ZMB Member Matthias Epple
ZMB Member
Matthias Epple
Next ZMB-Member
Prof. Dr. Matthias Epple
Group
Inorganic ChemistryFaculty of Chemistry
University of Duisburg-Essen
Universitätsstr. 2
45141 Essen
- +49 201 183 2402
- Website
- Selected Publications
- Publication Metrics
- ZMB Research Program
Molecular and Chemical Cell Biology
Research Overview
- Synthesis and functionalization of inorganic nanoparticles, e.g. for gene and drug delivery and immunization
- Synthesis and characterization of metallic and bimetallic nanoparticles
- Development and application of biomaterials: polymers, ceramics, metals, composites; in close collaboration with physicians
- Study of biominerals with high-end solid-state chemical methods
- Biomimetic crystallization of inorganic materials, pathological crystallization phenomena
- Reactivity of solids
Selected Publications
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Barium sulphate microparticles are taken up by three different cell types: HeLa, THP-1, and hMSCIn: Acta Biomaterialia Vol. 164 (2023) pp. 577 - 587Online Full Text: dx.doi.org/
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Tissue engineering at the dentin-pulp interface using human treated dentin scaffolds conditioned with DMP1 or BMP2 plasmid DNA-carrying calcium phosphate nanoparticlesIn: Acta Biomaterialia Vol. 159 (2023) pp. 156 - 172Online Full Text: dx.doi.org/
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Covalent coupling of HIV-1 glycoprotein trimers to biodegradable calcium phosphate nanoparticles via genetically encoded aldehyde-tagsIn: Acta Biomaterialia Vol. 140 (2022) pp. 586 - 600Online Full Text: dx.doi.org/ (Open Access)
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Coating of cochlear implant electrodes with bioactive DNA-loaded calcium phosphate nanoparticles for the local transfection of stimulatory proteinsIn: Biomaterials Vol. 276 (2021)Online Full Text: dx.doi.org/
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Delivery of toll-like receptor 3 ligand poly(I:C) to the liver by calcium phosphate nanoparticles conjugated with an F4/80 antibody exerts an anti-hepatitis B virus effect in a mouse modelIn: Acta Biomaterialia Vol. 133 (2021) pp. 297 - 307Online Full Text: dx.doi.org/
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Gene transfection achieved by utilizing antibacterial calcium phosphate nanoparticles for enhanced regenerative therapyIn: Acta Biomaterialia Vol. 119 (2021) pp. 375 - 389Online Full Text: dx.doi.org/
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Silica-coated calcium phosphate nanoparticles for gene silencing of NF-κB p65 by siRNA and their impact on cellular players of inflammationIn: Biomaterials Vol. 276 (2021) pp. 121013Online Full Text: dx.doi.org/
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A pH-sensitive fluorescent protein sensor to follow the pathway of calcium phosphate nanoparticles into cellsIn: Acta Biomaterialia Vol. 111 (2020) pp. 406 - 417Online Full Text: dx.doi.org/
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Genetic immunization against hepatitis B virus with calcium phosphate nanoparticles in vitro and in vivoIn: Acta Biomaterialia Vol. 110 (2020) pp. 254 - 265Online Full Text: dx.doi.org/
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In vivo biodistribution of calcium phosphate nanoparticles after intravascular, intramuscular, intratumoral, and soft tissue administration in mice investigated by small animal PET/CTIn: Acta Biomaterialia Vol. 109 (2020) pp. 244 - 253Online Full Text: dx.doi.org/
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Reduction of inflammation in a chronic periodontitis model in rats by TNF-α gene silencing with a topically applied siRNA-loaded calcium phosphate pasteIn: Acta Biomaterialia Vol. 105 (2020) pp. 263 - 279Online Full Text: dx.doi.org/
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Ultrasmall gold nanoparticles (2 nm) can penetrate and enter cell nuclei in an in vitro 3D brain spheroid modelIn: Acta Biomaterialia Vol. 111 (2020) pp. 349 - 362Online Full Text: dx.doi.org/
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Calcium phosphate nanoparticle-mediated transfection in 2D and 3D mono- and co-culture cell modelsIn: Acta Biomaterialia Vol. 84 (2019) pp. 391 - 401Online Full Text: dx.doi.org/
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A systematic electron microscopic study on the uptake of barium sulphate nano-, submicro-, microparticles by bone marrow-derived phagocytosing cellsIn: Acta Biomaterialia Vol. 80 (2018) pp. 352 - 363Online Full Text: dx.doi.org/
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Review of potential health risks associated with nanoscopic calcium phosphateIn: Acta Biomaterialia Vol. 77 (2018) pp. 1 - 14Online Full Text: dx.doi.org/
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Avidin-conjugated calcium phosphate nanoparticles as a modular targeting system for the attachment of biotinylated molecules in vitro and in vivoIn: Acta Biomaterialia Vol. 57 (2017) pp. 414 - 425Online Full Text: dx.doi.org/
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Delivery of the TLR ligand poly(I:C) to liver cells in vitro and in vivo by calcium phosphate nanoparticles leads to a pronounced immunostimulationIn: Acta Biomaterialia Vol. 64 (2017) pp. 401 - 410Online Full Text: dx.doi.org/
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Multifunctional calcium phosphate nanoparticles for combining near-infrared fluorescence imaging and photodynamic therapyIn: Acta Biomaterialia Vol. 14 (2015) pp. 197 - 207Online Full Text: dx.doi.org/
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miR-542-3p exerts tumor suppressive functions in neuroblastoma by downregulating SurvivinIn: International Journal of Cancer Vol. 136 (2015) Nr. 6, pp. 1308 - 1320Online Full Text: dx.doi.org/ (Open Access)
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MSC-derived exosomes : a novel tool to treat therapy-refractory graft-versus-host diseaseIn: Leukemia Vol. 28 (2014) Nr. 4, pp. 970 - 973Online Full Text: dx.doi.org/
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Targeting and activation of antigen-specific B-cells by calcium phosphate nanoparticles, loaded with protein antigenIn: Biomaterials Vol. 35 (2014) Nr. 23, pp. 6098 - 6105Online Full Text: dx.doi.org/
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The relevance of biomaterials to the prevention and treatment of osteoporosisIn: Acta Biomaterialia Vol. 10 (2014) Nr. 5, pp. 1793 - 1805Online Full Text: dx.doi.org/
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Ultrastructural organization and micromechanical properties of shark tooth enameloidIn: Acta Biomaterialia Vol. 10 (2014) Nr. 9, pp. 3959 - 3968Online Full Text: dx.doi.org/
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Mechanism of the uptake of cationic and anionic calcium phosphate nanoparticles by cellsIn: Acta Biomaterialia Vol. 9 (2013) Nr. 7, pp. 7527 - 7535Online Full Text: dx.doi.org/
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Silver as Antibacterial Agent : Ion, Nanoparticle, and MetalIn: Angewandte Chemie International Edition Vol. 52 (2013) Nr. 6, pp. 1636 - 1653Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/
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A new tool for the transfection of corneal endothelial cells : calcium phosphate nanoparticlesIn: Acta Biomaterialia Vol. 8 (2012) Nr. 3, pp. 1156 - 1163Online Full Text: dx.doi.org/
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Cell type-specific responses of peripheral blood mononuclear cells to silver nanoparticlesIn: Acta Biomaterialia Vol. 7 (2011) Nr. 9, pp. 3505 - 3514Online Full Text: dx.doi.org/
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Quantitative determination of the composition of multi-shell calcium phosphate-oligonucleotide nanoparticles and their application for the activation of dendritic cellsIn: Acta Biomaterialia Vol. 7 (2011) Nr. 11, pp. 4029 - 4036Online Full Text: dx.doi.org/
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Uptake and intracellular distribution of silver nanoparticles in human mesenchymal stem cellsIn: Acta Biomaterialia Vol. 7 (2011) Nr. 1, pp. 347 - 354Online Full Text: dx.doi.org/
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Effect of hydroxyapatite on the biodegradation and the biomechanical stability of polyester nanocomposites for orthopaedic applicationsIn: Acta Biomaterialia Vol. 6 (2010) Nr. 3, pp. 763 - 775Online Full Text: dx.doi.org/
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SiRNA-loaded multi-shell nanoparticles incorporated into a multilayered film as a reservoir for gene silencingIn: Biomaterials Vol. 31 (2010) Nr. 23, pp. 6013 - 6018Online Full Text: dx.doi.org/
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The resorption of nanocrystalline calcium phosphates by osteoclast-like cellsIn: Acta Biomaterialia Vol. 6 (2010) Nr. 8, pp. 3223 - 3233Online Full Text: dx.doi.org/
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The use of calcium phosphate nanoparticles encapsulating toll-like receptor ligands and the antigen hemagglutinin to induce dendritic cell maturation and T cell activationIn: Biomaterials Vol. 31 (2010) Nr. 21, pp. 5627 - 5633Online Full Text: dx.doi.org/
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Calcium phosphate nanoparticles as efficient carriers for photodynamic therapy against cells and bacteriaIn: Biomaterials Vol. 30 (2009) Nr. 19, pp. 3324 - 3331Online Full Text: dx.doi.org/
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The use of size-defined DNA-functionalized calcium phosphate nanoparticles to minimise intracellular calcium disturbance during transfectionIn: Biomaterials Vol. 30 (2009) Nr. 35, pp. 6794 - 6802Online Full Text: dx.doi.org/
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Calcium phosphate crystals induce cell death in human vascular smooth muscle cells : A potential mechanism in atherosclerotic plaque destabilizationIn: Circulation Research Vol. 103 (2008) pp. e28 - e32Online Full Text: dx.doi.org/
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From metal complexes to nanominerals : the formation of inorganic nanoparticles on fibrils of transferrinIn: Angewandte Chemie International Edition Vol. 47 (2008) Nr. 27, pp. 4960 - 4961Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/
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Inorganic nanoparticles as carriers of nucleic acids into cellsIn: Angewandte Chemie International Edition Vol. 47 (2008) Nr. 8, pp. 1382 - 1395Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/
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X-ray Microcomputer Tomography for the Study of Biomineralized Endo- and Exoskeletons of AnimalsIn: Chemical Reviews Vol. 108 (2008) Nr. 11, pp. 4734 - 4741Online Full Text: dx.doi.org/
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X-ray micro computer tomography for the study of bio¬minera¬lized endo- and exoskeletons of animalsIn: Chemical Reviews Vol. 108 (2008) pp. 4734 - 4741
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Performance of functionally graded implants of polylactides and calcium phosphate/calcium carbonate in an ovine model for computer assisted craniectomy and cranioplastyIn: Biomaterials Vol. 28 (2007) Nr. 3, pp. 475 - 485Online Full Text: dx.doi.org/
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Effective transfection of cells with multi-shell calcium phosphate-DNA nanoparticlesIn: Biomaterials Vol. 27 (2006) Nr. 16, pp. 3147 - 3153Online Full Text: dx.doi.org/
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Morphological characterization and in vitro biocompatibility of a porous nickel-titanium alloyIn: Biomaterials Vol. 26 (2005) Nr. 29, pp. 5801 - 5807Online Full Text: dx.doi.org/
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A novel method to produce hydroxyapatite objects with interconnecting porosity that avoids sinteringIn: Biomaterials Vol. 25 (2004) Nr. 16, pp. 3335 - 3340Online Full Text: dx.doi.org/
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A thorough physicochemical characterisation of 14 calcium phosphate-based bone substitution materials in comparison to natural boneIn: Biomaterials Vol. 25 (2004) Nr. 6, pp. 987 - 994Online Full Text: dx.doi.org/
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Geometrically structured implants for cranial reconstruction made of biodegradable polyesters and calcium phosphate/calcium carbonateIn: Biomaterials Vol. 25 (2004) Nr. 7-8, pp. 1239 - 1247Online Full Text: dx.doi.org/
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Inhibition of PMN apoptosis after adherence to dip-coated calcium phosphate surfaces on a NiTi shape memory alloyIn: Biomaterials Vol. 25 (2004) Nr. 19, pp. 4627 - 4632Online Full Text: dx.doi.org/
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Calcium phosphate coating of nickel-titanium shape-memory alloys : Coating procedure and adherence of leukocytes and plateletsIn: Biomaterials Vol. 24 (2003) Nr. 21, pp. 3689 - 3696Online Full Text: dx.doi.org/
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Carbonated calcium phosphates are suitable pH-stabilising fillers for biodegradable polyestersIn: Biomaterials Vol. 24 (2003) Nr. 12, pp. 2037 - 2043Online Full Text: dx.doi.org/
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Mechanically stable implants of synthetic bone mineral by cold isostatic pressingIn: Biomaterials Vol. 24 (2003) Nr. 25, pp. 4565 - 4571Online Full Text: dx.doi.org/
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Biological and Medical Significance of Calcium PhosphatesIn: Angewandte Chemie International Edition Vol. 41 (2002) Nr. 17, pp. 3130 - 3146Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/
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Continuous synthesis of amorphous carbonated apatitesIn: Biomaterials Vol. 23 (2002) Nr. 12, pp. 2553 - 2559Online Full Text: dx.doi.org/
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Easy assessment of the biocompatibility of Ni-Ti alloys by in vitro cell culture experiments on a functionally graded Ni-NiTi-Ti materialIn: Biomaterials Vol. 23 (2002) Nr. 23, pp. 4549 - 4555Online Full Text: dx.doi.org/
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Basic Principles of Thermoanalytical Techniques and Their Applications in Preparative ChemistryIn: Angewandte Chemie International Edition Vol. 34 (1995) Nr. 11, pp. 1171 - 1187Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/