Dr. Katarzyna Kliza

Decoding Post-Translational Modification Signalling Networks

Max-Planck Institute of Molecular Physiology, Dortmund

Phone: +49 231 133 2366
Email

ADP-ribosylation is a crucial chemical modification of biomolecules, including proteins and nucleic acids. This modification plays a pivotal role in driving and regulating dynamic cell state transitions, such as those involved in DNA repair, cell cycle progression, and stem cell differentiation. These cellular changes are tightly controlled by a complex ADP-ribosylation system comprised of enzymes, interactors, and regulatory factors. Any disruption in the balance of this network can result in pathological conditions, such as carcinogenesis.

This project aims to unravel the mechanisms governed by the ADP-ribosylation system that control cell state transitions. We will employ a multifaceted and interdisciplinary approach that includes proteomics, biochemistry, and molecular biology techniques. The long-term objective of this project is to identify novel therapeutic targets within the ADP-ribosylation network, which could serve as the basis for targeted interventions in the treatment of diseases such as cancer.