Dr. Simon Poepsel

Structure and Biochemistry of Epigenetic Regulators

University of Cologne

Phone: +49 221 478 96987
Email

The dynamics of cellular states, such as differentiation or proliferative activity, are controlled by the coordinated regulation of genes. Chemical modifications of histone proteins, core components of chromatin, help to select genes for activation or repression. We are interested in understanding the mechanisms by which histone modifying enzymes are regulated to faithfully establish and maintain patterns of gene activity, thereby determining cell state transitions.
In this project, we are focusing on a histone lysine demethylase, JARID1B, that is essential for malignant cellular phenotypes of melanoma cancer cells. To understand its mechanism of function, we are employing biochemical and structural biology approaches, using e.g. cryo-electron microscopy. Specifically, we are addressing how the engagement of JARID1B with its chromatin substrates and other interaction partners regulates its activity or demethylation independent functions, opening up novel therapeutic opportunities.