B01

© Kaiser

Project Area B - Chemical Biology

Prof. Dr. Markus Kaiser

Chemical Biology

University of Duisburg-Essen

Phone: +49 201 183 4980
Email

Developing chemical tools for investigating cell state transitions

This project deals with the development of chemical tools for deciphering molecular mechanisms of cell state transitions. In subproject 1, we will investigate chemical strategies to achieve targeted protein degradation, e.g. by the design and synthesis of chemically novel PROTACs. These studies will include the development of new E3 ubiquitin ligase recruiting units. In subproject 2, we will generate small molecule tools for acute perturbation of the metastatic switch. To this end, we will explore structure-activity relationships as well as the biological scope and selectivity of established inhibitors of metastasis. In the long term, these studies should result in the development of novel anticancer agents with complementary bioactivities to current chemotherapeutics.

Project Members

Niko Molke

niko.molke@.uni-due.de

Lukas Schrapp

lukas.schrapp@.uni-due.de

Publications

    Journal articles

  • Pol, Savina Abraham; Liljenberg, Sara; Barr, Jack; Simon, Gina; Wong-Dilworth, Luis; Paterson, Danielle L.; Berishvili, Vladimir P.; Bottanelli, Francesca; Kaschani, Farnusch; Kaiser, Markus; Pettersson, Mariell; Hellerschmied, Doris
    Induced degradation of SNAP-fusion proteins
    In: RSC Chemical Biology (2024) in press
    Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ (Open Access)
  • Pleuger, Richard; Cozma, Christian; Hohoff, Simone; Denkhaus, Christian; Dudziak, Alexander; Kaschani, Farnusch; Kaiser, Markus; Musacchio, Andrea; Vetter, Ingrid R.; Westermann, Stefan
    Microtubule end-on attachment maturation regulates Mps1 association with its kinetochore receptor
    In: Current Biology Vol. 34 (2024) Nr. 11, pp. 2279 - 2293.e6
    Online Full Text: dx.doi.org/ (Open Access)
  • Beaufort, Nathalie; Ingendahl, Linda; Merdanovic, Melisa; Schmidt, Andree; Podlesainski, David; Richter, Tim; Neumann, Thorben; Kuszner, Michael; Vetter, Ingrid R.; Stege, Patricia; Burston, Steven G.; Filipovic, Anto; Ruiz-Blanco, Yasser B.; Bravo Rodriguez, Kenny; Mieres-Perez, Joel; Beuck, Christine; Uebel, Stephan; Zobawa, Monika; Schillinger, Jasmin; Malik, Rainer; Todorov-Völgyi, Katalin; Rey, Juliana; Roberti, Annabell; Hagemeier, Birte; Wefers, Benedikt; Müller, Stephan A.; Wurst, Wolfgang; Sanchez-Garcia, Elsa; Zimmermann, Alexander; Hu, Xiao-Yu; Clausen, Tim; Huber, Robert; Lichtenthaler, Stefan F.; Schmuck, Carsten; Giese, Michael; Kaiser, Markus; Ehrmann, Michael; Dichgans, Martin
    Rational correction of pathogenic conformational defects in HTRA1
    In: Nature Communications Vol. 15 (2024) Nr. 1, 5944
    Online Full Text: dx.doi.org/ (Open Access)
  • Day, Matthew; Tetik, Bilal; Parlak, Milena; Almeida-Hernández, Yasser; Räschle, Markus; Kaschani, Farnusch; Siegert, Heike; Marko, Anika; Sanchez-Garcia, Elsa; Kaiser, Markus; Barker, Isabel A.; Pearl, Laurence H.; Oliver, Antony W.; Boos, Dominik
    TopBP1 utilises a bipartite GINS binding mode to support genome replication
    In: Nature Communications Vol. 15 (2024) Nr. 1, 1797
    Online Full Text: dx.doi.org/; Online Full Text: dx.doi.org/ (Open Access)
  • Hoi, David M.; Junker, Sabryna; Junk, Lukas; Schwechel, Kristin; Fischel, Katharina; Podlesainski, David; Hawkins, Paige M.E.; van Geelen, Lasse; Kaschani, Farnusch; Leodolter, Julia; Morreale, Francesca Ester; Kleine, Stefan; Guha, Somraj; Rumpel, Klaus; Schmiedel, Volker M.; Weinstabl, Harald; Meinhart, Anton; Payne, Richard J.; Kaiser, Markus; Hartl, Markus; Boehmelt, Guido; Kazmaier, Uli; Kalscheuer, Rainer; Clausen, Tim
    Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival
    In: Cell Vol. 186 (2023) Nr. 10, pp. 2176 - 2192.e22
    Online Full Text: dx.doi.org/ (Open Access)
  • Fehr, Lorenz; Sewald, Leonard; Huber, Robert; Kaiser, Markus
    Facile Multicomponent Synthesis of Oxazolidinones from Primary Amines and Cesium (Hydrogen)Carbonate
    In: European Journal of Organic Chemistry Vol. 26 (2023) Nr. 27, e202300135
    Online Full Text: dx.doi.org/ (Open Access)
  • Blüggel, Mike; Kröning, Alexander; Kracht, Matthias; van den Boom, Johannes; Dabisch, Matthias; Göhring, Anna; Kaschani, Farnusch; Kaiser, Markus; Bayer, Peter; Meyer, Hemmo; Beuck, Christine
    The UBX domain in UBXD1 organizes ubiquitin binding at the C-terminus of the VCP/p97 AAA-ATPase
    In: Nature Communications Vol. 14 (2023) Nr. 1, 3258
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Carvalho, Luís A. R.; Ross, Breyan; Fehr, Lorenz; Bolgi, Oguz; Wöhrle, Svenja; Lum, Kenneth M.; Podlesainski, David; Vieira, Andreia C.; Kiefersauer, Reiner; Félix, Rita; Rodrigues, Tiago; Lucas, Susana D.; Groß, Olaf; Geiss‐Friedlander, Ruth; Cravatt, Benjamin F.; Huber, Robert; Kaiser, Markus; Moreira, Rui
    Chemoproteomics‐Enabled Identification of 4‐Oxo‐β‐Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9
    In: Angewandte Chemie International Edition Vol. 61 (2022) Nr. 47, e202210498
    Online Full Text: dx.doi.org/ (Open Access)
  • Chauvistré, Heike; Shannan, Batool; Daignault-Mill, Sheena M.; Ju, Robert J.; Picard, Daniel; Egetemaier, Stefanie; Váraljai, Renáta; Gibhardt, Christine S.; Sechi, Antonio; Kaschani, Farnusch; Keminer, Oliver; Stehbens, Samantha J.; Liu, Qin; Yin, Xiangfan; Jeyakumar, Kirujan; Vogel, Felix C. E.; Krepler, Clemens; Rebecca, Vito W.; Kubat, Linda; Lueong, Smiths S.; Forster, Jan; Horn, Susanne; Remke, Marc; Ehrmann, Michael; Paschen, Annette; Becker, Jürgen; Helfrich, Iris; Rauh, Daniel; Kaiser, Markus; Gul, Sheraz; Herlyn, Meenhard; Bogeski, Ivan; Rodríguez-López, José Neptuno; Haass, Nikolas K.; Schadendorf, Dirk; Rösch, Alexander
    Persister state-directed transitioning and vulnerability in melanoma
    In: Nature Communications Vol. 13 (2022) Nr. 1, 3055
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Dorsch, Madeleine; Kowalczyk, Manuela; Planque, Mélanie; Heilmann, Geronimo; Urban, Sebastian; Dujardin, Philip; Forster, Jan; Ueffing, Kristina; Nothdurft, Silke; Oeck, Sebastian; Paul, Annika; Liffers, Sven T.; Kaschani, Farnusch; Kaiser, Markus; Schramm, Alexander; Siveke, Jens; Winslow, Monte M.; Fendt, Sarah-Maria; Nalbant, Perihan; Grüner, Barbara M.
    Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis
    In: Cell Reports Vol. 37 (2021) Nr. 8, 110056
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)

    • Preprints

  • Blümke, Anika; Hagemeier, Birte; Ripkens, Kamilla; Schulze, Nina; Strzala, Michal; Koci, Michelle; Kaschani, Farnusch; Kaiser, Markus; Erkelenz, Michael; Schlücker, Sebastian; Merdanovic, Melisa; Poepsel, Simon; Hellerschmied-Jelinek, Doris; Burston, Steve; Ehrmann, Michael
    A non-autonomous protein quality control mechanism targeting tau aggregate propagation
    (2024)
    Online Full Text: dx.doi.org/ (Open Access)
  • Brenner, Joel Cyrille; Zirden, Linda; Almeida-Hernandez, Yasser; Kaschani, Farnusch; Kaiser, Markus; Sanchez-Garcia, Elsa; Poepsel, Simon; Hellerschmied-Jelinek, Doris
    Conformational plasticity of a BiP-GRP94 chaperone complex
    (2024)
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)