 Oct. 2; 13:452 doi: 10.1186/1471-2407-13-452. Künkele A, Grosse-Lordemann A, Schramm A, Eggert A, Schulte JH, Bachmann HS
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• Cloning and characterization of the GNA11 promoter and its regulation by early growth response 1.
  Basic Clin Pharmacol Toxicol. 2013 Nov; 113(5):316-24 doi: 10.1111/bcpt. 12100. Epub 2013 Jul 19. Klenke S, Siffert W, Frey UH.
  Zum PubMed Artikel

• RANKL-associated suppression of particle-induced osteolysis in an aged model of Calcitonin and ?-CGRP deficiency. 
  Biomaterials. 2013; 34(12):2911-9. Kauther MD, Neuerburg C, Wefelnberg F, Bachmann HS, Schlepper R, Hilken G, Broecker-Preuss M, Grabellus F, Schilling AF, Jäger M, Wedemeyer C.
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• Decreased expression of miR-133a but not of miR-1 is associated with signs of heart failure in patients undergoing coronary bypass surgery.
  Cardiology. 2013; 125(2):125-30.  Danowski N, Manthey I, Jakob HG, Siffert W, Peters J, Frey UH.
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• Expression of aquaporin 5 and the AQP5 polymorphism A(-1364)C in association with peritumoral brain edema in meningioma patients.
  Neurooncol. 2013; 112(2): 297-305. Lambertz N, Hindy NE, Adler C, Rump K, Adamzik M, Keyvani K, Bankfalvi A, Siffert W, Erol Sandalcioglu I, Bachmann HS.
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• The functional Aquaporin 1 -783G/C-polymorphism is associated with survival in patients with glioblastoma multiforme.    
  J Surg oncol 2013 Dec; 108(7):492-8. doi: 10.1002/jso 23421. Epub 2013 Sp 6. El Hindy N, Rump K, Lambertz N, Zhu Y, frey UH, Bankfalvi A, Siffert W, Sure U, Perters J, Adamzik M, Sandalcioglu IE.
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• Risk factors for thrombus formation on the Amplatzer Cardiac Plug after left atrial appendage occlusion.
  JACC Cardiovasc Interv. 2013; 6(6):606-13. Plicht B, Konorza TF, Kahlert P, Al-Rashid F, Kaelsch H, Jánosi RA, Buck T, Bachmann HS, Siffert W, Heusch G, Erbel R.
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• Deoxyhypusine hydroxylase from Plasmodium vivax, the neglected human malaria parasite: molecular cloning, expression and specific inhibition by the 5-LOX inhibitor zileuton. 
  PloS One. 2013; 8(3):e58318. Atemnkeng VA, Pink M, Schmitz-Spanke S, Wu XJ, Dong LL, Zhao KH, May C, Laufer S, Langer B, Kaiser A.
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• Institutional profile: Institute of Pharmacogenetics at the University Hospital Essen.
  Pharmacogenomics 2013; 14(3):241-3. Siffert W.
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• Aquaporin 1 and 5 expression evoked by the ?2 adrenoreceptor agonist terbutaline and lipopolysaccharide in mice and in the human monocytic cell line THP-1 is differentially regulated.
  Shock 2013 Nov;405(5):430-6 doi: 10.1097/SHK. Rump K, Brendt P, Frey UH, Schäfer ST, Siffert W, Peters J, Adamzik M.
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2012

• The GNB3 C825T polymorphism influences platelet aggregation in human whole blood.
  Pharmacogenet Genomics. 2012; 22(1): 43-9. Dusse F, Frey UH, Bilalic A, Dirkmann D, Görlinger K, Siffert W, Peters J.
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• A rapid and robust assay for the determination of the amino acid hypusine as a possible biomarker for a high-throughput screening of antimalarials and for the diagnosis and therapy of different diseases.
  Amino Acids. 2012; 42(5):1651. Kaiser A, Khomutov AR, Simonian A, Agostinelli E.
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• In vitro and in vivo silencing of plasmodial dhs and eIf-5a genes in a putative, non-canonical RNAi-related pathway.
  BMC Microbiol. 2012; 12:107. Schwentke A, Krepstakies M, Mueller AK, Hammerschmidt-Kamper C, Motaal BA, Bernhard T, Hauber J, Kaiser A.
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• The -1364A/C Aquaporin 5 Gene Promoter Polymorphism Is Not Associated with Menière's Disease. 
  ISRN Otolaryngol 2012; 2012:706896. Arweiler-Harbeck D, Saidi F, Lang S, Peters J, Siffert W, Adamzik M.
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• Therapy of uncomplicated falciparum malaria in Europe: MALTHER - a prospective observational multicentre study.
  Malar J. 2012; 11:212. Bouchaud O, Mühlberger N, Parola P, Calleri G, Matteelli A, Peyerl-Hoffmann G, Méchaï F, Gautret P, Clerinx J, Kremsner PG, Jelinek T, Kaiser A, Beltrame A, Schmid ML, Kern P, Probst M, Bartoloni A, Weinke T, Grobusch MP.
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2011

• Aquaporin 5 gene promoter--1364A/C polymorphism associated with 30-day survival in severe sepsis.
  Anesthesiology. 2011; 114(4): 912-7. Adamzik M, Frey UH, Möhlenkamp S, Scherag A, Waydhas C, Marggraf G, Dammann M, Steinmann J, Siffert W, Peters J.
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• Calcitonin substitution in calcitonin deficiency reduces particle-induced osteolysis.
  BMC Musculoskelet Disord. 2011; 12: 186. Kauther MD, Bachmann HS, Neuerburg L, Broecker-Preuss M, Hilken G, Grabellus F, Koehler G, von Knoch M, Wedemeyer C.
  Zum PubMed Artikel

• Genetic interactions in the ß-adrenoceptor/G-protein signal transduction pathway and survival after coronary artery bypass grafting: a pilot study.
  Br J Anaesth. 2011; 107(6): 869-78. Frey UH, Kottenberg E, Kamler M, Leineweber K, Manthey I, Heusch G, Siffert W, Peters J.
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• High ALK Receptor Tyrosine Kinase Expression Supersedes ALK Mutation as a Determining Factor of an Unfavorable Phenotype in Primary Neuroblastoma.
  Clin Cancer Res. 2011; 17(15): 5082-5092. Schulte JH, Bachmann HS, Brockmeyer B, DePreter K, Oberthuer A, Ackermann S, Kahlert Y, Pajtler K, Theissen J, Westermann F, Vandesompele J, Speleman F, Berthold F, Eggert A, Brors B, Hero B, Schramm A, Fischer M.
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• Improvement of non-steroidal anti-inflammatory drug-induced gastrointestinal symptoms during proton pump inhibitor treatment: are G-protein ß3 subunit genotype, Helicobacter pylori status, and environmental factors response modifiers?
  Digestion. 2011;84(4): 289-98. Holtmann G, van Rensburg C, Schwan T, Sander P, Siffert W.
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• The NFKB1 promoter polymorphism (94ins/delATTG) alters nuclear translocation of NF-KB1 in monocytes following lipopolysaccharide stimulation and is associated with increased mortality in sepsis
  Infection. 2011;39 2: S102-S102. Adamzik M, Schaefer S, Frey UH, Becker A, Kreutzer M, Winning S, Frede S, Steinmann J, Fandrey J, Zacharowski K, Siffert W, Peters J, Hartmann M.
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• Regulatory BCL2 promoter polymorphism (-938C>A) is associated with adverse outcome in patients with prostate carcinoma.
  Int J Cancer. 2011;129(10): 2390-9. Bachmann HS, Heukamp LC, Schmitz KJ, Hilburn CF, Kahl P, Buettner R, Nückel H, Eisenhardt A, Rübben H, Schmid KW, Siffert W, Eggert A, Schramm A, Schulte JH.
  Zum PubMed Artikel

• Role of the GNAS1 T393C polymorphism in patients with glioblastoma multiforme.
  J Clin Neurosci. 2011; 18(11): 1495-9. El Hindy N, Lambertz N, Bachmann HS, Frey UH, Adamzik M, Zhu Y, Sure U, Siffert W, Sandalcioglu IE.
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• The prevalence of the c-kit exon 10 variant, M541L, in aggressive fibromatosis does not differ from the general population.
  J Clin Pathol. 2011; 64(11): 1021-4. Grabellus F, Worm K, Sheu SY, Siffert W, Schmid KW, Bachmann HS.
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• Association of the CC genotype of the regulatory BCL2 promoter polymorphism (-938C>A) with better 2-year survival in patients with glioblastoma multiforme.
  J Neurosurg. 2011; 114(6): 1631-9. El Hindy N, Bachmann HS, Lambertz N, Adamzik M, Nückel H, Worm K, Zhu Y, Sure U, Siffert W, Sandalcioglu IE.
  Zum PubMed Artikel

• Toll-like receptor 4 single-nucleotide polymorphisms Asp299Gly and Thr399Ile in head and neck squamous cell carcinomas.
  J Transl Med. 2011; 9: 139. Bergmann C, Bachmann HS, Bankfalvi A, Lotfi R, Pütter C, Wild CA, Schuler PJ, Greve J, Hoffmann TK, Lang S, Scherag A, Lehnerdt GF.
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• A novel aspect of GNAS imprinting: higher maternal expression of G(alpha)s in human lymphoblasts, peripheral blood mononuclear cells, mammary adipose tissue, and heart.
  Mol Cell Endocrinol. 2011; 341(1-2): 63-70. Klenke S, Siffert W, Frey UH.
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• The GNB3 C825T polymorphism as a pharmacogenetic marker in the treatment of hypertension, obesity, and depression.
  Pharmacogenet Genomics. 2011; 21(9): 594-606. Klenke S, Kussmann M, Siffert W.
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• SNPs in genes encoding G proteins in pharmacogenetics.
  Pharmacogenomics. 2011; 12(5): 633-54. Klenke S, Siffert W.
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• Influence of the 393T>C polymorphism of the GNAS1 gene on the intensity of opiate withdrawal.
  Pharmacopsychiatry. 2011; 44(4): 159-60. Bachmann HS, Lieb B, Bonnet U, Specka M, Augener S, Siffert W, Scherbaum N.
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• Lack of association of the genotype in the GNAS Fok I polymorphism and prostate cancer.
  Urol Int. 2011;87(1): 80-6. Eisenhardt A, Scherag A, Jöckel KH, Reis H, Rübben H, Siffert W.
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