A03

© D.Schuhmann / UDE

Project Area A - Biology and Molecular Oncology

Prof. Dr. Hemmo Meyer

Molecular Biology I

University of Duisburg-Essen

Phone: +49 201 183 4217
Email

VCP/p97-cofactor complexes at the intersection of DNA repair and checkpoint control

Meyer will concentrate on deconvolving the functions of the VCP/p97 ATPase and its many cofactor proteins in DNA damage responses. He will use a systematic combination of mass spectrometry, PROTAC-induced protein degradation and cell-free reconstitution approaches. The aim is to identify targets and dissect the exact role of p97-cofactor complexes in alternative DNA damage repair pathways and checkpoint signaling that control cell state transitions, and then explore the relevance for genomic stability and survival in cancer cell models.

Project Members

Dr. Maike Reinders

maike.giesing@uni-due.de

Daniella Munro

daniella.munro@uni-due.de

Alexander Kröning

alexander.kroening@uni-due.de

Sandra Koska

sandra.koska@uni-due.de

Publications

    Journal articles

  • Kück, Anja; van den Boom, Johannes; Koska, Sandra; Ron, David; Meyer, Hemmo
    Alternating binding and p97-mediated dissociation of SDS22 and I3 recycles active PP1 between holophosphatases
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Vol. 121 (2024) Nr. 36, e2408787121
    Online Full Text: dx.doi.org/ (Open Access)
  • Gahlot, Pinki; Kravic, Bojana; Rota, Giulia; van den Boom, Johannes; Levantovsky, Sophie; Schulze, Nina; Maspero, Elena; Polo, Simona; Behrends, Christian; Meyer, Hemmo
    Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH
    In: Molecular Cell (2024) pp. 1556 - 1569.e10
    Online Full Text: dx.doi.org/ (Open Access)
  • Meyer, Hemmo; Kravic, Bojana
    The Endo-Lysosomal Damage Response
    In: Annual Review of Biochemistry Vol. 93 (2024) Nr. 1, pp. 367 - 387
    Online Full Text: dx.doi.org/ (Open Access)
  • van den Boom, Johannes; Marini, Guendalina; Meyer, Hemmo; Saibil, Helen R
    Structural basis of ubiquitin-independent PP1 complex disassembly by p97
    In: The EMBO Journal Vol. 42 (2023) Nr. 14, e113110
    Online Full Text: dx.doi.org/ (Open Access)
  • Meyer, Hemmo; van den Boom, Johannes
    Targeting of client proteins to the VCP/p97/Cdc48 unfolding machine
    In: Frontiers in Molecular Biosciences Vol. 10 (2023) 1142989
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Blüggel, Mike; Kröning, Alexander; Kracht, Matthias; van den Boom, Johannes; Dabisch, Matthias; Göhring, Anna; Kaschani, Farnusch; Kaiser, Markus; Bayer, Peter; Meyer, Hemmo; Beuck, Christine
    The UBX domain in UBXD1 organizes ubiquitin binding at the C-terminus of the VCP/p97 AAA-ATPase
    In: Nature Communications Vol. 14 (2023) Nr. 1, 3258
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Kravić, Bojana; Bionda, Tihana; Siebert, Alexander; Gahlot, Pinki; Levantovsky, Sophie; Behrends, Christian; Meyer, Hemmo
    Ubiquitin profiling of lysophagy identifies actin stabilizer CNN2 as a target of VCP/p97 and uncovers a link to HSPB1
    In: Molecular Cell Vol. 82 (2022) Nr. 14, pp. 2633 - 2649.e7
    Online Full Text: dx.doi.org/ (Open Access)
  • Kröning, Alexander; van den Boom, Johannes; Kracht, Matthias; Kück, Anja; Meyer, Hemmo
    Ubiquitin-directed AAA+ ATPase p97/VCP unfolds stable proteins crosslinked to DNA for proteolysis by SPRTN
    In: The Journal of Biological Chemistry (JBC) Vol. 298 (2022) Nr. 6, 101976
    Online Full Text: dx.doi.org/ (Open Access)