ZMB Member Stefan Raunser

ZMB Member
Stefan Raunser

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portrait photo of ZMB member Stefan Raunser
© MPI/Raunser

Prof. Dr. Stefan Raunser

Group

Structural Biochemistry

Max Planck Institute of Molecular Physiology
Otto-Hahn-Str. 11
44227 Dortmund

Research Overview

In general, our research focuses on structural and functional studies of macromolecular protein complexes. Its three research groups focus on important biological questions concerning processes at or in the cell membrane, in particular toxin-mediated membrane permeation, membrane homeostasis, and membrane fusion. Furthermore, we want to understand the molecular details of muscle contraction and the dynamics of chromatin.
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Selected Publications

    Journal articles

  • Polley, Soumitra; Raisch, Tobias; Ghetti, Sabrina; Körner, Marie; Terbeck, Melina; Gräter, Frauke; Raunser, Stefan; Aponte-Santamaría, Camilo; Vetter, Ingrid R.; Musacchio, Andrea
    Structure of the human KMN complex and implications for regulation of its assembly
    In: Nature Structural & Molecular Biology Vol. 31 (2024) Nr. 6, pp. 861 - 873
    Online Full Text: dx.doi.org/ (Open Access)
  • Raisch, Tobias; Ciossani, Giuseppe; d’Amico, Ennio; Cmentowski, Verena; Carmignani, Sara; Maffini, Stefano; Merino, Felipe; Wohlgemuth, Sabine; Vetter, Ingrid R.; Raunser, Stefan; Musacchio, Andrea
    Structure of the RZZ complex and molecular basis of Spindly‐driven corona assembly at human kinetochores
    In: The EMBO Journal Vol. 41 (2022) Nr. 9, e110411
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Pesenti, Marion E.; Raisch, Tobias; Conti, Duccio; Walstein, Kai; Hoffmann, Ingrid; Vogt, Dorothee; Prumbaum, Daniel; Vetter, Ingrid R.; Raunser, Stefan; Musacchio, Andrea
    Structure of the human inner kinetochore CCAN complex and its significance for human centromere organization
    In: Molecular Cell Vol. 82 (2022) Nr. 11, pp. 2113 - 2131.e8
    Online Full Text: dx.doi.org/ (Open Access)
  • Ludwig, Anna-Kristin; De Miroschedji, Kyra; Döppner, Thorsten R.; Börger, Verena; Ruesing, Johannes; Rebmann, Vera; Durst, Stephan; Jansen, Sören; Bremer, Michel; Behrmann, Elmar; Singer, Bernhard B.; Jastrow, Holger; Kuhlmann, Jan Dominik; El Magraoui, Fouzi; Meyer, Helmut E.; Hermann, Dirk M.; Opalka, Bertram; Raunser, Stefan; Epple, Matthias; Horn, Peter; Giebel, Bernd
    Precipitation with polyethylene glycol followed by washing and pelleting by ultracentrifugation enriches extracellular vesicles from tissue culture supernatants in small and large scales
    In: Journal of Extracellular Vesicles (JEV) Vol. 7 (2018) Nr. 1, pp. 1528109
    Online Full Text: dx.doi.org/ (Open Access)
  • Pesenti, Marion E; Prumbaum, Daniel; Auckland, Philip; Smith, Charlotte M; Faesen, Alex C; Petrovic, Arsen; Erent, Muriel; Maffini, Stefano; Pentakota, Satyakrishna; Weir, John R; Lin, Yu-Chih; Raunser, Stefan; McAinsh, Andrew D; Musacchio, Andrea
    Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80.
    In: Molecular Cell Vol. 71 (2018) Nr. 6, pp. 923 - 939.e10
    Online Full Text: dx.doi.org/ (Open Access)
  • Mosalaganti, Shyamal; Keller, Jenny; Altenfeld, Anika; Winzker, Michael; Rombaut, Pascaline; Saur, Michael; Petrovic, Arsen; Wehenke, Annemarie; Wohlgemuth, Sabine; Müller, Franziska; Maffini, Stefano; Bange, Tanja; Herzog, Franz; Waldmann, Herbert; Raunser, Stefan; Musacchio, Andrea
    Structure of the RZZ complex and molecular basis of its interaction with Spindly
    In: The Journal of Cell Biology (JCB) Vol. 216 (2017) Nr. 4, pp. 961 - 981
    Online Full Text: dx.doi.org/ (Open Access)
  • Liu, Yahui; Petrovic, Arsen; Rombaut, Pascaline; Mosalaganti, Shyamal; Keller, Jenny; Raunser, Stefan; Herzog, Franz; Musacchio, Andrea
    Insights from the reconstitution of the divergent outer kinetochore of Drosophila melanogaster
    In: Open Biology Vol. 6 (2016) Nr. 2, 150236
    Online Full Text: dx.doi.org/ (Open Access)
  • Friese, Alexandra; Musacchio, Andrea; Herzog, Franz; Raunser, Stefan; Petrovic, Arsen; Prumbaum, Daniel; Fischböck, Josef; Huis in ‘t Veld,, Pim J.; Faesen, Alex C.
    Molecular requirements for the inter-subunit interaction and kinetochore recruitment of SKAP and Astrin
    In: Nature Communications Vol. 7 (2016) pp. 11407
    Online Full Text: dx.doi.org/ (Open Access)
  • Poepsel, Simon; Sprengel, Andreas; Sacca, Barbara; Kaschani, Farnusch; Kaiser, Markus; Gatsogiannis, Christos; Raunser, Stefan; Clausen, Tim; Ehrmann, Michael
    Determinants of amyloid fibril degradation by the PDZ protease HTRA1
    In: Nature Chemical Biology Vol. 11 (2015) Nr. 11, pp. 862 - 869
    Online Full Text: dx.doi.org/ Online Full Text (Open Access)
  • Erkelenz, Michael; Bauer, Dennis M.; Meyer, Rebecca; Gatsogiannis, Christos; Raunser, Stefan; Sacca, Barbara; Niemeyer, Christof M.
    A facile method for preparation of tailored scaffolds for DNA-origami
    In: Small Vol. 10 (2014) Nr. 1, pp. 73 - 77
    Online Full Text: dx.doi.org/
  • Petrovic, Arsen; Mosalaganti, Shyamal; Keller, Jenny; Mattiuzzo, Marta; Overlack, Katharina; Krenn, Veronica; De Antoni, Anna; Wohlgemuth, Sabine; Cecatiello, Valentina; Pasqualato, Sebastiano; Raunser, Stefan; Musacchio, Andrea
    Modular Assembly of RWD Domains on the Mis12 Complex Underlies Outer Kinetochore Organization
    In: Molecular Cell Vol. 53 (2014) Nr. 4, pp. 591 - 605
    Online Full Text: dx.doi.org/ (Open Access)
  • Basilico, Federica; Maffini, Stefano; Weir, John R.; Prumbaum, Daniel; Rojas, Ana M.; Zimniak, Tomasz; De Antoni, Anna; Jeganathan, Sadasivam; Voss, Beate; Van Gerwen, Suzan; Krenn, Veronica; Massimiliano, Lucia; Valencia, Alfonso; Vetter, Ingrid R.; Herzog, Franz; Raunser, Stefan; Pasqualato, Sebastiano; Musacchio, Andrea
    The pseudo GTPase CENP-M drives human kinetochore assembly
    In: eLife Vol. 3 (2014) pp. e02978
    Online Full Text: dx.doi.org/ (Open Access)
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